{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T22:30:09Z","timestamp":1775082609942,"version":"3.50.1"},"reference-count":171,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T00:00:00Z","timestamp":1668211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sirius University budgetary funds","award":["NRB-RND-2116"],"award-info":[{"award-number":["NRB-RND-2116"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Channelopathies are a large group of systemic disorders whose pathogenesis is associated with dysfunctional ion channels. Aberrant transmembrane transport of K+, Na+, Ca2+ and Cl\u2212 by these channels in the brain induces central nervous system (CNS) channelopathies, most commonly including epilepsy, but also migraine, as well as various movement and psychiatric disorders. Animal models are a useful tool for studying pathogenesis of a wide range of brain disorders, including channelopathies. Complementing multiple well-established rodent models, the zebrafish (Danio rerio) has become a popular translational model organism for neurobiology, psychopharmacology and toxicology research, and for probing mechanisms underlying CNS pathogenesis. Here, we discuss current prospects and challenges of developing genetic, pharmacological and other experimental models of major CNS channelopathies based on zebrafish.<\/jats:p>","DOI":"10.3390\/ijms232213979","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T02:29:32Z","timestamp":1668392972000},"page":"13979","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Towards Zebrafish Models of CNS Channelopathies"],"prefix":"10.3390","volume":"23","author":[{"given":"Tatiana O.","family":"Kolesnikova","sequence":"first","affiliation":[{"name":"Neurobiology Program, Sirius University of Science and Technology, 354349 Sochi, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantin A.","family":"Demin","sequence":"additional","affiliation":[{"name":"Institute of Translational Biomedicine, St. Petersburg State University, 199034 St. Petersburg, Russia"},{"name":"Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, 197341 St. Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6218-9660","authenticated-orcid":false,"given":"Fabiano V.","family":"Costa","sequence":"additional","affiliation":[{"name":"Neurobiology Program, Sirius University of Science and Technology, 354349 Sochi, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantin N.","family":"Zabegalov","sequence":"additional","affiliation":[{"name":"Neurobiology Program, Sirius University of Science and Technology, 354349 Sochi, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5562-0715","authenticated-orcid":false,"given":"Murilo S.","family":"de Abreu","sequence":"additional","affiliation":[{"name":"Moscow Institute of Physics and Technology, 141701 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0623-8496","authenticated-orcid":false,"given":"Elena V.","family":"Gerasimova","sequence":"additional","affiliation":[{"name":"Neurobiology Program, Sirius University of Science and Technology, 354349 Sochi, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7525-1950","authenticated-orcid":false,"given":"Allan V.","family":"Kalueff","sequence":"additional","affiliation":[{"name":"Neurobiology Program, Sirius University of Science and Technology, 354349 Sochi, Russia"},{"name":"Institute of Translational Biomedicine, St. Petersburg State University, 199034 St. Petersburg, Russia"},{"name":"Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, 197341 St. Petersburg, Russia"},{"name":"Moscow Institute of Physics and Technology, 141701 Moscow, Russia"},{"name":"Laboratory of Preclinical Bioscreening, Granov Russian Research Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, 197758 St. Petersburg, Russia"},{"name":"Ural Federal University, 620002 Yekaterinburg, Russia"},{"name":"Scientific Research Institute of Neurosciences and Medicine, 630117 Novosibirsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1527-3458.2001.tb00196.x","article-title":"Ion channel diseases of the central nervous system","volume":"7","author":"Li","year":"2001","journal-title":"CNS Drug Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3345\/kjp.2014.57.1.1","article-title":"Channelopathies","volume":"57","author":"Kim","year":"2014","journal-title":"Korean J. 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