{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T21:39:06Z","timestamp":1768253946955,"version":"3.49.0"},"reference-count":62,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,13]],"date-time":"2022-11-13T00:00:00Z","timestamp":1668297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"National Science Centre, Krak\u00f3w, Poland","doi-asserted-by":"publisher","award":["2012\/06\/A\/NZ3\/00022"],"award-info":[{"award-number":["2012\/06\/A\/NZ3\/00022"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Recent years have provided more and more evidence confirming the important role of Wnt\/\u03b2-catenin signaling in the pathophysiology of mental illnesses, including cocaine use disorder. High relapse rates, which is a hallmark of drug addiction, prompt the study of changes in Wnt signaling elements (Wnt5a, Wnt7b, and Ctnnb1) in the motivational aspects of cocaine use and early drug-free period (3 days after the last exposure to cocaine). For this purpose, an animal model of intravenous cocaine self-administration and two types of drug-free period (extinction training and abstinence in the home cage) were used. The studies showed that chronic cocaine self-administration mainly disturbs the expression of Wnt5a and Ctnnb1 (the gene encoding \u03b2-catenin) in the examined brain structures (striatum and hippocampus), and the examined types of early abstinence are characterized by a different pattern of changes in the expression of these genes. At the same time, in cocaine self-administrated animals, there were no changes in the level of Wnt5a and \u03b2-catenin proteins at the tested time points. Moreover, exposure to cocaine induces a significant reduction in the striatal and hippocampal expression of miR-374 and miR-544, which can regulate Wnt5a levels post-transcriptionally. In summary, previous observations from experimenter-administered cocaine have not been fully validated in the cocaine self-administration model. Yoked cocaine administration appears to disrupt Wnt signaling more than cocaine self-administration. The condition of the cocaine-free period, the routes of drug administration, and the motivational aspect of drug administration play an important role in the type of drug-induced molecular changes observed. Furthermore, in-depth research involving additional brain regions is needed to determine the exact role of Wnt signaling in short-term and long-lasting plasticity as well as in the motivational aspects of cocaine use, and thus to assess its potential as a target for new drug therapy for cocaine use disorder.<\/jats:p>","DOI":"10.3390\/ijms232214011","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T02:29:32Z","timestamp":1668392972000},"page":"14011","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cocaine and Its Abstinence Condition Modulate Striatal and Hippocampal Wnt Signaling in a Male Rat Model of Drug Self-Administration"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9376-0564","authenticated-orcid":false,"given":"Dawid","family":"Gawli\u0144ski","sequence":"first","affiliation":[{"name":"Department of Drug Addiction Pharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, Sm\u0119tna 12 Street, 31-343 Krak\u00f3w, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7015-154X","authenticated-orcid":false,"given":"Kinga","family":"Gawli\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Drug Addiction Pharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, Sm\u0119tna 12 Street, 31-343 Krak\u00f3w, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6646-6140","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Frankowska","sequence":"additional","affiliation":[{"name":"Department of Drug Addiction Pharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, Sm\u0119tna 12 Street, 31-343 Krak\u00f3w, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4321-7942","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Filip","sequence":"additional","affiliation":[{"name":"Department of Drug Addiction Pharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, Sm\u0119tna 12 Street, 31-343 Krak\u00f3w, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1176\/appi.ajp.2020.20091382","article-title":"Substance Use Disorders and Addiction: Mechanisms, Trends, and Treatment Implications","volume":"177","author":"Kalin","year":"2020","journal-title":"Am. J. Psychiatry"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1007\/s11606-019-05074-8","article-title":"Pharmacotherapy for Cocaine Use Disorder-a Systematic Review and Meta-Analysis","volume":"34","author":"Chan","year":"2019","journal-title":"J. Gen. Intern. Med."},{"key":"ref_3","unstructured":"(2022, September 01). A World Drug Report. Available online: https:\/\/www.unodc.org\/unodc\/data-and-analysis\/wdr2021.html."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/jnc.13863","article-title":"Role of Wnt\/\u03b2-Catenin Pathway in the Nucleus Accumbens in Long-Term Cocaine-Induced Neuroplasticity: A Possible Novel Target for Addiction Treatment","volume":"140","author":"Cuesta","year":"2017","journal-title":"J. Neurochem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1111\/adb.12377","article-title":"Wnt\/\u03b2-Catenin Pathway in the Prefrontal Cortex Is Required for Cocaine-Induced Neuroadaptations","volume":"22","author":"Cuesta","year":"2017","journal-title":"Addict. Biol."},{"key":"ref_6","first-page":"112","article-title":"Are Changes in the Wnt\/\u03b2-Catenin Pathway Involved in Cocaine and Stress-Induced Long-Term Neuroadaptations?","volume":"2","author":"Cuesta","year":"2017","journal-title":"J. Add. Pre. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.semcdb.2015.05.002","article-title":"Spatial and Temporal Aspects of Wnt Signaling and Planar Cell Polarity during Vertebrate Embryonic Development","volume":"42","author":"Sokol","year":"2015","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1749-8104-3-32","article-title":"Wnts Acting through Canonical and Noncanonical Signaling Pathways Exert Opposite Effects on Hippocampal Synapse Formation","volume":"3","author":"Davis","year":"2008","journal-title":"Neural Dev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3389\/fncel.2019.00227","article-title":"Wnt Signaling Deregulation in the Aging and Alzheimer\u2019s Brain","volume":"13","author":"Palomer","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40659-016-0071-x","article-title":"Wnt-5a-Regulated MiR-101b Controls COX2 Expression in Hippocampal Neurons","volume":"49","author":"Codocedo","year":"2016","journal-title":"Biol. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"640","DOI":"10.4161\/cbt.313","article-title":"Developmental Expression of Wnt Signaling Factors in Mouse Brain","volume":"1","author":"Sweet","year":"2002","journal-title":"Cancer Biol. Ther."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"a008003","DOI":"10.1101\/cshperspect.a008003","article-title":"Wnt Signaling in the Vertebrate Central Nervous System: From Axon Guidance to Synaptic Function","volume":"4","author":"Salinas","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"dev165902","DOI":"10.1242\/dev.165902","article-title":"Wnt Signalling: Conquering Complexity","volume":"145","author":"Wiese","year":"2018","journal-title":"Development"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"108148","DOI":"10.1016\/j.drugalcdep.2020.108148","article-title":"Cocaine Use and Overdose Mortality in the United States: Evidence from Two National Data Sources, 2002-2018","volume":"214","author":"Cano","year":"2020","journal-title":"Drug Alcohol Depend."},{"key":"ref_15","first-page":"112","article-title":"Substance Misuse and Substance Use Disorders: Why Do They Matter in Healthcare?","volume":"128","author":"McLellan","year":"2017","journal-title":"Trans. Am. Clin. Climatol. Assoc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"zcaa025","DOI":"10.1093\/narcan\/zcaa025","article-title":"Addressing Cancer Signal Transduction Pathways with Antisense and SiRNA Oligonucleotides","volume":"2","author":"Juliano","year":"2020","journal-title":"NAR Cancer"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1023\/A:1020929526688","article-title":"Repeated Cocaine Self-Administration Causes Multiple Changes in Rat Frontal Cortex Gene Expression","volume":"27","author":"Freeman","year":"2002","journal-title":"Neurochem. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0306-4522(01)00432-8","article-title":"Cocaine-Responsive Gene Expression Changes in Rat Hippocampus","volume":"108","author":"Freeman","year":"2001","journal-title":"Neuroscience"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1046\/j.1471-4159.2001.00252.x","article-title":"Chronic Cocaine-Mediated Changes in Non-Human Primate Nucleus Accumbens Gene Expression","volume":"77","author":"Freeman","year":"2001","journal-title":"J. Neurochem."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Schwendt, M., and Knackstedt, L.A. (2021). Extinction vs. Abstinence: A Review of the Molecular and Circuit Consequences of Different Post-Cocaine Experiences. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22116113"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1177\/0269881118821113","article-title":"Alternation in Dopamine D2-like and Metabotropic Glutamate Type 5 Receptor Density Caused by Differing Housing Conditions during Abstinence from Cocaine Self-Administration in Rats","volume":"33","author":"Frankowska","year":"2019","journal-title":"J. Psychopharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Gawli\u0144ska, K., Frankowska, M., Gawli\u0144ski, D., Piechota, M., Korosty\u0144ski, M., and Filip, M. (2020). Cocaine Administration and Its Abstinence Conditions Modulate Neuroglia. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21217970"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s00018-015-2076-y","article-title":"WNT-5A: Signaling and Functions in Health and Disease","volume":"73","author":"Kumawat","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1159\/000495932","article-title":"Wnt-5a Promotes Neural Development and Differentiation by Regulating CDK5 via Ca2+\/Calpain Pathway","volume":"51","author":"Shu","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3389\/fncel.2017.00281","article-title":"Wnt5a Promotes Cortical Neuron Survival by Inhibiting Cell-Cycle Activation","volume":"11","author":"Zhou","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5873","DOI":"10.1523\/JNEUROSCI.0183-09.2009","article-title":"Wnt5a Induces Simultaneous Cortical Axon Outgrowth and Repulsive Axon Guidance through Distinct Signaling Mechanisms","volume":"29","author":"Li","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1750-1326-5-3","article-title":"Wnt-5a Occludes A\u03b2 Oligomer-Induced Depression of Glutamatergic Transmission in Hippocampal Neurons","volume":"5","author":"Cerpa","year":"2010","journal-title":"Mol. Neurodegener."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/stem.3121","article-title":"Wnt5a Promotes Differentiation and Development of Adult-Born Neurons in the Hippocampus by Noncanonical Wnt Signaling","volume":"38","author":"Arredondo","year":"2020","journal-title":"Stem Cells"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"7395","DOI":"10.1038\/s41598-021-86708-y","article-title":"Wnt5a Promotes Hippocampal Postsynaptic Development and GluN2B-Induced Expression via the EIF2\u03b1 HRI Kinase","volume":"11","author":"Oliva","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.celrep.2017.09.023","article-title":"A Wnt\/Calcium Signaling Cascade Regulates Neuronal Excitability and Trafficking of NMDARs","volume":"21","author":"McQuate","year":"2017","journal-title":"Cell Rep."},{"key":"ref_31","first-page":"E619","article-title":"Wnt5a Is Essential for Hippocampal Dendritic Maintenance and Spatial Learning and Memory in Adult Mice","volume":"114","author":"Chen","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/s41467-017-02440-0","article-title":"Non-Canonical Wnt Signaling Regulates Neural Stem Cell Quiescence during Homeostasis and after Demyelination","volume":"9","author":"Chavali","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"jcs216101","DOI":"10.1242\/jcs.216101","article-title":"Wnt7b Signalling through Frizzled-7 Receptor Promotes Dendrite Development by Coactivating CaMKII and JNK","volume":"131","author":"Ferrari","year":"2018","journal-title":"J. Cell Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3389\/fncel.2013.00103","article-title":"WNT Signalling in Neuronal Maturation and Synaptogenesis","volume":"7","author":"Rosso","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.pbb.2009.08.003","article-title":"Self-Administered and Passive Cocaine Infusions Produce Different Effects on Corticosterone Concentrations in the Medial Prefrontal Cortex (MPC) of Rats","volume":"94","author":"Palamarchouk","year":"2009","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.neuron.2008.05.024","article-title":"Cocaine but Not Natural Reward Self-Administration nor Passive Cocaine Infusion Produces Persistent LTP in the VTA","volume":"59","author":"Chen","year":"2008","journal-title":"Neuron"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1017\/S1461145713000916","article-title":"Short-Term Abstinence from Cocaine Self-Administration, but Not Passive Cocaine Infusion, Elevates ACaMKII Autophosphorylation in the Rat Nucleus Accumbens and Medial Prefrontal Cortex","volume":"17","author":"Caffino","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2007.04.074","article-title":"Active versus Passive Cocaine Administration: Differences in the Neuroadaptive Changes in the Brain Dopaminergic System","volume":"1157","author":"Mierzejewski","year":"2007","journal-title":"Brain Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s12640-018-9910-6","article-title":"Effects of Cocaine Self-Administration and Its Extinction on the Rat Brain Cannabinoid CB1 and CB2 Receptors","volume":"34","author":"Bystrowska","year":"2018","journal-title":"Neurotox. Res."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Bystrowska, B., Frankowska, M., Smaga, I., Niedzielska-Andres, E., Pomierny-Chamio\u0142o, L., and Filip, M. (2019). Cocaine-Induced Reinstatement of Cocaine Seeking Provokes Changes in the Endocannabinoid and N-Acylethanolamine Levels in Rat Brain Structures. Molecules, 24.","DOI":"10.3390\/molecules24061125"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1037\/a0016498","article-title":"Yoked Delivery of Cocaine Is Aversive and Protects against the Motivation for Drug in Rats","volume":"123","author":"Twining","year":"2009","journal-title":"Behav. Neurosci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"40716","DOI":"10.1038\/srep40716","article-title":"Activation of Wnt\/\u03b2-Catenin Signalling via GSK3 Inhibitors Direct Differentiation of Human Adipose Stem Cells into Functional Hepatocytes","volume":"7","author":"Huang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.neuropharm.2009.03.006","article-title":"Cocaine-Induced Hyperactivity and Sensitization Are Dependent on GSK3","volume":"56","author":"Miller","year":"2009","journal-title":"Neuropharmacology"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Miller, J.S., Barr, J.L., Harper, L.J., Poole, R.L., Gould, T.J., and Unterwald, E.M. (2014). The GSK3 Signaling Pathway Is Activated by Cocaine and Is Critical for Cocaine Conditioned Reward in Mice. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0088026"},{"key":"ref_45","first-page":"409","article-title":"MicroRNAs: From Mechanism to Organism. Front","volume":"8","author":"Dexheimer","year":"2020","journal-title":"Cell Dev. Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/B978-0-444-63233-3.00005-1","article-title":"Epigenetic Mechanisms Underlying Nervous System Diseases","volume":"147","author":"Qureshi","year":"2018","journal-title":"Handb. Clin. Neurol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.conb.2017.02.014","article-title":"MiRNAs in Synapse Development and Synaptic Plasticity","volume":"45","author":"Hu","year":"2017","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Meruvu, S., Schutz, L.F., and Choudhury, M. (2021). Nutritional Influence on MiRNA Epigenetic Regulation: Effect of Maternal Diet and MiRNAs on the Fetal Metabolic Programming. Mol. Nutr. Mother Infant, 401\u2013420.","DOI":"10.1016\/B978-0-12-813862-5.00016-5"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation","volume":"9","author":"Hayder","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"536","DOI":"10.3389\/fncel.2019.00536","article-title":"MiRNA-Dependent Control of Homeostatic Plasticity in Neurons","volume":"13","author":"Dubes","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"11197","DOI":"10.1038\/s41598-020-68144-6","article-title":"Cocaine-Regulated MicroRNA MiR-124 Controls Poly (ADP-Ribose) Polymerase-1 Expression in Neuronal Cells","volume":"10","author":"Dash","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1261\/rna.2775511","article-title":"MicroRNA-Seq Reveals Cocaine-Regulated Expression of Striatal MicroRNAs","volume":"17","author":"Kiraly","year":"2011","journal-title":"RNA"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1007\/s12035-017-0584-5","article-title":"Cocaine-Mediated Downregulation of MiR-124 Activates Microglia by Targeting KLF4 and TLR4 Signaling","volume":"55","author":"Periyasamy","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1007\/s12035-016-9817-2","article-title":"Prolonged Induction of MiR-212\/132 and REST Expression in Rat Striatum Following Cocaine Self-Administration","volume":"54","author":"Frankowska","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"108585","DOI":"10.1016\/j.drugalcdep.2021.108585","article-title":"MicroRNA Regulation Related to the Protective Effects of Environmental Enrichment against Cocaine-Seeking Behavior","volume":"221","author":"Vannan","year":"2021","journal-title":"Drug Alcohol Depend."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jpsychires.2019.03.028","article-title":"Peripheral Blood MicroRNA Levels in Females with Cocaine Use Disorder","volume":"114","author":"Viola","year":"2019","journal-title":"J. Psychiatr. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/jnr.23963","article-title":"Sex Differences, Gender and Addiction","volume":"95","author":"Becker","year":"2017","journal-title":"J. Neurosci. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1111\/adb.12400","article-title":"How to Study Sex Differences in Addiction Using Animal Models","volume":"21","author":"Carroll","year":"2016","journal-title":"Addict. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1038\/npp.2015.156","article-title":"Response of the Ubiquitin-Proteasome System to Memory Retrieval After Extended-Access Cocaine or Saline Self-Administration","volume":"40","author":"Werner","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.pharep.2019.05.001","article-title":"Extinction Training Following Cocaine or MDMA Self-Administration Produces Discrete Changes in D2-like and MGlu5 Receptor Density in the Rat Brain","volume":"71","author":"Frankowska","year":"2019","journal-title":"Pharmacol. Rep."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"9192","DOI":"10.1096\/fj.202000163R","article-title":"Maternal High-Sugar Diet Changes Offspring Vulnerability to Reinstatement of Cocaine-Seeking Behavior: Role of Melanocortin-4 Receptors","volume":"34","author":"Frankowska","year":"2020","journal-title":"FASEB J."},{"key":"ref_62","unstructured":"Paxinos, G., and Watson, C. (1998). The Rat Brain in Stereotaxic Coordinates, Academic Press. [4th ed.]."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/22\/14011\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:17:23Z","timestamp":1760145443000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/22\/14011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,13]]},"references-count":62,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["ijms232214011"],"URL":"https:\/\/doi.org\/10.3390\/ijms232214011","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,13]]}}}