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Okinawa","award":["MND-MAB-D-112098"],"award-info":[{"award-number":["MND-MAB-D-112098"]}]},{"name":"Foundation for the Development of Internal Medicine in Okinawa","award":["CGH-MR-A11109"],"award-info":[{"award-number":["CGH-MR-A11109"]}]},{"name":"Foundation for the Development of Internal Medicine in Okinawa","award":["04-02-001"],"award-info":[{"award-number":["04-02-001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Adrenomedullin, a peptide with vasodilatory, natriuretic, and diuretic effects, may be a novel agent for treating heart failure. Heart failure is associated with an increased risk of atrial fibrillation (AF), but the effects of adrenomedullin on atrial arrhythmogenesis remain unclear. This study investigated whether adrenomedullin modulates the electrophysiology of the atria (AF substrate) or pulmonary vein (PV; AF trigger) arrhythmogenesis. Conventional microelectrode or whole-cell patch clamps were used to study the effects of adrenomedullin (10, 30, and 100 pg\/mL) on the electrical activity, mechanical response, and ionic currents of isolated rabbit PV and sinoatrial node tissue preparations and single PV cardiomyocytes. At 30 and 100 pg\/mL, adrenomedullin significantly reduced the spontaneous beating rate of the PVs from 2.0 \u00b1 0.4 to 1.3 \u00b1 0.5 and 1.1 \u00b1 0.5 Hz (reductions of 32.9% \u00b1 7.1% and 44.9 \u00b1 8.4%), respectively, and reduced PV diastolic tension by 12.8% \u00b1 4.1% and 14.5% \u00b1 4.1%, respectively. By contrast, adrenomedullin did not affect sinoatrial node beating. In the presence of L-NAME (a nitric oxide synthesis inhibitor, 100 \u03bcM), adrenomedullin (30 pg\/mL) did not affect the spontaneous beating rate or diastolic tension of the PVs. In the single-cell experiments, adrenomedullin (30 pg\/mL) significantly reduced the L-type calcium current (ICa-L) and reverse-mode current of the sodium\u2013calcium exchanger (NCX). Adrenomedullin reduces spontaneous PV activity and PV diastolic tension by reducing ICa-L and NCX current and thus may be useful for treating atrial tachyarrhythmia.<\/jats:p>","DOI":"10.3390\/ijms232214064","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T02:28:04Z","timestamp":1668479284000},"page":"14064","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Adrenomedullin on Atrial Electrophysiology and Pulmonary Vein Arrhythmogenesis"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9670-9708","authenticated-orcid":false,"given":"Chye-Gen","family":"Chin","sequence":"first","affiliation":[{"name":"Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11042, Taiwan"},{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, 111 Hsin-Lung Road, Sec. 3, Taipei 11696, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Moustafa","family":"Elimam","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, Mansoura International Hospital, Mansoura 35511, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fong-Jhih","family":"Lin","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11042, Taiwan"},{"name":"Department of Biomedical Engineering, National Defense Medical Center, Taipei 11490, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-Chang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, National Defense Medical Center, Taipei 11490, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Kuo","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, 111 Hsin-Lung Road, Sec. 3, Taipei 11696, Taiwan"},{"name":"Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11042, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Yu","family":"Lu","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Sijhih Cathay General Hospital, New Taipei City 22174, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5735-6249","authenticated-orcid":false,"given":"Satoshi","family":"Higa","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology and Pacing Laboratory, Division of Cardiovascular Medicine, Makiminato Central Hospital, Okinawa 901-2131, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Ann","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 40227, Taiwan"},{"name":"Cardiovascular Center, Taichung Veterans General Hospital, Taichung 40705, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Hsiung","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, 111 Hsin-Lung Road, Sec. 3, Taipei 11696, Taiwan"},{"name":"Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11042, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7224-4491","authenticated-orcid":false,"given":"Yi-Jen","family":"Chen","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11042, Taiwan"},{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, 111 Hsin-Lung Road, Sec. 3, Taipei 11696, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1146\/annurev.physiol.61.1.363","article-title":"Adrenomedullin and the control of fluid and electrolyte homeostasis","volume":"61","author":"Samson","year":"1999","journal-title":"Annu. Rev. Physiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1124\/pr.54.2.233","article-title":"International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors","volume":"54","author":"Poyner","year":"2002","journal-title":"Pharmacol. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/ejhf.1366","article-title":"Adrenomedullin in heart failure: Pathophysiology and therapeutic application","volume":"21","author":"Voors","year":"2019","journal-title":"Eur. J. Heart Fail."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1172\/JCI117573","article-title":"Plasma levels of adrenomedullin, a newly identified hypotensive peptide, in patients with hypertension and renal failure","volume":"94","author":"Ishimitsu","year":"1994","journal-title":"J. Clin. Investig."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1161\/01.HYP.27.1.102","article-title":"Plasma adrenomedullin concentrations in essential hypertension","volume":"27","author":"Kohno","year":"1996","journal-title":"Hypertension"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Martinez-Herrero, S., and Martinez, A. (2022). Adrenomedullin: Not Just Another Gastrointestinal Peptide. Biomolecules, 12.","DOI":"10.3390\/biom12020156"},{"key":"ref_7","first-page":"138","article-title":"Adrenomedullin, a multifunctional regulatory peptide","volume":"21","author":"Hinson","year":"2000","journal-title":"Endocr. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/ejhf.1437","article-title":"Bio-adrenomedullin as a marker of congestion in patients with new-onset and worsening heart failure","volume":"21","author":"Kremer","year":"2019","journal-title":"Eur. J. Heart Fail."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1016\/j.bbadis.2012.12.014","article-title":"Biomarkers and diagnostics in heart failure","volume":"1832","author":"Gaggin","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/s41440-021-00806-y","article-title":"Translational studies of adrenomedullin and related peptides regarding cardiovascular diseases","volume":"45","author":"Kita","year":"2022","journal-title":"Hypertens. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1111\/jphp.12299","article-title":"Pharmacological characterisation of the mechanisms underlying the relaxant effect of adrenomedullin in the rat carotid artery","volume":"66","author":"Passaglia","year":"2014","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"292","DOI":"10.3389\/fimmu.2018.00292","article-title":"Adrenomedullin and Adrenomedullin-Targeted Therapy As Treatment Strategies Relevant for Sepsis","volume":"9","author":"Geven","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.mcna.2012.07.007","article-title":"Atrial fibrillation in heart failure","volume":"96","author":"Lardizabal","year":"2012","journal-title":"Med. Clin. N. Am."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1161\/01.CIR.100.18.1879","article-title":"Initiation of atrial fibrillation by ectopic beats originating from the pulmonary veins: Electrophysiological characteristics, pharmacological responses, and effects of radiofrequency ablation","volume":"100","author":"Chen","year":"1999","journal-title":"Circulation"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1161\/01.CIR.0000086979.39843.7B","article-title":"Intra-atrial pressure increases rate and organization of waves emanating from the superior pulmonary veins during atrial fibrillation","volume":"108","author":"Kalifa","year":"2003","journal-title":"Circulation"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"H2888","DOI":"10.1152\/ajpheart.00312.2007","article-title":"The effect of adrenomedullin on the L-type calcium current in myocytes from septic shock rats: Signaling pathway","volume":"293","author":"Zhang","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/j.jacc.2006.12.038","article-title":"Prognostic value of midregional pro-adrenomedullin in patients with acute myocardial infarction: The LAMP (Leicester Acute Myocardial Infarction Peptide) study","volume":"49","author":"Khan","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"R140","DOI":"10.1152\/ajpregu.00853.2009","article-title":"Key roles of endothelin-1 and p38 MAPK in the regulation of atrial stretch response","volume":"300","author":"Kerkela","year":"2011","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1365-2796.2010.02287.x","article-title":"Circulating cardiovascular biomarkers in recurrent atrial fibrillation: Data from the GISSI-atrial fibrillation trial","volume":"269","author":"Latini","year":"2011","journal-title":"J. Intern. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1016\/j.jacc.2010.05.049","article-title":"Assessment of conventional cardiovascular risk factors and multiple biomarkers for the prediction of incident heart failure and atrial fibrillation","volume":"56","author":"Smith","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/DDDT.S225220","article-title":"Safety, Tolerability, and Pharmacokinetics of Adrenomedullin in Healthy Males: A Randomized, Double-Blind, Phase 1 Clinical Trial","volume":"14","author":"Kita","year":"2020","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1161\/01.CIR.101.5.498","article-title":"Hemodynamic, renal, and hormonal effects of adrenomedullin infusion in patients with congestive heart failure","volume":"101","author":"Nagaya","year":"2000","journal-title":"Circulation"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1161\/01.HYP.33.2.689","article-title":"Role of nitric oxide\u2013cGMP pathway in adrenomedullin-induced vasodilation in the rat","volume":"33","author":"Hayakawa","year":"1999","journal-title":"Hypertension"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1161\/01.ATV.0000184759.91369.f8","article-title":"Adrenomedullin: A protective factor for blood vessels","volume":"25","author":"Kato","year":"2005","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1136\/hrt.2006.089359","article-title":"Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veins","volume":"93","author":"Chang","year":"2007","journal-title":"Heart"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"H1034","DOI":"10.1152\/ajpheart.00337.2003","article-title":"Role of cyclooxygenase in ventricular effects of adrenomedullin: Is adrenomedullin a double-edged sword in sepsis?","volume":"286","author":"Mittra","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"H1842","DOI":"10.1152\/ajpheart.00388.2005","article-title":"Gs and Gi coupling of adrenomedullin in adult rat ventricular myocytes","volume":"290","author":"Mittra","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1161\/01.CIR.95.9.2318","article-title":"Negative inotropic effect of adrenomedullin in isolated adult rabbit cardiac ventricular myocytes","volume":"95","author":"Ikenouchi","year":"1997","journal-title":"Circulation"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Chan, C.S., Lin, Y.K., Chen, Y.C., Lu, Y.Y., Chen, S.A., and Chen, Y.J. (2019). Heart Failure Differentially Modulates Natural (Sinoatrial Node) and Ectopic (Pulmonary Veins) Pacemakers: Mechanism and Therapeutic Implication for Atrial Fibrillation. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20133224"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Chin, C.G., Chen, Y.C., Lin, Y.K., Lu, Y.Y., Cheng, W.L., Chung, C.C., Chen, S.A., and Chen, Y.J. (2022). Effect of macrophage migration inhibitory factor on pulmonary vein arrhythmogenesis through late sodium current. Europace.","DOI":"10.1093\/europace\/euac152"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1093\/europace\/euaa100","article-title":"Klotho modulates electrical activity and calcium homeostasis in pulmonary vein cardiomyocytes via PI3K\/Akt signalling","volume":"22","author":"Hung","year":"2020","journal-title":"Europace"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/22\/14064\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:18:11Z","timestamp":1760145491000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/22\/14064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,15]]},"references-count":31,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["ijms232214064"],"URL":"https:\/\/doi.org\/10.3390\/ijms232214064","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,15]]}}}