{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:56:26Z","timestamp":1790816186691,"version":"4.1.0"},"reference-count":172,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T00:00:00Z","timestamp":1668816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Discovery Grants from NSERC","doi-asserted-by":"publisher","award":["RGPIN-2020-05230"],"award-info":[{"award-number":["RGPIN-2020-05230"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Discovery Grants from NSERC","doi-asserted-by":"publisher","award":["RGPIN-2018-06470"],"award-info":[{"award-number":["RGPIN-2018-06470"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FRQNT","award":["RGPIN-2020-05230"],"award-info":[{"award-number":["RGPIN-2020-05230"]}]},{"name":"FRQNT","award":["RGPIN-2018-06470"],"award-info":[{"award-number":["RGPIN-2018-06470"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The cortex of the adrenal gland is organized into concentric zones that produce distinct steroid hormones essential for body homeostasis in mammals. Mechanisms leading to the development, zonation and maintenance of the adrenal cortex are complex and have been studied since the 1800s. However, the advent of genetic manipulation and transgenic mouse models over the past 30 years has revolutionized our understanding of these mechanisms. This review lists and details the distinct Cre recombinase mouse strains available to study the adrenal cortex, and the remarkable progress total and conditional knockout mouse models have enabled us to make in our understanding of the molecular mechanisms regulating the development and maintenance of the adrenal cortex.<\/jats:p>","DOI":"10.3390\/ijms232214388","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T03:05:11Z","timestamp":1668999911000},"page":"14388","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Transgenic Mouse Models to Study the Development and Maintenance of the Adrenal Cortex"],"prefix":"10.3390","volume":"23","author":[{"given":"Nour","family":"Abou Nader","sequence":"first","affiliation":[{"name":"Centre de Recherche en Reproduction et Fertilit\u00e9, Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al, Saint-Hyacinthe, QC J2S 7C6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0089-9955","authenticated-orcid":false,"given":"Gustavo","family":"Zamberlam","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Reproduction et Fertilit\u00e9, Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al, Saint-Hyacinthe, QC J2S 7C6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Boyer","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Reproduction et Fertilit\u00e9, Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al, Saint-Hyacinthe, QC J2S 7C6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,19]]},"reference":[{"key":"ref_1","first-page":"412","article-title":"Struktur und Embryonale Entwickelung der Nebennieren bei Saugetieren. 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