{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:54:15Z","timestamp":1791932055682,"version":"4.3.4"},"reference-count":195,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T00:00:00Z","timestamp":1668816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI144112 and R01AI146917"],"award-info":[{"award-number":["R01AI144112 and R01AI146917"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Epstein\u2013Barr virus (EBV) is one of eight known herpesviruses with the potential to infect humans. Globally, it is estimated that between 90\u201395% of the population has been infected with EBV. EBV is an oncogenic virus that has been strongly linked to various epithelial malignancies such as nasopharyngeal and gastric cancer. Recent evidence suggests a link between EBV and breast cancer. Additionally, there are other, rarer cancers with weaker evidence linking them to EBV. In this review, we discuss the currently known epithelial malignancies associated with EBV. Additionally, we discuss and establish which treatments and therapies are most recommended for each cancer associated with EBV.<\/jats:p>","DOI":"10.3390\/ijms232214389","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T03:05:11Z","timestamp":1668999911000},"page":"14389","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Epstein\u2013Barr Virus (EBV) Epithelial Associated Malignancies: Exploring Pathologies and Current Treatments"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8841-3314","authenticated-orcid":false,"given":"Oren","family":"Shechter","sequence":"first","affiliation":[{"name":"Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23501, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G.","family":"Sausen","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23501, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa S.","family":"Gallo","sequence":"additional","affiliation":[{"name":"Tel-Aviv Sourasky Medical Center, Division of Dermatology, Tel-Aviv 6423906, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3357-1817","authenticated-orcid":false,"given":"Harel","family":"Dahari","sequence":"additional","affiliation":[{"name":"The Program for Experimental and Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronen","family":"Borenstein","sequence":"additional","affiliation":[{"name":"The Program for Experimental and Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"9829","DOI":"10.1038\/s41598-019-45986-3","article-title":"A reliable Epstein-Barr Virus classification based on phylogenomic and population analyses","volume":"9","author":"Zanella","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1126\/science.1252786","article-title":"Virology. Epstein-Barr virus turns 50","volume":"343","author":"Lieberman","year":"2014","journal-title":"Science"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e130","DOI":"10.1038\/emm.2014.109","article-title":"EBV and human cancer","volume":"47","author":"Ko","year":"2015","journal-title":"Exp. Mol. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev-pathmechdis-012418-013023","article-title":"Epstein-Barr Virus and Cancer","volume":"14","author":"Farrell","year":"2019","journal-title":"Annu. Rev. Pathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S1286-4579(00)00277-X","article-title":"Detection of Epstein-Barr virus in salivas and throat washings in healthy adults and children","volume":"2","author":"Ikuta","year":"2000","journal-title":"Microbes Infect."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jcv.2018.03.001","article-title":"Primary Epstein-Barr virus infection","volume":"102","author":"Dunmire","year":"2018","journal-title":"J. Clin. Virol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1017\/S0950268817002515","article-title":"The role of the early social environment on Epstein Barr virus infection: A prospective observational design using the Millennium Cohort Study","volume":"145","author":"Gares","year":"2017","journal-title":"Epidemiol. Infect."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"12055","DOI":"10.1128\/JVI.76.23.12055-12068.2002","article-title":"Complete genomic sequence of an Epstein-Barr virus-related herpesvirus naturally infecting a new world primate: A defining point in the evolution of oncogenic lymphocryptoviruses","volume":"76","author":"Rivailler","year":"2002","journal-title":"J. Virol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Romero-Masters, J.C., Huebner, S.M., Ohashi, M., Bristol, J.A., Benner, B.E., Barlow, E.A., Turk, G.L., Nelson, S.E., Baiu, D.C., and Van Sciver, N. (2020). B cells infected with Type 2 Epstein-Barr virus (EBV) have increased NFATc1\/NFATc2 activity and enhanced lytic gene expression in comparison to Type 1 EBV infection. PLoS Pathog., 16.","DOI":"10.1371\/journal.ppat.1008365"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/0042-6822(86)90429-0","article-title":"Geographical prevalence of two types of Epstein-Barr virus","volume":"154","author":"Zimber","year":"1986","journal-title":"Virology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.bjid.2020.06.004","article-title":"Genotypes of Epstein-Barr virus (EBV1\/EBV2) in individuals with infectious mononucleosis in the metropolitan area of Belem, Brazil, between 2005 and 2016","volume":"24","author":"Monteiro","year":"2020","journal-title":"Braz. J. Infect. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4510","DOI":"10.1073\/pnas.81.14.4510","article-title":"Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2","volume":"81","author":"Fingeroth","year":"1984","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"11217","DOI":"10.1128\/JVI.01673-08","article-title":"Molecular basis of the interaction between complement receptor type 2 (CR2\/CD21) and Epstein-Barr virus glycoprotein gp350","volume":"82","author":"Young","year":"2008","journal-title":"J. Virol."},{"key":"ref_14","first-page":"549","article-title":"Epstein-Barr virus infection and persistence in nasopharyngeal epithelial cells","volume":"33","author":"Tsang","year":"2014","journal-title":"Chin. J. Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1128\/jvi.66.6.3409-3414.1992","article-title":"Epstein-Barr virus enters B cells and epithelial cells by different routes","volume":"66","author":"Miller","year":"1992","journal-title":"J. Virol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1128\/jvi.61.5.1416-1420.1987","article-title":"Identification of gp350 as the viral glycoprotein mediating attachment of Epstein-Barr virus (EBV) to the EBV\/C3d receptor of B cells: Sequence homology of gp350 and C3 complement fragment C3d","volume":"61","author":"Nemerow","year":"1987","journal-title":"J. Virol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1099\/vir.0.009571-0","article-title":"Epstein-Barr virus BDLF2-BMRF2 complex affects cellular morphology","volume":"90","author":"Loesing","year":"2009","journal-title":"J. Gen. Virol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"13214","DOI":"10.1128\/JVI.05580-11","article-title":"Fusion of Epstein-Barr virus with epithelial cells can be triggered by alphavbeta5 in addition to alphavbeta6 and alphavbeta8, and integrin binding triggers a conformational change in glycoproteins gHgL","volume":"85","author":"Chesnokova","year":"2011","journal-title":"J. Virol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"20464","DOI":"10.1073\/pnas.0907508106","article-title":"Fusion of epithelial cells by Epstein-Barr virus proteins is triggered by binding of viral glycoproteins gHgL to integrins alphavbeta6 or alphavbeta8","volume":"106","author":"Chesnokova","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e01413-17","DOI":"10.1128\/JVI.01413-17","article-title":"The Epstein-Barr Virus Episome Maneuvers between Nuclear Chromatin Compartments during Reactivation","volume":"92","author":"Moquin","year":"2018","journal-title":"J. Virol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e01390-20","DOI":"10.1128\/JVI.01390-20","article-title":"Epstein-Barr Virus Episome Physically Interacts with Active Regions of the Host Genome in Lymphoblastoid Cells","volume":"94","author":"Wang","year":"2020","journal-title":"J. Virol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.coviro.2015.09.007","article-title":"Epstein-Barr virus latency: Current and future perspectives","volume":"14","author":"Kempkes","year":"2015","journal-title":"Curr. Opin. Virol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Sausen, D.G., Bhutta, M.S., Gallo, E.S., Dahari, H., and Borenstein, R. (2021). Stress-Induced Epstein-Barr Virus Reactivation. Biomolecules, 11.","DOI":"10.3390\/biom11091380"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"587380","DOI":"10.3389\/fimmu.2020.587380","article-title":"Epstein-Barr Virus and Systemic Autoimmune Diseases","volume":"11","author":"Houen","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_25","unstructured":"Rathee, M., and Jain, P. (2022). Hairy Leukoplakia. StatPearls, Statpearls Publishing."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"816098","DOI":"10.3389\/fmolb.2021.816098","article-title":"Epstein-Barr Virus and Neurological Diseases","volume":"8","author":"Zhang","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1126\/science.abj8222","article-title":"Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis","volume":"375","author":"Bjornevik","year":"2022","journal-title":"Science"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4052","DOI":"10.1128\/JVI.03395-12","article-title":"Modeling the acute and chronic phases of Theiler murine encephalomyelitis virus infection","volume":"87","author":"Zhang","year":"2013","journal-title":"J. Virol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/S0140-6736(64)91524-7","article-title":"Virus Particles in Cultured Lymphoblasts from Burkitt\u2019s Lymphoma","volume":"1","author":"Epstein","year":"1964","journal-title":"Lancet"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e132","DOI":"10.1038\/emm.2014.82","article-title":"EBV-driven B-cell lymphoproliferative disorders: From biology, classification and differential diagnosis to clinical management","volume":"47","author":"Ok","year":"2015","journal-title":"Exp. Mol. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"20160271","DOI":"10.1098\/rstb.2016.0271","article-title":"Epstein-Barr virus-associated lymphomas","volume":"372","author":"Rickinson","year":"2017","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"17378","DOI":"10.3390\/ijms140917378","article-title":"Emerging roles of small Epstein-Barr virus derived non-coding RNAs in epithelial malignancy","volume":"14","author":"Lung","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.2217\/fon-2019-0232","article-title":"Epstein-Barr virus and risk of breast cancer: A systematic review and meta-analysis","volume":"15","author":"Farahmand","year":"2019","journal-title":"Future Oncol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.path.2020.09.009","article-title":"Lymphoepithelial Carcinoma of Salivary Glands","volume":"14","author":"Thompson","year":"2021","journal-title":"Surg. Pathol. Clin."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/PAS.0000000000001173","article-title":"Epstein-Barr Virus-Associated Pulmonary Carcinoma: Proposing an Alternative Term and Expanding the Histologic Spectrum of Lymphoepithelioma-like Carcinoma of the Lung","volume":"43","author":"Yeh","year":"2019","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Becnel, D., Abdelghani, R., Nanbo, A., Avilala, J., Kahn, J., Li, L., and Lin, Z. (2021). Pathogenic Role of Epstein-Barr Virus in Lung Cancers. Viruses, 13.","DOI":"10.3390\/v13050877"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Farhadi, A., Namdari, S., Chong, P.P., Geramizadeh, B., Behzad-Behbahani, A., Sekawi, Z., and Sharifzadeh, S. (2022). Epstein-Barr virus infection is associated with the nuclear factor-kappa B p65 signaling pathway in renal cell carcinoma. BMC Urol., 22.","DOI":"10.1186\/s12894-022-00964-2"},{"key":"ref_38","first-page":"41","article-title":"Expression of Epstein-Barr virus in renal cell carcinoma","volume":"18","author":"Shimakage","year":"2007","journal-title":"Oncol. Rep."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/j.1464-410X.2005.05682.x","article-title":"Epstein-Barr virus infection in sarcomatoid renal cell carcinoma tissues","volume":"96","author":"Kim","year":"2005","journal-title":"BJU Int."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3790","DOI":"10.1002\/jcp.27144","article-title":"Epstein-Barr virus and thyroid cancer: The role of viral expressed proteins","volume":"234","author":"Moghoofei","year":"2019","journal-title":"J. Cell Physiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.prp.2017.01.020","article-title":"Evaluation of the presence of Epstein-Barr virus (EBV) in Iranian patients with thyroid papillary carcinoma","volume":"213","author":"Homayouni","year":"2017","journal-title":"Pathol. Res. Pract."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.ygyno.2017.10.005","article-title":"Association between Epstein-Barr virus (EBV) and cervical carcinoma: A meta-analysis","volume":"148","author":"Neto","year":"2018","journal-title":"Gynecol. Oncol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3389\/fonc.2018.00113","article-title":"The Role of Epstein-Barr Virus in Cervical Cancer: A Brief Update","volume":"8","author":"Vranic","year":"2018","journal-title":"Front. Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/(SICI)1096-9071(199808)55:4<262::AID-JMV2>3.0.CO;2-Z","article-title":"Prevalence of papillomavirus, Epstein-Barr virus, cytomegalovirus, and herpes simplex virus type 2 in urinary bladder cancer","volume":"55","author":"Gazzaniga","year":"1998","journal-title":"J. Med. Virol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1442-2042.2008.02030.x","article-title":"Infiltration of Epstein-Barr virus-harboring lymphocytes occurs in a large subset of bladder cancers","volume":"15","author":"Abe","year":"2008","journal-title":"Int. J. Urol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1056\/NEJM199501053320103","article-title":"Association of Epstein-Barr virus with leiomyosarcomas in young people with AIDS","volume":"332","author":"McClain","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nrc.2016.92","article-title":"Epstein-Barr virus: More than 50 years old and still providing surprises","volume":"16","author":"Young","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Muller Coan, B.G., Cesarman, E., Acencio, M.L., and Elgui de Oliveira, D. (2022). Latent Membrane Protein 1 (LMP1) from Epstein-Barr Virus (EBV) Strains M81 and B95.8 Modulate miRNA Expression When Expressed in Immortalized Human Nasopharyngeal Cells. Genes, 13.","DOI":"10.3390\/genes13020353"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"26318","DOI":"10.1073\/pnas.2007946117","article-title":"Rewiring of B cell receptor signaling by Epstein-Barr virus LMP2A","volume":"117","author":"Fish","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_50","first-page":"40","article-title":"Epstein-Barr virus-associated B-cell lymphoproliferative disorders and lymphomas: A review","volume":"52","author":"Salas","year":"2020","journal-title":"Pathology"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.3892\/ijo.2015.2856","article-title":"Update on Epstein-Barr virus and gastric cancer (review)","volume":"46","author":"Kunita","year":"2015","journal-title":"Int. J. Oncol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s12275-018-8039-x","article-title":"Phylogenetic comparison of Epstein-Barr virus genomes","volume":"56","author":"Choi","year":"2018","journal-title":"J. Microbiol."},{"key":"ref_53","first-page":"e2009013","article-title":"EBV in Hodgkin Lymphoma","volume":"1","author":"Massini","year":"2009","journal-title":"Mediterr J. Hematol. Infect. Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1111\/his.14652","article-title":"Epstein-Barr virus infection patterns in nodular lymphocyte-predominant Hodgkin lymphoma","volume":"80","author":"Johrens","year":"2022","journal-title":"Histopathology"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Lorenzetti, M.A., De Matteo, E., Gass, H., Martinez Vazquez, P., Lara, J., Gonzalez, P., Preciado, M.V., and Chabay, P.A. (2010). Characterization of Epstein Barr virus latency pattern in Argentine breast carcinoma. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0013603"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13027-020-00292-w","article-title":"Immune landscape in Burkitt lymphoma reveals M2-macrophage polarization and correlation between PD-L1 expression and non-canonical EBV latency program","volume":"15","author":"Granai","year":"2020","journal-title":"Infect. Agent Cancer"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/978-981-10-7230-7_17","article-title":"EBV-Encoded Latent Genes","volume":"1045","author":"Kanda","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Murata, T., Sugimoto, A., Inagaki, T., Yanagi, Y., Watanabe, T., Sato, Y., and Kimura, H. (2021). Molecular Basis of Epstein-Barr Virus Latency Establishment and Lytic Reactivation. Viruses, 13.","DOI":"10.3390\/v13122344"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0022-1759(89)90219-6","article-title":"Strategy for the production of human monoclonal antibodies using in vitro activated B cells","volume":"123","author":"Borrebaeck","year":"1989","journal-title":"J. Immunol. Methods"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"6959","DOI":"10.1038\/sj.onc.1203217","article-title":"Epstein-barr virus transformation: Involvement of latent membrane protein 1-mediated activation of NF-kappaB","volume":"18","author":"Izumi","year":"1999","journal-title":"Oncogene"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/s41388-019-1003-3","article-title":"The Epstein-Barr virus nuclear antigen-1 upregulates the cellular antioxidant defense to enable B-cell growth transformation and immortalization","volume":"39","author":"Wang","year":"2020","journal-title":"Oncogene"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Szymula, A., Palermo, R.D., Bayoumy, A., Groves, I.J., Ba Abdullah, M., Holder, B., and White, R.E. (2018). Epstein-Barr virus nuclear antigen EBNA-LP is essential for transforming naive B cells, and facilitates recruitment of transcription factors to the viral genome. PLoS Pathog., 14.","DOI":"10.1371\/journal.ppat.1006890"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/nar\/gkt886","article-title":"Epstein-Barr virus-mediated transformation of B cells induces global chromatin changes independent to the acquisition of proliferation","volume":"42","author":"Hernando","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"E5199","DOI":"10.1073\/pnas.1503806112","article-title":"Epigenetic silencing of tumor suppressor genes during in vitro Epstein-Barr virus infection","volume":"112","author":"Saha","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e00226-19","DOI":"10.1128\/JVI.00226-19","article-title":"RNA Sequencing Analyses of Gene Expression during Epstein-Barr Virus Infection of Primary B Lymphocytes","volume":"93","author":"Wang","year":"2019","journal-title":"J. Virol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e01718-16","DOI":"10.1128\/JVI.01718-16","article-title":"Epstein-Barr Virus LMP1-Mediated Oncogenicity","volume":"91","author":"Wang","year":"2017","journal-title":"J. Virol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"24157","DOI":"10.1016\/S0021-9258(18)35741-7","article-title":"The Epstein-Barr virus LMP1 gene product induces A20 zinc finger protein expression by activating nuclear factor kappa B","volume":"267","author":"Laherty","year":"1992","journal-title":"J. Biol. Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"8801","DOI":"10.2147\/CMAR.S260583","article-title":"The Anti-Apoptotic Role of EBV-LMP1 in Lymphoma Cells","volume":"12","author":"Zeng","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e02624","DOI":"10.1016\/j.heliyon.2019.e02624","article-title":"The interplay between Epstein-Bar virus (EBV) with the p53 and its homologs during EBV associated malignancies","volume":"5","author":"Chatterjee","year":"2019","journal-title":"Heliyon"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.3892\/or.2015.3847","article-title":"LMP-1 induces survivin expression to inhibit cell apoptosis through the NF-kappaB and PI3K\/Akt signaling pathways in nasal NK\/T-cell lymphoma","volume":"33","author":"Sun","year":"2015","journal-title":"Oncol. Rep."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Hatton, O., Lambert, S.L., Krams, S.M., and Martinez, O.M. (2012). Src kinase and Syk activation initiate PI3K signaling by a chimeric latent membrane protein 1 in Epstein-Barr virus (EBV)+ B cell lymphomas. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0042610"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.virol.2010.10.029","article-title":"Epstein-Barr Virus nuclear antigen 1 (EBNA1) confers resistance to apoptosis in EBV-positive B-lymphoma cells through up-regulation of survivin","volume":"410","author":"Lu","year":"2011","journal-title":"Virology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/sj.cr.7290347","article-title":"Regulation of survivin and CDK4 by Epstein-Barr virus encoded latent membrane protein 1 in nasopharyngeal carcinoma cell lines","volume":"15","author":"Ai","year":"2005","journal-title":"Cell Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-4598-9-1","article-title":"Epstein-Barr virus-encoded EBNA1 inhibits the canonical NF-kappaB pathway in carcinoma cells by inhibiting IKK phosphorylation","volume":"9","author":"Valentine","year":"2010","journal-title":"Mol. Cancer"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.molcel.2005.02.029","article-title":"Structure of the p53 binding domain of HAUSP\/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization","volume":"18","author":"Saridakis","year":"2005","journal-title":"Mol. Cell"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.virol.2021.07.009","article-title":"Characterization of a cancer-associated Epstein-Barr virus EBNA1 variant reveals a novel interaction with PLOD1 and PLOD3","volume":"562","author":"Shire","year":"2021","journal-title":"Virology"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1089\/gtmb.2018.0009","article-title":"High Expression of PLOD1 Drives Tumorigenesis and Affects Clinical Outcome in Gastrointestinal Carcinoma","volume":"22","author":"Wang","year":"2018","journal-title":"Genet. Test Mol. Biomark."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"121","DOI":"10.7150\/jca.35763","article-title":"Overexpressing PLOD family genes predict poor prognosis in gastric cancer","volume":"11","author":"Li","year":"2020","journal-title":"J. Cancer"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"e00238-19","DOI":"10.1128\/JVI.00238-19","article-title":"Mechanisms of B-Cell Oncogenesis Induced by Epstein-Barr Virus","volume":"93","author":"Saha","year":"2019","journal-title":"J. Virol."},{"key":"ref_80","first-page":"61","article-title":"The EBNA3 Family: Two Oncoproteins and a Tumour Suppressor that Are Central to the Biology of EBV in B Cells","volume":"391","author":"Allday","year":"2015","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1172\/JCI58092","article-title":"EBNA3B-deficient EBV promotes B cell lymphomagenesis in humanized mice and is found in human tumors","volume":"122","author":"White","year":"2012","journal-title":"J. Clin. Invest."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"16242","DOI":"10.1073\/pnas.1418974111","article-title":"Epstein-Barr virus replicating in epithelial cells","volume":"111","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Yu, F., Lu, Y., Li, Y., Uchio, Y., Pangnguriseng, U.A., Kartika, A.V., Iizasa, H., Yoshiyama, H., and Loh, K.S. (2020). Epstein-Barr Virus Infection of Pseudostratified Nasopharyngeal Epithelium Disrupts Epithelial Integrity. Cancers, 12.","DOI":"10.3390\/cancers12092722"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"5009","DOI":"10.1038\/s41467-018-07308-5","article-title":"Vasculogenic mimicry formation in EBV-associated epithelial malignancies","volume":"9","author":"Xiang","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1158\/0008-5472.CAN-21-2292","article-title":"EBV Infection in Epithelial Malignancies Induces Resistance to Antitumor Natural Killer Cells via F3-Mediated Platelet Aggregation","volume":"82","author":"Duan","year":"2022","journal-title":"Cancer Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"583463","DOI":"10.3389\/fonc.2020.583463","article-title":"EBV-Positive Gastric Cancer: Current Knowledge and Future Perspectives","volume":"10","author":"Sun","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/mt.2013.257","article-title":"Therapeutic evaluation of Epstein-Barr virus-encoded latent membrane protein-1 targeted DNAzyme for treating of nasopharyngeal carcinomas","volume":"22","author":"Cao","year":"2014","journal-title":"Mol. Ther."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"600","DOI":"10.3389\/fonc.2020.00600","article-title":"Targeting Epstein-Barr Virus in Nasopharyngeal Carcinoma","volume":"10","author":"Hau","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Tavakoli, A., Monavari, S.H., Solaymani Mohammadi, F., Kiani, S.J., Armat, S., and Farahmand, M. (2020). Association between Epstein-Barr virus infection and gastric cancer: A systematic review and meta-analysis. BMC Cancer, 20.","DOI":"10.1186\/s12885-020-07013-x"},{"key":"ref_90","first-page":"151","article-title":"Expression of Epstein-Barr nuclear antigen 1 in gastric carcinoma cells is associated with enhanced tumorigenicity and reduced cisplatin sensitivity","volume":"36","author":"Cheng","year":"2010","journal-title":"Int. J. Oncol."},{"key":"ref_91","first-page":"58","article-title":"The Ras-association domain family (RASSF) members and their role in human tumourigenesis","volume":"1776","author":"Adams","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1007\/s10120-020-01059-3","article-title":"Epstein-Barr virus-encoded miR-BART5-5p upregulates PD-L1 through PIAS3\/pSTAT3 modulation, worsening clinical outcomes of PD-L1-positive gastric carcinomas","volume":"23","author":"Yoon","year":"2020","journal-title":"Gastric Cancer"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/carcin\/bgaa123","article-title":"ARID1A deficiency in EBV-positive gastric cancer is partially regulated by EBV-encoded miRNAs, but not by DNA promotor hypermethylation","volume":"42","author":"Kase","year":"2021","journal-title":"Carcinogenesis"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/s11262-021-01854-9","article-title":"Eukaryotic initiating factor eIF4E is targeted by EBV-encoded miR-BART11-3p and regulates cell cycle and apoptosis in EBV-associated gastric carcinoma","volume":"57","author":"Wang","year":"2021","journal-title":"Virus Genes"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.virol.2015.05.007","article-title":"Epstein-Barr virus latent membrane protein 2A mediated activation of Sonic Hedgehog pathway induces HLA class Ia downregulation in gastric cancer cells","volume":"484","author":"Banerjee","year":"2015","journal-title":"Virology"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/s10120-018-0880-4","article-title":"EBV-associated gastric cancer evades T-cell immunity by PD-1\/PD-L1 interactions","volume":"22","author":"Sasaki","year":"2019","journal-title":"Gastric Cancer"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1007\/s10120-021-01215-3","article-title":"Landscape of EBV-positive gastric cancer","volume":"24","author":"Saito","year":"2021","journal-title":"Gastric Cancer"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Dos Santos, M., Lequesne, J., Leconte, A., Corbinais, S., Parzy, A., Guilloit, J.M., Varatharajah, S., Brachet, P.E., Dorbeau, M., and Vaur, D. (2022). Perioperative treatment in resectable gastric cancer with spartalizumab in combination with fluorouracil, leucovorin, oxaliplatin and docetaxel (FLOT): A phase II study (GASPAR). BMC Cancer, 22.","DOI":"10.1186\/s12885-022-09623-z"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1038\/s41598-021-81667-w","article-title":"PD-L1 overexpression in EBV-positive gastric cancer is caused by unique genomic or epigenomic mechanisms","volume":"11","author":"Nakano","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1001\/jamaoncol.2020.3370","article-title":"Efficacy and Safety of Pembrolizumab or Pembrolizumab Plus Chemotherapy vs Chemotherapy Alone for Patients With First-line, Advanced Gastric Cancer: The KEYNOTE-062 Phase 3 Randomized Clinical Trial","volume":"6","author":"Shitara","year":"2020","journal-title":"JAMA Oncol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"567","DOI":"10.2217\/fon-2016-0475","article-title":"Epstein-Barr virus gene expression and latency pattern in gastric carcinomas: A systematic review","volume":"13","author":"Ribeiro","year":"2017","journal-title":"Future Oncol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0140-6736(21)00797-2","article-title":"First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): A randomised, open-label, phase 3 trial","volume":"398","author":"Janjigian","year":"2021","journal-title":"Lancet"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"e000775","DOI":"10.1136\/esmoopen-2020-000775","article-title":"Improved efficacy of taxanes and ramucirumab combination chemotherapy after exposure to anti-PD-1 therapy in advanced gastric cancer","volume":"4","author":"Sasaki","year":"2020","journal-title":"ESMO Open"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"775312","DOI":"10.3389\/fcell.2021.775312","article-title":"The Basally Expressed p53-M.Mediated Homeostatic Function","volume":"9","author":"Nagpal","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"29987","DOI":"10.1074\/jbc.M303977200","article-title":"Protein profiling with Epstein-Barr nuclear antigen-1 reveals an interaction with the herpesvirus-associated ubiquitin-specific protease HAUSP\/USP7","volume":"278","author":"Holowaty","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1128\/JVI.05623-11","article-title":"Contributions of the Epstein-Barr virus EBNA1 protein to gastric carcinoma","volume":"86","author":"Sivachandran","year":"2012","journal-title":"J. Virol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1038\/oncsis.2012.18","article-title":"The tumor suppressor RASSF10 is upregulated upon contact inhibition and frequently epigenetically silenced in cancer","volume":"1","author":"Richter","year":"2012","journal-title":"Oncogenesis"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"324","DOI":"10.4143\/crt.2016.544","article-title":"A National Study of Survival Trends and Conditional Survival in Nasopharyngeal Carcinoma: Analysis of the National Population-Based Surveillance Epidemiology and End Results Registry","volume":"50","author":"Lv","year":"2018","journal-title":"Cancer Res. Treat."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"e180","DOI":"10.1016\/S2214-109X(19)30488-7","article-title":"Global burden of cancer attributable to infections in 2018: A worldwide incidence analysis","volume":"8","author":"Georges","year":"2020","journal-title":"Lancet Glob. Health"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1158\/1055-9965.EPI-20-1702","article-title":"The Evolving Epidemiology of Nasopharyngeal Carcinoma","volume":"30","author":"Chang","year":"2021","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1158\/1055-9965.EPI-06-0353","article-title":"The enigmatic epidemiology of nasopharyngeal carcinoma","volume":"15","author":"Chang","year":"2006","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.2147\/DDDT.S172538","article-title":"Macrocyclic lactones inhibit nasopharyngeal carcinoma cells proliferation through PAK1 inhibition and reduce in vivo tumor growth","volume":"12","author":"Gallardo","year":"2018","journal-title":"Drug Des. Devel. Ther."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Beyene, E.T., Ketema, S.G., Alebachew, A.N., Saleh, M.Y., and Gebremariam, T.A. (2021). Descriptive epidemiology of nasopharyngeal carcinoma at Tikur Anbessa Hospital, Ethiopia. BMC Cancer, 21.","DOI":"10.1186\/s12885-021-08311-8"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1002\/ijc.30525","article-title":"Risk of nasopharyngeal carcinoma penetrates across immigrant generations: A migrant cohort study of 2.3 million Jewish Israeli adolescents","volume":"140","author":"Rottenberg","year":"2017","journal-title":"Int. J. Cancer"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1111\/cas.14381","article-title":"Circulating Epstein-Barr virus microRNAs BART7-3p and BART13-3p as novel biomarkers in nasopharyngeal carcinoma","volume":"111","author":"Lu","year":"2020","journal-title":"Cancer Sci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/s13046-021-02010-9","article-title":"Current approach and novel perspectives in nasopharyngeal carcinoma: The role of targeting proteasome dysregulation as a molecular landmark in nasopharyngeal cancer","volume":"40","author":"Yarza","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1038\/2281053a0","article-title":"Epstein-Barr virus in Burkitt\u2019s lymphoma and nasopharyngeal carcinoma. Antibodies to EBV associated membrane and viral capsid antigens in Burkitt lymphoma patients","volume":"228","author":"Gunven","year":"1970","journal-title":"Nature"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/path.5249","article-title":"Plasma Epstein-Barr virus DNA as an archetypal circulating tumour DNA marker","volume":"247","author":"Lam","year":"2019","journal-title":"J. Pathol."},{"key":"ref_119","first-page":"581","article-title":"Epstein-Barr virus and nasopharyngeal carcinoma","volume":"33","author":"Young","year":"2014","journal-title":"Chin. J. Cancer"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"154","DOI":"10.5501\/wjv.v1.i6.154","article-title":"Roles of the PI3K\/Akt pathway in Epstein-Barr virus-induced cancers and therapeutic implications","volume":"1","author":"Chen","year":"2012","journal-title":"World J. Virol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.bjorl.2019.04.002","article-title":"In vivo and in vitro study of co-expression of LMP1 and Cripto-1 in nasopharyngeal carcinoma","volume":"86","author":"Ye","year":"2020","journal-title":"Braz. J. Otorhinolaryngol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"640207","DOI":"10.3389\/fonc.2021.640207","article-title":"The Role of EBV-Encoded LMP1 in the NPC Tumor Microenvironment: From Function to Therapy","volume":"11","author":"Lo","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/1097-0142(20000815)89:4<715::AID-CNCR1>3.0.CO;2-9","article-title":"Association of latent membrane protein 1 and matrix metalloproteinase 9 with metastasis in nasopharyngeal carcinoma","volume":"89","author":"Horikawa","year":"2000","journal-title":"Cancer"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/s41419-021-03639-2","article-title":"EBV-LMP1 promotes radioresistance by inducing protective autophagy through BNIP3 in nasopharyngeal carcinoma","volume":"12","author":"Xu","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1128\/jvi.66.5.2689-2697.1992","article-title":"Epstein-Barr virus latent gene transcription in nasopharyngeal carcinoma cells: Coexpression of EBNA1, LMP1, and LMP2 transcripts","volume":"66","author":"Brooks","year":"1992","journal-title":"J. Virol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1128\/JVI.79.3.1789-1802.2005","article-title":"The Epstein-Barr virus-encoded LMP2A and LMP2B proteins promote epithelial cell spreading and motility","volume":"79","author":"Allen","year":"2005","journal-title":"J. Virol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.semcancer.2019.09.006","article-title":"Translational genomics of nasopharyngeal cancer","volume":"61","author":"Tsang","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Zhu, S., Chen, J., Xiong, Y., Kamara, S., Gu, M., Tang, W., Chen, S., Dong, H., Xue, X., and Zheng, Z.M. (2020). Novel EBV LMP-2-affibody and affitoxin in molecular imaging and targeted therapy of nasopharyngeal carcinoma. PLoS Pathog., 16.","DOI":"10.1371\/journal.ppat.1008223"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0065-230X(00)79006-3","article-title":"Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?","volume":"79","author":"Longnecker","year":"2000","journal-title":"Adv. Cancer Res."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Lo, A.K., Dawson, C.W., Lung, H.L., Wong, K.L., and Young, L.S. (2020). The Therapeutic Potential of Targeting BARF1 in EBV-Associated Malignancies. Cancers, 12.","DOI":"10.3390\/cancers12071940"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1182\/blood-2004-10-3967","article-title":"Macrophage colony-stimulating factor receptor c-fms is a novel target of imatinib","volume":"105","author":"Dewar","year":"2005","journal-title":"Blood"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1158\/0008-5472.CAN-07-5252","article-title":"Reconstitution of nasopharyngeal carcinoma-type EBV infection induces tumorigenicity","volume":"68","author":"Seto","year":"2008","journal-title":"Cancer Res."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"12962","DOI":"10.1073\/pnas.1205309109","article-title":"Multipronged attenuation of macrophage-colony stimulating factor signaling by Epstein-Barr virus BARF1","volume":"109","author":"Shim","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"15438","DOI":"10.1038\/s41598-018-33758-4","article-title":"Tracking EBV-encoded RNAs (EBERs) from the nucleus to the excreted exosomes of B-lymphocytes","volume":"8","author":"Ahmed","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.semcancer.2011.12.007","article-title":"Role of EBER and BARF1 in nasopharyngeal carcinoma (NPC) tumorigenesis","volume":"22","author":"Takada","year":"2012","journal-title":"Semin. Cancer Biol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.cell.2015.01.015","article-title":"EBV noncoding RNA binds nascent RNA to drive host PAX5 to viral DNA","volume":"160","author":"Lee","year":"2015","journal-title":"Cell"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"24291","DOI":"10.18632\/oncotarget.4552","article-title":"EBV-encoded RNA via TLR3 induces inflammation in nasopharyngeal carcinoma","volume":"6","author":"Li","year":"2015","journal-title":"Oncotarget"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.3389\/fonc.2019.01120","article-title":"Epstein-Barr Virus BART Long Non-coding RNAs Function as Epigenetic Modulators in Nasopharyngeal Carcinoma","volume":"9","author":"Verhoeven","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/CEJ.0000000000000221","article-title":"BART miRNAs: An unimaginable force in the development of nasopharyngeal carcinoma","volume":"26","author":"Wang","year":"2017","journal-title":"Eur. J. Cancer Prev."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/path.5018","article-title":"EBV-encoded miRNAs target ATM-mediated response in nasopharyngeal carcinoma","volume":"244","author":"Lung","year":"2018","journal-title":"J. Pathol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1002\/cncr.28001","article-title":"Early detection of nasopharyngeal carcinoma by plasma Epstein-Barr virus DNA analysis in a surveillance program","volume":"119","author":"Chan","year":"2013","journal-title":"Cancer"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1200\/JCO.2018.77.7847","article-title":"Analysis of Plasma Epstein-Barr Virus DNA in Nasopharyngeal Cancer After Chemoradiation to Identify High-Risk Patients for Adjuvant Chemotherapy: A Randomized Controlled Trial","volume":"36","author":"Chan","year":"2018","journal-title":"J. Clin. Oncol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1177\/0194599813520136","article-title":"Trans-oral brush biopsies and quantitative PCR for EBV DNA detection and screening of nasopharyngeal carcinoma","volume":"150","author":"Ng","year":"2014","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1093\/annonc\/mdz106","article-title":"Complementary roles of MRI and endoscopic examination in the early detection of nasopharyngeal carcinoma","volume":"30","author":"King","year":"2019","journal-title":"Ann. Oncol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1056\/NEJMoa1905287","article-title":"Gemcitabine and Cisplatin Induction Chemotherapy in Nasopharyngeal Carcinoma","volume":"381","author":"Zhang","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1200\/JCO.21.00396","article-title":"Gemcitabine Plus Cisplatin Versus Fluorouracil Plus Cisplatin as First-Line Therapy for Recurrent or Metastatic Nasopharyngeal Carcinoma: Final Overall Survival Analysis of GEM20110714 Phase III Study","volume":"39","author":"Hong","year":"2021","journal-title":"J. Clin. Oncol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1200\/JCO.2021.39.15_suppl.LBA2","article-title":"JUPITER-02: Randomized, double-blind, phase III study of toripalimab or placebo plus gemcitabine and cisplatin as first-line treatment for recurrent or metastatic nasopharyngeal carcinoma (NPC)","volume":"39","author":"Xu","year":"2021","journal-title":"J. Clin. Oncol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1038\/s41591-021-01444-0","article-title":"Toripalimab or placebo plus chemotherapy as first-line treatment in advanced nasopharyngeal carcinoma: A multicenter randomized phase 3 trial","volume":"27","author":"Mai","year":"2021","journal-title":"Nat. Med."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"6438","DOI":"10.1111\/jcmm.15291","article-title":"Loss of AKR1C1 is a good prognostic factor in advanced NPC cases and increases chemosensitivity to cisplatin in NPC cells","volume":"24","author":"Zhou","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/cam4.982","article-title":"BEX3 contributes to cisplatin chemoresistance in nasopharyngeal carcinoma","volume":"6","author":"Gao","year":"2017","journal-title":"Cancer Med."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s12094-017-1777-0","article-title":"SEOM clinical guideline in nasopharynx cancer (2017)","volume":"20","author":"Pastor","year":"2018","journal-title":"Clin. Transl. Oncol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/lary.26139","article-title":"Patterns of nodal failure after intensity modulated radiotherapy for nasopharyngeal carcinoma","volume":"127","author":"Li","year":"2017","journal-title":"Laryngoscope"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.ejca.2007.03.022","article-title":"Chemoradiation comparing cisplatin versus carboplatin in locally advanced nasopharyngeal cancer: Randomised, non-inferiority, open trial","volume":"43","author":"Chitapanarux","year":"2007","journal-title":"Eur. J. Cancer"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"e15951","DOI":"10.1097\/MD.0000000000015951","article-title":"Oncologic outcomes of IMRT versus CRT for nasopharyngeal carcinoma: A meta-analysis","volume":"98","author":"Luo","year":"2019","journal-title":"Medicine"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"119","DOI":"10.14338\/IJPT-20-00082.1","article-title":"A Systematic Review of Proton Therapy for the Management of Nasopharyngeal Cancer","volume":"8","author":"Lee","year":"2021","journal-title":"Int. J. Part. Ther."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40463-020-00482-x","article-title":"5-year outcomes of salvage endoscopic nasopharyngectomy for recurrent nasopharyngeal carcinoma","volume":"50","author":"Thamboo","year":"2021","journal-title":"J. Otolaryngol. Head Neck Surg."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S1470-2045(20)30673-2","article-title":"Endoscopic surgery compared with intensity-modulated radiotherapy in resectable locally recurrent nasopharyngeal carcinoma: A multicentre, open-label, randomised, controlled, phase 3 trial","volume":"22","author":"Liu","year":"2021","journal-title":"Lancet Oncol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"703954","DOI":"10.3389\/fonc.2021.703954","article-title":"Comparing the Effectiveness of Endoscopic Surgeries With Intensity-Modulated Radiotherapy for Recurrent rT3 and rT4 Nasopharyngeal Carcinoma: A Meta-Analysis","volume":"11","author":"Peng","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3322\/caac.21754","article-title":"Breast Cancer Statistics, 2022","volume":"72","author":"Giaquinto","year":"2022","journal-title":"CA Cancer J. Clin."},{"key":"ref_161","first-page":"39","article-title":"Epstein-Barr virus in epithelial cell tumors: A breast cancer study","volume":"55","author":"Labrecque","year":"1995","journal-title":"Cancer Res."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1159\/000502131","article-title":"Epstein-Barr Virus Infection and Increased Sporadic Breast Carcinoma Risk: A Meta-Analysis","volume":"29","author":"Jin","year":"2020","journal-title":"Med. Princ. Pract."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13000-022-01234-3","article-title":"Association of PD-1\/PD-L1 expression and Epstein--Barr virus infection in patients with invasive breast cancer","volume":"17","author":"Zhang","year":"2022","journal-title":"Diagn. Pathol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ebiom.2016.05.025","article-title":"Epstein-Barr Virus Infection of Mammary Epithelial Cells Promotes Malignant Transformation","volume":"9","author":"Hu","year":"2016","journal-title":"EBioMedicine"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"5705","DOI":"10.1128\/JVI.00076-07","article-title":"Dysregulation of HER2\/HER3 signaling axis in Epstein-Barr virus-infected breast carcinoma cells","volume":"81","author":"Lin","year":"2007","journal-title":"J. Virol."},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Dowran, R., Joharinia, N., Safaei, A., Bakhtiyarizadeh, S., Alidadi Soleimani, A., Alizadeh, R., Mir-Shiri, S., and Sarvari, J. (2019). No detection of EBV, BKV and JCV in breast cancer tissue samples in Iran. BMC Res. Notes, 12.","DOI":"10.1186\/s13104-019-4178-3"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.21873\/invivo.12860","article-title":"Incidence of Epstein-Barr Virus Among Women With Breast Cancer Using Monoclonal Antibodies for Latent Membrane Protein 1 (LMP1)","volume":"36","author":"Salih","year":"2022","journal-title":"Vivo"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s12105-020-01172-w","article-title":"Lymphoepithelial Carcinoma of Salivary Gland EBV-association in Endemic versus Non-Endemic Patients: A Report of 16 Cases","volume":"14","author":"Whaley","year":"2020","journal-title":"Head Neck Pathol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1615\/CritRevOncog.2019031618","article-title":"Epstein-Barr Virus and Thyroid Cancer","volume":"24","author":"Almeida","year":"2019","journal-title":"Crit. Rev. Oncog."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"368","DOI":"10.3389\/fimmu.2018.00368","article-title":"Epstein-Barr Virus(+) Smooth Muscle Tumors as Manifestation of Primary Immunodeficiency Disorders","volume":"9","author":"Magg","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.prp.2018.10.037","article-title":"EBV as a potential risk factor for hepatobiliary system cancer: A meta-analysis with 918 cases","volume":"215","author":"Chen","year":"2019","journal-title":"Pathol. Res. Pract"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jhep.2019.03.018","article-title":"Immunogenomic landscape of hepatocellular carcinoma with immune cell stroma and EBV-positive tumor-infiltrating lymphocytes","volume":"71","author":"Kang","year":"2019","journal-title":"J. Hepatol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/2211738507666190122111224","article-title":"Drug Combinations in Breast Cancer Therapy","volume":"7","author":"Fisusi","year":"2019","journal-title":"Pharm. Nanotechnol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1001\/jamaoncol.2015.3062","article-title":"Effectiveness of an Adjuvant Chemotherapy Regimen for Early-Stage Breast Cancer: A Systematic Review and Network Meta-analysis","volume":"1","author":"Fujii","year":"2015","journal-title":"JAMA Oncol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.3390\/curroncol28030168","article-title":"Current Landscape of Targeted Therapy in Hormone Receptor-Positive and HER2-Negative Breast Cancer","volume":"28","author":"Andrahennadi","year":"2021","journal-title":"Curr. Oncol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"NP402","DOI":"10.1177\/0145561320923170","article-title":"Is Surgery an Inevitable Treatment for Advanced Salivary Lymphoepithelial Carcinoma? Three Case Reports","volume":"100","author":"Lv","year":"2021","journal-title":"Ear Nose Throat J."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1007\/s12032-014-0957-9","article-title":"A clinical analysis of 37 cases with lymphoepithelial carcinoma of the major salivary gland treated by surgical resection and postoperative radiotherapy: A single institution study","volume":"31","author":"Li","year":"2014","journal-title":"Med. Oncol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/1746-1596-8-115","article-title":"Lymphoepithelial-like carcinoma of the parotid gland: A case report and a brief review of the western literature","volume":"8","author":"Ambrosio","year":"2013","journal-title":"Diagn. Pathol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"e393","DOI":"10.1016\/j.cllc.2018.12.008","article-title":"Immunotherapy for LELC: Case Report and a Focused Review","volume":"20","author":"Darrason","year":"2019","journal-title":"Clin. Lung Cancer"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.2147\/OTT.S290113","article-title":"Pulmonary Lymphoepithelioma-Like Carcinoma Treated with Immunotherapy or Chemotherapy: A Single Institute Experience","volume":"14","author":"Fu","year":"2021","journal-title":"Oncol. Targets Ther."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"626566","DOI":"10.3389\/fonc.2021.626566","article-title":"Immune Checkpoint Blockade Therapy May Be a Feasible Option for Primary Pulmonary Lymphoepithelioma-like Carcinoma","volume":"11","author":"Wu","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.euo.2019.09.002","article-title":"First-line Treatment of Metastatic Renal Cell Carcinoma: A Systematic Review and Network Meta-analysis","volume":"2","author":"Hahn","year":"2019","journal-title":"Eur. Urol. Oncol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"507","DOI":"10.3322\/caac.21411","article-title":"Treatment of renal cell carcinoma: Current status and future directions","volume":"67","author":"Barata","year":"2017","journal-title":"CA Cancer J. Clin."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fendo.2020.00082","article-title":"New Therapies for Advanced Thyroid Cancer","volume":"11","author":"Laha","year":"2020","journal-title":"Front. Endocrinol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ygyno.2020.05.035","article-title":"Simple conization and pelvic lymphadenectomy in early-stage cervical cancer: A retrospective analysis and review of the literature","volume":"158","author":"Li","year":"2020","journal-title":"Gynecol. Oncol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1001\/jama.2020.17598","article-title":"Bladder Cancer: A Review","volume":"324","author":"Lenis","year":"2020","journal-title":"JAMA"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.crad.2017.01.013","article-title":"Loco-regional treatment of HCC: Current status","volume":"72","author":"Crocetti","year":"2017","journal-title":"Clin. Radiol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s00066-021-01854-6","article-title":"Indications of IMRT, PRT and CIRT for HCC from comparisons of dosimetry and normal tissue complication possibility","volume":"198","author":"Sun","year":"2022","journal-title":"Strahlenther. Onkol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1435302","DOI":"10.1155\/2018\/1435302","article-title":"Transarterial Radioembolization (TARE) Agents beyond (90)Y-Microspheres","volume":"2018","author":"Bouvry","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"31","DOI":"10.5582\/bst.2022.01044","article-title":"Use of chemotherapy to treat hepatocellular carcinoma","volume":"16","author":"Hou","year":"2022","journal-title":"Biosci. Trends"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1002\/hep.32447","article-title":"Emerging immunotherapy for HCC: A guide for hepatologists","volume":"75","author":"Foerster","year":"2022","journal-title":"Hepatology"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1750-9378-9-38","article-title":"Global burden of deaths from Epstein-Barr virus attributable malignancies 1990\u20132010","volume":"9","author":"Khan","year":"2014","journal-title":"Infect. Agent Cancer"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"4315","DOI":"10.1007\/s00018-020-03538-3","article-title":"Vaccination against the Epstein-Barr virus","volume":"77","author":"Ruhl","year":"2020","journal-title":"Cell Mol. Life Sci."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"734471","DOI":"10.3389\/fimmu.2021.734471","article-title":"Epstein Barr Virus: Development of Vaccines and Immune Cell Therapy for EBV-Associated Diseases","volume":"12","author":"Cui","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"7349268","DOI":"10.1155\/2017\/7349268","article-title":"Epstein-Barr Virus as a Promising Immunotherapeutic Target for Nasopharyngeal Carcinoma Treatment","volume":"2017","author":"Teow","year":"2017","journal-title":"J. Pathog."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/22\/14389\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:21:55Z","timestamp":1760145715000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/22\/14389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,19]]},"references-count":195,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["ijms232214389"],"URL":"https:\/\/doi.org\/10.3390\/ijms232214389","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,19]]}}}