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The range of antiviral activity of Triazavirin has been significantly expanded during recent years; in particular, it has been shown that Triazavirin exhibits activity against tick-borne encephalitis, Rift Valley fever, West Nile fever, and other infections of viral etiology. This drug has been approved for treatment of influenza and acute respiratory infections by the Russian Ministry of Health on the basis of comprehensive clinical trials involving over 450 patients. Triazavirin was found to be a highly effective and well-tolerated drug, allowing its over-the-counter sale. The recently published data on the use of Triazavirin in clinical practice for the treatment of patients with COVID-19 are discussed, with special attention paid to potential biological targets for this drug.<\/jats:p>","DOI":"10.3390\/ijms232314537","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T08:29:58Z","timestamp":1669105798000},"page":"14537","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Triazavirin\u2014A Novel Effective Antiviral Drug"],"prefix":"10.3390","volume":"23","author":[{"given":"Oleg N.","family":"Chupakhin","sequence":"first","affiliation":[{"name":"Department of Organic and Biomolecular Chemistry, Institute of Chemical Engineering, Ural Federal University, 620002 Ekaterinburg, Russia"},{"name":"Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 620990 Ekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir L.","family":"Rusinov","sequence":"additional","affiliation":[{"name":"Department of Organic and Biomolecular Chemistry, Institute of Chemical Engineering, Ural Federal University, 620002 Ekaterinburg, Russia"},{"name":"Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 620990 Ekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7997-3686","authenticated-orcid":false,"given":"Mikhail V.","family":"Varaksin","sequence":"additional","affiliation":[{"name":"Department of Organic and Biomolecular Chemistry, Institute of Chemical Engineering, Ural Federal University, 620002 Ekaterinburg, Russia"},{"name":"Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 620990 Ekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeny N.","family":"Ulomskiy","sequence":"additional","affiliation":[{"name":"Department of Organic and Biomolecular Chemistry, Institute of Chemical Engineering, Ural Federal University, 620002 Ekaterinburg, Russia"},{"name":"Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 620990 Ekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6040-5155","authenticated-orcid":false,"given":"Konstantin V.","family":"Savateev","sequence":"additional","affiliation":[{"name":"Department of Organic and Biomolecular Chemistry, Institute of Chemical Engineering, Ural Federal University, 620002 Ekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilya I.","family":"Butorin","sequence":"additional","affiliation":[{"name":"Department of Organic and Biomolecular Chemistry, Institute of Chemical Engineering, Ural Federal University, 620002 Ekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, The Key Laboratory of Cardiovascular Research, Ministry of Education, College of Pharmacy, Harbin Medical University, Harbin 150086, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, The Key Laboratory of Cardiovascular Research, Ministry of Education, College of Pharmacy, Harbin Medical University, Harbin 150086, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9140-358X","authenticated-orcid":false,"given":"Valery N.","family":"Charushin","sequence":"additional","affiliation":[{"name":"Department of Organic and Biomolecular Chemistry, Institute of Chemical Engineering, Ural Federal University, 620002 Ekaterinburg, Russia"},{"name":"Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 620990 Ekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.tips.2020.03.006","article-title":"Ongoing Clinical Trials for the Management of the COVID-19 Pandemic","volume":"41","author":"Lythgoe","year":"2020","journal-title":"Trends Pharmacol. 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