{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:03:02Z","timestamp":1782964982909,"version":"3.54.5"},"reference-count":26,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T00:00:00Z","timestamp":1669075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funding Autoimmune Research Charity","award":["166185"],"award-info":[{"award-number":["166185"]}]},{"name":"Funding Autoimmune Research Charity","award":["1176388"],"award-info":[{"award-number":["1176388"]}]},{"name":"Funding Autoimmune Research Charity","award":["Paed_RP_008_20190926"],"award-info":[{"award-number":["Paed_RP_008_20190926"]}]},{"name":"Funding Autoimmune Research Charity","award":["30158"],"award-info":[{"award-number":["30158"]}]},{"name":"Funding Autoimmune Research Charity","award":["166185"],"award-info":[{"award-number":["166185"]}]},{"name":"Funding Autoimmune Research Charity","award":["1176388"],"award-info":[{"award-number":["1176388"]}]},{"name":"Funding Autoimmune Research Charity","award":["Paed_RP_008_20190926"],"award-info":[{"award-number":["Paed_RP_008_20190926"]}]},{"name":"Funding Autoimmune Research Charity","award":["30158"],"award-info":[{"award-number":["30158"]}]},{"name":"Kidney Research UK","award":["166185"],"award-info":[{"award-number":["166185"]}]},{"name":"Kidney Research UK","award":["1176388"],"award-info":[{"award-number":["1176388"]}]},{"name":"Kidney Research UK","award":["Paed_RP_008_20190926"],"award-info":[{"award-number":["Paed_RP_008_20190926"]}]},{"name":"Kidney Research UK","award":["30158"],"award-info":[{"award-number":["30158"]}]},{"name":"Wellcome Trust Institutional Strategic Support Fund","award":["166185"],"award-info":[{"award-number":["166185"]}]},{"name":"Wellcome Trust Institutional Strategic Support Fund","award":["1176388"],"award-info":[{"award-number":["1176388"]}]},{"name":"Wellcome Trust Institutional Strategic Support Fund","award":["Paed_RP_008_20190926"],"award-info":[{"award-number":["Paed_RP_008_20190926"]}]},{"name":"Wellcome Trust Institutional Strategic Support Fund","award":["30158"],"award-info":[{"award-number":["30158"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>IgA vasculitis (IgAV) is the most common form of paediatric vasculitis, with up to 50% of patients experiencing kidney inflammation. Much remains unknown about IgAV, but it is believed to arise due to galactose-deficient IgA1 promoting an auto-inflammatory response. This study assesses whether urinary IgA can be detected in children with IgAV to allow further evaluation of IgA1 and whether it has any relationship with nephritis. Urinary and serum IgA concentrations were measured using commercially available ELISA kits. Patients were grouped into IgAV nephritis (IgAVN) or IgAV without nephritis (IgAVwoN). Fifty-nine children were included: IgAVN n = 12, IgAVwoN n = 35, and healthy controls (HC) n = 12, with a mean age of 8.2 \u00b1 4.1 years. Urinary IgA concentrations were statistically significantly higher in patients with IgAV (107.1 \u00b1 136.3 \u03bcg\/mmol) compared to HC (50.6 \u00b1 26.3 \u03bcg\/mmol; p = 0.027) and IgAVN (229.8 \u00b1 226.3 \u03bcg\/mmol) compared to both IgAVwoN (65.0 \u00b1 37.8 \u03bcg\/mmol; p = 0.002) and HC (p &lt; 0.001). Urinary IgA concentrations were able to distinguish between renal status (AUC 0.838, 95%CI [0.704\u20130.973], p &lt; 0.001) and did not correlate with proteinuria (r = 0.124; p = 0.407). Urinary IgA concentrations are increased in children with IgAVN, and it has the potential to act as a non-invasive biofluid to further evaluate nephritis in this disease.<\/jats:p>","DOI":"10.3390\/ijms232314548","type":"journal-article","created":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T02:10:54Z","timestamp":1669169454000},"page":"14548","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Increased Urinary IgA in Paediatric IgA Vasculitis Nephritis"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4954-7915","authenticated-orcid":false,"given":"Julien","family":"Marro","sequence":"first","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool L12 2AP, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6648-6881","authenticated-orcid":false,"given":"Andrew J.","family":"Chetwynd","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool L12 2AP, UK"},{"name":"Centre for Proteome Research, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool L12 2AP, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael D.","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool L12 2AP, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1532-2390","authenticated-orcid":false,"given":"Louise","family":"Oni","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool L12 2AP, UK"},{"name":"Department of Paediatric Nephrology, Alder Hey Children\u2019s NHS Foundation Trust Hospital, Liverpool L14 5AB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1136\/annrheumdis-2018-214142","article-title":"Cardiovascular, thromboembolic and renal outcomes in IgA vasculitis (Henoch-Sch\u00f6nlein purpura): A retrospective cohort study using routinely collected primary care data","volume":"78","author":"Tracy","year":"2019","journal-title":"Ann. 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