{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T15:18:25Z","timestamp":1782746305726,"version":"3.54.5"},"reference-count":58,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Program for Strategic Academic Leadership","award":["Priority-2030"],"award-info":[{"award-number":["Priority-2030"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Susceptibility and resilience to post-traumatic stress disorder (PTSD) are recognized, but their mechanisms are not understood. Here, the hexobarbital sleep test (HST) was used to elucidate mechanisms of PTSD resilience or susceptibility. A HST was performed in rats 30 days prior to further experimentation. Based on the HST, the rats were divided into groups: (1) fast metabolizers (FM; sleep duration &lt; 15 min); (2) slow metabolizers (SM; sleep duration \u2265 15 min). Then the SM and FM groups were subdivided into stressed (10 days predator scent, 15 days rest) and unstressed subgroups. Among stressed animals, only SMs developed experimental PTSD, and had higher plasma corticosterone (CORT) than stressed FMs. Thus, resilience or susceptibility to PTSD was consistent with changes in glucocorticoid metabolism. Stressed SMs had a pronounced decrease in hippocampal dopamine associated with increased expressions of catecholamine-O-methyl-transferase and DA transporter. In stressed SMs, a decrease in monoaminoxidase (MAO) A was associated with increased expressions of hippocampal MAO-A and MAO-B. BDNF gene expression was increased in stressed FMs and decreased in stressed SMs. These results demonstrate relationships between the microsomal oxidation phenotype, CORT concentration, and anxiety, and they help further the understanding of the role of the liver\u2013brain axis during PTSD.<\/jats:p>","DOI":"10.3390\/ijms232314575","type":"journal-article","created":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T02:10:54Z","timestamp":1669169454000},"page":"14575","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Mechanisms of Susceptibility and Resilience to PTSD: Role of Dopamine Metabolism and BDNF Expression in the Hippocampus"],"prefix":"10.3390","volume":"23","author":[{"given":"Vadim E.","family":"Tseilikman","sequence":"first","affiliation":[{"name":"School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga B.","family":"Tseilikman","sequence":"additional","affiliation":[{"name":"School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia"},{"name":"Department of Basic Medicine, Chelyabinsk State University, 454001 Chelyabinsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton A.","family":"Pashkov","sequence":"additional","affiliation":[{"name":"School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia"},{"name":"Federal Neurosurgical Center, 630048 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7659-5483","authenticated-orcid":false,"given":"Irina S.","family":"Ivleva","sequence":"additional","affiliation":[{"name":"Pavlov Department of Physiology, Institute of Experimental Medicine, 197376 Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina N.","family":"Karpenko","sequence":"additional","affiliation":[{"name":"Pavlov Department of Physiology, Institute of Experimental Medicine, 197376 Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladislav A.","family":"Shatilov","sequence":"additional","affiliation":[{"name":"School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxim S.","family":"Zhukov","sequence":"additional","affiliation":[{"name":"School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3117-9299","authenticated-orcid":false,"given":"Julia O.","family":"Fedotova","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroendocrinology, Pavlov Institute of Physiology, 199034 Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8096-5974","authenticated-orcid":false,"given":"Marina V.","family":"Kondashevskaya","sequence":"additional","affiliation":[{"name":"Avtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, 117418 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7280-1021","authenticated-orcid":false,"given":"H. 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