{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T18:53:59Z","timestamp":1784919239572,"version":"3.55.0"},"reference-count":57,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Technology","award":["110-2320-B-039-051-MY3"],"award-info":[{"award-number":["110-2320-B-039-051-MY3"]}]},{"name":"Ministry of Science and Technology","award":["CMU106-ASIA-20"],"award-info":[{"award-number":["CMU106-ASIA-20"]}]},{"name":"Ministry of Science and Technology","award":["CMU109-MF-81"],"award-info":[{"award-number":["CMU109-MF-81"]}]},{"DOI":"10.13039\/501100007300","name":"Taipei and China Medical University","doi-asserted-by":"publisher","award":["110-2320-B-039-051-MY3"],"award-info":[{"award-number":["110-2320-B-039-051-MY3"]}],"id":[{"id":"10.13039\/501100007300","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007300","name":"Taipei and China Medical University","doi-asserted-by":"publisher","award":["CMU106-ASIA-20"],"award-info":[{"award-number":["CMU106-ASIA-20"]}],"id":[{"id":"10.13039\/501100007300","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007300","name":"Taipei and China Medical University","doi-asserted-by":"publisher","award":["CMU109-MF-81"],"award-info":[{"award-number":["CMU109-MF-81"]}],"id":[{"id":"10.13039\/501100007300","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Psoriasis is a chronic autoimmune disease, and until now, it remains an incurable disease. Therefore, the development of new drugs or agents that ameliorate the disease will have marketing potential. Taiwanofungus camphoratus (TC) is a specific fungus in Taiwan. It is demonstrated to have anticancer, anti-inflammation, and hepatoprotective effects. However, the effects of TC fermented extract on psoriasis are under investigation. In this research, we studied the ability of TC on antioxidative activity and the efficacy of TC on interleukin-17 (IL-17A)-induced intracellular oxidative stress, inflammation-relative, and proliferation-relative protein expression in human keratinocytes. The results of a DPPH radical scavenging assay, reducing power assay, and hydroxyl peroxide inhibition assay indicated that TC has a potent antioxidant ability. Furthermore, TC could reduce IL-17A-induced intracellular ROS generation and restore the NADPH level. In the investigation of pathogenesis, we discovered TC could regulate inflammatory and cell proliferation pathways via p-IKK\u03b1\/p-p65 and p-mTOR\/p-p70S6k signaling pathways in human keratinocytes. In conclusion, TC showed characteristics such as antioxidant, anti-inflammatory, and anti-psoriatic-associated responses. It is expected to be developed as a candidate for oxidative-stress-induced skin disorders or psoriasis treatment.<\/jats:p>","DOI":"10.3390\/ijms232314623","type":"journal-article","created":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T09:50:52Z","timestamp":1669197052000},"page":"14623","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Fermented Taiwanofungus camphoratus Extract Ameliorates Psoriasis-Associated Response in HaCaT Cells via Modulating NF-\ud835\udf05B and mTOR Pathways"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2568-4512","authenticated-orcid":false,"given":"Jia-Wei","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Cosmeceutics, China Medical University, Taichung 406, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0264-2536","authenticated-orcid":false,"given":"Po-Yuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, China Medical University Hospital, Taichung 404, Taiwan"},{"name":"School of Medicine, China Medical University, Taichung 404, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5935-6755","authenticated-orcid":false,"given":"Yueh-Hsiung","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan"},{"name":"Department of Biotechnology, Asia University, Taichung 413, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao-Xin","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Cosmeceutics, China Medical University, Taichung 406, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Ching","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Cosmeceutics, China Medical University, Taichung 406, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1586-910X","authenticated-orcid":false,"given":"Hsiu-Mei","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Cosmeceutics, China Medical University, Taichung 406, Taiwan"},{"name":"Ph.D. Program for Biotechnology Industry, School of Life Sciences, China Medical University, Taichung 406, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,23]]},"reference":[{"key":"ref_1","first-page":"7","article-title":"Current knowledge on psoriasis and autoimmune diseases","volume":"6","author":"Soler","year":"2016","journal-title":"Psoriasis"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nri2622","article-title":"Skin immune sentinels in health and disease","volume":"9","author":"Nestle","year":"2009","journal-title":"Nat. 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