{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:51:53Z","timestamp":1791831113421,"version":"4.3.4"},"reference-count":51,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:00Z","timestamp":1669248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Immunosenescence encompasses a spectrum of lymphocyte phenotypic alterations. The aim of the study was to evaluate immunosenescent effect of two different forms of chronic inflammation, Systemic Lupus Erythematosous (SLE), a systemic autoimmune disease, and End-Stage Kidney Disease (ESKD), a chronic inflammatory disorder. Certain lymphocyte surface molecules, including CD31, CD45RA, CCR7, CD28, CD57, for T, and IgD, CD27 for B lymphocytes, were analyzed by flow cytometry in 30 SLE and 53 ESKD patients on hemodialysis (HD), and results were compared to 31 healthy controls (HC) of similar age, gender, and nationality. Significant Lymphopenia was evident in both SLE and ESKD-HD patients, compared to HC, affecting B cells 75.4 (14.4\u2013520.8), 97 (32\u2013341), and 214 (84\u2013576) cells\/\u03bcL, respectively, p &lt; 0.0001, and CD4 cells 651.2 (71.1\u20131478.2), 713 (234\u20131509), and 986 (344\u20131591) cells\/\u03bcL, respectively, p &lt; 0.0001. The allocation of B cell subpopulations was remarkably different between SLE and ESKD-HD patients. SLE showed a clear shift to senescence (CD19IgD-CD27\u2212) cells, compared to ESKD-HD and HC, 11.75 (10)% vs. 8 (6) vs. 8.1 (10), respectively. Regarding T lymphocytes, Central Memory CD8 cells predominated in both SLE and ESKD-HD patients compared to HC, 53 (50)%, 52 (63), and 24 (64)%, respectively, while ESKD-HD but not SLE patients also had increased expression of CD4CD28\u2212 and CD8CD28\u2212 cells. In conclusion, both diseases are followed by significant lymphopenia; however, the senescent phenomenon affects the B lymphocyte compartment in SLE patients and T lymphocytes in ESKD-HD patients.<\/jats:p>","DOI":"10.3390\/ijms232314688","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T02:05:37Z","timestamp":1669341937000},"page":"14688","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Different Types of Chronic Inflammation Engender Distinctive Immunosenescent Profiles in Affected Patients"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6874-7173","authenticated-orcid":false,"given":"Eleni","family":"Moysidou","sequence":"first","affiliation":[{"name":"School of Medicine, Aristotle University of Thessaloniki, 45642 Thesaloniki, Greece"},{"name":"Department of Nephrology, Hippokration Hospital, 54642 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Lioulios","sequence":"additional","affiliation":[{"name":"School of Medicine, Aristotle University of Thessaloniki, 45642 Thesaloniki, Greece"},{"name":"Department of Nephrology, Hippokration Hospital, 54642 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliki","family":"Xochelli","sequence":"additional","affiliation":[{"name":"Department of Immunology, National Histocompatibility Center, Hippokration General Hospital, 54642 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliki","family":"Nikolaidou","sequence":"additional","affiliation":[{"name":"Department of Immunology, National Histocompatibility Center, Hippokration General Hospital, 54642 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9565-6931","authenticated-orcid":false,"given":"Michalis","family":"Christodoulou","sequence":"additional","affiliation":[{"name":"School of Medicine, Aristotle University of Thessaloniki, 45642 Thesaloniki, Greece"},{"name":"Department of Nephrology, Hippokration Hospital, 54642 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoi","family":"Mitsoglou","sequence":"additional","affiliation":[{"name":"School of Medicine, Aristotle University of Thessaloniki, 45642 Thesaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stamatia","family":"Stai","sequence":"additional","affiliation":[{"name":"School of Medicine, Aristotle University of Thessaloniki, 45642 Thesaloniki, Greece"},{"name":"Department of Nephrology, Hippokration Hospital, 54642 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asimina","family":"Fylaktou","sequence":"additional","affiliation":[{"name":"Department of Immunology, National Histocompatibility Center, Hippokration General Hospital, 54642 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikaterini","family":"Papagianni","sequence":"additional","affiliation":[{"name":"School of Medicine, Aristotle University of Thessaloniki, 45642 Thesaloniki, Greece"},{"name":"Department of Nephrology, Hippokration Hospital, 54642 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2496-9863","authenticated-orcid":false,"given":"Maria","family":"Stangou","sequence":"additional","affiliation":[{"name":"School of Medicine, Aristotle University of Thessaloniki, 45642 Thesaloniki, Greece"},{"name":"Department of Nephrology, Hippokration Hospital, 54642 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Lioulios, G., Fylaktou, A., Papagianni, A., and Stangou, M. 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