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The potassium channel Kv1.3 in microglia has been reported as a promising therapeutic target in neurological diseases in which neuroinflammation is involved, such as multiple sclerosis (MS), Alzheimer\u2019s disease (AD), Parkinson\u2019s disease (PD), and middle cerebral artery occlusion\/reperfusion (MCAO\/R). Currently, little is known about the relationship between Kv1.3 and epilepsy. In this study, we found that Kv1.3 was upregulated in microglia in the KA-induced mouse epilepsy model. Importantly, blocking Kv1.3 with its specific small-molecule blocker 5-(4-phenoxybutoxy)psoralen (PAP-1) reduced seizure severity, prolonged seizure latency, and decreased neuronal loss. Mechanistically, we further confirmed that blockade of Kv1.3 suppressed proinflammatory microglial activation and reduced proinflammatory cytokine production by inhibiting the Ca2+\/NF-\u03baB signaling pathway. These results shed light on the critical function of microglial Kv1.3 in epilepsy and provided a potential therapeutic target.<\/jats:p>","DOI":"10.3390\/ijms232314693","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T02:05:37Z","timestamp":1669341937000},"page":"14693","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Blockade of Kv1.3 Potassium Channel Inhibits Microglia-Mediated Neuroinflammation in Epilepsy"],"prefix":"10.3390","volume":"23","author":[{"given":"Xinyi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pathophysiology, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China"},{"name":"Hubei Provincial Key Laboratory of Developmentally Originated Disease, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyu","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China"},{"name":"Hubei Provincial Key Laboratory of Developmentally Originated Disease, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China"},{"name":"Hubei Provincial Key Laboratory of Developmentally Originated Disease, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China"},{"name":"Hubei Provincial Key Laboratory of Developmentally Originated Disease, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghao","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China"},{"name":"Hubei Provincial Key Laboratory of Developmentally Originated Disease, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China"},{"name":"Hubei Provincial Key Laboratory of Developmentally Originated Disease, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taoxiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Hubei Provincial Key Laboratory of Developmentally Originated Disease, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China"},{"name":"Department of Physiology, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biwen","family":"Peng","sequence":"additional","affiliation":[{"name":"Hubei Provincial Key Laboratory of Developmentally Originated Disease, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China"},{"name":"Department of Physiology, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanhong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Immunology, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China"},{"name":"Hubei Provincial Key Laboratory of Developmentally Originated Disease, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4659-4388","authenticated-orcid":false,"given":"Song","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China"},{"name":"Hubei Provincial Key Laboratory of Developmentally Originated Disease, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China"},{"name":"Hubei Provincial Key Laboratory of Developmentally 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Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nrneurol.2010.178","article-title":"The role of inflammation in epilepsy","volume":"7","author":"Vezzani","year":"2011","journal-title":"Nat. Rev. Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"8523","DOI":"10.1523\/JNEUROSCI.21-21-08523.2001","article-title":"Physiological and structural evidence for hippocampal involvement in persistent seizure susceptibility after traumatic brain injury","volume":"21","author":"Golarai","year":"2001","journal-title":"J. Neurosci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/ng.3153","article-title":"Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy","volume":"47","author":"Simons","year":"2015","journal-title":"Nat. Genet."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1474-4422(13)70003-6","article-title":"Prevalence of active convulsive epilepsy in sub-Saharan Africa and associated risk factors: Cross-sectional and case-control studies","volume":"12","author":"Ngugi","year":"2013","journal-title":"Lancet Neurol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/nrneurol.2012.181","article-title":"Pharmacoresistance and the role of surgery in difficult to treat epilepsy","volume":"8","author":"Wiebe","year":"2012","journal-title":"Nat. Rev. Neurol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"a022699","DOI":"10.1101\/cshperspect.a022699","article-title":"Immunity and Inflammation in Epilepsy","volume":"6","author":"Vezzani","year":"2015","journal-title":"Cold. Spring Harb. Perspect. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1007\/s00259-022-05719-7","article-title":"[(18)F]DPA-714 PET imaging for the quantitative evaluation of early spatiotemporal changes of neuroinflammation in rat brain following status epilepticus","volume":"49","author":"Kaneko","year":"2022","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.neuropharm.2014.10.027","article-title":"Neuromodulatory properties of inflammatory cytokines and their impact on neuronal excitability","volume":"96","author":"Vezzani","year":"2015","journal-title":"Neuropharmacology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1600-0404.2007.00882.x","article-title":"Increased plasma levels of cytokines after seizures in localization-related epilepsy","volume":"116","author":"Lehtimaki","year":"2007","journal-title":"Acta Neurol. Scand."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"5054","DOI":"10.1523\/JNEUROSCI.19-12-05054.1999","article-title":"Interleukin-1beta immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: Functional evidence for enhancement of electrographic seizures","volume":"19","author":"Vezzani","year":"1999","journal-title":"J. Neurosci."},{"key":"ref_12","first-page":"3130","article-title":"n-3 Docosapentaenoic acid-derived protectin D1 promotes resolution of neuroinflammation and arrests epileptogenesis","volume":"141","author":"Frigerio","year":"2018","journal-title":"Brain"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12974-018-1063-2","article-title":"Systemic autoinflammation with intractable epilepsy managed with interleukin-1 blockade","volume":"15","author":"DeSena","year":"2018","journal-title":"J. Neuroinflamm."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1002\/ana.25374","article-title":"Tocilizumab treatment for new onset refractory status epilepticus","volume":"84","author":"Jun","year":"2018","journal-title":"Ann. Neurol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1111\/epi.13387","article-title":"Anti-tumor necrosis factor alpha therapy (adalimumab) in Rasmussen\u2019s encephalitis: An open pilot study","volume":"57","author":"Lagarde","year":"2016","journal-title":"Epilepsia"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"868","DOI":"10.4161\/hv.28400","article-title":"Targeting inflammation as a therapeutic strategy for drug-resistant epilepsies: An update of new immune-modulating approaches","volume":"10","author":"Vitaliti","year":"2014","journal-title":"Hum. Vaccin. Immunother."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e135391","DOI":"10.1172\/jci.insight.135391","article-title":"Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus","volume":"6","author":"Sano","year":"2021","journal-title":"JCI Insight"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/s12974-022-02560-5","article-title":"Conditional knockout of ASK1 in microglia\/macrophages attenuates epileptic seizures and long-term neurobehavioural comorbidities by modulating the inflammatory responses of microglia\/macrophages","volume":"19","author":"Zhang","year":"2022","journal-title":"J. Neuroinflamm."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1080\/14728222.2021.1908263","article-title":"Potassium channels as prominent targets and tools for the treatment of epilepsy","volume":"25","author":"Nikitin","year":"2021","journal-title":"Expert. Opin. Ther. Targets."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1177\/1073858418763752","article-title":"Potassium Channel Gain of Function in Epilepsy: An Unresolved Paradox","volume":"24","author":"Niday","year":"2018","journal-title":"Neuroscientist"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"32697","DOI":"10.1074\/jbc.273.49.32697","article-title":"ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide","volume":"273","author":"Kalman","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"776","DOI":"10.4049\/jimmunol.173.2.776","article-title":"K+ channel expression during B cell differentiation: Implications for immunomodulation and autoimmunity","volume":"173","author":"Wulff","year":"2004","journal-title":"J. Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"46307","DOI":"10.1074\/jbc.M304388200","article-title":"Differential voltage-dependent K+ channel responses during proliferation and activation in macrophages","volume":"278","author":"Vicente","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.expneurol.2016.06.011","article-title":"Targeting Kv1.3 channels to reduce white matter pathology after traumatic brain injury","volume":"283","author":"Reeves","year":"2016","journal-title":"Exp. Neurol."},{"key":"ref_25","first-page":"4195","article-title":"Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson\u2019s disease","volume":"130","author":"Sarkar","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e2013545118","DOI":"10.1073\/pnas.2013545118","article-title":"Unique molecular characteristics and microglial origin of Kv1.3 channel-positive brain myeloid cells in Alzheimer\u2019s disease","volume":"118","author":"Ramesha","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1093\/brain\/awx346","article-title":"Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer\u2019s disease: Preclinical proof of concept","volume":"141","author":"Maezawa","year":"2018","journal-title":"Brain"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"113399","DOI":"10.1016\/j.expneurol.2020.113399","article-title":"Kv1.3 channel blockade alleviates cerebral ischemia\/reperfusion injury by reshaping M1\/M2 phenotypes and compromising the activation of NLRP3 inflammasome in microglia","volume":"332","author":"Ma","year":"2020","journal-title":"Exp. Neurol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3389\/fnmol.2018.00217","article-title":"Kainate Receptors: Role in Epilepsy","volume":"11","author":"Sihra","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1126\/science.1088208","article-title":"CB1 cannabinoid receptors and on-demand defense against excitotoxicity","volume":"302","author":"Marsicano","year":"2003","journal-title":"Science"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13578-020-00387-2","article-title":"Dynorphin activation of kappa opioid receptor promotes microglial polarization toward M2 phenotype via TLR4\/NF-kappaB pathway","volume":"10","author":"Liu","year":"2020","journal-title":"Cell Biosci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"856","DOI":"10.3389\/fphar.2019.00856","article-title":"Amentoflavone Affects Epileptogenesis and Exerts Neuroprotective Effects by Inhibiting NLRP3 Inflammasome","volume":"10","author":"Rong","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"627557","DOI":"10.3389\/fphar.2021.627557","article-title":"Agmatine Alleviates Epileptic Seizures and Hippocampal Neuronal Damage by Inhibiting Gasdermin D-Mediated Pyroptosis","volume":"12","author":"Li","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1002\/glia.23847","article-title":"Biophysical basis for Kv1.3 regulation of membrane potential changes induced by P2X4-mediated calcium entry in microglia","volume":"68","author":"Nguyen","year":"2020","journal-title":"Glia"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.niox.2021.01.001","article-title":"Nitric oxide displays a biphasic effect on calcium dynamics in microglia","volume":"108","author":"Maksoud","year":"2021","journal-title":"Nitric. Oxide"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/epi4.12560","article-title":"Different pharmacoresistance of focal epileptic spasms, generalized epileptic spasms, and generalized epileptic spasms combined with focal seizures","volume":"7","author":"Takahashi","year":"2022","journal-title":"Epilepsia Open"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/brain\/awh682","article-title":"Molecular and cellular mechanisms of pharmacoresistance in epilepsy","volume":"129","author":"Remy","year":"2006","journal-title":"Brain"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/nrneurol.2012.229","article-title":"Genetics: Mutations in potassium channel KCNT1-a novel driver of epilepsy pathogenesis","volume":"8","author":"Kingwell","year":"2012","journal-title":"Nat. Rev. Neurol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1085\/jgp.201511444","article-title":"A novel epileptic encephalopathy mutation in KCNB1 disrupts Kv2.1 ion selectivity, expression, and localization","volume":"146","author":"Thiffault","year":"2015","journal-title":"J. Gen. Physiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"103848","DOI":"10.1016\/j.ejmg.2020.103848","article-title":"A de novo heterozygous mutation in KCNC2 gene implicated in severe developmental and epileptic encephalopathy","volume":"63","author":"Vetri","year":"2020","journal-title":"Eur. J. Med. Genet."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/epi4.12353","article-title":"A novel homozygous KCNQ3 loss-of-function variant causes non-syndromic intellectual disability and neonatal-onset pharmacodependent epilepsy","volume":"4","author":"Lauritano","year":"2019","journal-title":"Epilepsia Open"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1093\/brain\/122.5.817","article-title":"A novel mutation in the human voltage-gated potassium channel gene (Kv1.1) associates with episodic ataxia type 1 and sometimes with partial epilepsy","volume":"122","author":"Zuberi","year":"1999","journal-title":"Brain"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1212\/WNL.0000000000003309","article-title":"Dominant KCNA2 mutation causes episodic ataxia and pharmacoresponsive epilepsy","volume":"87","author":"Corbett","year":"2016","journal-title":"Neurology"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/cns.12402","article-title":"Psora-4, a Kv1.3 Blocker, Enhances Differentiation and Maturation in Neural Progenitor Cells","volume":"21","author":"Zhou","year":"2015","journal-title":"CNS Neurosci. Ther."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.brainres.2007.03.017","article-title":"Seizure activity affects neuroglial Kv1 channel immunoreactivities in the gerbil hippocampus","volume":"1151","author":"Kim","year":"2007","journal-title":"Brain Res."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Anton, R., Ghenghea, M., Ristoiu, V., Gattlen, C., Suter, M.R., Cojocaru, P.A., Popa-Wagner, A., Catalin, B., and Deftu, A.F. (2021). Potassium Channels Kv1.3 and Kir2.1 But Not Kv1.5 Contribute to BV2 Cell Line and Primary Microglial Migration. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22042081"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"7139","DOI":"10.1523\/JNEUROSCI.1251-05.2005","article-title":"Microglia Kv1.3 channels contribute to their ability to kill neurons","volume":"25","author":"Fordyce","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/glia.23078","article-title":"Differential Kv1.3, KCa3.1, and Kir2.1 expression in \u201cclassically\u201d and \u201calternatively\u201d activated microglia","volume":"65","author":"Nguyen","year":"2017","journal-title":"Glia"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Charolidi, N., Schilling, T., and Eder, C. (2015). Microglial Kv1.3 Channels and P2Y12 Receptors Differentially Regulate Cytokine and Chemokine Release from Brain Slices of Young Adult and Aged Mice. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0128463"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1007\/s13311-022-01198-8","article-title":"Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4) Mitigates Seizures","volume":"19","author":"Zeng","year":"2022","journal-title":"Neurotherapeutics"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1161\/CIRCULATIONAHA.118.038379","article-title":"RIPK1 Expression Associates With Inflammation in Early Atherosclerosis in Humans and Can Be Therapeutically Silenced to Reduce NF-kappaB Activation and Atherogenesis in Mice","volume":"143","author":"Karunakaran","year":"2021","journal-title":"Circulation"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"11151","DOI":"10.1093\/nar\/gkz873","article-title":"The regulation of sequence specific NF-kappaB DNA binding and transcription by IKKbeta phosphorylation of NF-kappaB p50 at serine 80","volume":"47","author":"Smith","year":"2019","journal-title":"Nucleic. Acids Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nri.2017.142","article-title":"NF-kappaB, inflammation, immunity and cancer: Coming of age","volume":"18","author":"Taniguchi","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41392-020-00312-6","article-title":"Targeting NF-kappaB pathway for the therapy of diseases: Mechanism and clinical study","volume":"5","author":"Yu","year":"2020","journal-title":"Signal. Transduct. Target. Ther."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12974-021-02133-y","article-title":"The effect of dipeptidyl peptidase IV on disease-associated microglia phenotypic transformation in epilepsy","volume":"18","author":"Zheng","year":"2021","journal-title":"J. Neuroinflamm."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e51404","DOI":"10.15252\/embr.202051404","article-title":"Absence of RNA-binding protein FXR2P prevents prolonged phase of kainate-induced seizures","volume":"22","author":"Lo","year":"2021","journal-title":"EMBO Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/s41419-021-04450-9","article-title":"TRPV1 channel mediates NLRP3 inflammasome-dependent neuroinflammation in microglia","volume":"12","author":"Zhang","year":"2021","journal-title":"Cell Death Dis."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/23\/14693\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:26:11Z","timestamp":1760145971000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/23\/14693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,24]]},"references-count":58,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["ijms232314693"],"URL":"https:\/\/doi.org\/10.3390\/ijms232314693","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,24]]}}}