{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T17:15:37Z","timestamp":1765041337921,"version":"build-2065373602"},"reference-count":85,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Priority-2030, Strategic Project #4\/1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Stress-induced conditions are associated with impaired cerebral blood flow (CBF) and increased risk of dementia and stroke. However, these conditions do not develop in resilient humans and animals. Here the effects of predator stress (PS, cat urine scent, ten days) on CBF and mechanisms of CBF regulation were compared in PS-susceptible (PSs) and PS-resilient (PSr) rats. Fourteen days post-stress, the rats were segregated into PSs and PSr groups based on a behavior-related anxiety index (AI). CBF and its endothelium-dependent changes were measured in the parietal cortex by laser Doppler flowmetry. The major findings are: (1) PS susceptibility was associated with reduced basal CBF and endothelial dysfunction. In PSr rats, the basal CBF was higher, and endothelial dysfunction was attenuated. (2) CBF was inversely correlated with the AI of PS-exposed rats. (3) Endothelial dysfunction was associated with a decrease in eNOS mRNA in PSs rats compared to the PSr and control rats. (4) Brain dopamine was reduced in PSs rats and increased in PSr rats. (5) Plasma corticosterone of PSs was reduced compared to PSr and control rats. (6) A hypercoagulation state was present in PSs rats but not in PSr rats. Thus, potential stress resilience mechanisms that are protective for CBF were identified.<\/jats:p>","DOI":"10.3390\/ijms232314729","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T01:58:46Z","timestamp":1669600726000},"page":"14729","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cerebral Blood Flow in Predator Stress-Resilient and -Susceptible Rats and Mechanisms of Resilience"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8096-5974","authenticated-orcid":false,"given":"Marina V.","family":"Kondashevskaya","sequence":"first","affiliation":[{"name":"Avtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow 117418, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7280-1021","authenticated-orcid":false,"given":"H. Fred","family":"Downey","sequence":"additional","affiliation":[{"name":"School of Medical Biology, South Ural State University, Chelyabinsk 454080, Russia"},{"name":"Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX 76107, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vadim E.","family":"Tseilikman","sequence":"additional","affiliation":[{"name":"School of Medical Biology, South Ural State University, Chelyabinsk 454080, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4625-6522","authenticated-orcid":false,"given":"Valery V.","family":"Alexandrin","sequence":"additional","affiliation":[{"name":"Institute of General Pathology and Pathophysiology, Moscow 125315, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1014-752X","authenticated-orcid":false,"given":"Kseniya A.","family":"Artem\u2019yeva","sequence":"additional","affiliation":[{"name":"Avtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow 117418, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina V.","family":"Aleksankina","sequence":"additional","affiliation":[{"name":"Avtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow 117418, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga B.","family":"Tseilikman","sequence":"additional","affiliation":[{"name":"School of Medical Biology, South Ural State University, Chelyabinsk 454080, Russia"},{"name":"School of Basic Medicine, Chelyabinsk State University, Chelyabinsk 117418, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton A.","family":"Pashkov","sequence":"additional","affiliation":[{"name":"School of Medical Biology, South Ural State University, Chelyabinsk 454080, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna V.","family":"Goryacheva","sequence":"additional","affiliation":[{"name":"Institute of General Pathology and Pathophysiology, Moscow 125315, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina S.","family":"Ivleva","sequence":"additional","affiliation":[{"name":"Pavlov Department of Physiology, Institute of Experimental Medicine, Saint Petersburg 197376, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina N.","family":"Karpenko","sequence":"additional","affiliation":[{"name":"Pavlov Department of Physiology, Institute of Experimental Medicine, Saint Petersburg 197376, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladislav A.","family":"Shatilov","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Chelyabinsk State University, Chelyabinsk 117418, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8102-173X","authenticated-orcid":false,"given":"Eugenia B.","family":"Manukhina","sequence":"additional","affiliation":[{"name":"School of Medical Biology, South Ural State University, Chelyabinsk 454080, Russia"},{"name":"Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX 76107, USA"},{"name":"Institute of General Pathology and Pathophysiology, Moscow 125315, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.neuropharm.2011.04.023","article-title":"Animal model for PTSD: From clinical concept to translational research","volume":"62","author":"Cohen","year":"2012","journal-title":"Neuropharmacology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1196\/annals.1314.014","article-title":"Animal models of post-traumatic stress disorder: The use of cut off behavioral criteria","volume":"1032","author":"Cohen","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3109\/09540261.2012.736367","article-title":"Review of somatic symptoms in post-traumatic stress disorder","volume":"25","author":"Gupta","year":"2013","journal-title":"Int. Rev. Psychiatry"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1097\/PSY.0b013e3182303775","article-title":"Medical comorbidity of full and partial posttraumatic stress disorder in US adults: Results from Wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions","volume":"73","author":"Pietrzak","year":"2011","journal-title":"Psychosom. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.ahj.2013.07.031","article-title":"Posttraumatic stress disorder and risk for coronary heart disease: A meta-analytic review","volume":"166","author":"Edmondson","year":"2013","journal-title":"Am. Heart J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1002\/da.23271","article-title":"Involvement of the brain-heart axis in the link between PTSD and cardiovascular disease","volume":"39","author":"Seligowski","year":"2022","journal-title":"Depress. Anxiety"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s12576-017-0525-0","article-title":"Relationship between cognitive function and regulation of cerebral blood flow","volume":"67","author":"Ogoh","year":"2017","journal-title":"J. Physiol. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e004572","DOI":"10.1161\/CIRCOUTCOMES.117.004572","article-title":"Post-traumatic stress disorder and cardiovascular diseases: A cohort study of men and women involved in cleaning the debris of the World Trade Center Complex","volume":"11","author":"Remch","year":"2018","journal-title":"Circ. Cardiovasc. Qual. Outcomes."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Liu, Y., Li, B., Feng, N., Pu, H., Zhang, X., Lu, H., and Yin, H. (2016). Perfusion deficits and functional connectivity alterations in memory-related regions of patients with post-traumatic stress disorder. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0156016"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1152\/japplphysiol.00502.2018","article-title":"Cerebral blood flow regulation and cognitive function in women with posttraumatic stress disorder","volume":"125","author":"Ogoh","year":"2018","journal-title":"J. Appl. Physiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1037\/a0038039","article-title":"A quantitative meta-analysis of neurocognitive functioning in posttraumatic stress disorder","volume":"141","author":"Scott","year":"2015","journal-title":"Psychol. Bull."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1177\/0891988720957088","article-title":"Risk of dementia in posttraumatic stress disorder","volume":"34","author":"Elias","year":"2021","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.psychres.2006.12.003","article-title":"Measures of endothelial dysfunction in plasma of patients with posttraumatic stress disorder","volume":"158","author":"Hepp","year":"2008","journal-title":"Psychiatry Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e003010","DOI":"10.1161\/JAHA.115.003010","article-title":"Posttraumatic stress disorder is associated with worse endothelial function among veterans","volume":"5","author":"Grenon","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e043060","DOI":"10.1136\/bmjopen-2020-043060","article-title":"Key dimensions of post-traumatic stress disorder and endothelial dysfunction: A protocol for a mechanism-focused cohort study","volume":"11","author":"Cleveland","year":"2021","journal-title":"BMJ Open"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1176\/ajp.156.6.902","article-title":"Previous exposure to trauma and PTSD effects of subsequent trauma: Results from the Detroit Area Survey of Trauma","volume":"156","author":"Breslau","year":"1999","journal-title":"Am. J. Psychiatry"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.expneurol.2016.07.002","article-title":"Understanding resilience: New approaches for preventing and treating PTSD","volume":"284","author":"Horn","year":"2016","journal-title":"Exp. Neurol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1080\/08964289.2016.1170661","article-title":"Adapting to stress: Understanding the neurobiology of resilience","volume":"43","author":"Osorio","year":"2017","journal-title":"Behav. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"856998","DOI":"10.3389\/fpsyt.2022.856998","article-title":"The molecular basis of resilience: A narrative review","volume":"13","author":"Ryan","year":"2022","journal-title":"Front. Psychiatry"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1152\/japplphysiol.00694.2019","article-title":"Cardiac injury in rats with experimental posttraumatic stress disorder and mechanisms of its limitation in experimental posttraumatic stress disorder-resistant rats","volume":"130","author":"Manukhina","year":"2021","journal-title":"J. Appl. Physiol. (1985)"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s10571-017-0517-x","article-title":"Posttraumatic stress disorder disturbs coronary tone and its regulatory mechanisms","volume":"38","author":"Lazuko","year":"2018","journal-title":"Cell Mol. Neurobiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1152\/japplphysiol.01123.2017","article-title":"Intermittent hypoxia improves behavioral and adrenal gland dysfunction induced by post-traumatic stress disorder in rats","volume":"125","author":"Manukhina","year":"2018","journal-title":"J. Appl. Physiol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Manukhina, E.B., Tseilikman, V.E., Karpenko, M.N., Pestereva, N.S., Tseilikman, O.B., Komelkova, M.V., Kondashevskaya, M.V., Goryacheva, A.V., Lapshin, M.S., and Platkovskii, P.O. (2020). Intermittent hypoxic conditioning alleviates post-traumatic stress disorder-induced damage and dysfunction of rat visceral organs and brain. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21010345"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"187","DOI":"10.4149\/gpb_2019003","article-title":"Chronic predator scent stress alters serotonin and dopamine levels in the rat thalamus and hypothalamus, respectively","volume":"38","author":"Dremencov","year":"2019","journal-title":"Gen. Physiol. Biophys."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1055\/a-0975-9268","article-title":"Post-traumatic stress disorder chronification via monoaminoxidase and cortisol metabolism","volume":"51","author":"Tseilikman","year":"2019","journal-title":"Horm. Metab. Res."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Tseilikman, V., Komelkova, M., Kondashevskaya, M.V., Manukhina, E., Downey, H.F., Chereshnev, V., Chereshneva, M., Platkovskii, P., Goryacheva, A., and Pashkov, A. (2021). A rat model of post-traumatic stress syndrome causes phenotype-associated morphological changes and hypofunction of the adrenal gland. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222413235"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Tseilikman, V., Lapshin, M., Klebanov, I., Chrousos, G., Vasilieva, M., Pashkov, A., Fedotova, J., Tseilikman, D., Shatilov, V., and Manukhina, E. (2022). The link between activities of hepatic 11beta-hydroxysteroid dehydrogenase-1 and monoamine oxidase-A in the brain following repeated predator stress: Focus on heightened anxiety. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23094881"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s12028-008-9143-2","article-title":"Dopamine D2-receptor-mediated increase in vascular and endothelial NOS activity ameliorates cerebral vasospasm after subarachnoid hemorrhage in vitro","volume":"10","author":"Caudell","year":"2009","journal-title":"Neurocrit. Care"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e1381","DOI":"10.7717\/peerj.1381","article-title":"Effects of acute levodopa challenge on resting cerebral blood flow in Parkinson\u2019s Disease patients assessed using pseudo-continuous arterial spin labeling","volume":"3","author":"Chen","year":"2015","journal-title":"Peer J."},{"key":"ref_30","first-page":"55","article-title":"How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions","volume":"21","author":"Sapolsky","year":"2000","journal-title":"Endocr. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1159\/000049028","article-title":"Plasma and cerebrospinal fluid Interleukin-6 concentrations in posttraumatic stress disorder","volume":"9","author":"Baker","year":"2001","journal-title":"Neuroimmunomodulation"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/13651501.2019.1699575","article-title":"Alexithymia, suicide ideation, affective temperaments and homocysteine levels in drug na\u00efve patients with post-traumatic stress disorder: An exploratory study in the everyday \u2018real world\u2019 clinical practice","volume":"24","author":"Vellante","year":"2020","journal-title":"Int. J. Psychiatry Clin. Pract."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Smagin, D.A., Kovalenko, I.L., Galyamina, A.G., Belozertseva, I.V., Tamkovich, N.V., Baranov, K.O., and Kudryavtseva, N.N. (2021). Chronic lithium treatment affects anxious behaviors and the expression of serotonergic genes in midbrain raphe nuclei of defeated male mice. Biomedicines, 9.","DOI":"10.1101\/2021.01.04.425168"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"S75","DOI":"10.1097\/00005344-200111002-00018","article-title":"Endothelial dysfunction and stroke","volume":"38","author":"Cosentino","year":"2001","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"770387","DOI":"10.3389\/fncel.2021.770387","article-title":"PTSD as an endothelial disease: Insights from COVID-19","volume":"15","author":"Sfera","year":"2021","journal-title":"Front. Cell Neurosci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"115108","DOI":"10.1016\/j.bcp.2022.115108","article-title":"Cardiovascular risk factors and molecular routes underlying endothelial dysfunction: Novel opportunities for primary prevention","volume":"202","author":"Benincasa","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.2174\/138920111798280974","article-title":"Role of endothelial nitric oxide in cerebrovascular regulation","volume":"12","author":"Atochin","year":"2011","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e13111","DOI":"10.1111\/apha.13111","article-title":"Endothelium-dependent responses in the microcirculation observed in vivo","volume":"224","author":"Rosenblum","year":"2018","journal-title":"Acta Physiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/GME.0000000000001036","article-title":"Trauma exposure and endothelial function among midlife women","volume":"25","author":"Thurston","year":"2018","journal-title":"Menopause"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s11920-016-0739-5","article-title":"Anxiety disorders and cardiovascular disease","volume":"18","author":"Celano","year":"2016","journal-title":"Curr. Psychiatry Rep."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/hup.2470","article-title":"Influence of depression and anxiety on circulating endothelial progenitor cells in patients with acute coronary syndromes","volume":"30","author":"Felice","year":"2015","journal-title":"Hum. Psychopharmacol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1108\/13639510710753207","article-title":"Post-traumatic stress symptoms and cortisol patterns among police officers","volume":"30","author":"Violanti","year":"2007","journal-title":"Policing An Intl. J. Police Strateg. Mgmt."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.brainres.2004.10.004","article-title":"Characterization of regional cerebral blood flow and expression of angiogenic growth factors in the frontal cortex of juvenile male SHRSP and SHR","volume":"1030","author":"Jesmin","year":"2004","journal-title":"Brain Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"101506","DOI":"10.1016\/j.redox.2020.101506","article-title":"Oxidative stress and inflammation contribute to traffic noise-induced vascular and cerebral dysfunction via uncoupling of nitric oxide synthases","volume":"34","author":"Daiber","year":"2020","journal-title":"Redox Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0021-9150(97)00202-5","article-title":"Psychosocial stress causes endothelial injury in cynomolgus monkeys via \u03b21- adrenoceptor activation","volume":"136","author":"Skantze","year":"1998","journal-title":"Atherosclerosis"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.atherosclerosis.2010.08.052","article-title":"Immobilization stress induces endothelial dysfunction by oxidative stress via the activation of angiotensin II\/its type I receptor pathway","volume":"213","author":"Chung","year":"2010","journal-title":"Atherosclerosis"},{"key":"ref_47","first-page":"1243","article-title":"Nitric oxide in the stress axis","volume":"13","author":"Day","year":"1998","journal-title":"Histol. Histopath."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s00424-011-1022-6","article-title":"How mental stress affects endothelial function","volume":"462","author":"Toda","year":"2011","journal-title":"Pflugers Arch."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1093\/cvr\/cvn231","article-title":"Glucocorticoid response elements and 11 \u03b2-hydroxysteroid dehydrogenases in the regulation of endothelial nitric oxide synthase expression","volume":"81","author":"Liu","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"13357","DOI":"10.1073\/pnas.96.23.13357","article-title":"Down\u2013regulation of the expression of endothelial NO synthase is likely to contribute to glucocorticoid-mediated hypertension","volume":"96","author":"Wallerath","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"7836","DOI":"10.1007\/s12035-019-1600-8","article-title":"Understanding the scientific basis of post-traumatic stress disorder (PTSD): Precision behavioral management overrides stigmatization","volume":"56","author":"Blum","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1000116","DOI":"10.4172\/2157-7412.1000116","article-title":"Diagnosis and healing in veterans suspected of suffering from post-traumatic stress disorder (PTSD) using reward gene testing and reward circuitry natural dopaminergic activation","volume":"3","author":"Blum","year":"2012","journal-title":"J. Genet. Syndr. Gene Ther."},{"key":"ref_53","first-page":"681","article-title":"Persistence and change of PTSD symptomatology\u2014A longitudinal co-twin control analysis of the Vietnam Era Twin Registry","volume":"39","author":"Arguelles","year":"2004","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1556\/2006.4.2015.008","article-title":"Putative dopamine agonist (KB220Z) attenuates lucid nightmares in PTSD patients: Role of enhanced brain reward functional connectivity and homeostasis redeeming joy","volume":"4","author":"McLaughlin","year":"2015","journal-title":"J. Behav. Addict."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"24","DOI":"10.17756\/jrds.2015-006","article-title":"Using the neuroadaptagen KB200z to ameliorate terrifying, lucid nightmares in RDS patients: The role of enhanced, brain-reward, functional connectivity and dopaminergic homeostasis","volume":"1","author":"McLaughlin","year":"2015","journal-title":"J. Reward. Defic. Syndr."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.brainres.2017.06.010","article-title":"Dopamine protects cerebral autoregulation and prevents hippocampal necrosis after traumatic brain injury via block of ERK MAPK in juvenile pigs","volume":"1670","author":"Curvello","year":"2017","journal-title":"Brain Res."},{"key":"ref_57","first-page":"84","article-title":"Striatal vessels receive phosphorylated tyrosine hydroxylase-rich innervation from midbrain dopaminergic neurons","volume":"26","author":"Lanciego","year":"2014","journal-title":"Front. Neuroanat."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0022-510X(78)90144-2","article-title":"Regional cerebral blood flow in parkinsonism. Measurement before and after levodopa","volume":"38","author":"Melamed","year":"1978","journal-title":"J. Neurol. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.bbrc.2019.08.080","article-title":"Dopamine D4 receptor protected against hyperglycemia-induced endothelial dysfunction via PI3K\/eNOS pathway","volume":"518","author":"Wang","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_60","first-page":"181","article-title":"Local cerebral blood flow in the dog during intravenous infusion of dopamine","volume":"13","author":"Zervas","year":"1980","journal-title":"Surg. Neurol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"117999","DOI":"10.1016\/j.neuroimage.2021.117999","article-title":"Dopaminergic modulation of regional cerebral blood flow: An arterial spin labelling study of genetic and pharmacological manipulation of COMT activity","volume":"234","author":"Martens","year":"2021","journal-title":"Neuroimage"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1056\/NEJMra012941","article-title":"Post-traumatic stress disorder","volume":"346","author":"Yehuda","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"112591","DOI":"10.1016\/j.bbr.2020.112591","article-title":"Individual susceptibility or resistance to posttraumatic stress disorder-like behaviours","volume":"386","author":"Lehner","year":"2020","journal-title":"Behav. Brain Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/HRP.0000000000000167","article-title":"Oxidative stress, inflammation, and neuroprogression in chronic PTSD","volume":"26","author":"Miller","year":"2018","journal-title":"Harv. Rev. Psychiatry"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1037\/a0035302","article-title":"From stress to inflammation and major depressive disorder: A social signal transduction theory of depression","volume":"140","author":"Slavich","year":"2014","journal-title":"Psychol. Bull."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jpsychires.2017.01.007","article-title":"Elevated C-reactive protein and posttraumatic stress pathology among survivors of the 9\/11 World Trade Center attacks","volume":"16","author":"Rosen","year":"2017","journal-title":"J. Psychiatr. Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/npp.2011.205","article-title":"Psychoneuroimmunology meets neuropsychopharmacology: Translational implications of the impact of inflammation on behavior","volume":"7","author":"Haroon","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/S2215-0366(15)00355-7","article-title":"Chronic inflammation: A new therapeutic target for post-traumatic stress disorder?","volume":"2","author":"Michopoulos","year":"2015","journal-title":"Lancet Psychiatry"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1037\/0022-006X.64.1.191","article-title":"Posttraumatic stress disorder, exposure to combat, and lower plasma cortisol among Vietnam veterans: Findings and clinical implications","volume":"64","author":"Boscarino","year":"1996","journal-title":"J. Consult. Clin. Psychol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0306-4530(99)00035-9","article-title":"The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders","volume":"25","author":"Heim","year":"2000","journal-title":"Psychoneuroendocrinology"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/S0006-3223(98)00131-0","article-title":"Elevated serum interleukin-6 (IL-6) and IL-6 receptor concentrations in posttraumatic stress disorder following accidental man-made traumatic events","volume":"45","author":"Maes","year":"1999","journal-title":"Biol. Psychiatry"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1161\/01.RES.0000171805.24799.fa","article-title":"Procoagulant soluble tissue factor is released from endothelial cells in response to inflammatory cytokines","volume":"96","author":"Szotowski","year":"2005","journal-title":"Circ. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.jpsychires.2006.06.009","article-title":"Evidence for low-grade systemic proinflammatory activity in patients with posttraumatic stress disorder","volume":"41","author":"Hepp","year":"2007","journal-title":"J. Psychiatr. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1001\/archpsyc.64.1.109","article-title":"Prospective study of posttraumatic stress disorder symptoms and coronary heart disease in the Normative Aging Study","volume":"64","author":"Kubzansky","year":"2007","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/01.PSY.0000039753.23250.20","article-title":"Association of negative life event stress with coagulation activity in elderly Alzheimer caregivers","volume":"65","author":"Dimsdale","year":"2003","journal-title":"Psychosom. Med."},{"key":"ref_76","first-page":"548","article-title":"Hypercoagulation in chronic post-traumatic stress disorder","volume":"13","author":"Robicsek","year":"2011","journal-title":"Isr. Med. Assoc. J."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1097\/PSY.0b013e318245d950","article-title":"Stress-induced alterations in coagulation: Assessment of a new hemoconcentration correction technique","volume":"74","author":"Austin","year":"2012","journal-title":"Psychosom. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.thromres.2008.05.014","article-title":"Prothrombotic changes with acute psychological stress: Combined effect of hemoconcentration and genuine coagulation activation","volume":"123","author":"Kudielka","year":"2009","journal-title":"Thromb. Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1097\/01.psy.0000221229.43272.9d","article-title":"Altered blood coagulation in patients with posttraumatic stress disorder","volume":"68","author":"Hepp","year":"2006","journal-title":"Psychosom. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1055\/s-0033-1357487","article-title":"Stress and hemostasis: An update","volume":"39","author":"Austin","year":"2013","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Theofilis, P., Sagris, M., Oikonomou, E., Antonopoulos, A.S., Siasos, G., Tsioufis, C., and Tousoulis, D. (2021). Inflammatory Mechanisms Contributing to Endothelial Dysfunction. Biomedicines, 9.","DOI":"10.3390\/biomedicines9070781"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s11920-020-1140-y","article-title":"Gender- and sex-based contributors to sex differences in PTSD","volume":"22","author":"Christiansen","year":"2020","journal-title":"Curr. Psychiatry Rep."},{"key":"ref_83","first-page":"34","article-title":"Gender differences in trauma and posttraumatic stress disorder","volume":"5","author":"Breslau","year":"2002","journal-title":"J. Gend. Specif. Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1176\/appi.ajp.158.11.1923","article-title":"Gender differences in patients with posttraumatic stress disorder in a general psychiatric practice","volume":"158","author":"Zlotnick","year":"2001","journal-title":"Am. J. Psychiatry"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/0471142301.ns0945s64","article-title":"Animal models of post-traumatic stress disorder","volume":"64","author":"Cohen","year":"2013","journal-title":"Curr. Protoc. 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