{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:49:50Z","timestamp":1778860190589,"version":"3.51.4"},"reference-count":41,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Agence Nationale de la Recherche (ANR TOLIM-MUNPAL project)"},{"name":"Universit\u00e9 Paris Cit\u00e9"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>This paper aimed to investigate the influence of polymorphisms in the FCGR2A gene encoding R131H FcgRIIA variants and in the FCGR3B gene (108G &gt; C, 114C &gt; T, 194 A &gt; G, 233C &gt; A, 244 G &gt; A and 316G &gt; A) encoding FcgRIIIB-NA1, -NA2 and -SH variants on malaria susceptibility and antibody responses against P. falciparum merozoite antigens in Beninese children. An active malaria follow-up was conducted in infants from birth to 24 months of age in Allada, Benin. FCGR3B exon 3 was sequenced and FCGR2A exon 4 was genotyped. Antibodies directed to GLURP and MSP3 were quantified by ELISA. Association studies were performed using mixed-effect models. Individual carriage of FCGR3B 194 AA genotype was associated with a high number of malaria infections and a low level of IgG1 against MSP3 and GLURP-R0. High parasitemia and increased malaria infections were observed in infants carrying the FCGR3B*05 108C-114T-194A-233C-244A-316A haplotype. A reduced risk of malaria infections and low parasitemia were related to the carriages of the FCGR3B 108C-114T-194G-233C-244G-316A (FCGR3B*06), FCGR3B 108C\u2013114T\u2013194G\u2013233A\u2013244A\u2013316A (FCGR3B*03 encoding for FcgRIIIB-SH) haplotypes and FCGR3B 297 TT genotype. Our results highlight the impact of FCGR3B polymorphisms on the individual susceptibility to malaria and antibody responses against MSP3 and GLURP in Beninese children.<\/jats:p>","DOI":"10.3390\/ijms232314882","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T04:56:25Z","timestamp":1669611385000},"page":"14882","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Fc Gamma Receptor IIIB NA1\/NA2\/SH Polymorphisms Are Associated with Malaria Susceptibility and Antibody Levels to P. falciparum Merozoite Antigens in Beninese Children"],"prefix":"10.3390","volume":"23","author":[{"given":"Abdou Khadre Dit Jadir","family":"Fall","sequence":"first","affiliation":[{"name":"Institut de Recherche pour le D\u00e9veloppement, UMR 261 MERIT, Universit\u00e9 Paris Cit\u00e9, 75006 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Courtin","sequence":"additional","affiliation":[{"name":"Institut de Recherche pour le D\u00e9veloppement, UMR 261 MERIT, Universit\u00e9 Paris Cit\u00e9, 75006 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafiou","family":"Adamou","sequence":"additional","affiliation":[{"name":"Institut de Recherche pour le D\u00e9veloppement, UMR 261 MERIT, Universit\u00e9 Paris Cit\u00e9, 75006 Paris, France"},{"name":"Centre d\u2019Etude et de Recherche sur les Pathologies Associ\u00e9es \u00e0 la Grossesse et \u00e0 l\u2019Enfance, Cotonou 00229, Benin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofie","family":"Edslev","sequence":"additional","affiliation":[{"name":"Centre for Medical Parasitology, Department of International Health, Immunology and Microbiology, Department of Infectious Diseases, University of Copenhagen, Copenhagen University Hospital, Rigshospitalet, 2300 Copenhagen, Denmark"},{"name":"Bacteria, Parasites, and Fungi, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Hansen","sequence":"additional","affiliation":[{"name":"Centre for Medical Parasitology, Department of International Health, Immunology and Microbiology, Department of Infectious Diseases, University of Copenhagen, Copenhagen University Hospital, Rigshospitalet, 2300 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Domingo","sequence":"additional","affiliation":[{"name":"Institut de Recherche pour le D\u00e9veloppement, UMR 261 MERIT, Universit\u00e9 Paris Cit\u00e9, 75006 Paris, France"},{"name":"Centre d\u2019Etude et de Recherche sur les Pathologies Associ\u00e9es \u00e0 la Grossesse et \u00e0 l\u2019Enfance, Cotonou 00229, Benin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4713-755X","authenticated-orcid":false,"given":"Michael","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Department for Congenital Disorders, Statens Serum Institut, 2300 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bright","family":"Adu","sequence":"additional","affiliation":[{"name":"Centre for Medical Parasitology, Department of International Health, Immunology and Microbiology, Department of Infectious Diseases, University of Copenhagen, Copenhagen University Hospital, Rigshospitalet, 2300 Copenhagen, Denmark"},{"name":"Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra P.O. Box LG 581, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Milet","sequence":"additional","affiliation":[{"name":"Institut de Recherche pour le D\u00e9veloppement, UMR 261 MERIT, Universit\u00e9 Paris Cit\u00e9, 75006 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1808-472X","authenticated-orcid":false,"given":"Andr\u00e9","family":"Garcia","sequence":"additional","affiliation":[{"name":"Institut de Recherche pour le D\u00e9veloppement, UMR 261 MERIT, Universit\u00e9 Paris Cit\u00e9, 75006 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Theisen","sequence":"additional","affiliation":[{"name":"Centre for Medical Parasitology, Department of International Health, Immunology and Microbiology, Department of Infectious Diseases, University of Copenhagen, Copenhagen University Hospital, Rigshospitalet, 2300 Copenhagen, Denmark"},{"name":"Department for Congenital Disorders, Statens Serum Institut, 2300 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9982-594X","authenticated-orcid":false,"given":"Florence","family":"Migot-Nabias","sequence":"additional","affiliation":[{"name":"Institut de Recherche pour le D\u00e9veloppement, UMR 261 MERIT, Universit\u00e9 Paris Cit\u00e9, 75006 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8439-9976","authenticated-orcid":false,"given":"C\u00e9lia","family":"Dechavanne","sequence":"additional","affiliation":[{"name":"Institut de Recherche pour le D\u00e9veloppement, UMR 261 MERIT, Universit\u00e9 Paris Cit\u00e9, 75006 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"449","DOI":"10.4269\/ajtmh.1996.54.449","article-title":"Pattern of immunoglobulin isotype response to Plasmodium falciparum blood-stage antigens in individuals living in a holoendemic area of Senegal (Dielmo, west Africa)","volume":"54","author":"Aribot","year":"1996","journal-title":"Am. 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