{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:54:49Z","timestamp":1791608089389,"version":"4.3.4"},"reference-count":78,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hungarian Academy of Sciences (MTA)","award":["GINOP-2.3.2-15-2016-00021"],"award-info":[{"award-number":["GINOP-2.3.2-15-2016-00021"]}]},{"name":"National Laboratory on Human Reproduction","award":["GINOP-2.3.2-15-2016-00021"],"award-info":[{"award-number":["GINOP-2.3.2-15-2016-00021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Accumulating evidence are available on the involvement of l-arginine-nitric oxide (NO) system in complex biological processes and numerous clinical conditions. Particular attention was made to reveal the association of l-arginine and methylarginines to outcome measures of women undergoing in vitro fertilization (IVF). This review attempts to summarize the expression and function of the essential elements of this system with particular reference to the different stages of female reproduction. A literature search was performed on the PubMed and Google Scholar systems. Publications were selected for evaluation according to the results presented in the Abstract. The regulatory role of NO during the period of folliculogenesis, oocyte maturation, fertilization, embryogenesis, implantation, placentation, pregnancy, and delivery was surveyed. The major aspects of cellular l-arginine uptake via cationic amino acid transporters (CATs), arginine catabolism by nitric oxide synthases (NOSs) to NO and l-citrulline and by arginase to ornithine, and polyamines are presented. The importance of NOS inhibition by methylated arginines and the redox-sensitive elements of the process of NO generation are also shown. The l-arginine-NO system plays a crucial role in all stages of female reproduction. Insufficiently low or excessively high rates of NO generation may have adverse influences on IVF outcome.<\/jats:p>","DOI":"10.3390\/ijms232314908","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T01:42:02Z","timestamp":1669686122000},"page":"14908","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["The Role of L-Arginine-NO System in Female Reproduction: A Narrative Review"],"prefix":"10.3390","volume":"23","author":[{"given":"Jozsef","family":"Bodis","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Pecs School of Medicine, 7624 P\u00e9cs, Hungary"},{"name":"MTA-PTE Human Reproduction Scientific Research Group, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"National Laboratory on Human Reproduction, University of P\u00e9cs, 7622 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0638-2057","authenticated-orcid":false,"given":"Balint","family":"Farkas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Pecs School of Medicine, 7624 P\u00e9cs, Hungary"},{"name":"MTA-PTE Human Reproduction Scientific Research Group, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"National Laboratory on Human Reproduction, University of P\u00e9cs, 7622 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadett","family":"Nagy","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Pecs School of Medicine, 7624 P\u00e9cs, Hungary"},{"name":"MTA-PTE Human Reproduction Scientific Research Group, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"National Laboratory on Human Reproduction, University of P\u00e9cs, 7622 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalman","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Pecs School of Medicine, 7624 P\u00e9cs, Hungary"},{"name":"MTA-PTE Human Reproduction Scientific Research Group, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"National Laboratory on Human Reproduction, University of P\u00e9cs, 7622 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Endre","family":"Sulyok","sequence":"additional","affiliation":[{"name":"National Laboratory on Human Reproduction, University of P\u00e9cs, 7622 P\u00e9cs, Hungary"},{"name":"Faculty of Health Sciences, University of P\u00e9cs, 7621 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/288373a0","article-title":"The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine","volume":"288","author":"Furchgott","year":"1980","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Cziraki, A., Lenkey, Z., Sulyok, E., Szokodi, I., and Koller, A. (2020). L-arginine-nitric oxide-asymmetric dimethylarginine pathway and the coronary circulation: Translation of basic science results to clinical practice. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.569914"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00232-006-0875-7","article-title":"Structure and function of cationic amino acid transporters (CATs)","volume":"213","author":"Closs","year":"2006","journal-title":"J. Membr. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Van Winkle, L.J. (2010). Amino acid transport and metabolism regulate early embryo development: Species differences, clinical significance and evolutionary implications. Cells, 10.","DOI":"10.3390\/cells10113154"},{"key":"ref_5","first-page":"325","article-title":"Expression profiles of individual human oocytes using microarray technology","volume":"3","author":"Wellis","year":"2004","journal-title":"Reprod. Biomed. Online"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1095\/biolreprod.108.073890","article-title":"Select nutrients in the ovine uterine lumen. III. Cationic amino acid transporters in the ovine uterus and peri-implantation conceptuses","volume":"80","author":"Gao","year":"2009","journal-title":"Biol. Reprod."},{"key":"ref_7","first-page":"1113","article-title":"Tryptophan catabolism to serotonin and kynurenine in women undergoing in-vitro fertilization","volume":"69","author":"Sulyok","year":"2020","journal-title":"Psihol. Res."},{"key":"ref_8","first-page":"223","article-title":"Expression of serotonin receptors in mouse oocytes and preimplantation embryos","volume":"52","author":"Vesela","year":"2003","journal-title":"Psyhol. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1017\/S0967199404002862","article-title":"Serotonin localization and its functional significance during mouse preimplantation embryo development","volume":"12","author":"Rehak","year":"2004","journal-title":"Zygote"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1124\/mol.104.010124","article-title":"Intracellular cAMP and calcium signalling by serotonin in mouse cumulus-oocyte complexes","volume":"68","author":"Amireault","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1071\/RD10230","article-title":"Immunological mechanisms to establish embryo tolerance in early bovine pregnancy","volume":"23","author":"Groebner","year":"2011","journal-title":"Reprod. Fertil. Dev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0029-7844(96)00084-1","article-title":"Decreased plasma tryptophan in pregnancy","volume":"88","author":"Schrocksnadel","year":"1996","journal-title":"Obstet. Gynecol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1084\/jem.189.9.1363","article-title":"Inhibition of T cell proliferation by macrophage tryptophan catabolism","volume":"189","author":"Munn","year":"1999","journal-title":"Exp. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.14814\/phy2.12257","article-title":"Pregnant mice lacking indoleamine 2,3-digoxygenase exhibit preeclampsia phenotypes","volume":"3","author":"Santillan","year":"2015","journal-title":"Physiol. Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/0140-6736(92)90865-Z","article-title":"Accumulation of an endogenous inhibitor of NO synthesis in chronic renal failure","volume":"339","author":"Vallance","year":"1992","journal-title":"Lancet"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1006\/mgme.2000.3027","article-title":"Follic acid: Nutritional biochemistry, molecular biology, and role in disease processes","volume":"71","author":"Lucock","year":"2000","journal-title":"Mol. Genet. Metab."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1086\/321262","article-title":"Homocystine metabolism in children with Down syndrome","volume":"69","author":"Pogribna","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/ajcn\/81.1.147","article-title":"Congenital heart defects and abnormal maternal biomarkers of methionine and homocysteine metabolism","volume":"81","author":"Hobbes","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1097\/YCO.0000000000000046","article-title":"Lifetime requirement of the methionine cycle for neuronal development and maintenance","volume":"27","author":"Shea","year":"2014","journal-title":"Cuur. Opin. Psychiatry"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1530\/REP-15-0212","article-title":"Arginine methyltransferases mediate an epigenetic ovarian response to endometriosis","volume":"150","author":"Baumann","year":"2015","journal-title":"Reproduction"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1161\/ATVBAHA.109.185645","article-title":"Targeted metabolomics evaluation of arginine methylation and cardiovascular risk. Potential Mechanisms beyond nitric oxide synthase inhibition","volume":"29","author":"Wang","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1093\/humrep\/deq257","article-title":"Negative association of l-arginine methylation products with oocyte numbers","volume":"25","author":"Sulyok","year":"2010","journal-title":"Hum. Reprod. Adv. Acc."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/j.bbapap.2006.08.008","article-title":"Protein arginine methylation: Cellular functions and methods of analysis","volume":"1764","author":"Pahlich","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1007\/s00018-009-0010-x","article-title":"The protein aarginine methyltransferase family: An update about function, new perspectives and physiological role in humans","volume":"66","author":"Wolf","year":"2009","journal-title":"Cell Mol. Life Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4859","DOI":"10.1128\/MCB.20.13.4859-4869.2000","article-title":"Arginine N-methyltransferase 1 is required for early postimplantation mouse development, but cells deficient in the enzyme are viable","volume":"20","author":"Pawlak","year":"2000","journal-title":"Mol. Cell Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.molcel.2014.10.003","article-title":"PRMT5 Protects genomic integrity during global DNA demethylation in primordial germ cells and preimplantation embryos","volume":"56","author":"Kim","year":"2014","journal-title":"Mol. Cell"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"179572","DOI":"10.1242\/dev.179572","article-title":"Zebrafish prmt5 arginine methyltransferase is essential for germ cell development","volume":"146","author":"Zhu","year":"2019","journal-title":"Development"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"6464","DOI":"10.1073\/pnas.1232272100","article-title":"Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice","volume":"100","author":"Yadav","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"473","DOI":"10.3389\/fendo.2019.00473","article-title":"Epigenetics and female reproductive aging","volume":"10","author":"Chamani","year":"2019","journal-title":"Front. Endocrinol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.18632\/oncotarget.2875","article-title":"DNA methyloma and transcriptome sequencing in human ovarian granulosa cells links age-related changes in gene expression to gene body methylation and 3\u2019-end CG density","volume":"6","author":"Yu","year":"2015","journal-title":"Oncotarget"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0305-0491(95)02138-8","article-title":"Comparative properties of arginases","volume":"114","author":"Jenkinson","year":"1996","journal-title":"Comp. Biochem. Physiol."},{"key":"ref_32","first-page":"515","article-title":"Arginase pathway in human endothelial cells in pathophysiological conditions","volume":"7","author":"Bachetti","year":"2003","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"E75","DOI":"10.1152\/ajpendo.2001.280.1.E75","article-title":"Regulatory role of arginase I and II in nitric oxide, polyamine and proline synthesis in endothelial cells","volume":"280","author":"Li","year":"2001","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1210\/er.2011-0012","article-title":"Polyamines in the reproductive landscap","volume":"32","author":"Lefevre","year":"2011","journal-title":"Endocrin. Rev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1152\/japplphysiol.91393.2008","article-title":"Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats","volume":"107","author":"Kim","year":"2009","journal-title":"J. Appl. Physiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1152\/physrev.00037.2016","article-title":"Arginase: A multifaceted enzyme important in health and disease","volume":"98","author":"Caldwell","year":"2018","journal-title":"Physiol. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1096\/fj.03-0115fje","article-title":"Ischemia-reperfusion selectively impairs nitric oxide-mediated dilatation in coronary arterioles: Counteracting role of arginase","volume":"17","author":"Hein","year":"2003","journal-title":"FASEB J."},{"key":"ref_38","first-page":"261","article-title":"Arginase activity of ovarian structures in cows of brown swiss and its cross-breeds","volume":"85","author":"Aksu","year":"2015","journal-title":"Veter. Arch."},{"key":"ref_39","first-page":"31","article-title":"Arginase status ln cattle reproductive system","volume":"75","author":"Razmi","year":"2005","journal-title":"Vet. Archiv."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Budani, M.C., and Tiboni, G.M. (2021). Novel insights on the role of nitric oxide in ovary: A review of literature. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18030980"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"752410","DOI":"10.3389\/fendo.2021.752410","article-title":"Role of nitric oxide in the regulation of reproduction: A review","volume":"12","author":"Luo","year":"2021","journal-title":"Front. Endocrinol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1007\/s12031-014-0369-5","article-title":"Colocalization of cannabinoid receptor 1 with somatostatin and neuronal nitric oxide synthase in rat brain hypothalamus","volume":"55","author":"Zou","year":"2015","journal-title":"J. Mol. Neurosci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"bqaa010","DOI":"10.1210\/endocr\/bqaa010","article-title":"Evidence that nitric oxide is critical for LH surge generation in female sheep","volume":"161","author":"Lopez","year":"2020","journal-title":"Endocrinology"},{"key":"ref_44","first-page":"303","article-title":"Effect of nitric oxide on steroidogenesis in porcine granulosa cells during different stages of follicular development","volume":"144","author":"Masuda","year":"2021","journal-title":"Eur. J. Endocrinol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1093\/molehr\/5.5.396","article-title":"Inhibitory effects of nitric oxide on the expression and activity of aromatase in human granulosa cells","volume":"5","author":"Kabagu","year":"1999","journal-title":"Mol. Hum. Reprod."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e2012339118","DOI":"10.1073\/pnas.2012339118","article-title":"Nitric oxide resets kisspeptin excited GnRH neurons via PIP2 Replenishment","volume":"118","author":"Constantin","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0006-8993(01)03247-4","article-title":"Nitric oxide mediates leptin-induced preovulatory luteinzing hormone and prolactin surges in rats","volume":"923","author":"Watanobe","year":"2021","journal-title":"Brain Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1210\/endo.139.6.6054","article-title":"The role of nitric oxide in oocyte meiotic maturation and ovulation: Metiotic abnormalities of endothelial nitric oxide synthase knock-out mouse oocytes","volume":"139","author":"Olson","year":"1998","journal-title":"Endocrinology"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/(SICI)1098-2795(200004)55:4<412::AID-MRD9>3.0.CO;2-W","article-title":"Nitric oxide is essential for optimal meiotic maturation of murine cumulus-oocyte complexes in vitro","volume":"55","author":"Olson","year":"2000","journal-title":"Mol. Reprod. Dev."},{"key":"ref_50","first-page":"875","article-title":"Nitric oxide synthase production and nitric oxide regulation of preimplantation embryo development","volume":"58","author":"Tranguch","year":"1998","journal-title":"Biol. Reprod."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1006\/niox.1999.0251","article-title":"Reproductive function in female mice lacking the gene for endothelial nitric oxide synthase","volume":"3","author":"Darzen","year":"1999","journal-title":"Nitric Oxide"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0146-0005(00)80064-6","article-title":"Lessons learned from nitric oxide synthase knockout animals","volume":"24","author":"Huang","year":"2000","journal-title":"Semin. Perinatol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/1098-2795(200103)58:3<262::AID-MRD3>3.0.CO;2-8","article-title":"Requirement of nitric oxide for murine oocyte maturation, embryo development and trophoblast outgrowth in vitro","volume":"58","author":"Sengoku","year":"2001","journal-title":"Mol. Reprod. Dev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1095\/biolreprod58.4.875","article-title":"Nitric oxide as a regulator of embryonic development","volume":"58","author":"Gouge","year":"1998","journal-title":"Biol. Reprod."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/S0015-0282(01)01780-0","article-title":"Nitric oxide as a regulator in preimplantation embryo development and apoptosis","volume":"75","author":"Chen","year":"2001","journal-title":"Fertil. Steril."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.vph.2018.07.004","article-title":"Nitric oxide and the biology of pregnancy","volume":"110","author":"Zullino","year":"2018","journal-title":"Vasc. Pharmacol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1034\/j.1600-0412.1998.770805.x","article-title":"Increased circulatory an endogenous inhibitor of nitric oxide synthesis, in preeclampsia","volume":"77","author":"Petterson","year":"1998","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/0140-6736(93)92335-Q","article-title":"Plasma concentrations of endogenous inhibitor of nitric oxide synthesis in normal pregnancy and pre-eclampsia","volume":"342","author":"Fickling","year":"1993","journal-title":"Lancet"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0002-9378(98)70437-5","article-title":"Plasma concentration of asymmetric dimethylarginine, a natural inhibitor of nitric oxide synthase, in normal pregnancy and pre-eclampsia","volume":"178","author":"Holden","year":"1998","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/molehr\/gah116","article-title":"Uimari, P.; Tuomainen, T.P.; Salonen, I.T. Haplotypic association of DDAHI with susceptibility to pre-eclampsia","volume":"11","author":"Akbar","year":"2004","journal-title":"Mol. Hum. Reprod."},{"key":"ref_61","first-page":"436","article-title":"L-arginine metabolism in early-onset and late-onset","volume":"83","author":"Sulyok","year":"2013","journal-title":"Scand. J. Clin. Lab. Investig."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1093\/molehr\/3.8.639","article-title":"Nitric oxide and reproduction","volume":"8","author":"Roselli","year":"1997","journal-title":"Mol. Hum. Reprod."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1477-7827-10-49","article-title":"The effects of oxidative stress on female reproduction: A review","volume":"10","author":"Agarwal","year":"2012","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1089\/ars.2007.1964","article-title":"Redox consifderation in female reproductive function and assisted reproduction. From molecular mechanisms to health implications","volume":"10","author":"Agarwal","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1080\/14647273.2018.1535719","article-title":"Levels of total antioxidant capacity and 8-hydroxy-2\u2032-dehydroxyguanosine of serum and follicular fluid in women undergoing in vitro fertilization: Focusing on endometriosis","volume":"23","author":"Szegedi","year":"2020","journal-title":"Hum. Fertil."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.reprotox.2010.04.002","article-title":"Upper control limit of reactive oxygen species in follicular fluid beyond which viable embryo formation is not favourable","volume":"29","author":"Jana","year":"2010","journal-title":"Reprod. Toxicol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.fertnstert.2012.12.004","article-title":"Analysis of metabolism to select viable human embryos for transfer","volume":"99","author":"Gardner","year":"2013","journal-title":"Fertil. Steril."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S1567-5688(03)00033-3","article-title":"ADMA and oxidative stress","volume":"4","author":"Sydow","year":"2003","journal-title":"Atheroscler. Suppl."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"9220","DOI":"10.1073\/pnas.95.16.9220","article-title":"Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors","volume":"95","author":"Kalyanaraman","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1111\/j.1440-1681.2007.04638.x","article-title":"Arginase a critical regulator of nitric oxide synthesis and vascular function","volume":"34","author":"Durante","year":"2007","journal-title":"Clin. Exp. Pharm. Physiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"805","DOI":"10.3109\/09513590.2012.671390","article-title":"Assymetrical dimethylarginine levels on the implantation success of in vitro fertilization and embryo transfer","volume":"28","author":"Keskin","year":"2012","journal-title":"Gynecol. Endocrinol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1650S","DOI":"10.1093\/jn\/137.6.1650S","article-title":"The Pharmacodynamics of L-Arginine","volume":"137","year":"2007","journal-title":"J. Nutr."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.mvr.2005.10.006","article-title":"Quantifying the L-arginine paradox in vivo","volume":"71","author":"Vukosavljevic","year":"2006","journal-title":"Microvasc. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1071\/RD14293","article-title":"Arginine increases development of in vitro-produced porcine embryos and affects the protein arginine methyltransferase-dimethylarginine dimethylamino hydrolase-nitric oxide axis","volume":"27","author":"Redel","year":"2015","journal-title":"Reprod. Fertil. Develop."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1002\/mrd.22387","article-title":"Supplementation of ovine embryo culture medium with l-arginine improves embryo quality via nitric oxide production","volume":"85","author":"Santana","year":"2014","journal-title":"Mol. Reprod. Dev."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1093\/humrep\/14.7.1690","article-title":"Adjuvant L-arginine treatment for in-vitro fertilization in poor- responder patients","volume":"14","author":"Battaglia","year":"1999","journal-title":"Hum. Reprod."},{"key":"ref_77","first-page":"26","article-title":"The role of l-arginine in human pregnancy","volume":"22","year":"2011","journal-title":"Agro Food Ind. Hi Tech"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Greene, J.M., Feugang, J.M., Pfeiffer, K.E., Stokes, J.V., Bowers, S.D., and Ryan, P.L. (2013). L-arginine enhances cell proliferation and reduces apoptosis in human endometrial RL95-2 cells. Reprod. Biol. 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