{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:25:00Z","timestamp":1782231900530,"version":"3.54.5"},"reference-count":33,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Clinic Development Fund of Jiangsu Province","award":["BE2022782"],"award-info":[{"award-number":["BE2022782"]}]},{"name":"Clinic Development Fund of Jiangsu Province","award":["GJ2021010"],"award-info":[{"award-number":["GJ2021010"]}]},{"name":"Clinic Development Fund of Jiangsu Province","award":["GY2022019"],"award-info":[{"award-number":["GY2022019"]}]},{"name":"The International Cooperation Projects of Zhenjiang City","award":["BE2022782"],"award-info":[{"award-number":["BE2022782"]}]},{"name":"The International Cooperation Projects of Zhenjiang City","award":["GJ2021010"],"award-info":[{"award-number":["GJ2021010"]}]},{"name":"The International Cooperation Projects of Zhenjiang City","award":["GY2022019"],"award-info":[{"award-number":["GY2022019"]}]},{"name":"Science and Technology Planning Social Development Project of Zhenjiang City","award":["BE2022782"],"award-info":[{"award-number":["BE2022782"]}]},{"name":"Science and Technology Planning Social Development Project of Zhenjiang City","award":["GJ2021010"],"award-info":[{"award-number":["GJ2021010"]}]},{"name":"Science and Technology Planning Social Development Project of Zhenjiang City","award":["GY2022019"],"award-info":[{"award-number":["GY2022019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Strategies to enhance hippocampal precursor cells efficiently differentiate into neurons could be crucial for structural repair after neurodegenerative damage. FOXG1 has been shown to play an important role in pattern formation, cell proliferation, and cell specification during embryonic and early postnatal neurogenesis. Thus far, the role of FOXG1 in adult hippocampal neurogenesis is largely unknown. Utilizing CAG-loxp-stop-loxp-Foxg1-IRES-EGFP (Foxg1fl\/fl), a specific mouse line combined with CreAAV infusion, we successfully forced FOXG1 overexpressed in the hippocampal dentate gyrus (DG) of the genotype mice. Thereafter, we explored the function of FOXG1 on neuronal lineage progression and hippocampal neurogenesis in adult mice. By inhibiting p21cip1 expression, FOXG1-regulated activities enable the expansion of the precursor cell population. Besides, FOXG1 induced quiescent radial-glia like type I neural progenitor, giving rise to intermediate progenitor cells, neuroblasts in the hippocampal DG. Through increasing the length of G1 phase, FOXG1 promoted lineage-committed cells to exit the cell cycle and differentiate into mature neurons. The present results suggest that FOXG1 likely promotes neuronal lineage progression and thereby contributes to adult hippocampal neurogenesis. Elevating FOXG1 levels either pharmacologically or through other means could present a therapeutic strategy for disease related with neuronal loss.<\/jats:p>","DOI":"10.3390\/ijms232314979","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T01:52:20Z","timestamp":1669773140000},"page":"14979","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["FOXG1 Contributes Adult Hippocampal Neurogenesis in Mice"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9544-9366","authenticated-orcid":false,"given":"Jia","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China"},{"name":"Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Ru","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Fei","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hou-Zhen","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Zhong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Ning","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.cell.2009.10.020","article-title":"Adult neurogenesis modulates the hippocampus-dependent period of associative fear memory","volume":"139","author":"Kitamura","year":"2009","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1037\/0033-295X.99.2.195","article-title":"Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans","volume":"99","author":"Squire","year":"1992","journal-title":"Psychol. 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