{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:32:48Z","timestamp":1787319168178,"version":"build-2736575974"},"reference-count":52,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Heart failure is defined as a clinical syndrome consisting of key symptoms and is due to a structural and\/or functional alteration of the heart that results in increased intracardiac pressures and\/or inadequate cardiac output at rest and\/or during exercise. One of the key mechanisms determining myocardial dysfunction in heart failure is oxidative stress. MicroRNAs (miRNAs, miRs) are short, endogenous, conserved, single-stranded non-coding RNAs of around 21\u201325 nucleotides in length that act as regulators of multiple processes. A systematic review following the PRISMA guidelines was performed on the evidence on the interplay between microRNA and oxidative stress in heart failure. A search of Pubmed, Embase, Scopus, and Scopus direct databases using the following search terms: \u2018heart failure\u2019 AND \u2018oxidative stress\u2019 AND \u2018microRNA\u2019 or \u2018heart failure\u2019 AND \u2018oxidative stress\u2019 AND \u2018miRNA\u2019 was conducted and resulted in 464 articles. Out of them, 15 full text articles were eligible for inclusion in the qualitative analysis. Multiple microRNAs are involved in the processes associated with oxidative stress leading to heart failure development including mitochondrial integrity and function, antioxidant defense, iron overload, ferroptosis, and survival pathways.<\/jats:p>","DOI":"10.3390\/ijms232315013","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T03:49:13Z","timestamp":1669780153000},"page":"15013","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Crosstalk between microRNA and Oxidative Stress in Heart Failure: A Systematic Review"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8825-511X","authenticated-orcid":false,"given":"Dominika","family":"Klimczak-Tomaniak","sequence":"first","affiliation":[{"name":"Department of Cardiology, Hypertension and Internal Medicine, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6078-9037","authenticated-orcid":false,"given":"Julia","family":"Haponiuk-Skwarli\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hypertension and Internal Medicine, Medical University of Warsaw, 02-091 Warsaw, Poland"},{"name":"Department of Pediatric Cardiology and General Pediatrics, Doctoral School, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Kuch","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hypertension and Internal Medicine, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0160-3009","authenticated-orcid":false,"given":"Leszek","family":"P\u0105czek","sequence":"additional","affiliation":[{"name":"Department of Immunology, Transplantation and Internal Medicine, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1038\/s42003-022-03987-5","article-title":"Targeting non-coding RNA family members with artificial endonuclease XNAzymes","volume":"5","author":"Donde","year":"2022","journal-title":"Commun. 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