{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:05:13Z","timestamp":1790856313653,"version":"4.1.0"},"reference-count":98,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T00:00:00Z","timestamp":1669939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["31902123"],"award-info":[{"award-number":["31902123"]}]},{"name":"National Natural Science Foundation of China","award":["31672421"],"award-info":[{"award-number":["31672421"]}]},{"name":"National Natural Science Foundation of China","award":["32002175"],"award-info":[{"award-number":["32002175"]}]},{"name":"National Natural Science Foundation of China","award":["205\/040521400182"],"award-info":[{"award-number":["205\/040521400182"]}]},{"name":"Scientific Research Fund of Jinling Institute of Science and Technology","award":["31902123"],"award-info":[{"award-number":["31902123"]}]},{"name":"Scientific Research Fund of Jinling Institute of Science and Technology","award":["31672421"],"award-info":[{"award-number":["31672421"]}]},{"name":"Scientific Research Fund of Jinling Institute of Science and Technology","award":["32002175"],"award-info":[{"award-number":["32002175"]}]},{"name":"Scientific Research Fund of Jinling Institute of Science and Technology","award":["205\/040521400182"],"award-info":[{"award-number":["205\/040521400182"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Circular RNAs (circRNAs) are an abundant class of endogenous non-coding RNAs (ncRNAs) generated from exonic, intronic, or untranslated regions of protein-coding genes or intergenic regions. The diverse, stable, and specific expression patterns of circRNAs and their possible functions through cis\/trans regulation and protein-coding mechanisms make circRNA a research hotspot in various biological and pathological processes. It also shows practical value as biomarkers, diagnostic indicators, and therapeutic targets. This review summarized the characteristics, classification, biogenesis and elimination, detection and confirmation, and functions of circRNAs. We focused on research advances circRNAs in the mammalian ovary under conditions including ovarian cancer, polycystic ovarian syndrome (PCOS), and maternal aging, as well as during reproductive status, including ovarian follicle development and atresia. The roles of circRNAs in high reproductive traits in domestic animals were also summarized. Finally, we outlined some obstructive factors and prospects to work with circRNA, aiming to provide insights into the functional research interests of circRNAs in the reproduction and gynecology areas.<\/jats:p>","DOI":"10.3390\/ijms232315204","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T01:42:21Z","timestamp":1670204541000},"page":"15204","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["The Role of Circular RNAs in the Physiology and Pathology of the Mammalian Ovary"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9492-3425","authenticated-orcid":false,"given":"Jinbi","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Animal Science and Food Engineering, Jinling Institute of Technology, Nanjing 211169, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Jia","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8358-1223","authenticated-orcid":false,"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Qing","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuge","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingge","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Food Engineering, Jinling Institute of Technology, Nanjing 211169, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyong","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Food Engineering, Jinling Institute of Technology, Nanjing 211169, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengxiang","family":"Pan","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1073\/pnas.73.11.3852","article-title":"Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures","volume":"73","author":"Sanger","year":"1976","journal-title":"Proc. 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