{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T22:11:59Z","timestamp":1777327919959,"version":"3.51.4"},"reference-count":63,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T00:00:00Z","timestamp":1670284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministerio de Universidades","award":["UNI\/551\/2021"],"award-info":[{"award-number":["UNI\/551\/2021"]}]},{"name":"Fondos Next Generation EU; Universidad de La Laguna","award":["UNI\/551\/2021"],"award-info":[{"award-number":["UNI\/551\/2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Delayed cerebral ischemia (DCI) and vasospasm are two complications of subarachnoid hemorrhages (SAHs) which entail high risks of morbidity and mortality. However, it is unknown why only some patients who suffer SAHs will experience DCI and vasospasm. The purpose of this review is to describe the main genetic single nucleotide polymorphisms (SNPs) that have demonstrated a relationship with these complications. The SNP of the nitric oxide endothelial synthase (eNOS) has been related to the size and rupture of an aneurysm, as well as to DCI, vasospasm, and poor neurological outcome. The SNPs responsible for the asymmetric dimetilarginine and the high-mobility group box 1 have also been associated with DCI. An association between vasospasm and the SNPs of the eNOS, the haptoglobin, and the endothelin-1 receptor has been found. The SNPs of the angiotensin-converting enzyme have been related to DCI and poor neurological outcome. Studies on the SNPs of the Ryanodine Receptor yielded varying results regarding their association with vasospasm.<\/jats:p>","DOI":"10.3390\/ijms232315427","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T01:47:46Z","timestamp":1670377666000},"page":"15427","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A Review of Genetic Polymorphisms and Susceptibilities to Complications after Aneurysmal Subarachnoid Hemorrhage"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4615-6858","authenticated-orcid":false,"given":"Jose","family":"Medina-Su\u00e1rez","sequence":"first","affiliation":[{"name":"Research Unit, University Hospital of Gran Canaria Dr. Negr\u00edn, 35010 Gran Canaria, Spain"},{"name":"Department of Specific Teaching Methodologies, University of Las Palmas de Gran Canaria, 35004 Gran Canaria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1663-3673","authenticated-orcid":false,"given":"Francisco","family":"Rodr\u00edguez-Esparrag\u00f3n","sequence":"additional","affiliation":[{"name":"Research Unit, University Hospital of Gran Canaria Dr. Negr\u00edn, 35010 Gran Canaria, Spain"},{"name":"Instituto Universitario de Enfermedades Tropicales y Salud P\u00fablica de Canarias, Universidad de La Laguna, 38296 Tenerife, Spain"},{"name":"CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coralia","family":"Sosa-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Neurosurgery Unit, University Hospital of Gran Canaria Dr. Negr\u00edn, 35010 Gran Canaria, Spain"},{"name":"Department of Medical and Surgery Sciences, University of Las Palmas de Gran Canaria, 35016 Gran Canaria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Cazorla-Rivero","sequence":"additional","affiliation":[{"name":"Research Unit, University Hospital of Gran Canaria Dr. Negr\u00edn, 35010 Gran Canaria, Spain"},{"name":"University of La Laguna, 38200 Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura B.","family":"Torres-Mata","sequence":"additional","affiliation":[{"name":"Research Unit, University Hospital of Gran Canaria Dr. Negr\u00edn, 35010 Gran Canaria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aruma","family":"Jim\u00e9nez-O\u2019Shanahan","sequence":"additional","affiliation":[{"name":"Neurosurgery Unit, University Hospital of Gran Canaria Dr. Negr\u00edn, 35010 Gran Canaria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2522-1064","authenticated-orcid":false,"given":"Bernardino","family":"Clavo","sequence":"additional","affiliation":[{"name":"Research Unit, University Hospital of Gran Canaria Dr. Negr\u00edn, 35010 Gran Canaria, Spain"},{"name":"Instituto Universitario de Enfermedades Tropicales y Salud P\u00fablica de Canarias, Universidad de La Laguna, 38296 Tenerife, Spain"},{"name":"CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"RETIC de Investigaci\u00f3n en Servicios de Salud en Enfermedades Cr\u00f3nicas (REDISSEC), 28029 Madrid, Spain"},{"name":"Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Chronic Pain Unit, University Hospital of Gran Canaria Dr. Negr\u00edn, 35010 Gran Canaria, Spain"},{"name":"Radiation Oncology Department, University Hospital of Gran Canaria Dr. Negr\u00edn, 35010 Las Palmas de Gran Canaria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Morera-Molina","sequence":"additional","affiliation":[{"name":"Neurosurgery Unit, University Hospital of Gran Canaria Dr. Negr\u00edn, 35010 Gran Canaria, Spain"},{"name":"Department of Medical and Surgery Sciences, University of Las Palmas de Gran Canaria, 35016 Gran Canaria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11883-017-0690-x","article-title":"Delayed cerebral ischemia after subrachnoid hemorrhage: Beyond vasospasm and towards a multifactorial pathophysiology","volume":"19","author":"Geraghty","year":"2017","journal-title":"Curr. 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