{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:53:17Z","timestamp":1791928397566,"version":"4.3.4"},"reference-count":179,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T00:00:00Z","timestamp":1670544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Biologically active taxanes, present in small- to medium-sized evergreen conifers of various Taxus species, are widely used for their antioxidant, antimicrobial and anti-inflammatory effects, but mostly for their antitumour effects used in the treatment of solid tumours of the breast, ovary, lung, bladder, prostate, oesophagus and melanoma. More of the substances found in Taxus plant extracts have medical potential. Therefore, at the beginning of this review, we describe the methods of isolation, identification and determination of taxanes in different plant parts. One of the most important taxanes is paclitaxel, for which we summarize the pharmacokinetic parameters of its different formulations. We also describe toxicological risks during clinical therapy such as hypersensitivity, neurotoxicity, gastrointestinal, cardiovascular, haematological, skin and renal toxicity and toxicity to the respiratory system. Since the effect of the drug-form PTX is enhanced by various Taxus spp. extracts, we summarize published clinical intoxications and all fatal poisonings for the Taxus baccata plant. This showed that, despite their significant use in anticancer treatment, attention should also be focused on the risk of fatal intoxication due to ingestion of extracts from these plants, which are commonly found in our surroundings.<\/jats:p>","DOI":"10.3390\/ijms232415619","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T06:14:00Z","timestamp":1670566440000},"page":"15619","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Natural Taxanes: From Plant Composition to Human Pharmacology and Toxicity"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4478-8018","authenticated-orcid":false,"given":"\u013dubo\u0161","family":"Ni\u017enansk\u00fd","sequence":"first","affiliation":[{"name":"Department of Forensic Medicine and Toxicology, Health Care Surveillance Authority, Antolsk\u00e1 11, 85107 Bratislava, Slovakia"},{"name":"Institute of Forensic Medicine, Faculty of Medicine, Comenius University in Bratislava, Sasinkov\u00e1 4, 81108 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denisa","family":"Osinov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mal\u00e1 Hora 4a, 03601 Martin, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5058-5356","authenticated-orcid":false,"given":"Roman","family":"Kuruc","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine and Toxicology, Health Care Surveillance Authority, Antolsk\u00e1 11, 85107 Bratislava, Slovakia"},{"name":"Institute of Forensic Medicine, Faculty of Medicine, Comenius University in Bratislava, Sasinkov\u00e1 4, 81108 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Hengerics Szab\u00f3","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Education, J. Selye University, Bratislavsk\u00e1 cesta 3322, 94501 Kom\u00e1rno, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9867-7698","authenticated-orcid":false,"given":"Andrea","family":"Sz\u00f3r\u00e1dov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine and Toxicology, Health Care Surveillance Authority, Antolsk\u00e1 11, 85107 Bratislava, Slovakia"},{"name":"Institute of Forensic Medicine, Faculty of Medicine, Comenius University in Bratislava, Sasinkov\u00e1 4, 81108 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9287-1764","authenticated-orcid":false,"given":"Mari\u00e1n","family":"Mas\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynsk\u00e1 Dolina, Ilkovi\u010dova 6, 84215 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7174-6836","authenticated-orcid":false,"given":"\u017dofia","family":"Ni\u017enansk\u00e1","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine and Toxicology, Health Care Surveillance Authority, Antolsk\u00e1 11, 85107 Bratislava, Slovakia"},{"name":"Institute of Forensic Medicine, Faculty of Medicine, Comenius University in Bratislava, Sasinkov\u00e1 4, 81108 Bratislava, Slovakia"},{"name":"Department of Analytical Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynsk\u00e1 Dolina, Ilkovi\u010dova 6, 84215 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,9]]},"reference":[{"key":"ref_1","first-page":"10","article-title":"Taxus wallichiana (Zucc.), an Endangered Anti-Cancerous Plant: A Review","volume":"5","author":"Bhuju","year":"2018","journal-title":"Int. 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