{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:27:12Z","timestamp":1788827232723,"version":"build-2803163510"},"reference-count":82,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T00:00:00Z","timestamp":1670630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["2018YFA0107301"],"award-info":[{"award-number":["2018YFA0107301"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["81970773"],"award-info":[{"award-number":["81970773"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["81870625"],"award-info":[{"award-number":["81870625"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["82101084"],"award-info":[{"award-number":["82101084"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["82060173"],"award-info":[{"award-number":["82060173"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["2021M69898"],"award-info":[{"award-number":["2021M69898"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2018YFA0107301"],"award-info":[{"award-number":["2018YFA0107301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970773"],"award-info":[{"award-number":["81970773"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870625"],"award-info":[{"award-number":["81870625"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101084"],"award-info":[{"award-number":["82101084"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060173"],"award-info":[{"award-number":["82060173"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021M69898"],"award-info":[{"award-number":["2021M69898"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2018YFA0107301"],"award-info":[{"award-number":["2018YFA0107301"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["81970773"],"award-info":[{"award-number":["81970773"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["81870625"],"award-info":[{"award-number":["81870625"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["82101084"],"award-info":[{"award-number":["82101084"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["82060173"],"award-info":[{"award-number":["82060173"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021M69898"],"award-info":[{"award-number":["2021M69898"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Ectodysplasin A (EDA), a ligand of the TNF family, plays an important role in maintaining the homeostasis of the ocular surface. EDA is necessary for the development of the meibomian gland, the lacrimal gland, as well as the proliferation and barrier function of the corneal epithelium. The mutation of EDA can induce the destruction of the ocular surface resulting in keratopathy, abnormality of the meibomian gland and maturation of the lacrimal gland. Experimental animal studies showed that a prenatal ultrasound-guided intra-amniotic injection or postnatal intravenous administration of soluble recombinant EDA protein can efficiently prevent the development of ocular surface abnormalities in EDA mutant animals. Furthermore, local application of EDA could restore the damaged ocular surface to some extent. Hence, a recombinant EDA-based therapy may serve as a novel paradigm to treat ocular surface disorders, such as meibomian gland dysfunction and corneal epithelium abnormalities.<\/jats:p>","DOI":"10.3390\/ijms232415700","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T01:42:27Z","timestamp":1670809347000},"page":"15700","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The Role of Ectodysplasin A on the Ocular Surface Homeostasis"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9226-5887","authenticated-orcid":false,"given":"Shangkun","family":"Ou","sequence":"first","affiliation":[{"name":"Eye Institute of Xiamen University and Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen 361000, China"},{"name":"Fujian Provincial Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen 361000, China"},{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen 361000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mani Vimalin","family":"Jeyalatha","sequence":"additional","affiliation":[{"name":"Eye Institute of Xiamen University and Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen 361000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Mao","sequence":"additional","affiliation":[{"name":"Eye Institute of Xiamen University and Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen 361000, China"},{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen 361000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Graduate School of Medicine, Osaka 5650871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3191-0838","authenticated-orcid":false,"given":"Chao","family":"Chen","sequence":"additional","affiliation":[{"name":"Eye Institute of Xiamen University and Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen 361000, China"},{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen 361000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Eye Institute of Xiamen University and Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen 361000, China"},{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen 361000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Liu","sequence":"additional","affiliation":[{"name":"Eye Institute of Xiamen University and Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen 361000, China"},{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen 361000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Liang","sequence":"additional","affiliation":[{"name":"Eye Institute of Xiamen University and Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen 361000, China"},{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen 361000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijie","family":"Lin","sequence":"additional","affiliation":[{"name":"Eye Institute of Xiamen University and Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen 361000, China"},{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen 361000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2885-9496","authenticated-orcid":false,"given":"Yiming","family":"Wu","sequence":"additional","affiliation":[{"name":"Eye Institute of Xiamen University and Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen 361000, China"},{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen 361000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Li","sequence":"additional","affiliation":[{"name":"Eye Institute of Xiamen University and Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen 361000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7458-2590","authenticated-orcid":false,"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Eye Institute of Xiamen University and Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen 361000, China"},{"name":"Fujian Provincial Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen 361000, China"},{"name":"Xiang\u2019an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/stem.5530120501","article-title":"A family of ligands for the TNF receptor superfamily","volume":"12","author":"Cosman","year":"1994","journal-title":"Stem Cells"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1093\/hmg\/8.11.2079","article-title":"Ectodysplasin is a collagenous trimeric type II membrane protein with a tumor necrosis factor-like domain and co-localizes with cytoskeletal structures at lateral and apical surfaces of cells","volume":"8","author":"Ezer","year":"1999","journal-title":"Hum. Mol. Genet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.tig.2013.08.006","article-title":"The ectodysplasin pathway: From diseases to adaptations","volume":"30","author":"Sadier","year":"2014","journal-title":"Trends Genet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"18819","DOI":"10.1074\/jbc.M101280200","article-title":"Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A","volume":"276","author":"Schneider","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1093\/hmg\/7.11.1661","article-title":"The anhidrotic ectodermal dysplasia gene (EDA) undergoes alternative splicing and encodes ectodysplasin-A with deletion mutations in collagenous repeats","volume":"7","author":"Bayes","year":"1998","journal-title":"Hum. Mol. Genet."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1126\/science.290.5491.523","article-title":"Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors","volume":"290","author":"Yan","year":"2000","journal-title":"Science"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1016\/j.febslet.2010.04.058","article-title":"p53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss","volume":"584","author":"Brosh","year":"2010","journal-title":"Febs Lett."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/ajmg.1320530207","article-title":"Ectodermal Dysplasias\u2014A Clinical Classification and a Causal Review","volume":"53","author":"Pinheiro","year":"1994","journal-title":"Am. J. Med. Genet."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/j.str.2003.11.009","article-title":"The crystal structures of EDA-A1 and EDA-A2: Splice variants with distinct receptor specificity","volume":"11","author":"Hymowitz","year":"2003","journal-title":"Structure"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1111\/j.1365-2133.2010.09670.x","article-title":"Mutations in EDARADD account for a small proportion of hypohidrotic ectodermal dysplasia cases","volume":"162","author":"Chassaing","year":"2010","journal-title":"Br. J. Derm."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"20742","DOI":"10.1074\/jbc.M002691200","article-title":"TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles","volume":"275","author":"Kojima","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"8766","DOI":"10.1073\/pnas.132636999","article-title":"TRAF6-deficient mice display hypohidrotic ectodermal dysplasia","volume":"99","author":"Naito","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1093\/hmg\/ddi405","article-title":"TAB2, TRAF6 and TAK1 are involved in NF-kappaB activation induced by the TNF-receptor, Edar and its adaptator Edaradd","volume":"14","author":"Morlon","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1158\/1541-7786.MCR-09-0484","article-title":"Crosstalk of EDA-A2\/XEDAR in the p53 signaling pathway","volume":"8","author":"Tanikawa","year":"2010","journal-title":"Mol. Cancer Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"44953","DOI":"10.1074\/jbc.M207923200","article-title":"Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK pathways by X-linked ectodermal dysplasia receptor","volume":"277","author":"Sinha","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s10911-013-9277-5","article-title":"Ectodysplasin\/NF-\u03baB signaling in embryonic mammary gland development","volume":"18","author":"Lindfors","year":"2013","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.archoralbio.2004.11.019","article-title":"The Ectodysplasin and NFkappaB signalling pathways in odontogenesis","volume":"50","author":"Courtney","year":"2005","journal-title":"Arch. Oral. Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1087-0024.2005.10129.x","article-title":"Edar signaling in the control of hair follicle development","volume":"10","author":"Botchkarev","year":"2005","journal-title":"J. Investig. Derm. Symp. Proc."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1093\/hmg\/ddg325","article-title":"Inducible mEDA-A1 transgene mediates sebaceous gland hyperplasia and differential formation of two types of mouse hair follicles","volume":"12","author":"Cui","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.devcel.2009.05.011","article-title":"Reciprocal requirements for EDA\/EDAR\/NF-kappaB and Wnt\/beta-catenin signaling pathways in hair follicle induction","volume":"17","author":"Zhang","year":"2009","journal-title":"Dev. Cell"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1006\/dbio.2000.9955","article-title":"TNF signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is regulated by Wnt and activin during tooth organogenesis","volume":"229","author":"Laurikkala","year":"2001","journal-title":"Dev. Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4723","DOI":"10.1242\/dev.143909","article-title":"Molecular dynamics of Dkk4 modulates Wnt action and regulates meibomian gland development","volume":"143","author":"Sima","year":"2016","journal-title":"Development"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Voutilainen, M., Lindfors, P.H., Trela, E., L\u00f6nnblad, D., Shirokova, V., Elo, T., Rysti, E., Schmidt-Ullrich, R., Schneider, P., and Mikkola, M.L. (2015). Ectodysplasin\/NF-\u03baB Promotes Mammary Cell Fate via Wnt\/\u03b2-catenin Pathway. PLoS Genet., 11.","DOI":"10.1371\/journal.pgen.1005676"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"112170","DOI":"10.1016\/j.yexcr.2020.112170","article-title":"Ectodysplasin A receptor (EDAR) promotes colorectal cancer cell proliferation via regulation of the Wnt\/\u03b2-catenin signaling pathway","volume":"395","author":"Wang","year":"2020","journal-title":"Exp. Cell Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"9075","DOI":"10.1073\/pnas.0600825103","article-title":"Generation of the primary hair follicle pattern","volume":"103","author":"Mou","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5744","DOI":"10.1073\/pnas.1110627109","article-title":"Ectodysplasin regulates hormone-independent mammary ductal morphogenesis via NF-\u03baB","volume":"109","author":"Voutilainen","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1006\/excr.2001.5331","article-title":"Signaling and subcellular localization of the TNF receptor Edar","volume":"269","author":"Koppinen","year":"2001","journal-title":"Exp. Cell Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1038\/nm.4420","article-title":"A microRNA screen reveals that elevated hepatic ectodysplasin A expression contributes to obesity-induced insulin resistance in skeletal muscle","volume":"23","author":"Awazawa","year":"2017","journal-title":"Nat. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.1074\/jbc.M008356200","article-title":"The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A","volume":"276","author":"Kumar","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1242\/dev.02708","article-title":"Ectodysplasin has a dual role in ectodermal organogenesis: Inhibition of Bmp activity and induction of Shh expression","volume":"134","author":"Pummila","year":"2007","journal-title":"Development"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.1038\/s41598-017-04637-1","article-title":"Ectodysplasin target gene Fgf20 regulates mammary bud growth and ductal invasion and branching during puberty","volume":"7","author":"Elo","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1600-0625.1998.tb00297.x-i1","article-title":"Interactions between epidermal growth factor and the Tabby mutation in skin","volume":"7","author":"Isaacs","year":"1998","journal-title":"Exp. Derm."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"13391","DOI":"10.1074\/jbc.M117.803809","article-title":"Ectodysplasin A protein promotes corneal epithelial cell proliferation","volume":"292","author":"Li","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1093\/hmg\/10.9.953","article-title":"Ectodysplasin is released by proteolytic shedding and binds to the EDAR protein","volume":"10","author":"Elomaa","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.4161\/cc.5.21.3403","article-title":"EDA signaling and skin appendage development","volume":"5","author":"Cui","year":"2006","journal-title":"Cell Cycle"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/ng0895-409","article-title":"X-linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein","volume":"13","author":"Kere","year":"1996","journal-title":"Nat. Genet."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1681\/ASN.2017101112","article-title":"Lipoxins Regulate the Early Growth Response-1 Network and Reverse Diabetic Kidney Disease","volume":"29","author":"Brennan","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_38","first-page":"469","article-title":"[Clinical and genetic analysis of a child with X-linked hypohidrotic ectodermal dysplasia]","volume":"38","author":"Duan","year":"2021","journal-title":"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"642432","DOI":"10.3389\/fendo.2021.642432","article-title":"Ectodysplasin A Is Increased in Non-Alcoholic Fatty Liver Disease, But Is Not Associated With Type 2 Diabetes","volume":"12","author":"Bayliss","year":"2021","journal-title":"Front. Endocrinol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0960-9822(02)00687-5","article-title":"Identification of a Novel Death Domain-Containing Adaptor Molecule for Ectodysplasin-A Receptor that Is Mutated in crinkled Mice","volume":"12","author":"Yan","year":"2002","journal-title":"Curr. Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S1567-133X(03)00092-9","article-title":"Ectodysplasin, Edar and TNFRSF19 are expressed in complementary and overlapping patterns during mouse embryogenesis","volume":"3","author":"Pispa","year":"2003","journal-title":"Gene Expr. Patterns"},{"key":"ref_42","first-page":"1378","article-title":"Intercellular growth factor signaling and the development of mouse tracheal submucosal glands","volume":"233","author":"Rawlins","year":"2005","journal-title":"Dev. Dyn. Off. Publ. Am. Assoc. Anat."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e59653","DOI":"10.7554\/eLife.59653","article-title":"Lack of airway submucosal glands impairs respiratory host defenses","volume":"9","author":"Ostedgaard","year":"2020","journal-title":"Elife"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/jcmm.13311","article-title":"Ectodysplasin A regulates epithelial barrier function through sonic hedgehog signalling pathway","volume":"22","author":"Li","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1002\/ajmg.a.32916","article-title":"Neonatal treatment with recombinant ectodysplasin prevents respiratory disease in dogs with X-linked ectodermal dysplasia","volume":"149a","author":"Mauldin","year":"2009","journal-title":"Am. J. Med. Genet. A"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1007\/s00431-013-1985-8","article-title":"Early respiratory and ocular involvement in X-linked hypohidrotic ectodermal dysplasia","volume":"172","author":"Dietz","year":"2013","journal-title":"Eur. J. Pediatr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"113297","DOI":"10.1016\/j.yexcr.2022.113297","article-title":"Ectodysplasin-A mRNA in exosomes released from activated hepatic stellate cells stimulates macrophage response","volume":"419","author":"Marrero","year":"2022","journal-title":"Exp. Cell Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.jid.2015.09.002","article-title":"Ectodysplasin A Pathway Contributes to Human and Murine Skin Repair","volume":"136","author":"Garcin","year":"2016","journal-title":"J. Investig. Derm."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"4907","DOI":"10.1242\/dev.01377","article-title":"Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendages","volume":"131","author":"Mustonen","year":"2004","journal-title":"Development"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.cell.2013.01.016","article-title":"Modeling recent human evolution in mice by expression of a selected EDAR variant","volume":"152","author":"Kamberov","year":"2013","journal-title":"Cell"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s10911-018-9399-x","article-title":"Attenuation of Mammary Gland Dysplasia and Feeding Difficulties in Tabby Mice by Fetal Therapy","volume":"23","author":"Wahlbuhl","year":"2018","journal-title":"J. Mammary Gland. Biol. Neoplasia"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"dev176693","DOI":"10.1242\/dev.176693","article-title":"Ectodysplasin-A signaling is a key integrator in the lacrimal gland-cornea feedback loop","volume":"146","author":"Kuony","year":"2019","journal-title":"Development"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ajpath.2015.09.019","article-title":"Meibomian Gland Absence Related Dry Eye in Ectodysplasin A Mutant Mice","volume":"186","author":"Wang","year":"2016","journal-title":"Am. J. Pathol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Zhang, X., Jeyalatha, M.J., Qu, Y., He, X., Ou, S., Bu, J., Jia, C., Wang, J., Wu, H., and Liu, Z. (2017). Dry Eye Management: Targeting the Ocular Surface Microenvironment. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18071398"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.preteyeres.2016.04.005","article-title":"Goblet cells of the conjunctiva: A review of recent findings","volume":"54","author":"Gipson","year":"2016","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"Des174","DOI":"10.1167\/iovs.17-23528","article-title":"Advances in Functional Restoration of the Lacrimal Glands","volume":"59","author":"Hirayama","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.exer.2017.06.020","article-title":"Meibomian glands, meibum, and meibogenesis","volume":"163","author":"Butovich","year":"2017","journal-title":"Exp. Eye Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/IOP.0000000000000702","article-title":"Embryologic and Fetal Development of the Human Eyelid","volume":"32","author":"Tawfik","year":"2016","journal-title":"Ophthalmic. Plast. Reconstr. Surg."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/jid.2008.318","article-title":"Analysis of the temporal requirement for eda in hair and sweat gland development","volume":"129","author":"Cui","year":"2009","journal-title":"J. Investig. Derm."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"92","DOI":"10.7326\/0003-4819-74-1-92","article-title":"Anhidrotic ectodermal dysplasia: Predisposition to bronchial disease","volume":"74","author":"Beahrs","year":"1971","journal-title":"Ann. Intern. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1136\/adc.62.10.989","article-title":"Clinical aspects of X-linked hypohidrotic ectodermal dysplasia","volume":"62","author":"Clarke","year":"1987","journal-title":"Arch. Dis. Child."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1399-0004.1985.tb00373.x","article-title":"Expression of X-linked hypohidrotic ectodermal dysplasia in six males and in their mothers","volume":"28","author":"Kaitila","year":"1985","journal-title":"Clin. Genet."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/BF00293886","article-title":"Hypohidrotic ectodermal dysplasia. Clinical study of a family of 30 over three generations","volume":"81","author":"Gilgenkrantz","year":"1989","journal-title":"Hum. Genet."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00417-004-0868-0","article-title":"Ocular symptoms and signs in patients with ectodermal dysplasia syndromes","volume":"242","author":"Kaercher","year":"2004","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1086\/521988","article-title":"Significant correction of disease after postnatal administration of recombinant ectodysplasin A in canine X-linked ectodermal dysplasia","volume":"81","author":"Casal","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1124\/jpet.118.256040","article-title":"Prenatal Treatment of X-Linked Hypohidrotic Ectodermal Dysplasia using Recombinant Ectodysplasin in a Canine Model","volume":"370","author":"Margolis","year":"2019","journal-title":"J. Pharm. Exp. Ther."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Cui, C.Y., Kunisada, M., Piao, Y., Childress, V., Ko, M.S., and Schlessinger, D. (2010). Dkk4 and Eda regulate distinctive developmental mechanisms for subtypes of mouse hair. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0010009"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/nm861","article-title":"Permanent correction of an inherited ectodermal dysplasia with recombinant EDA","volume":"9","author":"Gaide","year":"2003","journal-title":"Nat. Med."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Kuramoto, T., Yokoe, M., Hashimoto, R., Hiai, H., and Serikawa, T. (2011). A rat model of hypohidrotic ectodermal dysplasia carries a missense mutation in the Edaradd gene. BMC Genet., 12.","DOI":"10.1186\/1471-2156-12-91"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0002-9440(10)62956-2","article-title":"X-linked anhidrotic ectodermal dysplasia disruption yields a mouse model for ocular surface disease and resultant blindness","volume":"167","author":"Cui","year":"2005","journal-title":"Am. J. Pathol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S1542-0124(12)70613-4","article-title":"Growth factors in the tear film: Role in tissue maintenance, wound healing, and ocular pathology","volume":"5","author":"Klenkler","year":"2007","journal-title":"Ocul. Surf."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.survophthal.2019.08.007","article-title":"Management of meibomian gland dysfunction: A review","volume":"65","author":"Sabeti","year":"2020","journal-title":"Surv. Ophthalmol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13023-019-1288-x","article-title":"Natural history of X-linked hypohidrotic ectodermal dysplasia: A 5-year follow-up study","volume":"15","author":"Wohlfart","year":"2020","journal-title":"Orphanet. J. Rare Dis."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","article-title":"TFOS DEWS II Definition and Classification Report","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul. Surf."},{"key":"ref_75","first-page":"296","article-title":"Bone morphogenetic proteins and growth and differentiation factors in the human cornea","volume":"40","author":"You","year":"1999","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1167\/iovs.09-3425","article-title":"Expression of CXCL9, -10, -11, and CXCR3 in the tear film and ocular surface of patients with dry eye syndrome","volume":"51","author":"Yoon","year":"2010","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0002-9394(73)90649-1","article-title":"Corneal changes in ectodermal dysplasia. Case report, histopathology, and differential diagnosis","volume":"75","author":"Wilson","year":"1973","journal-title":"Am. J. Ophthalmol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0002-9394(74)90078-6","article-title":"Ocular manifestations of the ectrodactyly, ectodermal dysplasia, cleft lip-palate syndrome","volume":"78","author":"Baum","year":"1974","journal-title":"Am. J. Ophthalmol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/414913a","article-title":"Gene defect in ectodermal dysplasia implicates a death domain adapter in development","volume":"414","author":"Headon","year":"2001","journal-title":"Nature"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"30769","DOI":"10.1074\/jbc.M111.267997","article-title":"Molecular and therapeutic characterization of anti-ectodysplasin A receptor (EDAR) agonist monoclonal antibodies","volume":"286","author":"Kowalczyk","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/ijd.14048","article-title":"Hypohidrotic ectodermal dysplasia: Clinical and molecular review","volume":"57","year":"2018","journal-title":"Int. J. Derm."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1038\/jid.2014.264","article-title":"Prenatal therapy in developmental disorders: Drug targeting via intra-amniotic injection to treat X-linked hypohidrotic ectodermal dysplasia","volume":"134","author":"Hermes","year":"2014","journal-title":"J. Investig. Derm."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/24\/15700\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:37:59Z","timestamp":1760146679000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/24\/15700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,10]]},"references-count":82,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["ijms232415700"],"URL":"https:\/\/doi.org\/10.3390\/ijms232415700","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,10]]}}}