{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:15:40Z","timestamp":1790936140705,"version":"4.1.0"},"reference-count":77,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Diabetes is considered a new pandemic of the modern world, and the number of sufferers is steadily increasing. Sustained hyperglycemia promotes the production of free radicals and leads to persistent, low-grade inflammation. Oxidative stress causes mitochondrial destruction, which along with activation of the hexosamine pathway, nuclear factor-\u03baB (Nf-\u03bab), p38 mitogen-activated protein kinase (p38 MAPK), c-jun NH2 terminal kinase\/stress-activated protein kinase (JNK\/SAPK) or toll-like receptors (TLRs), leads to pancreatic \u03b2-cell dysfunction. However, there is also the protective mechanism that counteracts oxidative stress and inflammation in diabetes, mitophagy, which is a mitochondrial autophagy. An important part of the strategy to control diabetes is to lead a healthy lifestyle based on, among other things, regular physical activity, giving up smoking, eating a balanced diet containing ingredients with antioxidant potential, including vegetables and fruits, and using hypoglycemic pharmacotherapy. Tobacco smoke is a recognized modifiable risk factor for many diseases including diabetes, and it has been shown that the risk of the disease increases in proportion to the intensity of smoking. Physical activity as another component of therapy can effectively reduce glucose fluctuations, and high intensity interval exercise appears to have the most beneficial effect. A proper diet not only increases cellular sensitivity to insulin, but is also able to reduce inflammation and oxidative stress. Pharmacotherapy for diabetes can also affect oxidative stress and inflammation. Some oral drugs, such as metformin, pioglitazone, vildagliptin, liraglutide, and exenatide, cause a reduction in markers of oxidative stress and\/or inflammation, while the new drug Imeglimin reverses pancreatic \u03b2-cell dysfunction. In studies of sitagliptin, vildagliptin and exenatide, beneficial effects on oxidative stress and inflammation were achieved by, among other things, reducing glycemic excursions. For insulin therapy, no corresponding correlation was observed. Insulin did not reduce oxidative stress parameters. There was no correlation between glucose variability and oxidative stress in patients on insulin therapy. The data used in this study were obtained by searching PubMed online databases, taking into account recent studies.<\/jats:p>","DOI":"10.3390\/ijms232415743","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T04:34:20Z","timestamp":1670819660000},"page":"15743","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":119,"title":["The Influence of Lifestyle and Treatment on Oxidative Stress and Inflammation in Diabetes"],"prefix":"10.3390","volume":"23","author":[{"given":"Magdalena","family":"Wronka","sequence":"first","affiliation":[{"name":"Department of Nephrocardiology, Medical University of Lodz, ul. Zeromskiego 113, 90-549 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4463-2731","authenticated-orcid":false,"given":"Julia","family":"Krzemi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Nephrocardiology, Medical University of Lodz, ul. Zeromskiego 113, 90-549 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6799-4746","authenticated-orcid":false,"given":"Ewelina","family":"M\u0142ynarska","sequence":"additional","affiliation":[{"name":"Department of Nephrocardiology, Medical University of Lodz, ul. Zeromskiego 113, 90-549 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Rysz","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, ul. Zeromskiego 113, 90-549 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Franczyk","sequence":"additional","affiliation":[{"name":"Department of Nephrocardiology, Medical University of Lodz, ul. Zeromskiego 113, 90-549 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,12]]},"reference":[{"key":"ref_1","unstructured":"Sapra, A., and Bhandari, P. (2022). Diabetes Mellitus. StatPearls, StatPearls Publishing."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"American Diabetes Association Professional Practice Committee (2022). 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2022. Diabetes Care, 45, S17\u2013S38.","DOI":"10.2337\/dc22-S002"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"American Diabetes Association Professional Practice Committee, Draznin, B., Aroda, V.R., Bakris, G., Benson, G., Brown, F.M., Freeman, R., Green, J., Huang, E., and Isaacs, D. (2022). 9. Pharmacologic Approaches to Glycemic Treatment: Standards of Medical Care in Diabetes-2022. Diabetes Care, 45, S125\u2013S143.","DOI":"10.2337\/dc22-S009"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"American Diabetes Association Professional Practice Committee, Draznin, B., Aroda, V.R., Bakris, G., Benson, G., Brown, F.M., Freeman, R., Green, J., Huang, E., and Isaacs, D. (2022). 8. Obesity and Weight Management for the Prevention and Treatment of Type 2 Diabetes: Standards of Medical Care in Diabetes-2022. Diabetes Care, 45, S113\u2013S124.","DOI":"10.2337\/dc22-S008"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"American Diabetes Association Professional Practice Committee, Draznin, B., Aroda, V.R., Bakris, G., Benson, G., Brown, F.M., Freeman, R., Green, J., Huang, E., and Isaacs, D. (2022). 6. Glycemic Targets: Standards of Medical Care in Diabetes-2022. Diabetes Care, 45, S83\u2013S96.","DOI":"10.2337\/dc22-S006"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"American Diabetes Association Professional Practice Committee, Draznin, B., Aroda, V.R., Bakris, G., Benson, G., Brown, F.M., Freeman, R., Green, J., Huang, E., and Isaacs, D. (2022). 14. Children and Adolescents: Standards of Medical Care in Diabetes-2022. Diabetes Care, 45, S208\u2013S231.","DOI":"10.2337\/dc22-S014"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"American Diabetes Association Professional Practice Committee, Draznin, B., Aroda, V.R., Bakris, G., Benson, G., Brown, F.M., Freeman, R., Green, J., Huang, E., and Isaacs, D. (2022). 13. Older Adults: Standards of Medical Care in Diabetes-2022. Diabetes Care, 45, S195\u2013S207.","DOI":"10.2337\/dc22-S013"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"American Diabetes Association Professional Practice Committee, Draznin, B., Aroda, V.R., Bakris, G., Benson, G., Brown, F.M., Freeman, R., Green, J., Huang, E., and Isaacs, D. (2022). 15. Management of Diabetes in Pregnancy: Standards of Medical Care in Diabetes-2022. Diabetes Care, 45, S232\u2013S243.","DOI":"10.2337\/dc22-S015"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"American Diabetes Association Professional Practice Committee, Draznin, B., Aroda, V.R., Bakris, G., Benson, G., Brown, F.M., Freeman, R., Green, J., Huang, E., and Isaacs, D. (2022). 4. Comprehensive Medical Evaluation and Assessment of Comorbidities: Standards of Medical Care in Diabetes-2022. Diabetes Care, 45, S46\u2013S59.","DOI":"10.2337\/dc22-S004"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"8609213","DOI":"10.1155\/2020\/8609213","article-title":"Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus","volume":"2020","author":"Yaribeygi","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"674","DOI":"10.2174\/156652407782564408","article-title":"Oxidative stress and the JNK pathway are involved in the development of type 1 and type 2 diabetes","volume":"7","author":"Kaneto","year":"2007","journal-title":"Curr. Mol. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s11684-019-0729-1","article-title":"Oxidative stress and diabetes: Antioxidative strategies","volume":"14","author":"Zhang","year":"2020","journal-title":"Front. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e141138","DOI":"10.1172\/jci.insight.141138","article-title":"Mitophagy protects \u03b2 cells from inflammatory damage in diabetes","volume":"5","author":"Sidarala","year":"2020","journal-title":"JCI Insight"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"757","DOI":"10.2147\/CIA.S158513","article-title":"Oxidative stress, aging, and diseases","volume":"13","author":"Liguori","year":"2018","journal-title":"Clin. Interv. Aging"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"American Diabetes Association Professional Practice Committee (2022). 3. Prevention or Delay of Type 2 Diabetes and Associated Comorbidities: Standards of Medical Care in Diabetes-2022. Diabetes Care, 45, S39\u2013S45.","DOI":"10.2337\/dc22-S003"},{"key":"ref_16","first-page":"1764","article-title":"Effect of Physical activity on Insulin Resistance, Inflammation and Oxidative Stress in Diabetes Mellitus","volume":"7","author":"Venkatasamy","year":"2013","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1177\/1479164115579003","article-title":"Impact of exercise on diurnal and nocturnal markers of glycaemic variability and oxidative stress in obese individuals with type 2 diabetes or impaired glucose tolerance","volume":"12","author":"Farabi","year":"2015","journal-title":"Diab. Vasc. Dis. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1089\/acm.2009.0560","article-title":"Effect of t\u2019ai chi exercise on biochemical profiles and oxidative stress indicators in obese patients with type 2 diabetes","volume":"16","author":"Chen","year":"2010","journal-title":"J. Altern. Complement. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jbmt.2021.01.004","article-title":"The effect of pilates on metabolic control and oxidative stress of diabetics type 2\u2014A randomized controlled clinical trial","volume":"27","author":"Souza","year":"2021","journal-title":"J. Bodyw. Mov. Ther."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"101397","DOI":"10.1016\/j.redox.2019.101397","article-title":"Effects of diets high in animal or plant protein on oxidative stress in individuals with type 2 diabetes: A randomized clinical trial","volume":"29","author":"Markova","year":"2020","journal-title":"Redox Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ctcp.2012.12.002","article-title":"Effect of daily supplementation of fruits on oxidative stress indices and glycaemic status in type 2 diabetes mellitus","volume":"19","author":"Hegde","year":"2013","journal-title":"Complement. Ther. Clin. Pract."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.clnesp.2019.10.015","article-title":"Impact of Rutin and Vitamin C combination on oxidative stress and glycemic control in patients with type 2 diabetes","volume":"35","author":"Ragheb","year":"2020","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1017\/S0007114520001336","article-title":"Effect of daily consumption of cranberry beverage on insulin sensitivity and modification of cardiovascular risk factors in adults with obesity: A pilot, randomised, placebo-controlled study","volume":"124","author":"Hsia","year":"2020","journal-title":"Br. J. Nutr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.5604\/17322693.1224259","article-title":"Endogenous mechanisms of reactive oxygen species (ROS) generation","volume":"70","author":"Sarniak","year":"2016","journal-title":"Postepy Hig. Med. Dosw."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.cellsig.2012.01.008","article-title":"Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling","volume":"24","author":"Ray","year":"2012","journal-title":"Cell Signal."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3904\/kjim.2015.404","article-title":"Effects of valsartan and amlodipine on oxidative stress in type 2 diabetic patients with hypertension: A randomized, multicenter study","volume":"32","author":"Kim","year":"2017","journal-title":"Korean J. Intern. Med."},{"key":"ref_27","first-page":"9","article-title":"Defining ROS in Biology and Medicine","volume":"1","author":"Li","year":"2016","journal-title":"React. Oxyg. Species"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4310469","DOI":"10.1155\/2017\/4310469","article-title":"Oxidative Stress in Disease and Aging: Mechanisms and Therapies 2016","volume":"2017","author":"Simon","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.freeradbiomed.2015.05.036","article-title":"Oxidative stress response and Nrf2 signaling in aging","volume":"88 Pt B","author":"Zhang","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"6635460","DOI":"10.1155\/2021\/6635460","article-title":"The Keap1-Nrf2 System: A Mediator between Oxidative Stress and Aging","volume":"2021","author":"Yu","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"104413","DOI":"10.1016\/j.archger.2021.104413","article-title":"Oxidative stress, antioxidants, hormesis and calorie restriction: The current perspective in the biology of aging","volume":"95","author":"Mehdi","year":"2021","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"100982","DOI":"10.1016\/j.arr.2019.100982","article-title":"Ageing, age-related diseases and oxidative stress: What to do next?","volume":"57","author":"Luo","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"ref_33","first-page":"111","article-title":"Oxidative stress and inflammatory markers in prediabetes and diabetes","volume":"70","author":"Luc","year":"2019","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.dsx.2019.01.040","article-title":"The effects of inflammation, aging and oxidative stress on the pathogenesis of diabetes mellitus (type 2 diabetes)","volume":"13","author":"Halim","year":"2019","journal-title":"Diabetes Metab. Syndr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"8152","DOI":"10.1002\/jcp.27603","article-title":"Insulin resistance: Review of the underlying molecular mechanisms","volume":"234","author":"Yaribeygi","year":"2019","journal-title":"J. Cell Physiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"109007","DOI":"10.1016\/j.diabres.2021.109007","article-title":"Oxidative stress in youth with type 1 diabetes: Not only a matter of gender, age, and glycemic control","volume":"179","author":"Morandi","year":"2021","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1161\/CIRCRESAHA.110.223545","article-title":"Oxidative stress and diabetic complications","volume":"107","author":"Giacco","year":"2010","journal-title":"Circ. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"8852759","DOI":"10.1155\/2021\/8852759","article-title":"The Role of Oxidative Stress and Antioxidants in Diabetic Wound Healing","volume":"2021","author":"Deng","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.mito.2020.01.002","article-title":"Redox homeostasis, oxidative stress and mitophagy","volume":"51","author":"Pappa","year":"2020","journal-title":"Mitochondrion"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e106283","DOI":"10.15252\/embj.2020106283","article-title":"ATAD3B is a mitophagy receptor mediating clearance of oxidative stress-induced damaged mitochondrial DNA","volume":"40","author":"Shu","year":"2021","journal-title":"EMBO J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1161\/CIRCRESAHA.117.311082","article-title":"Autophagy and Mitophagy in Cardiovascular Disease","volume":"120","author":"Kroemer","year":"2017","journal-title":"Circ. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.neuint.2017.02.007","article-title":"Mitophagy in neurodegeneration and aging","volume":"109","author":"Fivenson","year":"2017","journal-title":"Neurochem. Int."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.jsams.2017.03.014","article-title":"Exercise intensity, redox homeostasis and inflammation in type 2 diabetes mellitus","volume":"20","author":"Mallard","year":"2017","journal-title":"J. Sci. Med. Sport"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1007\/s00125-016-4170-6","article-title":"The effects of 2 weeks of interval vs continuous walking training on glycaemic control and whole-body oxidative stress in individuals with type 2 diabetes: A controlled, randomised, crossover trial","volume":"60","author":"Karstoft","year":"2017","journal-title":"Diabetologia"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.jdiacomp.2018.09.008","article-title":"Glycemic, inflammatory and oxidative stress responses to different high-intensity training protocols in type 1 diabetes: A randomized clinical trial","volume":"32","author":"Farinha","year":"2018","journal-title":"J. Diabetes Complicat."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Hoseini, R., Rahim, H.A., and Ahmed, J.K. (2022). Concurrent alteration in inflammatory biomarker gene expression and oxidative stress: How aerobic training and vitamin D improve T2DM. BMC Complement. Med. Ther., 22.","DOI":"10.1186\/s12906-022-03645-7"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.je.2016.12.017","article-title":"Smoking and the risk of type 2 diabetes in Japan: A systematic review and meta-analysis","volume":"27","author":"Akter","year":"2017","journal-title":"J. Epidemiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"104154","DOI":"10.1016\/j.ebiom.2022.104154","article-title":"Appraising the causal role of smoking in multiple diseases: A systematic review and meta-analysis of Mendelian randomization studies","volume":"82","author":"Larsson","year":"2022","journal-title":"EBioMedicine"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.2337\/dc17-1818","article-title":"Effects of Smoking Versus Nonsmoking on Postprandial Glucose Metabolism in Heavy Smokers Compared with Nonsmokers","volume":"41","author":"Bagger","year":"2018","journal-title":"Diabetes Care"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e169","DOI":"10.1093\/pubmed\/fdy106","article-title":"Cigarette smoking as a risk factor for type 2 diabetes in women compared with men: A systematic review and meta-analysis of prospective cohort studies","volume":"41","author":"Yuan","year":"2019","journal-title":"J. Public Health"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1080\/14767058.2018.1500547","article-title":"Association between cigarette smoking during pregnancy and gestational diabetes mellitus: A meta-analysis","volume":"33","author":"Wang","year":"2020","journal-title":"J. Matern. Fetal Neonatal. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.freeradbiomed.2016.01.006","article-title":"Ascorbic acid supplementation improves skeletal muscle oxidative stress and insulin sensitivity in people with type 2 diabetes: Findings of a randomized controlled study","volume":"93","author":"Mason","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"618","DOI":"10.2337\/dc20-1893","article-title":"Effects of Vitamin C Supplementation on Glycemic Control and Cardiovascular Risk Factors in People with Type 2 Diabetes: A GRADE-Assessed Systematic Review and Meta-analysis of Randomized Controlled Trials","volume":"44","author":"Mason","year":"2021","journal-title":"Diabetes Care"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1373\/clinchem.2006.076992","article-title":"Effects of alpha-tocopherol and mixed tocopherol supplementation on markers of oxidative stress and inflammation in type 2 diabetes","volume":"53","author":"Wu","year":"2007","journal-title":"Clin. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/dmrr.2439","article-title":"\u03b2-Carotene, \u03b1-tocopherol and ascorbic acid: Differential profile of antioxidant, inflammatory status and regulation of gene expression in human mononuclear cells of diabetic donors","volume":"29","author":"Costa","year":"2013","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jcjd.2016.09.004","article-title":"A Randomized Controlled Clinical Trial Investigating the Effects of Omega-3 Fatty Acids and Vitamin E Co-Supplementation on Biomarkers of Oxidative Stress, Inflammation and Pregnancy Outcomes in Gestational Diabetes","volume":"41","author":"Jamilian","year":"2017","journal-title":"Can. J. Diabetes"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.nut.2006.08.012","article-title":"Muscadine grape products intake, diet and blood constituents of non-diabetic and type 2 diabetic subjects","volume":"22","author":"Banini","year":"2006","journal-title":"Nutrition"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.2337\/dc12-1652","article-title":"Grape polyphenols prevent fructose-induced oxidative stress and insulin resistance in first-degree relatives of type 2 diabetic patients","volume":"36","author":"Hokayem","year":"2013","journal-title":"Diabetes Care"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/09637486.2016.1229760","article-title":"Effects of pomegranate juice consumption on oxidative stress in patients with type 2 diabetes: A single-blind, randomized clinical trial","volume":"68","author":"Sohrab","year":"2017","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1556\/APhysiol.95.2008.4.5","article-title":"Effect of a dietary supplement containing blueberry and sea buckthorn concentrate on antioxidant capacity in type 1 diabetic children","volume":"95","author":"Dunca","year":"2008","journal-title":"Acta Physiol. Hung."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1017\/S0007114518002192","article-title":"Co-ingestion of whole eggs or egg whites with glucose protects against postprandial hyperglycaemia-induced oxidative stress and dysregulated arginine metabolism in association with improved vascular endothelial function in prediabetic men","volume":"120","author":"McDonald","year":"2018","journal-title":"Br. J. Nutr."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1017\/S0007114517003610","article-title":"Replacing carbohydrate during a glucose challenge with the egg white portion or whole eggs protects against postprandial impairments in vascular endothelial function in prediabetic men by limiting increases in glycaemia and lipid peroxidation","volume":"119","author":"McDonald","year":"2018","journal-title":"Br. J. Nutr."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1093\/ajcn\/nqy048","article-title":"Effect of a high-egg diet on cardiometabolic risk factors in people with type 2 diabetes: The Diabetes and Egg (DIABEGG) Study-randomized weight-loss and follow-up phase","volume":"107","author":"Fuller","year":"2018","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/jhn.12792","article-title":"Oxidative stress and nitrate\/nitrite (NOx) status following citrulline supplementation in type 2 diabetes: A randomised, double-blind, placebo-controlled trial","volume":"34","author":"Azizi","year":"2021","journal-title":"J. Hum. Nutr. Diet."},{"key":"ref_65","unstructured":"Feingold, K.R., Anawalt, B., Boyce, A., Chrousos, G., de Herder, W.W., Dhatariya, K., Dungan, K., Hershman, J.M., Hofland, J., and Kalra, S. (2000). Schroeder EBManagement of Type 2 Diabetes: Selecting Amongst Available Pharmacological Agents. Endotext, MDText.com, Inc."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/pedi.12374","article-title":"Influence of initial insulin dosage on blood glucose dynamics of children and adolescents with newly diagnosed type 1 diabetes mellitus","volume":"18","author":"Wang","year":"2017","journal-title":"Pediatr. Diabetes"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.diabet.2014.01.004","article-title":"Impact of flexible insulin therapy on blood glucose variability, oxidative stress and inflammation in type 1 diabetic patients: The VARIAFIT study","volume":"40","author":"Benhamou","year":"2014","journal-title":"Diabetes Metab."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.diabres.2010.11.030","article-title":"Effect of metformin on oxidative stress, nitrosative stress and inflammatory biomarkers in type 2 diabetes patients","volume":"93","author":"Chakraborty","year":"2011","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.dsx.2017.11.003","article-title":"Effect of metformin combined with lifestyle modification versus lifestyle modification alone on proinflammatory-oxidative status in drug-na\u00efve pre-diabetic and diabetic patients: A randomized controlled study","volume":"12","author":"Bulatova","year":"2018","journal-title":"Diabetes Metab. Syndr."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.dsx.2015.08.016","article-title":"Anti oxidant potential of Metformin and Pioglitazone in Type 2 Diabetes Mellitus: Beyond their anti glycemic effect","volume":"10","author":"Singh","year":"2016","journal-title":"Diabetes Metab. Syndr."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.jdiacomp.2013.05.006","article-title":"Comparative effects of pioglitazone and metformin on oxidative stress markers in newly diagnosed type 2 diabetes patients: A randomized clinical trial","volume":"27","author":"Mirmiranpour","year":"2013","journal-title":"J. Diabetes Complicat."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1080\/14656566.2017.1353080","article-title":"The efficacy and safety of adding either vildagliptin or glimepiride to ongoing metformin therapy in patients with type 2 diabetes mellitus","volume":"18","author":"Kim","year":"2017","journal-title":"Expert Opin. Pharmacother."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.2337\/dc12-0199","article-title":"Reduction of oxidative stress and inflammation by blunting daily acute glucose fluctuations in patients with type 2 diabetes: Role of dipeptidyl peptidase-IV inhibition","volume":"35","author":"Rizzo","year":"2012","journal-title":"Diabetes Care"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1089\/dia.2010.0048","article-title":"Effect of exenatide on inflammatory and oxidative stress markers in patients with type 2 diabetes mellitus","volume":"13","author":"Wu","year":"2011","journal-title":"Diabetes Technol. Ther."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1210\/jc.2014-2291","article-title":"Liraglutide reduces oxidative stress and restores heme oxygenase-1 and ghrelin levels in patients with type 2 diabetes: A prospective pilot study","volume":"100","author":"Rizzo","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/dom.14277","article-title":"Mechanism of action of Imeglimin: A novel therapeutic agent for type 2 diabetes","volume":"23","author":"Vial","year":"2021","journal-title":"Diabetes Obes. 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