{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:37:33Z","timestamp":1788406653503,"version":"build-2803163510"},"reference-count":41,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Key Project of Regional Innovation and Development Joint Fund of National Natural Science Foundation of China","award":["U20A2056"],"award-info":[{"award-number":["U20A2056"]}]},{"name":"The Key Project of Regional Innovation and Development Joint Fund of National Natural Science Foundation of China","award":["2021JJB130431"],"award-info":[{"award-number":["2021JJB130431"]}]},{"name":"The Key Project of Regional Innovation and Development Joint Fund of National Natural Science Foundation of China","award":["ISA2022105"],"award-info":[{"award-number":["ISA2022105"]}]},{"name":"The Key Project of Regional Innovation and Development Joint Fund of National Natural Science Foundation of China","award":["2019RS3022"],"award-info":[{"award-number":["2019RS3022"]}]},{"name":"Youth Foundation of Guangxi Natural Science Foundation","award":["U20A2056"],"award-info":[{"award-number":["U20A2056"]}]},{"name":"Youth Foundation of Guangxi Natural Science Foundation","award":["2021JJB130431"],"award-info":[{"award-number":["2021JJB130431"]}]},{"name":"Youth Foundation of Guangxi Natural Science Foundation","award":["ISA2022105"],"award-info":[{"award-number":["ISA2022105"]}]},{"name":"Youth Foundation of Guangxi Natural Science Foundation","award":["2019RS3022"],"award-info":[{"award-number":["2019RS3022"]}]},{"name":"Open Foundation of the Key Laboratory of Agro-Ecological Processes in Subtropical Region, Chinese Academy of Sciences","award":["U20A2056"],"award-info":[{"award-number":["U20A2056"]}]},{"name":"Open Foundation of the Key Laboratory of Agro-Ecological Processes in Subtropical Region, Chinese Academy of Sciences","award":["2021JJB130431"],"award-info":[{"award-number":["2021JJB130431"]}]},{"name":"Open Foundation of the Key Laboratory of Agro-Ecological Processes in Subtropical Region, Chinese Academy of Sciences","award":["ISA2022105"],"award-info":[{"award-number":["ISA2022105"]}]},{"name":"Open Foundation of the Key Laboratory of Agro-Ecological Processes in Subtropical Region, Chinese Academy of Sciences","award":["2019RS3022"],"award-info":[{"award-number":["2019RS3022"]}]},{"name":"Special Funds for Construction of Innovative Provinces in Hunan Province","award":["U20A2056"],"award-info":[{"award-number":["U20A2056"]}]},{"name":"Special Funds for Construction of Innovative Provinces in Hunan Province","award":["2021JJB130431"],"award-info":[{"award-number":["2021JJB130431"]}]},{"name":"Special Funds for Construction of Innovative Provinces in Hunan Province","award":["ISA2022105"],"award-info":[{"award-number":["ISA2022105"]}]},{"name":"Special Funds for Construction of Innovative Provinces in Hunan Province","award":["2019RS3022"],"award-info":[{"award-number":["2019RS3022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>To investigate developmental changes in immunity and different responses to weaning stress of piglets from different breeds during suckling and weaning periods, a total of 30 litters of Taoyuan black (TB) piglets, Xiangcun black (XB) piglets, and Duroc (DR) piglets (ten litters per breed) were selected at 1, 10, 21, and 24 days of age, respectively. The results showed that the liver index of TB piglets was higher at 10 days of age than that of the other days of age and breeds. Regardless of the days of age, TB and XB piglets had a higher plasma IgA level and lower ileal IgM level than in the DR piglets, and XB piglets had a lower plasma IgG level than the other breeds. TB and XB piglets had a higher IL-6 level and lower IL-17 level in plasma at 24 days of age than DR piglets, regardless of the days of age. The ileal levels of IL-2, IL-10, IFN-\u03b3, and TNF-\u03b1 were lower in the TB and XB piglets at 24 days of age than in the DR piglets. The ileal expression levels of IRAK1, CD14, MyD88, and NF-\u03baB were down-regulated in the TB and XB piglets at 24 days of age compared to those in the DR piglets. These findings suggest that there were differences in the development of immune function among different pig breeds. Moreover, TB and XB piglets presented stronger resistance to weaning stress than the DR piglets, which may be related to the immune regulation mediated by the MyD88\/NF-\u03baB signaling pathway.<\/jats:p>","DOI":"10.3390\/ijms232415781","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T01:56:06Z","timestamp":1670896566000},"page":"15781","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Developmental Changes of Immunity and Different Responses to Weaning Stress of Chinese Indigenous Piglets and Duroc Piglets during Suckling and Weaning Periods"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0017-680X","authenticated-orcid":false,"given":"Sujuan","family":"Ding","sequence":"first","affiliation":[{"name":"Key Laboratory of Agro-Ecological Processes in Subtropical Region, Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China"},{"name":"College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing 100008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Cheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Agro-Ecological Processes in Subtropical Region, Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China"},{"name":"College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing 100008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0118-5708","authenticated-orcid":false,"given":"Md. Abul Kalam","family":"Azad","sequence":"additional","affiliation":[{"name":"Key Laboratory of Agro-Ecological Processes in Subtropical Region, Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China"},{"name":"College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing 100008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Agro-Ecological Processes in Subtropical Region, Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China"},{"name":"College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing 100008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Agro-Ecological Processes in Subtropical Region, Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China"},{"name":"College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing 100008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangfeng","family":"Kong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Agro-Ecological Processes in Subtropical Region, Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China"},{"name":"College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing 100008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1002\/JLB.3RU0120-090RR","article-title":"Maintenance of gut barrier integrity after injury: Trust your gut microRNAs","volume":"110","author":"Morris","year":"2021","journal-title":"J. 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