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China","award":["MOST109-2314-B-037-062-"],"award-info":[{"award-number":["MOST109-2314-B-037-062-"]}]},{"name":"Childhood Burn Foundation of the Republic of China","award":["109-2314-B-037-020-MY3"],"award-info":[{"award-number":["109-2314-B-037-020-MY3"]}]},{"name":"Childhood Burn Foundation of the Republic of China","award":["110KK030"],"award-info":[{"award-number":["110KK030"]}]},{"name":"Childhood Burn Foundation of the Republic of China","award":["KMU-TC111A02-0"],"award-info":[{"award-number":["KMU-TC111A02-0"]}]},{"name":"Childhood Burn Foundation of the Republic of China","award":["KMUH-110-0R32"],"award-info":[{"award-number":["KMUH-110-0R32"]}]},{"name":"Childhood Burn Foundation of the Republic of China","award":["KMTTH-110-R005"],"award-info":[{"award-number":["KMTTH-110-R005"]}]},{"name":"Childhood Burn Foundation of the Republic of China","award":["Proj-110-12"],"award-info":[{"award-number":["Proj-110-12"]}]},{"name":"Childhood Burn Foundation of the Republic of China","award":["Proj-111-12"],"award-info":[{"award-number":["Proj-111-12"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Muscle loss and weakness after a burn injury are typically the consequences of neuronal dysregulation and metabolic change. Hypermetabolism has been noted to cause muscle atrophy. However, the mechanism underlying the development of burn-induced motor neuropathy and its contribution to muscle atrophy warrant elucidation. Current therapeutic interventions for burn-induced motor neuropathy demonstrate moderate efficacy and have side effects, which limit their usage. We previously used a third-degree burn injury rodent model and found that irisin\u2014an exercise-induced myokine\u2014exerts a protective effect against burn injury-induced sensory and motor neuropathy by attenuating neuronal damage in the spinal cord. In the current study, spinal irisin gene delivery was noted to attenuate burn injury-induced sciatic nerve demyelination and reduction of neuromuscular junction innervation. Spinal overexpression of irisin leads to myelination rehabilitation and muscular innervation through the modulation of brain-derived neurotrophic factor and glial-cell-line-derived neurotrophic factor expression along the sciatic nerve to the muscle tissues and thereby modulates the Akt\/mTOR pathway and metabolic derangement and prevents muscle atrophy.<\/jats:p>","DOI":"10.3390\/ijms232415899","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T05:27:23Z","timestamp":1670995643000},"page":"15899","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Spinal Irisin Gene Delivery Attenuates Burn Injury-Induced Muscle Atrophy by Promoting Axonal Myelination and Innervation of Neuromuscular Junctions"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4675-6615","authenticated-orcid":false,"given":"Sheng-Hua","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 801, Taiwan"},{"name":"Department of Anesthesiology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan"},{"name":"Department of Anesthesiology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6643-1071","authenticated-orcid":false,"given":"I-Cheng","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan"},{"name":"Department of Anesthesiology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan"},{"name":"Department of Anesthesiology, Kaohsiung Municipal Siaogang Hospital, Kaohsiung 812, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Ming","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, National Sun Yat-Sun University, Kaohsiung 804, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Fang","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 801, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee-Yin","family":"Chai","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, National Sun Yat-Sun University, Kaohsiung 804, Taiwan"},{"name":"Department of Pathology, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan"},{"name":"Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Hong","family":"Tai","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, National Sun Yat-Sun University, Kaohsiung 804, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Hung","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Plastic Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan"},{"name":"Department of Surgery, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan"},{"name":"Regeneration Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan"},{"name":"Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan"},{"name":"Department of Surgery, Division of Plastic Surgery, Kaohsiung Municipal Siaogang Hospital, Kaohsiung 812, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41572-020-0145-5","article-title":"Burn injury","volume":"6","author":"Jeschke","year":"2020","journal-title":"Nat. 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