{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:04:34Z","timestamp":1790438674235,"version":"4.1.0"},"reference-count":67,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Normandy University (Normandy, France)"},{"name":"Normandy Rouen University (Rouen, France)"},{"name":"INSERM (Paris, France)"},{"name":"Institute of Research and Innovation in Biomedicine (IRIB)"},{"name":"french ministry of research, the Conseil R\u00e9gional de Normandie (Normandy, France)"},{"name":"Fonds Europ\u00e9en de D\u00e9veloppement R\u00e9gional (FEDER)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cerebral palsy (CP) is defined as permanent disorders of movement and posture. Prematurity and hypoxia\u2013ischemia (HI) are risk factors of CP, and boys display a greater vulnerability to develop CP. Magnesium sulfate (MgSO4) is administered to mothers at risk of preterm delivery as a neuroprotective agent. However, its effectiveness is only partial at long term. To prolong MgSO4 effects, it was combined with 4-phenylbutyrate (4-PBA). A mouse model of neonatal HI, generating lesions similar to those reported in preterms, was realized. At short term, at the behavioral and cellular levels, and in both sexes, the MgSO4\/4-PBA association did not alter the total prevention induced by MgSO4 alone. At long term, the association extended the MgSO4 preventive effects on HI-induced motor and cognitive deficits. This might be sustained by the promotion of oligodendrocyte precursor differentiation after HI at short term, which led to improvement of white matter integrity at long term. Interestingly, at long term, at a behavioral level, sex-dependent responses to HI were observed. This might partly be explained by early sex-dependent pathological processes that occur after HI. Indeed, at short term, apoptosis through mitochondrial pathways seemed to be activated in females but not in males, and only the MgSO4\/4-PBA association seemed to counter this apoptotic process.<\/jats:p>","DOI":"10.3390\/ijms232415947","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T03:01:51Z","timestamp":1671073311000},"page":"15947","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of MgSO4 Alone or Associated with 4-PBA on Behavior and White Matter Integrity in a Mouse Model of Cerebral Palsy: A Sex- and Time-Dependent Study"],"prefix":"10.3390","volume":"23","author":[{"given":"Lou","family":"Legouez","sequence":"first","affiliation":[{"name":"INSERM U1245 \u201cCancer and Brain Genomics\u201d\u2014Team \u201cGenetics and Pathophysiology of Neurodevelopmental Disorders\u201d, IRIB, 76000 Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9r\u00e9nice","family":"Le Dieu-Lugon","sequence":"additional","affiliation":[{"name":"INSERM U1245 \u201cCancer and Brain Genomics\u201d\u2014Team \u201cGenetics and Pathophysiology of Neurodevelopmental Disorders\u201d, IRIB, 76000 Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sh\u00e9rine","family":"Feillet","sequence":"additional","affiliation":[{"name":"INSERM U1245 \u201cCancer and Brain Genomics\u201d\u2014Team \u201cGenetics and Pathophysiology of Neurodevelopmental Disorders\u201d, IRIB, 76000 Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00ebtan","family":"Riou","sequence":"additional","affiliation":[{"name":"INSERM U1234 \u201cPan\u2019Ther\u201d, Flow Cytometry Core\u2014IRIB, 76000 Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Yeddou","sequence":"additional","affiliation":[{"name":"INSERM U1245 \u201cCancer and Brain Genomics\u201d\u2014Team \u201cGenetics and Pathophysiology of Neurodevelopmental Disorders\u201d, IRIB, 76000 Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibault","family":"Plouchart","sequence":"additional","affiliation":[{"name":"INSERM U1245 \u201cCancer and Brain Genomics\u201d\u2014Team \u201cGenetics and Pathophysiology of Neurodevelopmental Disorders\u201d, IRIB, 76000 Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Dourmap","sequence":"additional","affiliation":[{"name":"INSERM U1245 \u201cCancer and Brain Genomics\u201d\u2014Team \u201cGenetics and Pathophysiology of Neurodevelopmental Disorders\u201d, IRIB, 76000 Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Anne","family":"Le Ray","sequence":"additional","affiliation":[{"name":"INSERM U1245 \u201cCancer and Brain Genomics\u201d\u2014Team \u201cGenetics and Pathophysiology of Neurodevelopmental Disorders\u201d, IRIB, 76000 Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2858-148X","authenticated-orcid":false,"given":"St\u00e9phane","family":"Marret","sequence":"additional","affiliation":[{"name":"INSERM U1245 \u201cCancer and Brain Genomics\u201d\u2014Team \u201cGenetics and Pathophysiology of Neurodevelopmental Disorders\u201d, IRIB, 76000 Rouen, France"},{"name":"Department of Neonatal Paediatrics and Intensive Care-Neuropediatric, CHU, Rouen Hospital, 76000 Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno J.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"INSERM U1245 \u201cCancer and Brain Genomics\u201d\u2014Team \u201cGenetics and Pathophysiology of Neurodevelopmental Disorders\u201d, IRIB, 76000 Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Cleren","sequence":"additional","affiliation":[{"name":"INSERM U1245 \u201cCancer and Brain Genomics\u201d\u2014Team \u201cGenetics and Pathophysiology of Neurodevelopmental Disorders\u201d, IRIB, 76000 Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1001\/jama.296.13.1602","article-title":"Clinical and MRI correlates of cerebral palsy: The European Cerebral Palsy Study","volume":"296","author":"Bax","year":"2006","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.2147\/NDT.S235165","article-title":"Cerebral Palsy: Current Opinions on Definition, Epidemiology, Risk Factors, Classification and Treatment Options","volume":"16","author":"Sadowska","year":"2020","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/B978-0-444-52891-9.00016-6","article-title":"Pathophysiology of cerebral palsy","volume":"111","author":"Marret","year":"2013","journal-title":"Handb. Clin. Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/s41582-018-0043-6","article-title":"The complex aetiology of cerebral palsy","volume":"14","author":"Korzeniewski","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/dmcn.13021","article-title":"Australian Cerebral Palsy Register Group. Biological sex and the risk of cerebral palsy in Victoria, Australia","volume":"2","author":"Reid","year":"2016","journal-title":"Dev. Med. Child. Neurol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S1474-4422(08)70294-1","article-title":"Brain injury in premature infants: A complex amalgam of destructive and developmental disturbances","volume":"8","author":"Volpe","year":"2009","journal-title":"Lancet Neurol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.pediatrneurol.2015.01.016","article-title":"Pathophysiology and neuroprotection of global and focal perinatal brain injury: Lessons from animal models","volume":"52","author":"Titomanlio","year":"2015","journal-title":"Pediatr. Neurol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00401-017-1718-6","article-title":"White matter injury in the preterm infant: Pathology and mechanisms","volume":"134","author":"Back","year":"2017","journal-title":"Acta Neuropathol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/jnr.23828","article-title":"Sex-dependent consequences of neonatal brain hypoxia-ischemia in the rat","volume":"95","author":"Netto","year":"2017","journal-title":"J. Neurosci Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fneur.2016.00057","article-title":"Rodent Hypoxia-Ischemia Models for Cerebral Palsy Research: A Systematic Review","volume":"7","author":"Rumajogee","year":"2016","journal-title":"Front. Neurol."},{"key":"ref_11","first-page":"11","article-title":"The immune response after hypoxia-ischemia in a mouse model of preterm brain injury","volume":"5","author":"Albertsson","year":"2014","journal-title":"J. Neuroinflammation"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.bbr.2018.11.036","article-title":"Preventive and therapeutic effects of environmental enrichment in Wistar rats submitted to neonatal hypoxia-ischemia","volume":"359","author":"Arcego","year":"2019","journal-title":"Behav. Brain Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.nbd.2018.08.020","article-title":"Time- and sex-dependent efficacy of magnesium sulfate to prevent behavioral impairments and cerebral damage in a mouse model of cerebral palsy","volume":"120","author":"Daher","year":"2018","journal-title":"Neurobiol. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/mrm.22617","article-title":"Longitudinal MR Assessment of Hypoxic Ischemic Injury in the Immature Rat Brain","volume":"65","author":"Chatagner","year":"2011","journal-title":"Magn. Reson. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3109\/01443615.2011.638999","article-title":"Treatment with magnesium sulphate in pre-term birth: A systematic review and meta-analysis of observational studies","volume":"32","author":"Wolf","year":"2012","journal-title":"J. Obstet. Gynaecol."},{"key":"ref_16","first-page":"CD004661","article-title":"Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus","volume":"1","author":"Doyle","year":"2009","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1001\/jama.2014.11189","article-title":"School-age outcomes of very preterm infants after antenatal treatment with magnesium sulfate vs placebo","volume":"312","author":"Doyle","year":"2014","journal-title":"JAMA"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jpeds.2014.04.007","article-title":"School-age outcomes following a randomized controlled trial of magnesium sulfate for neuroprotection of preterm infants","volume":"165","author":"Chollat","year":"2014","journal-title":"J. Pediatr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/ijgo.13856","article-title":"FIGO good practice recommendations on magnesium sulfate administration for preterm fetal neuroprotection","volume":"155","author":"Shennan","year":"2021","journal-title":"Int. J. Gynaecol. Obstets."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.00012.2014","article-title":"Magnesium in man: Implications for health and disease","volume":"95","author":"Hoenderop","year":"2015","journal-title":"Physiol Rev."},{"key":"ref_21","first-page":"1","article-title":"The role of magnesium sulfate (MgSO4) in fetal neuroprotection","volume":"27","author":"Bachnas","year":"2019","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ijdevneu.2018.01.002","article-title":"Magnesium sulphate induces preconditioning in preterm rodent models of cerebral hypoxia-ischemia","volume":"70","author":"Koning","year":"2018","journal-title":"Int. J. Dev. Neurosci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1093\/jnen\/nlx073","article-title":"Magnesium Sulfate Prevents Neurochemical and Long-Term Behavioral Consequences of Neonatal Excitotoxic Lesions: Comparison Between Male and Female Mice","volume":"76","author":"Daher","year":"2017","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.ajog.2016.03.032","article-title":"Maternal magnesium sulfate fetal neuroprotective effects to the fetus: Inhibition of neuronal nitric oxide synthase and nuclear factor kappa-light-chain-enhancer of activated B cells activation in a rodent model","volume":"215","author":"Beloosesky","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"6338","DOI":"10.4049\/jimmunol.1101765","article-title":"Magnesium decreases inflammatory cytokine production: A novel innate immunomodulatory mechanism","volume":"188","author":"Sugimoto","year":"2012","journal-title":"J. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1177\/1933719107305864","article-title":"Neuroprotective effect of long-term MgSO4 administration after cerebral hypoxia-ischemia in newborn rats is related to the severity of brain damage","volume":"14","author":"Spandou","year":"2007","journal-title":"Reprod. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0006-8993(02)03395-4","article-title":"Magnesium pre-treatment reduces neuronal apoptosis in newborn rats in hypoxia-ischemia","volume":"955","author":"Atalay","year":"2002","journal-title":"Brain Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1469-8749.1995.tb12035.x","article-title":"Prevention by magnesium of excitotoxic neuronal death in the developing brain: An animal model for clinical intervention studies","volume":"37","author":"Marret","year":"1995","journal-title":"Dev. Med. Child. Neurol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/sj.jp.7211419","article-title":"Brain lesions in newborns exposed to high-dose magnesium sulfate during preterm labor","volume":"26","author":"Mittendorf","year":"2006","journal-title":"J. Perinatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e00315","DOI":"10.1002\/prp2.315","article-title":"Experimental and clinical evidence of differential effects of magnesium sulfate on neuroprotection and angiogenesis in the fetal brain","volume":"5","author":"Lecuyer","year":"2017","journal-title":"Pharmacol. Res. Perspect."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1126\/science.aad3839","article-title":"Oligodendrocyte precursors migrate along vasculature in the developing nervous system","volume":"351","author":"Tsai","year":"2016","journal-title":"Science"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1007\/s00018-019-03248-5","article-title":"Glutamate controls vessel-associated migration of GABA interneurons from the pial migratory route via NMDA receptors and endothelial protease activation","volume":"77","author":"Aligny","year":"2020","journal-title":"Cell Mol. Life Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/ana.410090206","article-title":"The influence of immaturity on hypoxic-ischemic brain damage in the rat","volume":"9","author":"Rice","year":"1981","journal-title":"Ann. Neurol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1124\/mol.104.001339","article-title":"Sodium 4-phenylbutyrate protects against cerebral ischemic injury","volume":"66","author":"Qi","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"6391","DOI":"10.1007\/s12035-016-0149-z","article-title":"HDAC Inhibitor Sodium Butyrate-Mediated Epigenetic Regulation Enhances Neuroprotective Function of Microglia During Ischemic Stroke","volume":"54","author":"Patnala","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.brainres.2017.11.005","article-title":"Histone acetylation of oligodendrocytes protects against white matter injury induced by inflammation and hypoxia-ischemia through activation of BDNF-TrkB signaling pathway in neonatal rats","volume":"1688","author":"Huang","year":"2018","journal-title":"Brain Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1167\/iovs.18-24890","article-title":"Increased ER Stress After Experimental Ischemic Optic Neuropathy and Improved RGC and Oligodendrocyte Survival After Treatment With Chemical Chaperon","volume":"60","author":"Kumar","year":"2019","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.jpeds.2012.11.084","article-title":"Ammonia control in children ages 2 months through 5 years with urea cycle disorders: Comparison of sodium phenylbutyrate and glycerol phenylbutyrate","volume":"162","author":"Smith","year":"2013","journal-title":"J. Pediatr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1111\/1471-0528.16238","article-title":"Magnesium sulphate for fetal neuroprotection at imminent risk for preterm delivery: A systematic review with meta-analysis and trial sequential analysis","volume":"127","author":"Wolf","year":"2020","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1080\/08035250600599727","article-title":"Gender differences in neurodevelopmental outcomes among extremely preterm, extremely-low-birthweight infants","volume":"95","author":"Hintz","year":"2006","journal-title":"Acta Paediatr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.4103\/1673-5374.241441","article-title":"Magnesium sulfate and fetal neuroprotection: Overview of clinical evidence","volume":"13","author":"Chollat","year":"2018","journal-title":"Neural Regen. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1124\/jpet.107.120188","article-title":"Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: Multiple mechanisms of action","volume":"321","author":"Kim","year":"2007","journal-title":"J. Pharmacol. Exp Ther."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1136\/fn.73.3.F174","article-title":"Acute effects of two different doses of magnesium sulphate in infants with birth asphyxia","volume":"73","author":"Levene","year":"1995","journal-title":"Arch. Dis. Child Fetal Neonatal Ed."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00701-005-0496-4","article-title":"Dose finding study of intravenous magnesium sulphate in transient focal cerebral ischemia in rats","volume":"147","author":"Westermaier","year":"2005","journal-title":"Acta Neurochir."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"15082","DOI":"10.1038\/nrdp.2015.82","article-title":"Cerebral palsy","volume":"2","author":"Graham","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1007\/s12098-017-2475-1","article-title":"Cerebral Palsy: An Overview","volume":"85","author":"Gulati","year":"2018","journal-title":"Indian J. Pediatr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/dmcn.14463","article-title":"Cognitive functioning in children with cerebral palsy","volume":"62","author":"Stadskleiv","year":"2020","journal-title":"Dev. Med. Child Neurol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1001\/jamaneurol.2018.4147","article-title":"Risk of Depression and Anxiety in Adults With Cerebral Palsy","volume":"76","author":"Smith","year":"2019","journal-title":"JAMA Neurol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.pediatrneurol.2019.02.016","article-title":"Dysmaturation of Premature Brain: Importance, Cellular Mechanisms, and Potential Interventions","volume":"95","author":"Volpe","year":"2019","journal-title":"Pediatr. Neurol."},{"key":"ref_50","first-page":"53569","article-title":"A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy","volume":"117","author":"Ferguson","year":"2016","journal-title":"J. Vis. Exp."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/nrneurol.2015.13","article-title":"The role of inflammation in perinatal brain injury","volume":"4","author":"Hagberg","year":"2015","journal-title":"Nat. Rev. Neurol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1111\/apa.12240","article-title":"Sex differences in cerebral palsy incidence and functional ability: A total population study","volume":"102","author":"Chounti","year":"2013","journal-title":"Acta Paediatr."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1017\/S0012162207000199.x","article-title":"Sex and the pathogenesis of cerebral palsy","volume":"49","author":"Johnston","year":"2007","journal-title":"Dev. Med. Child. Neurol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1111\/ejn.14664","article-title":"Why considering sex differences is a staple when studying encephalopathy of prematurity through rodent models","volume":"52","author":"Legouez","year":"2020","journal-title":"Eur. J. Neurosci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"38563","DOI":"10.1074\/jbc.M405461200","article-title":"Innate gender-based proclivity in response to cytotoxicity and programmed cell death pathway","volume":"279","author":"Du","year":"2004","journal-title":"Biol. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Charriaut-Marlangue, C., Besson, V.C., and Baud, O. (2017). Sexually Dimorphic Outcomes after Neonatal Stroke and Hypoxia-Ischemia. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19010061"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.neuint.2018.06.008","article-title":"Protective effect of 4-Phenylbutyrate against proteolipid protein mutation-induced endoplasmic reticulum stress and oligodendroglial cell death","volume":"118","author":"Wilding","year":"2018","journal-title":"Neurochem. Int."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.1038\/s41467-019-11119-7","article-title":"Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility","volume":"10","author":"Silva","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1002\/glia.23820","article-title":"Epigenetic regulation of oligodendrocyte differentiation: From development to demyelinating disorders","volume":"68","author":"Samudyata","year":"2020","journal-title":"Glia"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Tiane, A., Schepers, M., Rombaut, B., Hupperts, R., Prickaerts, J., Hellings, N., van den Hove, D., and Vanmierlo, T. (2019). From OPC to Oligodendrocyte: An Epigenetic Journey. Cells, 8.","DOI":"10.3390\/cells8101236"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.mcn.2017.11.010","article-title":"Chromatin remodeling and epigenetic regulation of oligodendrocyte myelination and myelin repair","volume":"87","author":"Koreman","year":"2018","journal-title":"Mol. Cell Neurosci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"5105","DOI":"10.2174\/1381612811319280009","article-title":"Potential roles of HDAC inhibitors in mitigating ischemia-induced brain damage and facilitating endogenous regeneration and recovery","volume":"19","author":"Fessler","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"ref_63","unstructured":"Buccafusco, J.J. (2009). The Behavioral Assessment of Sensorimotor Processes in the Mouse: Acoustic Startle, Sensory Gating, Locomotor Activity, Rotarod and Beam Walking. Method of Behavior Analysis in Neuroscience, Frontiers in Neuroscience. [2nd ed.]. Chapter 8."},{"key":"ref_64","first-page":"e3337","article-title":"Cylinder Test to Assess Sensory-motor Function in a Mouse Model of Parkinson\u2019s Disease","volume":"9","author":"Magno","year":"2019","journal-title":"Biol. Protoc."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0028-3908(00)00005-8","article-title":"CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury","volume":"39","author":"Schallert","year":"2000","journal-title":"Neuropharmacology"},{"key":"ref_66","unstructured":"Paxinos, G., Halliday, G., Watson, C., and Kassem, M.S. (2007). Atlas of the Developing Mouse Brain, Elsevier. [1st ed.]."},{"key":"ref_67","unstructured":"Paxinos, G., and Franklin, K.B.J. (2001). The Mouse Brain in Stereotaxic Coordinates, Academic Press. [2nd ed.]."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/24\/15947\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:41:41Z","timestamp":1760146901000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/24\/15947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,15]]},"references-count":67,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["ijms232415947"],"URL":"https:\/\/doi.org\/10.3390\/ijms232415947","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,15]]}}}