{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:54:20Z","timestamp":1791982460965,"version":"4.4.0"},"reference-count":470,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Nanomaterials (NM) arouse interest in various fields of science and industry due to their composition-tunable properties and the ease of modification. They appear currently as components of many consumer products such as sunscreen, dressings, sports clothes, surface-cleaning agents, computer devices, paints, as well as pharmaceutical and cosmetics formulations. The use of NPs in products for topical applications improves the permeation\/penetration of the bioactive compounds into deeper layers of the skin, providing a depot effect with sustained drug release and specific cellular and subcellular targeting. Nanocarriers provide advances in dermatology and systemic treatments. Examples are a non-invasive method of vaccination, advanced diagnostic techniques, and transdermal drug delivery. The mechanism of action of NPs, efficiency of skin penetration, and potential threat to human health are still open and not fully explained. This review gives a brief outline of the latest nanotechnology achievements in products used in topical applications to prevent and treat skin diseases. We highlighted aspects such as the penetration of NPs through the skin (influence of physical\u2013chemical properties of NPs, the experimental models for skin penetration, methods applied to improve the penetration of NPs through the skin, and methods applied to investigate the skin penetration by NPs). The review summarizes various therapies using NPs to diagnose and treat skin diseases (melanoma, acne, alopecia, vitiligo, psoriasis) and anti-aging and UV-protectant nano-cosmetics.<\/jats:p>","DOI":"10.3390\/ijms232415980","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T01:46:51Z","timestamp":1671155211000},"page":"15980","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":191,"title":["Nanoparticles for Topical Application in the Treatment of Skin Dysfunctions\u2014An Overview of Dermo-Cosmetic and Dermatological Products"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2742-3989","authenticated-orcid":false,"given":"Magdalena","family":"Raszewska-Famielec","sequence":"first","affiliation":[{"name":"Faculty of Physical Education and Health, University of Physical Education, Akademicka 2, 21-500 Bia\u0142a Podlaska, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6881-3161","authenticated-orcid":false,"given":"Jolanta","family":"Flieger","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Medical University of Lublin, Chod\u017aki 4A, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"key":"ref_1","unstructured":"Dowling, A., Cliff, R., Grobert, N., Hutton, D., Oliver, R., O\u2019Neill, O., Pethica, J., Pidgeon, N., Porritt, J., and Ryan, J. (2004). Nanoscience and Nanotechnologies: Opportunities and Uncertainties, The Royal Society & The Royal Academy of Engineering. Available online: http:\/\/sscottgraham.com\/314\/redesign4.pdf."},{"key":"ref_2","first-page":"3840","article-title":"Commission recommendation of 18 October 2011 on the definition of nanomaterial (2011\/696\/EU)","volume":"L275","author":"Potocnik","year":"2011","journal-title":"Off. J. Eur. Commun. Legis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.3762\/bjnano.9.98","article-title":"Review on nanoparticles and nanostructured materials: History, sources, toxicity and regulations","volume":"9","author":"Jeevanandam","year":"2018","journal-title":"Beilstein J. Nanotechnol."},{"key":"ref_4","unstructured":"United Nations (2014, August 21). Questions About Nanotechnology, Available online: https:\/\/www.epa.gov\/chemical-research\/research-nanomaterials."},{"key":"ref_5","unstructured":"Federal Drug Administration (2016, January 25). Considering Whether an FDA-Regulated Product Involves the Application of Nanotechnology, Available online: https:\/\/www.fda.gov\/RegulatoryInformation\/Guidances\/ucm257698.htm."},{"key":"ref_6","unstructured":"(2010). Nanotechnology\u2014Vocabulary\u2014Part 1: Core Terms. Standard No. ISO\/TS 80004-1:2010. Available online: https:\/\/www.iso.org\/standard\/51240.html."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1080\/10473289.2001.10464365","article-title":"An analytical method for the measurement of nonviable bioaerosols","volume":"51","author":"Menetrez","year":"2001","journal-title":"J. Air Waste Manag. Assoc."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/S0006-3495(91)82181-6","article-title":"Structures of bovine and human papillomaviruses. Analysis by cryoelectron microscopy and three-dimensional image reconstruction","volume":"60","author":"Baker","year":"1991","journal-title":"Biophys. J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/DAD.0b013e3181a58234","article-title":"Viral-associated nonmelanoma skin cancers: A review","volume":"31","author":"Dubina","year":"2009","journal-title":"Am. J. Dermatopathol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"MR17","DOI":"10.1116\/1.2815690","article-title":"Nanomaterials and nanoparticles: Sources and toxicity","volume":"2","author":"Buzea","year":"2007","journal-title":"Biointerphases"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s40097-018-0281-6","article-title":"Role of green silver nanoparticles synthesized from Symphytum officinale leaf extract in protec tion against UVB-induced photoaging","volume":"8","author":"Singh","year":"2018","journal-title":"J. Nanostruct. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"15029","DOI":"10.1038\/boneres.2015.29","article-title":"Nanomaterials and bone regeneration","volume":"3","author":"Gong","year":"2015","journal-title":"Bone Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00420-010-0556-9","article-title":"Odor identification ability and self-reported upper respiratory symptoms in workers at the post-9\/11 World Trade Center site","volume":"84","author":"Altman","year":"2011","journal-title":"Int. Arch. Occup. Environ. Health."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1097\/JOM.0b013e31821b177a","article-title":"World Trade Center Health Registry--a model for a nanomaterials exposure registry","volume":"53","author":"Cone","year":"2011","journal-title":"J. Occup. Environ. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.mattod.2013.07.004","article-title":"The fascinating world of nanoparticle research","volume":"16","author":"Heiligtag","year":"2013","journal-title":"Mater. Today"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1126\/science.1114397","article-title":"Toxic potential of materials at the nanolevel","volume":"311","author":"Nel","year":"2006","journal-title":"Science"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1016\/j.biomaterials.2007.12.040","article-title":"Comparison of nanoscale and microscale bioactive glass on the properties of P(3HB)\/Bioglass composites","volume":"29","author":"Misra","year":"2008","journal-title":"Biomaterials"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"022003","DOI":"10.1088\/2632-959X\/abf46b","article-title":"Nanotechnology in cosmetics pros and cons","volume":"2","author":"Yadwade","year":"2021","journal-title":"Nano Express"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/jid.2011.425","article-title":"Applications of nanotechnology in dermatology","volume":"132","author":"DeLouise","year":"2012","journal-title":"J. Investig. Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/sj.clpt.6100400","article-title":"Nanoparticles in medicine: Therapeutic applications and developments","volume":"83","author":"Zhang","year":"2008","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.nano.2011.05.016","article-title":"Nanoparticles: A boon to drug delivery, therapeutics, diagnostics and imaging","volume":"8","author":"Parveen","year":"2012","journal-title":"Nanomedicine"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jconrel.2011.06.004","article-title":"Inorganic nanoparticles for cancer imaging and therapy","volume":"155","author":"Huang","year":"2011","journal-title":"J. Control. Release"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"374","DOI":"10.3390\/macromol2030024","article-title":"Magnetic Nanoparticles for Medical Applications: Updated Review","volume":"2","author":"Mendizabal","year":"2022","journal-title":"Macromol"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"5887","DOI":"10.1021\/nn102055s","article-title":"A reexamination of active and passive tumor targeting by using rod-shaped gold nanocrystals and covalently conjugated peptide ligands","volume":"4","author":"Huang","year":"2010","journal-title":"ACS Nano"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1021\/mp800187d","article-title":"Tumor targeting of functionalized quantum dot-liposome hybrids by intravenous administration","volume":"6","author":"Tian","year":"2009","journal-title":"Mol. Pharm."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2174\/138161209787002870","article-title":"Targeted drugs and nanomedicine: Present and future","volume":"15","author":"Debbage","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.2147\/DDDT.S264648","article-title":"Potential of Nanoparticles as Permeation Enhancers and Targeted Delivery Options for Skin: Advantages and Disadvantages","volume":"14","author":"Ghasemiyeh","year":"2020","journal-title":"Drug Des. Devel. Ther."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4346","DOI":"10.1021\/es060589n","article-title":"Titanium dioxide (P25) produces reactive oxygen species in immortalized brain microglia (BV2): Implications for nanoparticle neurotoxicity","volume":"40","author":"Long","year":"2006","journal-title":"Environ. Sci. Technol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1021\/tx800179f","article-title":"Cytotoxicity of titanium dioxide nanoparticles in mouse fibroblast cells","volume":"21","author":"Jin","year":"2008","journal-title":"Chem. Res. Toxicol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1021\/nn800596w","article-title":"Cytotoxicity and genotoxicity of silver nanoparticles in human cells","volume":"3","author":"AshaRani","year":"2009","journal-title":"ACS Nano"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1743-8977-6-3","article-title":"Genotoxic responses to titanium dioxide nanoparticles and fullerene in gpt delta transgenic MEF cells","volume":"6","author":"Xu","year":"2009","journal-title":"Part. Fibre Toxicol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1002\/smll.200700378","article-title":"Size-dependent cytotoxicity of gold nanoparticles","volume":"3","author":"Pan","year":"2007","journal-title":"Small"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1021\/tx100050h","article-title":"Interfacing carbon nanotubes with living mammalian cells and cytotoxicity issues","volume":"23","author":"Cui","year":"2010","journal-title":"Chem. Res. Toxicol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3109\/17435390.2011.579630","article-title":"Interaction between combustion-generated organic nanoparticles and biological systems: In vitro study of cell toxicity and apoptosis in human keratinocytes","volume":"6","author":"Pedata","year":"2012","journal-title":"Nanotoxicology"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Gupta, V., Mohapatra, S., Mishra, H., Farooq, U., Kumar, K., Ansari, M.J., Aldawsari, M.F., Alalaiwe, A.S., Mirza, M.A., and Iqbal, Z. (2022). Nanotechnology in Cosmetics and Cosmeceuticals-A Review of Latest Advancements. Gels, 8.","DOI":"10.3390\/gels8030173"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1093\/toxsci\/kfj129","article-title":"Research strategies for safety evaluation of nanomaterials, part VII: Evaluating consumer exposure to nanoscale materials","volume":"91","author":"Thomas","year":"2006","journal-title":"Toxicol. Sci."},{"key":"ref_37","unstructured":"(2017, July 17). Scientific Committee on Emerging and Newly Identified Health Risks SCENIHR, Risk Assessment of Products of Nanotechnologies. Available online: http:\/\/ec.europa.eu\/health\/ph_risk\/committees\/04_scenihr\/docs\/scenihr_o_023.pdf."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Lee, C.C., Lin, Y.H., Hou, W.C., Li, M.H., and Chang, J.W. (2020). Exposure to ZnO\/TiO2 Nanoparticles Affects Health Outcomes in Cosmetics Salesclerks. Int. J. Environ. Res. Public Health, 17.","DOI":"10.21203\/rs.3.rs-44825\/v1"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12011-015-0550-x","article-title":"Toxicity of Nano-Titanium Dioxide (TiO2-NP) Through Various Routes of Exposure: A Review","volume":"172","author":"Shakeel","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"867.e1","DOI":"10.1016\/j.jaad.2013.08.022","article-title":"Photoprotection: Part II. Sunscreen: Development, efficacy, and controversies","volume":"69","author":"Jansen","year":"2013","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"29080","DOI":"10.1039\/D1RA06087B","article-title":"Lipid-based nanoparticles for psoriasis treatment: A review on conventional treatments, recent works, and future prospects","volume":"11","author":"Ahmad","year":"2021","journal-title":"RSC Adv."},{"key":"ref_42","unstructured":"Hamblin, M.R., Avci, P., and Prow, T.W. (2016). Inorganic Nanoparticles for Transdermal Drug Delivery and Topical Application. Nanoscience in Dermatology, Academic Press."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"895986","DOI":"10.1155\/2014\/895986","article-title":"Drug delivery nanoparticles in skin cancers","volume":"2014","author":"Dianzani","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4227","DOI":"10.1021\/es8032549","article-title":"Estimates of upper bounds and trends in nano-TiO2 production as a basis for exposure assessment","volume":"43","author":"Robichaud","year":"2009","journal-title":"Environ. Sci. Technol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1038\/jid.2010.204","article-title":"Airborne particle exposure and extrinsic skin aging","volume":"130","author":"Schikowski","year":"2010","journal-title":"J. Investig. Dermatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jconrel.2010.11.015","article-title":"Selective follicular targeting by modification of the particle sizes","volume":"150","author":"Patzelt","year":"2011","journal-title":"J. Control. Release"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1248\/bpb.33.1394","article-title":"Permeation pathway of macromolecules and nanospheres through skin","volume":"33","author":"Todo","year":"2010","journal-title":"Biol. Pharm. Bull."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.ejpb.2010.10.015","article-title":"Penetration and storage of particles in human skin: Perspectives and safety aspects","volume":"77","author":"Lademann","year":"2011","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ejpb.2006.10.019","article-title":"Nanoparticles--an efficient carrier for drug delivery into the hair follicles","volume":"66","author":"Lademann","year":"2007","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1159\/000056385","article-title":"Investigation of follicular penetration of topically applied substances","volume":"14","author":"Lademann","year":"2001","journal-title":"Skin Pharmacol. Appl. Skin Physiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.addr.2011.01.012","article-title":"Nanoparticles and microparticles for skin drug delivery","volume":"63","author":"Prow","year":"2011","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"197","DOI":"10.4161\/derm.1.4.9501","article-title":"Nanoparticles and their interactions with the dermal barrier","volume":"1","author":"Schneider","year":"2009","journal-title":"Dermato-endocrinology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"S157","DOI":"10.1016\/S0169-409X(02)00120-5","article-title":"Distribution of sunscreens on skin","volume":"54","author":"Schulz","year":"2002","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1159\/000235554","article-title":"Stratum corneum is an effective barrier to TiO2 and ZnO nanoparticle percutaneous absorption","volume":"22","author":"Filipe","year":"2009","journal-title":"Skin Pharmacol. Physiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1093\/toxsci\/kfq041","article-title":"Lack of significant dermal penetration of titanium dioxide from sunscreen formulations containing nano- and submicron-size TiO2 particles","volume":"115","author":"Sadrieh","year":"2010","journal-title":"Toxicol. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.biomaterials.2010.09.060","article-title":"Enhancing the transdermal delivery of rigid nanoparticles using the simultaneous application of ultrasound and sodium lauryl sulfate","volume":"32","author":"Lopez","year":"2011","journal-title":"Biomaterials"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1093\/toxsci\/kfr148","article-title":"Safety evaluation of sunscreen formulations containing titanium dioxide and zinc oxide nanoparticles in UVB sunburned skin: An in vitro and in vivo study","volume":"123","author":"Wiench","year":"2011","journal-title":"Toxicol. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1159\/000131080","article-title":"Assessment of quantum dot penetration into intact, tape-stripped, abraded and flexed rat skin","volume":"21","author":"Zhang","year":"2008","journal-title":"Skin Pharmacol. Physiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.taap.2007.12.022","article-title":"Biological interactions of quantum dot nanoparticles in skin and in human epidermal keratinocytes","volume":"228","author":"Zhang","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/toxsci\/kfp139","article-title":"Quantitative determination of skin penetration of PEG-coated CdSe quantum dots in dermabraded but not intact SKH-1 hairless mouse skin","volume":"111","author":"Gopee","year":"2009","journal-title":"Toxicol. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3109\/17435390.2011.569092","article-title":"Quantum dot penetration into viable human skin","volume":"6","author":"Prow","year":"2012","journal-title":"Nanotoxicology"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1021\/nl801323y","article-title":"In vivo skin penetration of quantum dot nanoparticles in the murine model: The effect of UVR","volume":"8","author":"Mortensen","year":"2008","journal-title":"Nano Lett."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1364\/BOE.2.001610","article-title":"Near-IR fluorescence and reflectance confocal microscopy for imaging of quantum dots in mammalian skin","volume":"2","author":"Mortensen","year":"2011","journal-title":"Biomed. Opt. Express"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"675","DOI":"10.3109\/17435390.2010.537381","article-title":"Quantification of human skin barrier function and susceptibility to quantum dot skin penetration","volume":"5","author":"Ravichandran","year":"2011","journal-title":"Nanotoxicology"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"9086","DOI":"10.1016\/j.biomaterials.2010.08.046","article-title":"Co-administration of protein drugs with gold nanoparticles to enable percutaneous delivery","volume":"31","author":"Huang","year":"2010","journal-title":"Biomaterials"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.colsurfb.2008.02.013","article-title":"In vitro permeation of gold nanoparticles through rat skin and rat intestine: Effect of particle size","volume":"65","author":"Sonavane","year":"2008","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0041-008X(82)90149-1","article-title":"Methods for in vitro percutaneous absorption studies. II. Animal models for human skin","volume":"62","author":"Bronaugh","year":"1982","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1046\/j.0022-202X.2003.22110.x","article-title":"Variations of hair follicle size and distribution in different body sites","volume":"122","author":"Otberg","year":"2004","journal-title":"J. Investig. Dermatol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.nano.2012.04.004","article-title":"Interaction of inorganic nanoparticles with the skin barrier: Current status and critical review","volume":"9","author":"Labouta","year":"2013","journal-title":"Nanomedicine"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1111\/jocd.13410","article-title":"Comparative skin penetration profiles of formulations including ultradeformable liposomes as potential nanocosmeceutical carriers","volume":"19","author":"Izquierdo","year":"2020","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1016\/j.bbamem.2008.03.003","article-title":"Lipid organization in human and porcine stratum corneum differs widely, while lipid mixtures with porcine ceramides model human stratum corneum lipid organization very closely","volume":"1778","author":"Caussin","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1600-0846.2006.00179.x","article-title":"Porcine ear skin: An in vitro model for human skin","volume":"13","author":"Jacobi","year":"2007","journal-title":"Skin Res. Technol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2131\/jts.35.107","article-title":"Study on penetration of titanium dioxide (TiO(2)) nanoparticles into intact and damaged skin in vitro","volume":"35","author":"Senzui","year":"2010","journal-title":"J. Toxicol. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"4989","DOI":"10.1039\/c1nr11109d","article-title":"Mechanism and determinants of nanoparticle penetration through human skin","volume":"3","author":"Labouta","year":"2011","journal-title":"Nanoscale"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.yrtph.2015.05.005","article-title":"Nanoparticles skin absorption: New aspects for a safety profile evaluation","volume":"72","author":"Mauro","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1007\/s11095-011-0561-z","article-title":"Gold nanoparticle penetration and reduced metabolism in human skin by toluene","volume":"28","author":"Labouta","year":"2011","journal-title":"Pharm. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000441038","article-title":"Effect of Frozen Human Epidermis Storage Duration and Cryoprotectant on Barrier Function Using Two Model Compounds","volume":"29","author":"Barbero","year":"2016","journal-title":"Skin Pharmacol. Physiol."},{"key":"ref_78","first-page":"163","article-title":"Skin models for the testing of transdermal drugs","volume":"8","author":"Abd","year":"2016","journal-title":"Clin. Pharmacol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ejpb.2015.06.020","article-title":"Applications and limitations of lipid nanoparticles in dermal and transdermal drug delivery via the follicular route","volume":"97","author":"Lauterbach","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/j.0906-6705.2005.00330.x","article-title":"Reorganization of hair follicles in human skin organ culture induced by cultured human follicle-derived cells","volume":"14","author":"Krugluger","year":"2005","journal-title":"Exp. Dermatol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/jat.3913","article-title":"Measurement of the penetration of 56 cosmetic relevant chemicals into and through human skin using a standardized protocol","volume":"40","author":"Hewitt","year":"2020","journal-title":"J. Appl. Toxicol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1159\/000365730","article-title":"The influence of the acyl chain on the transdermal penetration-enhancing effect of synthetic phytoceramides","volume":"28","author":"Veryser","year":"2015","journal-title":"Skin Pharmacol. Physiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"120987","DOI":"10.1016\/j.ijpharm.2021.120987","article-title":"How to define the experimental conditions of skin permeation assays for drugs presenting biopharmaceutical limitations? The experience with testosterone","volume":"607","author":"Caon","year":"2021","journal-title":"Int. J. Pharm."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.yrtph.2004.02.004","article-title":"In vitro predictions of skin absorption of caffeine, testosterone, and benzoic acid: A multi-centre comparison study","volume":"39","author":"Cage","year":"2004","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"ref_85","unstructured":"Organisation for Economic Co-operation and Development (2004, November 23). OECD Guidelines for the Testing of Chemicals, Section 4. Test No. 428: Skin Absorption: In Vitro Method, Available online: http:\/\/www.oecd-ilibrary.org\/environment\/test-no-428-skin-absorptionin-vitro-method_9789264071087-en."},{"key":"ref_86","unstructured":"SCCS (2010). Basic Criteria for the In Vitro Assessment of Dermal Absorption of Cosmetic Ingredients, SCCS. Available online: https:\/\/op.europa.eu\/en\/publication-detail\/-\/publication\/91793089-8206-4975-a6c9-078770655851."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.tiv.2005.04.004","article-title":"Reconstructed epidermis versus human and animal skin in skin absorption studies","volume":"19","author":"Schreiber","year":"2005","journal-title":"Toxicol. Vitr."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Simard, M., Julien, P., Fradette, J., and Pouliot, R. (2019). Modulation of the Lipid Profile of Reconstructed Skin Substitutes after Essential Fatty Acid Supplementation Affects Testosterone Permeability. Cells, 8.","DOI":"10.3390\/cells8101142"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"113802","DOI":"10.1016\/j.addr.2021.05.012","article-title":"Human skin equivalents: Impaired barrier function in relation to the lipid and protein properties of the stratum corneum","volume":"175","author":"Bouwstra","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/nbt875","article-title":"The potential environmental impact of engineered nanomaterials","volume":"21","author":"Colvin","year":"2003","journal-title":"Nat. Biotechnol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1289\/ehp.8871","article-title":"Nanoparticles: Health effects--pros and cons","volume":"114","author":"Gwinn","year":"2006","journal-title":"Environ. Health Perspect."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/toxsci\/kfi339","article-title":"Research strategies for safety evaluation of nanomaterials, part IV: Risk assessment of nanoparticles","volume":"89","author":"Tsuji","year":"2006","journal-title":"Toxicol. Sci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1080\/10408440601177780","article-title":"Grey goo on the skin? Nanotechnology, cosmetic and sunscreen safety","volume":"37","author":"Nohynek","year":"2007","journal-title":"Crit. Rev. Toxicol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/toxsci\/kfm169","article-title":"Nanotechnology safety concerns revisited","volume":"101","author":"Stern","year":"2008","journal-title":"Toxicol. Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/wnan.66","article-title":"Nanomaterial standards for efficacy and toxicity assessment","volume":"2","author":"Adiseshaiah","year":"2010","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/jps.21817","article-title":"Penetration of nanoparticles and nanomaterials in the skin: Fiction or reality?","volume":"99","author":"Baroli","year":"2010","journal-title":"J. Pharm Sci."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1166\/jbn.2010.1146","article-title":"Focus on skin as a possible port of entry for solid nanoparticles and the toxicological impact","volume":"6","author":"Smijs","year":"2010","journal-title":"J. Biomed. Nanotechnol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1600-0781.2011.00557.x","article-title":"Current sunscreen controversies: A critical review","volume":"27","author":"Burnett","year":"2011","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1080\/10837450.2019.1596133","article-title":"Cyproterone acetate-loaded nanostructured lipid carriers: Effect of particle size on skin penetration and follicular targeting","volume":"24","author":"Ghasemiyeh","year":"2019","journal-title":"Pharm. Dev. Technol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jconrel.2016.09.015","article-title":"Do nanoparticles have a future in dermal drug delivery?","volume":"246","author":"Patzelt","year":"2017","journal-title":"J. Control. Release."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Monteiro-Riviere, N.A. (2010). Structure and function of skin. Toxicology of the Skin\u2014Target Organ Series, Informa Healthcare.","DOI":"10.3109\/9781420079180"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Beck, R., Guterres, S., and Pohlmann, A. (2011). Nanocosmetics and Nanomedicines: New Approaches for Skin Care, Springer.","DOI":"10.1007\/978-3-642-19792-5"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1038\/sj.jid.5700733","article-title":"Penetration of metallic nanoparticles in human full-thickness skin","volume":"127","author":"Baroli","year":"2007","journal-title":"J. Investig. Dermatol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s13346-013-0149-8","article-title":"Overcoming the stratum corneum barrier: A nano approach","volume":"3","author":"Banerjee","year":"2013","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.tiv.2005.08.008","article-title":"The in vitro absorption of microfine zinc oxide and titanium dioxide through porcine skin","volume":"20","author":"Gamer","year":"2006","journal-title":"Toxicol. Vitr."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"875","DOI":"10.4155\/tde.14.56","article-title":"Getting under the skin: What is the potential of the transfollicular route in drug delivery?","volume":"5","author":"Rancan","year":"2014","journal-title":"Ther. Deliv."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"31","DOI":"10.15171\/apb.2016.06","article-title":"The Effect of Particle Size on the Deposition of Solid Lipid Nanoparticles in Different Skin Layers: A Histological Study","volume":"6","author":"Ghanbarzadeh","year":"2016","journal-title":"Adv. Pharm. Bull."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0939-6411(99)00075-2","article-title":"Vitamin A loaded solid lipid nanoparticles for topical use: Occlusive properties and drug targeting to the upper skin","volume":"49","author":"Jenning","year":"2000","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1021\/bm300545b","article-title":"Effect of size, surface charge, and hydrophobicity of poly(amidoamine) dendrimers on their skin penetration","volume":"13","author":"Yang","year":"2012","journal-title":"Biomacromolecules"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.colsurfb.2017.08.003","article-title":"Skin permeability and transdermal delivery route of 50-nm indomethacin-loaded PLGA nanoparticles","volume":"159","author":"Takeuchi","year":"2017","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"124866","DOI":"10.1016\/j.colsurfa.2020.124866","article-title":"Skin permeability and transdermal delivery route of 30-nm cyclosporin A-loaded nanoparticles using PLGA-PEG-PLGA triblock copolymer","volume":"600","author":"Takeuchi","year":"2020","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1007\/s12272-009-1713-0","article-title":"Physicochemical characterization and skin permeation of liposome formulations containing clindamycin phosphate","volume":"32","author":"Shanmugam","year":"2009","journal-title":"Arch. Pharm. Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/smll.201401913","article-title":"Interactions of skin with gold nanoparticles of different surface charge, shape, and functionality","volume":"11","author":"Fernandes","year":"2015","journal-title":"Small"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Talarska, P., Boruczkowski, M., and \u017burawski, J. (2021). Current Knowledge of Silver and Gold Nanoparticles in Laboratory Research-Application, Toxicity, Cellular Uptake. Nanomaterials, 11.","DOI":"10.3390\/nano11092454"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/toxsci\/kfj122","article-title":"Penetration of intact skin by quantum dots with diverse physicochemical properties","volume":"91","author":"Riviere","year":"2006","journal-title":"Toxicol. Sci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.ijpharm.2012.03.040","article-title":"Penetration and release studies of positively and negatively charged nanoemulsions--is there a benefit of the positive charge?","volume":"430","author":"Baspinar","year":"2012","journal-title":"Int. J. Pharm."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"115625","DOI":"10.1016\/j.carbpol.2019.115625","article-title":"Quaternized chitosan-coated nanoemulsions: A novel platform for improving the stability, anti-inflammatory, anti-cancer and transdermal properties of Plai extract","volume":"230","author":"Luesakul","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Shaker, D.S., Ishak, R.A.H., Ghoneim, A., and Elhuoni, M.A. (2019). Nanoemulsion: A review on mechanisms for the transdermal delivery of hydrophobic and hydrophilic drugs. Sci. Pharm., 87.","DOI":"10.3390\/scipharm87030017"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1159\/000270381","article-title":"Disposition of charged nanoparticles after their topical application to the skin","volume":"23","author":"Wu","year":"2010","journal-title":"Skin Pharmacol. Physiol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ijpharm.2011.03.049","article-title":"Liposome surface charge influence on skin penetration behaviour","volume":"411","author":"Gillet","year":"2011","journal-title":"Int. J. Pharm."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"e390","DOI":"10.1111\/j.1600-0846.2012.00656.x","article-title":"Influence of surface charge of gold nanorods on skin penetration","volume":"19","author":"Lee","year":"2013","journal-title":"Skin Res. Technol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nnano.2010.58","article-title":"Tuning payload delivery in tumour cylindroids using gold nanoparticles","volume":"5","author":"Kim","year":"2010","journal-title":"Nat. Nanotechnol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jconrel.2004.11.020","article-title":"Liposomes as carriers for dermal delivery of tretinoin: In vitro evaluation of drug permeation and vesicle-skin interaction","volume":"103","author":"Sinico","year":"2005","journal-title":"J. Control. Release"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.envint.2011.03.006","article-title":"Characterization of the effluent from a nanosilver producing washing machine","volume":"37","author":"Farkas","year":"2011","journal-title":"Environ. Int."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.colsurfb.2014.07.046","article-title":"In vivo penetration of bare and lipid-coated silica nanoparticles across the human stratum corneum","volume":"122","author":"Iannuccelli","year":"2014","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.biomaterials.2009.09.060","article-title":"The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function","volume":"31","author":"Huang","year":"2010","journal-title":"Biomaterials"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1038\/s41598-017-04229-z","article-title":"The Effect of shape on Cellular Uptake of Gold Nanoparticles in the forms of Stars, Rods, and Triangles","volume":"7","author":"Xie","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1039\/C9MH00664H","article-title":"The impact of nanoparticle shape on cellular internalisation and transport: What do the different analysis methods tell us?","volume":"6","author":"Wang","year":"2019","journal-title":"Mater. Horiz."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"16908","DOI":"10.1038\/srep16908","article-title":"Shape-dependent skin penetration of silver nanoparticles: Does it really matter?","volume":"5","author":"Tak","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.powtec.2017.07.086","article-title":"Delivery systems for cosmetics\u2014From manufacturing to the skin of natural antioxidants","volume":"322","author":"Costa","year":"2017","journal-title":"Powder Technol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jcis.2017.05.038","article-title":"Effect of binary solid lipid matrix of wax and triglyceride on lipid crystallinity, drug-lipid interaction and drug release of ibuprofen-loaded solid lipid nanoparticles (SLN) for dermal delivery","volume":"504","author":"Chantaburanan","year":"2017","journal-title":"J. Colloid Interface Sci."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jconrel.2005.09.045","article-title":"Lipid nanoparticles for skin penetration enhancement-correlation to drug localization within the particle matrix as determined by fluorescence and parelectric spectroscopy","volume":"110","author":"Regehly","year":"2005","journal-title":"J. Control. Release"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1080\/17425247.2017.1264386","article-title":"Solid lipid nanoparticles and nanostructured lipid carrier-based nanotherapeutics in treatment of psoriasis: A comparative study","volume":"14","author":"Arora","year":"2017","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"635","DOI":"10.4155\/tde.14.31","article-title":"Skin delivery aspects of benzoyl peroxide-loaded solid lipid nanoparticles for acne treatment","volume":"5","author":"Pokharkar","year":"2014","journal-title":"Ther. Deliv."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ejps.2017.11.023","article-title":"Formulations based on solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for cutaneous use: A review","volume":"112","author":"Amaral","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.ejpb.2017.04.008","article-title":"Development and evaluation of resveratrol, Vitamin E, and epigallocatechin gallate loaded lipid nanoparticles for skin care applications","volume":"117","author":"Chen","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.colsurfb.2015.02.046","article-title":"Formulation optimization and in vitro skin penetration of spironolactone loaded solid lipid nanoparticles","volume":"128","author":"Kelidari","year":"2015","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ijpharm.2013.02.037","article-title":"Ultra-small NLC for improved dermal delivery of coenyzme Q10","volume":"447","author":"Schwarz","year":"2013","journal-title":"Int. J. Pharm."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.colsurfb.2018.01.053","article-title":"Development of nanoparticles from natural lipids for topical delivery of thymol: Investigation of its anti-inflammatory properties","volume":"164","author":"Pivetta","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.ijpharm.2015.05.042","article-title":"LeciPlex, invasomes, and liposomes: A skin penetration study","volume":"490","author":"Shah","year":"2015","journal-title":"Int. J. Pharm."},{"key":"ref_141","first-page":"415","article-title":"Can drug-bearing liposomes penetrate intact skin?","volume":"58","author":"Williams","year":"2006","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4103\/0975-7406.92724","article-title":"Status of surfactants as penetration enhancers in transdermal drug delivery","volume":"4","author":"Som","year":"2012","journal-title":"J. Pharm. Bioallied Sci."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ejpb.2017.09.006","article-title":"Going skin deep: A direct comparison of penetration potential of lipid-based nanovesicles on the isolated perfused human skin flap model","volume":"121","author":"Ternullo","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Cristiano, M.C., Froiio, F., Spaccapelo, R., Mancuso, A., Nistic\u00f2, S.P., Udongo, B.P., Fresta, M., and Paolino, D. (2019). Sulforaphane-Loaded Ultradeformable Vesicles as A Potential Natural Nanomedicine for the Treatment of Skin Cancer Diseases. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12010006"},{"key":"ref_145","first-page":"482","article-title":"Acronychiabaueri Analogue Derivative-Loaded Ultradeformable Vesicles: Physicochemical Characterization and Potential Applications","volume":"83","author":"Primavera","year":"2017","journal-title":"Planta Med."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ejpb.2012.02.008","article-title":"Paclitaxel-loaded ethosomes\u00ae: Potential treatment of squamous cell carcinoma, a malignant transformation of actinic keratoses","volume":"81","author":"Paolino","year":"2012","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s10544-011-9590-y","article-title":"Ethosomes\u00ae and transfersomes\u00ae containing linoleic acid: Physicochemical and technological features of topical drug delivery carriers for the potential treatment of melasma disorders","volume":"14","author":"Celia","year":"2012","journal-title":"Biomed. Microdev."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1080\/00914037.2017.1332623","article-title":"Overview of preparation methods of polymeric and lipid-based (niosome, solid lipid, liposome) nanoparticles: A comprehensive review","volume":"67","author":"Amoabediny","year":"2018","journal-title":"Int. J. Polym. Mater."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.ijpharm.2017.06.083","article-title":"Pharmaceutical versatility of cationic niosomes derived from amino acid-based surfactants: Skin penetration behavior and controlled drug release","volume":"529","author":"Muzzalupo","year":"2017","journal-title":"Int. J. Pharm."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.24218\/jod.2017.6","article-title":"Tetracycline-niosomes versus tetracycline hydrochlo-ride-niosomes: How to modulate encapsulation and percutaneous permeation properties","volume":"1","author":"Tavano","year":"2017","journal-title":"J. Drug."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1080\/10837450.2018.1441302","article-title":"Essential oils in niosomes for enhanced transdermal delivery of felodipine","volume":"24","author":"Eid","year":"2019","journal-title":"Pharm. Dev. Technol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ijpharm.2015.08.036","article-title":"Development and ex vivo evaluation of 5-aminolevulinic acid-loaded niosomal formulations for topical photodynamic therapy","volume":"494","author":"Bragagni","year":"2015","journal-title":"Int. J. Pharm."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ijpharm.2011.11.032","article-title":"Physicochemical properties and skin permeation of Span 60\/Tween 60 niosomes of ellagic acid","volume":"423","author":"Junyaprasert","year":"2012","journal-title":"Int. J. Pharm."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1159\/000086666","article-title":"Liposomes and niosomes as topical drug delivery systems","volume":"18","author":"Choi","year":"2005","journal-title":"Skin Pharmacol. Physiol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1080\/17425247.2018.1444025","article-title":"Nanocrystal: A novel approach to overcome skin barriers for improved topical drug delivery","volume":"15","author":"Patel","year":"2018","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jconrel.2016.07.009","article-title":"Ethyl cellulose nanocarriers and nanocrystals differentially deliver dexamethasone into intact, tape-stripped or sodium lauryl sulfate-exposed ex vivo human skin\u2014assessment by intradermal microdialysis and extraction from the different skin layers","volume":"242","author":"Schumacher","year":"2016","journal-title":"J. Control. Release"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ijpharm.2011.08.026","article-title":"Lutein nanocrystals as antioxidant formulation for oral and dermal delivery","volume":"420","author":"Mitri","year":"2011","journal-title":"Int. J. Pharm."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.ijpharm.2017.08.108","article-title":"Dermal miconazole nitrate nanocrystals\u2014formulation development, increased antifungal efficacy & skin penetration","volume":"531","author":"Pyo","year":"2017","journal-title":"Int. J. Pharm."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1177\/117739280700200002","article-title":"Polymeric nanoparticles, nanospheres and nanocapsules, for cutaneous applications","volume":"2","author":"Guterres","year":"2007","journal-title":"Drug Target Insights"},{"key":"ref_160","first-page":"7","article-title":"Hydrogels as drug delivery systems; pros and cons","volume":"5","author":"Ghasemiyeh","year":"2019","journal-title":"Trends Pharm. Sci."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"281","DOI":"10.4155\/tde-2019-0019","article-title":"Formulation and characterization of glibenclamide and quercetin-loaded chitosan nanogels targeting skin permeation","volume":"10","author":"Chellappan","year":"2019","journal-title":"Ther. Deliv."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.4155\/tde-2017-0091","article-title":"Dendritic polymers for dermal drug delivery","volume":"8","author":"Dave","year":"2017","journal-title":"Ther. Deliv."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.ijpharm.2007.08.022","article-title":"Tyrosine-derived nanospheres for enhanced topical skin penetration","volume":"350","author":"Sheihet","year":"2008","journal-title":"Int. J. Pharm."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jconrel.2010.10.005","article-title":"Topical drug delivery by a polymeric nanosphere gel: Formulation optimization and in vitro and in vivo skin distribution studies","volume":"149","author":"Batheja","year":"2011","journal-title":"J. Control. Release"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"45292","DOI":"10.1038\/srep45292","article-title":"Effect of Size and Surface Charge of Gold Nanoparticles on their Skin Permeability: A Molecular Dynamics Study","volume":"7","author":"Gupta","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1039\/C4SC03549F","article-title":"Mesoporous silica nanoparticles for 19F magnetic resonance imaging, fluorescence imaging, and drug delivery","volume":"6","author":"Nakamura","year":"2015","journal-title":"Chem. Sci."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"6829","DOI":"10.1021\/nn301622h","article-title":"Skin penetration and cellular uptake of amorphous silica nanoparticles with variable size, surface functionalization, and colloidal stability","volume":"6","author":"Rancan","year":"2012","journal-title":"ACS Nano"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s13273-013-0010-7","article-title":"Effect of the size and surface charge of silica nanoparticles on cutaneous toxicity","volume":"9","author":"Park","year":"2013","journal-title":"Mol. Cell. Toxicol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1743-8977-9-3","article-title":"Amorphous silica nanoparticles size-dependently aggravate atopic dermatitis-like skin lesions following an intradermal injection","volume":"9","author":"Hirai","year":"2012","journal-title":"Part Fibre Toxicol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.addr.2008.03.016","article-title":"Gold nanoparticles in delivery applications","volume":"60","author":"Ghosh","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/smll.201001394","article-title":"A solid-in-oil dispersion of gold nanorods can enhance transdermal protein delivery and skin vaccination","volume":"7","author":"Pissuwan","year":"2011","journal-title":"Small"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1093\/toxsci\/kfp087","article-title":"Mechanisms of quantum dot nanoparticle cellular uptake","volume":"110","author":"Zhang","year":"2009","journal-title":"Toxicol. Sci."},{"key":"ref_173","first-page":"234","article-title":"Increased in vivo skin penetration of quantum dots with UVR and in vitro quantum dot cytotoxicity","volume":"7189","author":"Mortensen","year":"2009","journal-title":"Colloid. Quantum Dots Biomed. Appl. IV"},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Joshi, N., Duhan, V., Lingwal, N., Bhaskar, S., and Upadhyay, P. (2012). Adjuvant properties of thermal component of hyperthermia enhanced transdermal immunization: Effect on dendritic cells. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0032067"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"5593","DOI":"10.1016\/j.vaccine.2006.04.039","article-title":"Enhanced transdermal-immunization with diptheria-toxoid using local hyperthermia","volume":"24","author":"Upadhyay","year":"2006","journal-title":"Vaccine"},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Alkilani, A.Z., Nasereddin, J., Hamed, R., Nimrawi, S., Hussein, G., Abo-Zour, H., and Donnelly, R.F. (2022). Beneath the Skin: A Review of Current Trends and Future Prospects of Transdermal Drug Delivery Systems. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14061152"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3109\/02652048.2012.700956","article-title":"Polymeric nanospheres as strategy to increase the amount of triclosan retained in the skin: Passive diffusion vs. iontophoresis","volume":"30","author":"Merino","year":"2013","journal-title":"J. Microencapsul."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ejpb.2017.02.001","article-title":"Formulation and ex vivo evaluation of polymeric nanoparticles for controlled delivery of corticosteroids to the skin and the corneal epithelium","volume":"115","author":"Balzus","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_179","unstructured":"Chen, H.Y., Zhao, Q., Su, K.L., and Lin, Y.-C. (2008, January 6\u20139). Development of transdermal delivery chip system: Deliver gold nanoparticles into human stratum corneume. Proceedings of the 3rd IEEE International Conference on Nano\/Micro Engineered and Molecular Systems, NEMS 2008, Sanya, China."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1002\/jps.22024","article-title":"Enhanced skin permeation of naltrexone by pulsed electromagnetic fields in human skin in vitro","volume":"99","author":"Krishnan","year":"2010","journal-title":"J. Pharm. Sci."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jconrel.2010.03.013","article-title":"Effects of ultrasound and sodium lauryl sulfate on the transdermal delivery of hydrophilic permeants: Comparative in vitro studies with full-thickness and split-thickness pig and human skin","volume":"145","author":"Seto","year":"2010","journal-title":"J. Control. Release"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1093\/toxsci\/kfq243","article-title":"Small amounts of zinc from zinc oxide particles in sunscreens applied outdoors are absorbed through human skin","volume":"118","author":"Gulson","year":"2010","journal-title":"Toxicol. Sci."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"021014","DOI":"10.1117\/1.3078813","article-title":"Determination of the cuticula thickness of human and porcine hairs and their potential influence on the penetration of nanoparticles into the hair follicles","volume":"14","author":"Lademann","year":"2009","journal-title":"J. Biomed. Opt."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1166\/jbn.2010.1155","article-title":"Penetration of quantum dot particles through human skin","volume":"6","author":"Gratieri","year":"2010","journal-title":"J. Biomed. Nanotechnol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1117\/1.1609200","article-title":"Quantification of the horny layer using tape stripping and microscopic techniques","volume":"8","author":"Lindemann","year":"2003","journal-title":"J. Biomed. Opt."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.jconrel.2011.01.006","article-title":"Ultrasound-mediated transdermal drug delivery: Mechanisms, scope, and emerging trends","volume":"152","author":"Polat","year":"2011","journal-title":"J. Control. Release"},{"key":"ref_187","first-page":"77","article-title":"Delivery systems for intradermal vaccination","volume":"351","author":"Kim","year":"2012","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ejps.2009.06.004","article-title":"Selective removal of stratum corneum by microdermabrasion to increase skin permeability","volume":"38","author":"Gill","year":"2009","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00403-003-0414-7","article-title":"Tape stripping and sodium dodecyl sulfate treatment increase the molecular weight cutoff of polyethylene glycol penetration across murine skin","volume":"295","author":"Tsai","year":"2003","journal-title":"Arch. Dermatol. Res."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.bbrc.2010.03.032","article-title":"Assessment of penetration of quantum dots through in vitro and in vivo human skin using the human skin equivalent model and the tape stripping method","volume":"394","author":"Jeong","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.1016\/j.biomaterials.2009.02.003","article-title":"Chemical enhancer induced changes in the mechanisms of transdermal delivery of zinc oxide nanoparticles","volume":"30","author":"Kuo","year":"2009","journal-title":"Biomaterials"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1159\/000338688","article-title":"Could chemical enhancement of gold nanoparticle penetration be extrapolated from established approaches for drug permeation?","volume":"25","author":"Labouta","year":"2012","journal-title":"Skin Pharmacol. Physiol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1021\/ar200022e","article-title":"Cancer theranostics with near-infrared light-activatable multimodal nanoparticles","volume":"44","author":"Melancon","year":"2011","journal-title":"Acc. Chem. Res."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1002\/smll.201200783","article-title":"Hollow copper sulfide nanoparticle-mediated transdermal drug delivery","volume":"8","author":"Ramadan","year":"2012","journal-title":"Small"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"7238","DOI":"10.1021\/jp057170o","article-title":"Calculated absorption and scattering properties of gold nanoparticles of different size, shape, and composition: Applications in biological imaging and biomedicine","volume":"110","author":"Jain","year":"2006","journal-title":"J. Phys. Chem. B."},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Stanciu, S. (2016). Multiphoton and Fluorescence Lifetime Imaging Microscopy in Studying Nanoparticle Pharmacokinetics in Skin and Liver. Micro and Nanotechnologies for Biotechnology, IntechOpen.","DOI":"10.5772\/61530"},{"key":"ref_197","first-page":"123","article-title":"Nuclear imaging approaches facilitating nanomedicine translation","volume":"154","author":"Teunissen","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1046\/j.1523-1747.2003.12102.x","article-title":"A cryotransmission electron microscopy study of skin barrier formation","volume":"120","author":"Dubochet","year":"2003","journal-title":"J. Investig. Dermatol."},{"key":"ref_199","unstructured":"Demir Sezer, A. (2014). Nanoparticles for Dermal and Transdermal Drug Delivery. Application of Nanotechnology in Drug Delivery, IntechOpen. Available online: https:\/\/www.intechopen.com\/chapters\/47025."},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Cheng, Y.C., Li, T.S., Su, H.L., Lee, P.C., and Wang, H.D. (2020). Transdermal Delivery Systems of Natural Products Applied to Skin Therapy and Care. Molecules, 25.","DOI":"10.3390\/molecules25215051"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.1016\/j.vaccine.2012.12.048","article-title":"Non-invasive delivery of nanoparticles to hair follicles: A perspective for transcutaneous immunization","volume":"31","author":"Mittal","year":"2013","journal-title":"Vaccine"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1200\/JCO.2004.11.070","article-title":"Exposure of melanoma cells to dacarbazine results in enhanced tumor growth and metastasis in vivo","volume":"22","author":"Lev","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1038\/sj.jid.5700374","article-title":"Multiphoton microscopy for the investigation of dermal penetration of nanoparticle-borne drugs","volume":"126","author":"Stracke","year":"2006","journal-title":"J. Investig. Dermatol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1038\/jid.2009.161","article-title":"In vivo real-time, multicolor, quantum dot lymphatic imaging","volume":"129","author":"Kosaka","year":"2009","journal-title":"J. Investig. Dermatol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1038\/jid.2010.293","article-title":"Paying \"particle\" attention to novel melanoma treatment strategies","volume":"130","author":"Weiss","year":"2010","journal-title":"J. Investig. Dermatol."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/mrm.20391","article-title":"Molecular MR imaging of melanoma angiogenesis with alphanubeta3-targeted paramagnetic nanoparticles","volume":"53","author":"Schmieder","year":"2005","journal-title":"Magn. Reson. Med."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.1096\/fj.10-157933","article-title":"MR angiogenesis imaging with Robo4- vs. alphaVbeta3-targeted nanoparticles in a B16\/F10 mouse melanoma model","volume":"24","author":"Boles","year":"2010","journal-title":"FASEB J."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"4859","DOI":"10.1166\/jnn.2010.2217","article-title":"Arginine-glycine-aspartic acid-conjugated dendrimer-modified quantum dots for targeting and imaging melanoma","volume":"10","author":"Li","year":"2010","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1172\/JCI45600","article-title":"Multimodal silica nanoparticles are effective cancer-targeted probes in a model of human melanoma","volume":"121","author":"Benezra","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1111\/j.1600-0846.2011.00601.x","article-title":"Emerging applications of nanomedicine in dermatology","volume":"19","author":"Saraceno","year":"2013","journal-title":"Skin Res. Technol."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s00109-004-0629-x","article-title":"Differences in subcellular distribution and toxicity of green and red emitting CdTe quantum dots","volume":"83","author":"Bazzi","year":"2005","journal-title":"J. Mol. Med."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1016\/j.biomaterials.2009.02.008","article-title":"The biocompatibility of porous silicon in tissues of the eye","volume":"30","author":"Low","year":"2009","journal-title":"Biomaterials"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.2174\/138945011795906624","article-title":"Multifunctional mesoporous silica nanoparticles for combined therapeutic, diagnostic and targeted action in cancer treatment","volume":"12","author":"Rosenholm","year":"2011","journal-title":"Curr. Drug Targets"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1467-2494.2005.00264.x","article-title":"Elastic vesicles as topical\/transdermal drug delivery systems","volume":"27","author":"Choi","year":"2005","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2174\/156720109788680813","article-title":"Elastic liposomes for topical and transdermal drug delivery","volume":"6","author":"Benson","year":"2009","journal-title":"Curr. Drug Deliv."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1007\/s11095-009-9919-x","article-title":"Investigation of polylactic acid (PLA) nanoparticles as drug delivery systems for local dermatotherapy","volume":"26","author":"Rancan","year":"2009","journal-title":"Pharm. Res."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1016\/j.ejca.2010.02.037","article-title":"The in vivo efficacy of phthalocyanine-nanoparticle conjugates for the photodynamic therapy of amelanotic melanoma","volume":"46","author":"Camerin","year":"2010","journal-title":"Eur. J. Cancer"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1158\/1535-7163.MCT-10-0717","article-title":"Effective melanoma immunotherapy with interleukin-2 delivered by a novel polymeric nanoparticle","volume":"10","author":"Yao","year":"2011","journal-title":"Mol. Cancer Ther."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1038\/mt.2010.136","article-title":"Nanoparticles modified with tumor-targeting scFv deliver siRNA and miRNA for cancer therapy","volume":"18","author":"Chen","year":"2010","journal-title":"Mol. Ther."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1038\/jid.2010.222","article-title":"Targeted nanoparticles deliver siRNA to melanoma","volume":"130","author":"Chen","year":"2010","journal-title":"J. Investig. Dermatol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/nature08956","article-title":"Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles","volume":"464","author":"Davis","year":"2010","journal-title":"Nature"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1023\/A:1016486910719","article-title":"Long-circulating poly(ethylene glycol)-modified gelatin nanoparticles for intracellular delivery","volume":"19","author":"Kaul","year":"2002","journal-title":"Pharm. Res."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1158\/1078-0432.CCR-07-1441","article-title":"Therapeutic nanoparticles for drug delivery in cancer","volume":"14","author":"Cho","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"ref_224","first-page":"133","article-title":"Drug delivery and nanoparticles:applications and hazards","volume":"3","author":"Borm","year":"2008","journal-title":"Int. J. Nanomed."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1001\/archdermatol.2007.60","article-title":"Dermatologic toxicity of nanoengineered materials","volume":"144","author":"Nasir","year":"2008","journal-title":"Arch. Dermatol."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1073\/pnas.1011379108","article-title":"Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo","volume":"108","author":"Dhar","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.clindermatol.2009.06.005","article-title":"Nanotechnology and dermatology: Part I--potential of nanotechnology","volume":"28","author":"Nasir","year":"2010","journal-title":"Clin. Dermatol."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"4559","DOI":"10.1021\/nn100736c","article-title":"In vivo molecular photoacoustic tomography of melanomas targeted by bioconjugated gold nanocages","volume":"4","author":"Kim","year":"2010","journal-title":"ACS Nano"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1158\/1078-0432.CCR-08-1480","article-title":"Targeted photothermal ablation of murine melanomas with melanocyte-stimulating hormone analog-conjugated hollow gold nanospheres","volume":"15","author":"Lu","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1021\/bc0601929","article-title":"Peptide-labeled quantum dots for imaging GPCRs in whole cells and as single molecules","volume":"18","author":"Zhou","year":"2007","journal-title":"Bioconjug. Chem."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1166\/jbn.2010.1136","article-title":"Detection of the cancer marker CD146 expression in melanoma cells with semiconductor quantum dot label","volume":"6","author":"Zheng","year":"2010","journal-title":"J. Biomed. Nanotechnol."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1158\/1535-7163.MCT-09-1059","article-title":"Identification of internalizing human single-chain antibodies targeting brain tumor sphere cells","volume":"9","author":"Zhu","year":"2010","journal-title":"Mol. Cancer Ther."},{"key":"ref_233","first-page":"2604","article-title":"Homologous and heterologous regulation of alpha-melanocyte-stimulating hormone receptors in human and mouse melanoma cell lines","volume":"54","author":"Siegrist","year":"1994","journal-title":"Cancer Res."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S1357-2725(96)00074-X","article-title":"Binding and internalization of the melanocyte stimulating hormone receptor ligand [Nle4, D-Phe7] alpha-MSH in B16 melanoma cells","volume":"28","author":"Wong","year":"1996","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"12289","DOI":"10.1016\/S0021-9258(18)98894-0","article-title":"Diphtheria toxin-related alpha-melanocyte-stimulating hormone fusion toxin. Internal in-frame deletion from Thr387 to His485 results in the formation of a highly potent fusion toxin which is resistant to proteolytic degradation","volume":"266","author":"Wen","year":"1991","journal-title":"J. Biol. Chem."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/nn1455","article-title":"Anatomy and regulation of the central melanocortin system","volume":"8","author":"Cone","year":"2005","journal-title":"Nat. Neurosci."},{"key":"ref_237","first-page":"441","article-title":"MC(1) receptors are constitutively expressed on leucocyte subpopulations with antigen presenting and cytotoxic functions","volume":"126","author":"Nagaeva","year":"2001","journal-title":"Clin. Exp. Immunol."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.det.2007.06.005","article-title":"Melanocyte receptors: Clinical implications and therapeutic relevance","volume":"25","author":"Carlson","year":"2007","journal-title":"Dermatol. Clin."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/oby.2007.525","article-title":"Expression and localization of melanocortin-1 receptor in human adipose tissues of severely obese patients","volume":"15","author":"Hoch","year":"2007","journal-title":"Obesity"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1189\/jlb.0707463","article-title":"Diminishment of alpha-MSH anti-inflammatory activity in MC1r siRNA-transfected RAW264.7 macrophages","volume":"84","author":"Li","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/ni1112","article-title":"Toll-like receptor control of the adaptive immune responses","volume":"5","author":"Iwasaki","year":"2004","journal-title":"Nat. Immunol."},{"key":"ref_242","first-page":"913","article-title":"Who is really in control of skin immunity under physiological circumstances\u2014lymphocytes, dendritic cells or keratinocytes?","volume":"15","author":"Reich","year":"2006","journal-title":"Exp. Dermatol."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1038\/jid.2011.182","article-title":"Microbial symbiosis with the innate immune defense system of the skin","volume":"131","author":"Gallo","year":"2011","journal-title":"J. Investig. Dermatol."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"S258","DOI":"10.1067\/mai.2000.110159","article-title":"Allergen sensitization through the skin induces systemic allergic responses","volume":"106","author":"Beck","year":"2000","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jat.830","article-title":"Induced changes in total serum IgE concentration in the Brown Norway rat: Potential for identification of chemical respiratory allergens","volume":"22","author":"Warbrick","year":"2002","journal-title":"J. Appl. Toxicol."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0041-008X(02)00023-6","article-title":"Respiratory allergy and pulmonary irritation to trimellitic anhydride in Brown Norway rats","volume":"187","author":"Arts","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1146\/annurev.immunol.25.022106.141634","article-title":"Mucosal dendritic cells","volume":"25","author":"Iwasaki","year":"2007","journal-title":"Annu. Rev. Immunol."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.0105-2896.2009.00886.x","article-title":"Langerhans cells and more: Langerin-expressing dendritic cell subsets in the skin","volume":"234","author":"Romani","year":"2010","journal-title":"Immunol. Rev."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1038\/sj.jid.5700226","article-title":"40 nm, but not 750 or 1500 nm, nanoparticles enter epidermal CD1a+ cells after transcutaneous application on human skin","volume":"126","author":"Vogt","year":"2006","journal-title":"J. Investig. Dermatol."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1038\/jid.2008.356","article-title":"Nanoparticle-based targeting of vaccine compounds to skin antigen-presenting cells by hair follicles and their transport in mice","volume":"129","author":"Mahe","year":"2009","journal-title":"J. Investig. Dermatol."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/000155599750010931","article-title":"Eicosanoid and cytokine levels in acute skin irritation in response to tape stripping and capsaicin","volume":"79","author":"Reilly","year":"1999","journal-title":"Acta Derm. Venereol."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1084\/jem.155.3.863","article-title":"Depletion of epidermal langerhans cells and Ia immunogenicity from tape-stripped mouse skin","volume":"155","author":"Streilein","year":"1982","journal-title":"J. Exp. Med."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1111\/j.0022-202X.2004.22520.x","article-title":"A model system using tape stripping for characterization of Langerhans cell-precursors in vivo","volume":"122","author":"Holzmann","year":"2004","journal-title":"J. Investig. Dermatol."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/toxsci\/kfp057","article-title":"Single-walled and multi-walled carbon nanotubes promote allergic immune responses in mice","volume":"109","author":"Nygaard","year":"2009","journal-title":"Toxicol. Sci."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"265103","DOI":"10.1088\/0957-4484\/22\/26\/265103","article-title":"Up-regulation of T lymphocyte and antibody production by inflammatory cytokines released by macrophage exposure to multi-walled carbon nanotubes","volume":"22","author":"Grecco","year":"2011","journal-title":"Nanotechnology"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"314","DOI":"10.3181\/0810-RM-304","article-title":"Titanium dioxide nanoparticles aggravate atopic dermatitis-like skin lesions in NC\/Nga mice","volume":"234","author":"Yanagisawa","year":"2009","journal-title":"Exp. Biol. Med."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000094717","article-title":"Effects of photocatalytic agent on DS-Nh mice, developing atopic dermatitis-like eruption with an increase of Staphylococcus aureus","volume":"141","author":"Kambara","year":"2006","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1600-0781.1997.tb00214.x","article-title":"Structural and biochemical basis for the UVB-induced alterations in epidermal barrier function","volume":"13","author":"Holleran","year":"1997","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cis.2007.04.021","article-title":"The nanoparticle-protein complex as a biological entity; a complex fluids and surface science challenge for the 21st century","volume":"134","author":"Lynch","year":"2007","journal-title":"Adv. Colloid Interface Sci."},{"key":"ref_260","first-page":"75","article-title":"Recent advances in microparticle and nanoparticle delivery vehicles for mucosal vaccination","volume":"354","author":"McNeela","year":"2012","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jconrel.2009.06.029","article-title":"Dry-coated microprojection array patches for targeted delivery of immunotherapeutics to the skin","volume":"139","author":"Chen","year":"2009","journal-title":"J. Control. Release"},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1517\/17425240903304032","article-title":"Cutaneous short-interfering RNA therapy","volume":"6","author":"Geusens","year":"2009","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4110\/in.2010.10.3.85","article-title":"The impact of nanomaterials in immune system","volume":"10","author":"Jang","year":"2010","journal-title":"Immune Netw."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1210\/en.2009-1082","article-title":"Nanoparticles and the immune system","volume":"151","author":"Zolnik","year":"2010","journal-title":"Endocrinology"},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3109\/10717544.2010.544688","article-title":"Plasmid DNA-loaded chitosan\/TPP nanoparticles for topical gene delivery","volume":"18","year":"2011","journal-title":"Drug Deliv."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/jid.2009.63","article-title":"Nanotechnology in vaccine development: A step forward","volume":"129","author":"Nasir","year":"2009","journal-title":"J. Investig. Dermatol."},{"key":"ref_267","doi-asserted-by":"crossref","unstructured":"Fernando, G.J., Chen, X., Prow, T.W., Crichton, M.L., Fairmaid, E.J., Roberts, M.S., Frazer, I.H., Brown, L.E., and Kendall, M.A. (2010). Potent immunity to low doses of influenza vaccine by probabilistic guided micro-targeted skin delivery in a mouse model. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0010266"},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"6379","DOI":"10.1016\/j.vaccine.2011.04.080","article-title":"Targeting of HIV-p24 particle-based vaccine into differential skin layers induces distinct arms of the immune responses","volume":"29","author":"Liard","year":"2011","journal-title":"Vaccine"},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"021001","DOI":"10.1117\/1.3080714","article-title":"Strategy of topical vaccination with nanoparticles","volume":"14","author":"Jung","year":"2009","journal-title":"J. Biomed. Opt."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.addr.2007.05.017","article-title":"Nanotechnology in vaccine delivery","volume":"60","author":"Peek","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.vaccine.2008.11.046","article-title":"Incorporation of LpxL1, a detoxified lipopolysaccharide adjuvant, in influenza H5N1 virosomes increases vaccine immunogenicity","volume":"27","author":"Bungener","year":"2009","journal-title":"Vaccine"},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.copbio.2007.10.013","article-title":"Virus-like particles-universal molecular toolboxes","volume":"18","author":"Ludwig","year":"2007","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/wnan.146","article-title":"Nanoparticles through the skin: Managing conflicting results of inorganic and organic particles in cosmetics and pharmaceutics","volume":"3","author":"Bolzinger","year":"2011","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"950","DOI":"10.2174\/138945009789577918","article-title":"Drug targeting through pilosebaceous route","volume":"10","author":"Chourasia","year":"2009","journal-title":"Curr. Drug Targets"},{"key":"ref_275","doi-asserted-by":"crossref","unstructured":"Nasir, A., Friedman, A., and Wang, S. (2013). Nanoparticle-Based Epidermal and Dermal Vaccination. Nanotechnology in Dermatology, Springer.","DOI":"10.1007\/978-1-4614-5034-4"},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1002\/wrna.1250","article-title":"Not miR-ly micromanagers: The functions and regulatory networks of microRNAs in mammalian skin","volume":"5","author":"Riemondy","year":"2014","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jconrel.2017.11.013","article-title":"Towards topical microRNA-directed therapy for epidermal disorders","volume":"269","author":"Ross","year":"2018","journal-title":"J. Control. Release"},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/mt.2009.273","article-title":"First-in-human mutation-targeted siRNA phase Ib trial of an inherited skin disorder","volume":"18","author":"Leachman","year":"2010","journal-title":"Mol. Ther."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/74480","article-title":"Efficient delivery of transgenes to human hair follicle progenitor cells using topical lipoplex","volume":"18","author":"Domashenko","year":"2000","journal-title":"Nat. Biotechnol."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/sj.gt.3302915","article-title":"Gene transfer in human skin with different pseudotyped HIV-based vectors","volume":"14","author":"Hachiya","year":"2007","journal-title":"Gene Ther."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/gt.2010.32","article-title":"Pre-clinical evaluation of liposomal gene transfer to improve dermal and epidermal regeneration","volume":"17","author":"Branski","year":"2010","journal-title":"Gene Ther."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1038\/mt.2014.30","article-title":"Gold nanoparticles for nucleic acid delivery","volume":"22","author":"Ding","year":"2014","journal-title":"Mol. Ther."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.jconrel.2015.10.050","article-title":"Bridging small interfering RNA with giant therapeutic outcomes using nanometric liposomes","volume":"220","author":"Singh","year":"2015","journal-title":"J. Control. Release"},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/nnano.2011.37","article-title":"Nanoparticles reduce nickel allergy by capturing metal ions","volume":"6","author":"Vemula","year":"2011","journal-title":"Nat. Nanotechnol."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00403-011-1163-7","article-title":"Nanoparticles in dermatology","volume":"303","author":"Papakostas","year":"2011","journal-title":"Arch. Dermatol. Res."},{"key":"ref_286","doi-asserted-by":"crossref","unstructured":"Souto, E.B., Fernandes, A.R., Martins-Gomes, C., Coutinho, T.E., Durazzo, A., Lucarini, M., Souto, S.B., Silva, A.M., and Santini, A. (2020). Nanomaterials for Skin Delivery of Cosmeceuticals and Pharmaceuticals. Appl. Sci., 10.","DOI":"10.3390\/app10051594"},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1001\/archderm.138.11.1462","article-title":"Mechanisms of photoaging and chronological skin aging","volume":"138","author":"Fisher","year":"2002","journal-title":"Arch. Dermatol."},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.clindermatol.2007.09.010","article-title":"The latest on skin photoprotection","volume":"26","year":"2008","journal-title":"Clin. Dermatol."},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1615\/JLongTermEffMedImplants.v14.i4.40","article-title":"Photoprotection by sunscreens with topical antioxidants and systemic antioxidants to reduce sun exposure","volume":"14","author":"Edlich","year":"2004","journal-title":"J. Long Term Eff. Med. Implant."},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1038\/s41598-021-04663-0","article-title":"From Himba indigenous knowledge to engineered Fe2O3 UV-blocking green nanocosmetics","volume":"12","author":"Havenga","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2147\/NSA.S19419","article-title":"Titanium dioxide and zinc oxide nanoparticles in sunscreens: Focus on their safety and effectiveness","volume":"4","author":"Smijs","year":"2011","journal-title":"Nanotechnol. Sci. Appl."},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1111\/jocd.12436","article-title":"Skin penetration and UV-damage prevention by nanoberries","volume":"17","author":"Bucci","year":"2018","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_293","first-page":"6477","article-title":"Development and evaluation of sunscreen creams containing morin-encapsulated nanoparticles for enhanced UV radiation protection and antioxidant activity","volume":"10","author":"Shetty","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1529-8019.2009.01289.x","article-title":"Photoprotection: A review of the current and future technologies","volume":"23","author":"Wang","year":"2010","journal-title":"Dermatol. Ther."},{"key":"ref_295","doi-asserted-by":"crossref","unstructured":"Beck, R.C.R., Guterres, S.S., and Pohlmann, A.R. (2011). Nanosized and Nanoencapsulated sunscreens. NanoCosmetics and Nanomedicines, Springer.","DOI":"10.1007\/978-3-642-19792-5"},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1166\/jnn.2011.3135","article-title":"Nanostructured polymer and lipid carriers for sunscreen. Biological effects and skin permeation","volume":"11","author":"Marcato","year":"2011","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1038\/nmat4422","article-title":"A sunblock based on bioadhesive nanoparticles","volume":"14","author":"Deng","year":"2015","journal-title":"Nat. Mater."},{"key":"ref_298","doi-asserted-by":"crossref","unstructured":"Lee, S.C., Yoo, E., Lee, S.H., and Won, K. (2020). Preparation and Application of Light-Colored Lignin Nanoparticles for Broad-Spectrum Sunscreens. Polymers, 12.","DOI":"10.3390\/polym12030699"},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/phpp.12439","article-title":"A review of inorganic UV filters zinc oxide and titanium dioxide","volume":"35","author":"Schneider","year":"2019","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.watres.2018.03.062","article-title":"Trade-offs in ecosystem impacts from nanomaterial versus organic chemical ultraviolet filters in sunscreens","volume":"139","author":"Hanigan","year":"2018","journal-title":"Water Res."},{"key":"ref_301","doi-asserted-by":"crossref","unstructured":"Bennett, S.W., Zhou, D., Mielke, R., and Keller, A.A. (2012). Photoinduced disaggregation of TiO\u2082 nanoparticles enables transdermal penetration. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0048719"},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/ics.12463","article-title":"Zinc-containing compounds for personal care applications","volume":"40","author":"Abendrot","year":"2018","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"10621","DOI":"10.1021\/nn403118u","article-title":"Quantification of ZnO nanoparticle uptake, distribution, and dissolution within individual human macrophages","volume":"7","author":"James","year":"2013","journal-title":"ACS Nano"},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12989-014-0038-4","article-title":"Topically applied ZnO nanoparticles suppress allergen induced skin inflammation but induce vigorous IgE production in the atopic dermatitis mouse model","volume":"11","author":"Ilves","year":"2014","journal-title":"Part. Fibre Toxicol."},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"5957606","DOI":"10.1155\/2019\/5957606","article-title":"Development of a hybrid chitosan- and niacinamide-coupled ZnO nanoparticle composite for sun protection application","volume":"2019","author":"Jo","year":"2019","journal-title":"J. Nanomater."},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1021\/acsami.8b08431","article-title":"ZnO Nanoparticles Modified with an Amphipathic Peptide Show Improved Photoprotection in Skin","volume":"11","author":"Aditya","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"3468","DOI":"10.1038\/s41598-022-06828-x","article-title":"From Khoi-San indigenous knowledge to bioengineered CeO2 nanocrystals to exceptional UV-blocking green nanocosmetics","volume":"12","author":"Ditlopo","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.nano.2016.10.002","article-title":"Fullerene nanoparticle in dermatological and cosmetic applications","volume":"13","author":"Mousavi","year":"2017","journal-title":"Nanomedicine"},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1126\/science.254.5035.1183","article-title":"Radical reactions of c60","volume":"254","author":"Krusic","year":"1991","journal-title":"Science"},{"key":"ref_310","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1016\/j.bmcl.2005.12.011","article-title":"The water-soluble fullerene derivative \"Radical Sponge\" exerts cytoprotective action against UVA irradiation but not visible-light-catalyzed cytotoxicity in human skin keratinocytes","volume":"16","author":"Xiao","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"5262","DOI":"10.1021\/cr300475r","article-title":"Radical reactions of fullerenes: From synthetic organic chemistry to materials science and biology","volume":"113","author":"Tzirakis","year":"2013","journal-title":"Chem. Rev."},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jphotobiol.2010.09.006","article-title":"Super-highly hydroxylated fullerene derivative protects human keratinocytes from UV-induced cell injuries together with the decreases in intracellular ROS generation and DNA damages","volume":"102","author":"Saitoh","year":"2011","journal-title":"J. Photochem. Photobiol. B."},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/phpp.12050","article-title":"Photoprotective effects of inclusion complexes of fullerenes with polyvinylpyrrolidone","volume":"29","author":"Murakami","year":"2013","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_314","first-page":"1","article-title":"Systematic reviews of wound care management: (3) antimicrobial agents for chronic wounds; (4) diabetic foot ulceration","volume":"4","author":"Cullum","year":"2000","journal-title":"Health Technol. Assess."},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1046\/j.1365-2133.2002.04872.x","article-title":"Staphylococcus aureus: Colonizing features and influence of an antibacterial treatment in adults with atopic dermatitis","volume":"147","author":"Breuer","year":"2002","journal-title":"Br. J. Dermatol."},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1021\/es103316q","article-title":"120 years of nanosilver history: Implications for policy makers","volume":"45","author":"Nowack","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"4811","DOI":"10.1007\/s10904-020-01744-x","article-title":"Silver Nanoparticles and Silver Ions as Potential Antibacterial Agents","volume":"30","author":"Hamad","year":"2020","journal-title":"J. Inorg. Organomet. Polym."},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.biotechadv.2008.09.002","article-title":"Silver nanoparticles as a new generation of antimicrobials","volume":"27","author":"Rai","year":"2009","journal-title":"Biotechnol. Adv."},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"6900","DOI":"10.1021\/es2037405","article-title":"Environmental transformations of silver nanoparticles: Impact on stability and toxicity","volume":"46","author":"Levard","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.1021\/es7032718","article-title":"Nanoparticle silver released into water from commercially available sock fabrics","volume":"42","author":"Benn","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"ref_321","doi-asserted-by":"crossref","first-page":"3910","DOI":"10.1021\/es0871199","article-title":"Silver socks have cloudy lining","volume":"42","author":"Lubick","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"ref_322","first-page":"164","article-title":"Antimicrobial silver-montmorillonite nanoparticles to prolong the shelf life of fresh fruit salad","volume":"148","author":"Costa","year":"2011","journal-title":"Int. J. Food Microbiol."},{"key":"ref_323","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jhin.2005.04.015","article-title":"Antimicrobial effect of surgical masks coated with nanoparticles","volume":"62","author":"Li","year":"2006","journal-title":"J. Hosp. Infect."},{"key":"ref_324","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.12968\/bjon.2010.19.Sup5.77707","article-title":"The effects of silver dressings on chronic and burns wound healing","volume":"19","author":"Elliott","year":"2010","journal-title":"Br. J. Nurs."},{"key":"ref_325","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/cmdc.200600171","article-title":"Topical delivery of silver nanoparticles promotes wound healing","volume":"2","author":"Tian","year":"2007","journal-title":"ChemMedChem."},{"key":"ref_326","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1128\/AEM.02001-07","article-title":"Antibacterial activity and mechanism of action of the silver ion in Staphylococcus aureus and Escherichia coli","volume":"74","author":"Jung","year":"2008","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_327","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.colsurfb.2010.12.020","article-title":"Comparison of bactericidal activities of silver nanoparticles with common chemical disinfectants","volume":"84","author":"Chamakura","year":"2011","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/1574-6968.12460","article-title":"Effect of silver nanoparticles and silver ions on growth and adaptive response mechanisms of Pseudomonas putida mt-2","volume":"355","author":"Hachicho","year":"2014","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_329","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3109\/15563659609020246","article-title":"Silver products for medical indications: Risk-benefit assessment","volume":"34","author":"Fung","year":"1996","journal-title":"J. Toxicol. Clin. Toxicol."},{"key":"ref_330","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.toxlet.2009.01.020","article-title":"Expression of genes related to oxidative stress in the mouse brain after exposure to silver-25 nanoparticles","volume":"187","author":"Rahman","year":"2009","journal-title":"Toxicol. Lett."},{"key":"ref_331","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3109\/17435390.2010.506250","article-title":"Silver nanoparticles enhance thrombus formation through increased platelet aggregation and procoagulant activity","volume":"5","author":"Jun","year":"2011","journal-title":"Nanotoxicology"},{"key":"ref_332","doi-asserted-by":"crossref","first-page":"7025","DOI":"10.1039\/c0cc05271j","article-title":"Health impact and safety of engineered nanomaterials","volume":"47","author":"Teow","year":"2011","journal-title":"Chem. Commun."},{"key":"ref_333","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1289\/ehp.0901398","article-title":"Evaluation of silver nanoparticle toxicity in skin in vivo and keratinocytes in vitro","volume":"118","author":"Samberg","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"ref_334","doi-asserted-by":"crossref","first-page":"855","DOI":"10.2147\/IJN.S17065","article-title":"Acute and subchronic dermal toxicity of nanosilver in guinea pig","volume":"6","author":"Korani","year":"2011","journal-title":"Int. J. Nanomed."},{"key":"ref_335","first-page":"5831959","article-title":"Antibacterial Efficacy of Gold and Silver Nanoparticles Functionalized with the Ubiquicidin (29\u201341) Antimicrobial Peptide","volume":"2017","year":"2017","journal-title":"J. Nanomater."},{"key":"ref_336","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1525-1594.2007.00530.x","article-title":"Studies of photokilling of bacteria using titanium dioxide nanoparticles","volume":"32","author":"Tsuang","year":"2008","journal-title":"Artif. Organs"},{"key":"ref_337","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ijpharm.2006.10.017","article-title":"Sustained antibacterial effect of a hand rub gel incorporating chlorhexdine-loaded nanocapsules (Nanochlorex)","volume":"334","author":"Nhung","year":"2007","journal-title":"Int. J. Pharm."},{"key":"ref_338","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1038\/jid.2009.95","article-title":"Antimicrobial and healing efficacy of sustained release nitric oxide nanoparticles against Staphylococcus aureus skin infection","volume":"129","author":"Martinez","year":"2009","journal-title":"J. Investig. Dermatol."},{"key":"ref_339","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.jiec.2022.03.025","article-title":"New orchestrated of X-CuTiAP (en, trien, ETA and DMA) nanospheres with enhanced photocatalytic and antimicrobial activities","volume":"110","author":"Gnanamoorthy","year":"2022","journal-title":"J. Ind. Eng. Chem."},{"key":"ref_340","doi-asserted-by":"crossref","first-page":"111945","DOI":"10.1016\/j.optmat.2021.111945","article-title":"Synthesis and effective performance of Photocatalytic and Antimicrobial activities of Bauhinia tomentosa Linn plants using of gold nanoparticles","volume":"123","author":"Gnanamoorthy","year":"2022","journal-title":"Opt. Mater."},{"key":"ref_341","doi-asserted-by":"crossref","first-page":"3608","DOI":"10.1021\/acsabm.2c00384","article-title":"Borate Bioactive Glasses (BBG): Bone Regeneration, Wound Healing Applications, and Future Directions","volume":"5","author":"Ege","year":"2022","journal-title":"ACS Appl. Bio. Mater."},{"key":"ref_342","doi-asserted-by":"crossref","unstructured":"Okonkwo, U.A., and DiPietro, L.A. (2017). Diabetes and Wound Angiogenesis. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18071419"},{"key":"ref_343","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1039\/C9BM01691K","article-title":"Cu, Zn Doped Borate Bioactive Glasses: Antibacterial Efficacy and Dose-Dependent in Vitro Modulation of Murine Dendritic Cells","volume":"8","author":"Schuhladen","year":"2020","journal-title":"Biomater. Sci."},{"key":"ref_344","doi-asserted-by":"crossref","first-page":"22939","DOI":"10.1021\/acsami.8b04903","article-title":"Angiogenesis and Full-Thickness Wound Healing Efficiency of a Copper-Doped Borate Bioactive Glass\/Poly(lactic- co-glycolic acid) Dressing Loaded with Vitamin E in Vivo and in Vitro","volume":"10","author":"Hu","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_345","doi-asserted-by":"crossref","first-page":"5399","DOI":"10.1021\/acsbiomaterials.0c00528","article-title":"Bioactive Glasses: A Promising Therapeutic Ion Release Strategy for Enhancing Wound Healing","volume":"6","author":"Mehrabi","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_346","doi-asserted-by":"crossref","first-page":"8015","DOI":"10.1016\/j.actbio.2013.04.043","article-title":"Effect of bioactive borate glass microstructure on bone regeneration, angiogenesis, and hydroxyapatite conversion in a rat calvarial defect model","volume":"9","author":"Bi","year":"2013","journal-title":"Acta Biomater."},{"key":"ref_347","doi-asserted-by":"crossref","first-page":"128843","DOI":"10.1016\/j.matlet.2020.128843","article-title":"Preparation and Characterization of Sintered Bioactive Borate Glass Tape","volume":"282","author":"Sengupta","year":"2021","journal-title":"Mater. Lett."},{"key":"ref_348","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.biomaterials.2015.02.112","article-title":"Wound dressings composed of copper-doped borate bioactive glass microfibers stimulate angiogenesis and heal full-thickness skin defects in a rodent model","volume":"53","author":"Zhao","year":"2015","journal-title":"Biomaterials"},{"key":"ref_349","doi-asserted-by":"crossref","unstructured":"Rau, J.V., De Bonis, A., Curcio, M., Schuhladen, K., Barbaro, K., De Bellis, G., Teghil, R., and Boccaccini, A.R. (2020). Borate and Silicate Bioactive Glass Coatings Prepared by Nanosecond Pulsed Laser Deposition. Coatings, 10.","DOI":"10.3390\/coatings10111105"},{"key":"ref_350","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1111\/jace.17802","article-title":"Silver-Doped Sol-Gel Borate Glasses: Dose-Dependent Effect on Pseudomonas Aeruginosa Biofilms and Keratinocyte Function","volume":"105","author":"Naseri","year":"2022","journal-title":"J. Am. Ceram. Soc."},{"key":"ref_351","doi-asserted-by":"crossref","first-page":"E6162","DOI":"10.1073\/pnas.1606996113","article-title":"Keratinocytes contribute intrinsically to psoriasis upon loss of Tnip1 function","volume":"113","author":"Ippagunta","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_352","unstructured":"Gabros, S., Nessel, T.A., and Zito, P.M. (2022). Topical Corticosteroids, StatPearls."},{"key":"ref_353","first-page":"33","article-title":"Association between Vitamin D deficiency and psoriasis: An exploratory study","volume":"12","year":"2018","journal-title":"Int. J. Health Sci."},{"key":"ref_354","doi-asserted-by":"crossref","first-page":"82","DOI":"10.2174\/2589977512666200525154954","article-title":"Dithranol: An Insight into its Novel Delivery Cargos for Psoriasis Management","volume":"12","author":"Kadian","year":"2020","journal-title":"Curr. Drug Res. Rev."},{"key":"ref_355","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.jaad.2018.11.057","article-title":"Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with biologics","volume":"80","author":"Menter","year":"2019","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_356","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.2147\/IJN.S245326","article-title":"Recent Progress and Future Directions: The Nano-Drug Delivery System for the Treatment of Vitiligo","volume":"15","author":"Sun","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_357","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/ajd.12256","article-title":"Vitiligo treatment update","volume":"56","author":"Daniel","year":"2015","journal-title":"Australas. J. Dermatol."},{"key":"ref_358","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1080\/03639045.2019.1576722","article-title":"Dithranol-loaded nanostructured lipid carrier-based gel ameliorate psoriasis in imiquimod-induced mice psoriatic plaque model","volume":"45","author":"Sathe","year":"2019","journal-title":"Drug Dev. Ind. Pharm."},{"key":"ref_359","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1080\/08982104.2019.1593449","article-title":"Preparation, characterization, and in vivo evaluation of cyclosporine cationic liposomes for the treatment of psoriasis","volume":"30","author":"Walunj","year":"2020","journal-title":"J. Liposome Res."},{"key":"ref_360","first-page":"825","article-title":"Capsaicin-loaded vesicular systems designed for enhancing localized delivery for psoriasis therapy","volume":"44","author":"Gupta","year":"2016","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_361","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.ijpharm.2012.01.045","article-title":"Physico-chemical characteristics of methotrexate-entrapped oleic acid-containing deformable liposomes for in vitro transepidermal delivery targeting psoriasis treatment","volume":"427","author":"Srisuk","year":"2012","journal-title":"Int. J. Pharm."},{"key":"ref_362","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.msec.2016.07.043","article-title":"Formulation and optimization of niosomes for topical diacerein delivery using 3-factor, 3-level Box-Behnken design for the management of psoriasis","volume":"69","author":"Moghddam","year":"2016","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_363","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.2147\/IJN.S156412","article-title":"Pivotal role of Acitretin nanovesicular gel for effective treatment of psoriasis: Ex vivo-in vivo evaluation study","volume":"13","author":"Hamed","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"ref_364","doi-asserted-by":"crossref","first-page":"110352","DOI":"10.1016\/j.colsurfb.2019.110352","article-title":"Loading of water-insoluble celastrol into niosome hydrogels for improved topical permeation and anti-psoriasis activity","volume":"182","author":"Meng","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_365","doi-asserted-by":"crossref","first-page":"362","DOI":"10.2174\/2211738507666190906123643","article-title":"Development of Topical Gel of Methotrexate Incorporated Ethosomes and Salicylic Acid for the Treatment of Psoriasis","volume":"7","author":"Chandra","year":"2019","journal-title":"Pharm. Nanotechnol."},{"key":"ref_366","doi-asserted-by":"crossref","unstructured":"Fathalla, D., Youssef, E.M.K., and Soliman, G.M. (2020). Liposomal and Ethosomal Gels for the Topical Delivery of Anthralin: Preparation, Comparative Evaluation and Clinical Assessment in Psoriatic Patients. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12050446"},{"key":"ref_367","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.ejps.2016.10.025","article-title":"Psoralen loaded liposomal nanocarriers for improved skin penetration and efficacy of topical PUVA in psoriasis","volume":"96","author":"Doppalapudi","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_368","doi-asserted-by":"crossref","unstructured":"Rashid, S.A., Bashir, S., Naseem, F., Farid, A., Rather, I.A., and Hakeem, K.R. (2021). Olive Oil Based Methotrexate Loaded Topical Nanoemulsion Gel for the Treatment of Imiquimod Induced Psoriasis-like Skin Inflammation in an Animal Model. Biology, 10.","DOI":"10.3390\/biology10111121"},{"key":"ref_369","doi-asserted-by":"crossref","unstructured":"Algahtani, M.S., Ahmad, M.Z., Nourein, I.H., and Ahmad, J. (2020). Co-Delivery of Imiquimod and Curcumin by Nanoemugel for Improved Topical Delivery and Reduced Psoriasis-Like Skin Lesions. Biomolecules, 10.","DOI":"10.3390\/biom10070968"},{"key":"ref_370","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.2217\/nnm-2018-0135","article-title":"Active natural oil-based nanoemulsion containing tacrolimus for synergistic antipsoriatic efficacy","volume":"13","author":"Sahu","year":"2018","journal-title":"Nanomedicine"},{"key":"ref_371","doi-asserted-by":"crossref","unstructured":"Somagoni, J., Boakye, C.H., Godugu, C., Patel, A.R., Mendonca Faria, H.A., Zucolotto, V., and Singh, M. (2014). Nanomiemgel--a novel drug delivery system for topical application--in vitro and in vivo evaluation. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0115952"},{"key":"ref_372","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.ijpharm.2016.01.042","article-title":"An elastic liposomal formulation for RNAi-based topical treatment of skin disorders: Proof-of-concept in the treatment of psoriasis","volume":"500","author":"Desmet","year":"2016","journal-title":"Int. J. Pharm."},{"key":"ref_373","doi-asserted-by":"crossref","first-page":"98","DOI":"10.4172\/0975-0851.1000385","article-title":"Implementation of Design of Experiments in Development and Optimization of Transfersomal Carrier System of Tacrolimus for the Dermal Management of Psoriasis in Albino Wistar Rat","volume":"10","author":"Parkash","year":"2018","journal-title":"J. Bioequiv. Availab."},{"key":"ref_374","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12951-020-00635-0","article-title":"Flexible liposomal gel dual-loaded with all-trans retinoic acid and betamethasone for enhanced therapeutic efficiency of psoriasis","volume":"18","author":"Wang","year":"2020","journal-title":"J. Nanobiotechnol."},{"key":"ref_375","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.2147\/IJN.S195048","article-title":"Preparation of sustained release apremilast-loaded PLGA nanoparticles: In vitro characterization and in vivo pharmacokinetic study in rats","volume":"14","author":"Anwer","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_376","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.colsurfb.2011.08.004","article-title":"Enhanced transdermal delivery of indomethacin-loaded PLGA nanoparticles by iontophoresis","volume":"88","author":"Tomoda","year":"2011","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_377","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jconrel.2012.06.021","article-title":"Development of paclitaxel-TyroSpheres for topical skin treatment","volume":"163","author":"Kilfoyle","year":"2012","journal-title":"J. Control. Release"},{"key":"ref_378","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1021\/mp400639e","article-title":"Polymeric micelle nanocarriers for the cutaneous delivery of tacrolimus: A targeted approach for the treatment of psoriasis","volume":"11","author":"Lapteva","year":"2014","journal-title":"Mol. Pharm."},{"key":"ref_379","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1166\/jnn.2016.11670","article-title":"Cationic Polymeric Nanocapsules as a Strategy to Target Dexamethasone to Viable Epidermis: Skin Penetration and Permeation Studies","volume":"16","author":"Beber","year":"2016","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_380","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1016\/j.nano.2017.06.009","article-title":"Liposphere mediated topical delivery of thymoquinone in the treatment of psoriasis","volume":"13","author":"Jain","year":"2017","journal-title":"Nanomedicine"},{"key":"ref_381","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.msec.2018.10.061","article-title":"Structure-based drug designing and identification of Woodfordia fruticosa inhibitors targeted against heat shock protein (HSP70-1) as suppressor for Imiquimod-induced psoriasis like skin inflammation in mice model","volume":"95","author":"Raghuwanshi","year":"2019","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_382","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.nano.2019.01.006","article-title":"Effects of topical methotrexate loaded gold nanoparticle in cutaneous inflammatory mouse model","volume":"17","author":"Fratoddi","year":"2019","journal-title":"Nanomedicine"},{"key":"ref_383","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jphotobiol.2017.07.007","article-title":"Development and in vitro assessment of psoralen and resveratrol co-loaded ultradeformable liposomes for the treatment of vitiligo","volume":"174","author":"Doppalapudi","year":"2017","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_384","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.colsurfb.2018.12.055","article-title":"Baicalin and berberine ultradeformable vesicles as potential adjuvant in vitiligo therapy","volume":"175","author":"Caddeo","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_385","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1111\/cbdd.12048","article-title":"Potent melanin production enhancement of human tyrosinase gene by Tat and an entrapment in elastic cationic niosomes: Potential application in vitiligo gene therapy","volume":"80","author":"Manosroi","year":"2012","journal-title":"Chem. Biol. Drug Des."},{"key":"ref_386","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.colsurfb.2014.02.005","article-title":"Topical delivery of clobetasol propionate loaded microemulsion based gel for effective treatment of vitiligo--part II: Rheological characterization and in vivo assessment through dermatopharmacokinetic and pilot clinical studies","volume":"119","author":"Patel","year":"2014","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_387","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3109\/1061186X.2015.1070855","article-title":"Nanosized ethosomes-based hydrogel formulations of methoxsalen for enhanced topical delivery against vitiligo: Formulation optimization, in vitro evaluation and preclinical assessment","volume":"24","author":"Garg","year":"2016","journal-title":"J. Drug Target."},{"key":"ref_388","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ijbiomac.2015.01.036","article-title":"Chitosan nanoparticles for targeting and sustaining minoxidil sulphate delivery to hair follicles","volume":"75","author":"Matos","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_389","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ejpb.2022.02.003","article-title":"Nanostructured lipid carriers loaded with an association of minoxidil and latanoprost for targeted topical therapy of alopecia","volume":"172","author":"Oliveira","year":"2022","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_390","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1208\/s12249-020-01863-1","article-title":"Latanoprost Loaded in Polymeric Nanocapsules for Effective Topical Treatment of Alopecia","volume":"21","author":"Oliveira","year":"2020","journal-title":"AAPS PharmSciTech"},{"key":"ref_391","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1208\/s12249-016-0519-x","article-title":"Preparation and Characterization of Minoxidil Loaded Nanostructured Lipid Carriers","volume":"18","author":"Wang","year":"2017","journal-title":"AAPS PharmSciTech"},{"key":"ref_392","doi-asserted-by":"crossref","first-page":"7921","DOI":"10.2147\/IJN.S225496","article-title":"Drug Delivery System Based on Minoxidil Nanoparticles Promotes Hair Growth in C57BL\/6 Mice","volume":"14","author":"Nagai","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_393","doi-asserted-by":"crossref","first-page":"4771","DOI":"10.1016\/j.bmcl.2007.06.057","article-title":"Evaluation of the permeability of hair growing ingredient encapsulated PLGA nanospheres to hair follicles and their hair growing effects","volume":"17","author":"Tsujimoto","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_394","doi-asserted-by":"crossref","first-page":"650","DOI":"10.2353\/ajpath.2008.061249","article-title":"Controlled delivery of T-box21 small interfering RNA ameliorates autoimmune alopecia (Alopecia Areata) in a C3H\/HeJ mouse model","volume":"172","author":"Nakamura","year":"2008","journal-title":"Am. J. Pathol."},{"key":"ref_395","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1080\/10837450701481181","article-title":"Development of liposomal systems of finasteride for topical applications: Design, characterization, and in vitro evaluation","volume":"12","author":"Kumar","year":"2007","journal-title":"Pharm. Dev. Technol."},{"key":"ref_396","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1002\/adhm.201300002","article-title":"In vivo treatment of Propionibacterium acnes infection with liposomal lauric acids","volume":"2","author":"Pornpattananangkul","year":"2013","journal-title":"Adv. Healthc. Mater."},{"key":"ref_397","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ijpharm.2009.07.025","article-title":"Formation of ion pairing as an alternative to improve encapsulation and stability and to reduce skin irritation of retinoic acid loaded in solid lipid nanoparticles","volume":"381","author":"Castro","year":"2009","journal-title":"Int. J. Pharm."},{"key":"ref_398","first-page":"590","article-title":"Benzoyl peroxide microsphere cream as monotherapy and combination treatment of acne","volume":"7","author":"Bikowski","year":"2008","journal-title":"J. Drugs Dermatol."},{"key":"ref_399","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1166\/jbn.2015.2139","article-title":"Topical Skin Cancer Therapy Using Doxorubicin-Loaded Cationic Lipid Nanoparticles and lontophoresis","volume":"11","author":"Huber","year":"2015","journal-title":"J. Biomed. Nanotechnol."},{"key":"ref_400","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1208\/s12249-017-0833-y","article-title":"Effective Skin Cancer Treatment by Topical Co-delivery of Curcumin and STAT3 siRNA Using Cationic Liposomes","volume":"19","author":"Jose","year":"2018","journal-title":"AAPS PharmSciTech"},{"key":"ref_401","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ijpharm.2016.09.014","article-title":"Effect of quercetin and resveratrol co-incorporated in liposomes against inflammatory\/oxidative response associated with skin cancer","volume":"513","author":"Caddeo","year":"2016","journal-title":"Int. J. Pharm."},{"key":"ref_402","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jconrel.2018.05.038","article-title":"Skin cancer treatment effectiveness is improved by iontophoresis of EGFR-targeted liposomes containing 5-FU compared with subcutaneous injection","volume":"283","author":"Petrilli","year":"2018","journal-title":"J. Control. Release"},{"key":"ref_403","doi-asserted-by":"crossref","first-page":"82205","DOI":"10.1039\/C6RA16310F","article-title":"Biosynthesized Vitis vinifera seed gold nanoparticles induce apoptotic cell death in A431 skin cancer cells","volume":"6","author":"Nirmala","year":"2016","journal-title":"RSC Adv."},{"key":"ref_404","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/smll.201400775","article-title":"Epirubicin-loaded superparamagnetic iron-oxide nanoparticles for transdermal delivery: Cancer therapy by circumventing the skin barrier","volume":"11","author":"Rao","year":"2015","journal-title":"Small"},{"key":"ref_405","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.pdpdt.2013.03.013","article-title":"Photodynamic therapeutic effect of indocyanine green entrapped in polymeric nanoparticles and their anti-EGFR-conjugate in skin cancer in CD1 mice","volume":"10","author":"Borai","year":"2013","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"ref_406","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ejpb.2015.01.015","article-title":"Bromelain nanoparticles protect against 7,12-dimethylbenz[a]anthracene induced skin carcinogenesis in mouse model","volume":"91","author":"Bhatnagar","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_407","doi-asserted-by":"crossref","first-page":"112440","DOI":"10.1016\/j.colsurfb.2022.112440","article-title":"Emerging trends of nanotechnology in advanced cosmetics","volume":"214","author":"Dubey","year":"2022","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_408","doi-asserted-by":"crossref","unstructured":"Mavridi-Printezi, A., Guernelli, M., Menichetti, A., and Montalti, M. (2020). Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics. Nanomaterials, 10.","DOI":"10.3390\/nano10112276"},{"key":"ref_409","doi-asserted-by":"crossref","unstructured":"Mohd-Setapar, S.H., John, C.P., Mohd-Nasir, H., Azim, M.M., Ahmad, A., and Alshammari, M.B. (2022). Application of Nanotechnology Incorporated with Natural Ingredients in Natural Cosmetics. Cosmetics, 9.","DOI":"10.3390\/cosmetics9060110"},{"key":"ref_410","doi-asserted-by":"crossref","unstructured":"Angelopoulou, P., Giaouris, E., and Gardikis, K. (2022). Applications and Prospects of Nanotechnology in Food and Cosmetics Preservation. Nanomaterials, 12.","DOI":"10.3390\/nano12071196"},{"key":"ref_411","doi-asserted-by":"crossref","unstructured":"Oliveira, C., Coelho, C., Teixeira, J.A., Ferreira-Santos, P., and Botelho, C.M. (2022). Nanocarriers as Active Ingredients Enhancers in the Cosmetic Industry\u2014The European and North America Regulation Challenges. Molecules, 27.","DOI":"10.3390\/molecules27051669"},{"key":"ref_412","doi-asserted-by":"crossref","unstructured":"Das, M.K., and Pathak, Y.V. (2020). Clinical toxicity of nanomedicines. Nano Medicine and Nano Safety, Springer.","DOI":"10.1007\/978-981-15-6255-6"},{"key":"ref_413","doi-asserted-by":"crossref","unstructured":"Gurunathan, S., Qasim, M., Park, C., Yoo, H., Choi, D.Y., Song, H., Park, C., Kim, J.H., and Hong, K. (2018). Cytotoxicity and Transcriptomic Analysis of Silver Nanoparticles in Mouse Embryonic Fibroblast Cells. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19113618"},{"key":"ref_414","doi-asserted-by":"crossref","unstructured":"Abbasi, B.H., Shah, M., Hashmi, S.S., Nazir, M., Naz, S., Ahmad, W., Khan, I.U., and Hano, C. (2019). Green Bio-Assisted Synthesis, Characterization and Biological Evaluation of Biocompatible ZnO NPs Synthesized from Different Tissues of Milk Thistle (Silybum marianum). Nanomaterials, 9.","DOI":"10.3390\/nano9081171"},{"key":"ref_415","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1080\/21691401.2017.1307216","article-title":"Assessment of radical scavenging, whitening and moisture retention activities of Panax ginseng berry mediated gold nanoparticles as safe and efficient novel cosmetic material","volume":"46","author":"Kim","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_416","doi-asserted-by":"crossref","first-page":"111004","DOI":"10.1016\/j.colsurfb.2020.111004","article-title":"A Novel Biochemical Study of Anti-Ageing Potential of Eucalyptus Camaldulensis Bark Waste Standardized Extract and Silver Nanoparticles","volume":"191","author":"Radwan","year":"2020","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_417","doi-asserted-by":"crossref","unstructured":"Shibuya, S., Ozawa, Y., Watanabe, K., Izuo, N., Toda, T., Yokote, K., and Shimizu, T. (2014). Palladium and platinum nanoparticles attenuate aging-like skin atrophy via antioxidant activity in mice. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0109288"},{"key":"ref_418","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jgr.2017.04.003","article-title":"Applications of Panax ginseng leaves-mediated gold nanoparticles in cosmetics relation to antioxidant, moisture retention, and whitening effect on B16BL6 cells","volume":"42","author":"Singh","year":"2018","journal-title":"J. Ginseng Res."},{"key":"ref_419","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1038\/s41598-019-39486-7","article-title":"Photoprotection of Cerium Oxide Nanoparticles against UVA radiation-induced Senescence of Human Skin Fibroblasts due to their Antioxidant Properties","volume":"9","author":"Li","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_420","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jconrel.2014.02.004","article-title":"Lecithin-based nanostructured gels for skin delivery: An update on state of art and recent applications","volume":"180","author":"Elnaggar","year":"2014","journal-title":"J. Control. Release"},{"key":"ref_421","doi-asserted-by":"crossref","unstructured":"Bi, Y., Xia, H., Li, L., Lee, R.J., Xie, J., Liu, Z., Qiu, Z., and Teng, L. (2019). Liposomal Vitamin D3 as an Anti-aging Agent for the Skin. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11070311"},{"key":"ref_422","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ijpharm.2010.05.006","article-title":"Preparation and characterization of liposomal coenzyme Q10 for in vivo topical application","volume":"395","author":"Lee","year":"2010","journal-title":"Int. J. Pharm."},{"key":"ref_423","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3109\/1061186X.2015.1077845","article-title":"Systematically optimized coenzyme q10-loaded novel proniosomal formulation for treatment of photo-induced aging in mice: Characterization, biocompatibility studies, biochemical estimations and anti-aging evaluation","volume":"24","author":"Yadav","year":"2016","journal-title":"J. Drug Target."},{"key":"ref_424","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1080\/02652048.2019.1617363","article-title":"Anti-aging formulation of rosmarinic acid-loaded ethosomes and liposomes","volume":"36","year":"2019","journal-title":"J. Microencapsul."},{"key":"ref_425","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.ejpb.2013.09.008","article-title":"The clinical efficacy of cosmeceutical application of liquid crystalline nanostructured dispersions of alpha lipoic acid as anti-wrinkle","volume":"86","author":"Sherif","year":"2014","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_426","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3109\/13880209.2011.596206","article-title":"Anti-aging efficacy of topical formulations containing niosomes entrapped with rice bran bioactive compounds","volume":"50","author":"Manosroi","year":"2012","journal-title":"Pharm. Biol."},{"key":"ref_427","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.ejpb.2004.05.010","article-title":"The effect of cholate on solubilisation and permeability of simple and protein-loaded phosphatidylcholine\/sodium cholate mixed aggregates designed to mediate transdermal delivery of macromolecules","volume":"58","author":"Marques","year":"2004","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_428","unstructured":"Chung, E.-J., Leon, L., and Rinaldi, C. (2019). Nanoemulsions. Nanoparticles for Biomedical Applications, Elsevier. [1st ed.]."},{"key":"ref_429","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1007\/s13346-019-00655-w","article-title":"Anti-pollution cosmetic-based one-step formation of w\/o\/w multiple emulsion containing D-biotin for skin protection: Fabrication and in vitro and in vivo evaluation","volume":"9","author":"Ali","year":"2019","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_430","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jphotobiol.2015.09.005","article-title":"Photoprotection by Punica granatum seed oil nanoemulsion entrapping polyphenol-rich ethyl acetate fraction against UVB-induced DNA damage in human keratinocyte (HaCaT) cell line","volume":"153","author":"Baccarin","year":"2015","journal-title":"J. Photochem. Photobiol. B."},{"key":"ref_431","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ijpharm.2010.04.029","article-title":"Enhancement of stability and skin permeation by sucrose stearate and cyclodextrins in progesterone nanoemulsions","volume":"393","author":"Klang","year":"2010","journal-title":"Int. J. Pharm."},{"key":"ref_432","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.ijpharm.2007.11.051","article-title":"Hydrogel-thickened nanoemulsion system for topical delivery of lipophilic drugs","volume":"353","author":"Mou","year":"2008","journal-title":"Int. J. Pharm."},{"key":"ref_433","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ejps.2014.12.006","article-title":"Topical delivery of acetyl hexapeptide-8 from different emulsions: Influence of emulsion composition and internal structure","volume":"68","author":"Hoppel","year":"2015","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_434","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/j.procbio.2015.08.001","article-title":"Bio\/sonochemical conversion of fish backbones into bioactive nanospheres","volume":"50","author":"Fernandes","year":"2015","journal-title":"Process Biochem."},{"key":"ref_435","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ijpharm.2018.01.054","article-title":"Dermal anti-oxidant, anti-inflammatory and anti-aging effects of Compritol ATO-based Resveratrol colloidal carriers prepared using mixed surfactants","volume":"541","author":"Abbas","year":"2018","journal-title":"Int. J. Pharm."},{"key":"ref_436","doi-asserted-by":"crossref","first-page":"3757","DOI":"10.1021\/cr010350j","article-title":"Reduced transition metal colloids: A novel family of reusable catalysts?","volume":"102","author":"Roucoux","year":"2002","journal-title":"Chem. Rev."},{"key":"ref_437","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1111\/j.1600-0625.2010.01128.x","article-title":"Protective effects of platinum nanoparticles against UV-light-induced epidermal inflammation","volume":"19","author":"Yoshihisa","year":"2010","journal-title":"Exp. Dermatol."},{"key":"ref_438","doi-asserted-by":"crossref","first-page":"326","DOI":"10.3109\/10715762.2010.532494","article-title":"SOD\/catalase mimetic platinum nanoparticles inhibit heat-induced apoptosis in human lymphoma U937 and HH cells","volume":"45","author":"Yoshihisa","year":"2011","journal-title":"Free Radic. Res."},{"key":"ref_439","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.saa.2012.10.063","article-title":"Antimicrobial and antitumor activity of platinum and palladium complexes of novel spherical aramides nanoparticles containing flexibilizing linkages: Structure-property relationship","volume":"103","author":"Elhusseiny","year":"2013","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"ref_440","unstructured":"Ishizuka, S. (1956). Generation of PAPLAL, Juseikai. (In Japanese)."},{"key":"ref_441","first-page":"635","article-title":"Antioxidant activity of PAPLAL a colloidal mixture of Pt and Pd metal to superoxide anion radical as studied by quantitative spin trapping ESR measurements","volume":"15","author":"Tajima","year":"2005","journal-title":"Clin. Phamacol. Ther."},{"key":"ref_442","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1080\/17435390.2020.1860264","article-title":"In vivo percutaneous permeation of gold nanomaterials in consumer cosmetics: Implication in dermal safety assessment of consumer nanoproducts","volume":"15","author":"Cao","year":"2021","journal-title":"Nanotoxicology"},{"key":"ref_443","doi-asserted-by":"crossref","unstructured":"Flieger, J., Flieger, W., Baj, J., and Maciejewski, R. (2021). Antioxidants: Classification, Natural Sources, Activity\/Capacity Measurements, and Usefulness for the Synthesis of Nanoparticles. Materials, 14.","DOI":"10.3390\/ma14154135"},{"key":"ref_444","doi-asserted-by":"crossref","unstructured":"Flieger, J., Franus, W., Panek, R., Szyma\u0144ska-Chargot, M., Flieger, W., Flieger, M., and Ko\u0142odziej, P. (2021). Green Synthesis of Silver Nanoparticles Using Natural Extracts with Proven Antioxidant Activity. Molecules, 26.","DOI":"10.3390\/molecules26164986"},{"key":"ref_445","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1039\/c0nr00875c","article-title":"Pharmacological potential of cerium oxide nanoparticles","volume":"3","author":"Celardo","year":"2011","journal-title":"Nanoscale"},{"key":"ref_446","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/ics.12131","article-title":"Aqueous dispersions of organogel nanoparticles\u2013potential systems for cosmetic and dermo-cosmetic applications","volume":"36","author":"Kirilov","year":"2014","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_447","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jcis.2017.01.115","article-title":"Curcumin-functionalized silk biomaterials for anti-aging utility","volume":"496","author":"Yang","year":"2017","journal-title":"J. Colloid Interface Sci."},{"key":"ref_448","first-page":"3420204","article-title":"Role of Nanotechnology in Cosmeceuticals: A Review of Recent Advances","volume":"2018","author":"Kaul","year":"2018","journal-title":"J. Pharm."},{"key":"ref_449","doi-asserted-by":"crossref","first-page":"843687","DOI":"10.1155\/2014\/843687","article-title":"Nanotechnology-based cosmeceuticals","volume":"2014","author":"Lohani","year":"2014","journal-title":"ISRN Dermatol."},{"key":"ref_450","doi-asserted-by":"crossref","unstructured":"Ferraris, C., Rimicci, C., Garelli, S., Ugazio, E., and Battaglia, L. (2021). Nanosystems in Cosmetic Products: A Brief Overview of Functional, Market, Regulatory and Safety Concerns. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13091408"},{"key":"ref_451","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/bmb\/ldg026","article-title":"Environmental effects and skin disease","volume":"68","author":"English","year":"2003","journal-title":"Br. Med. Bull."},{"key":"ref_452","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1039\/C4GC02261K","article-title":"Opportunities for greener alternatives in chemical formulations","volume":"17","author":"Jessop","year":"2015","journal-title":"Green Chem."},{"key":"ref_453","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.ejpb.2016.06.014","article-title":"Heptapeptide-loaded solid lipid nanoparticles for cosmetic anti-aging applications","volume":"108","author":"Suter","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_454","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1038\/s41598-017-02419-3","article-title":"Anti-Aging Potentials of Methylene Blue for Human Skin Longevity","volume":"7","author":"Xiong","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_455","doi-asserted-by":"crossref","unstructured":"Rembiesa, J., Ruzgas, T., Engblom, J., and Holefors, A. (2018). The Impact of Pollution on Skin and Proper Efficacy Testing for Anti-Pollution Claims. Cosmetics, 5.","DOI":"10.3390\/cosmetics5010004"},{"key":"ref_456","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1177\/1533210110392947","article-title":"Biological effects of pharmacological concentrations of biotin","volume":"16","year":"2011","journal-title":"J. Evid. Based Complement Altern. Med."},{"key":"ref_457","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jep.2016.05.002","article-title":"Eupafolin ameliorates COX-2 expression and PGE2 production in particulate pollutants-exposed human keratinocytes through ROS\/MAPKs pathways","volume":"189","author":"Lee","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"ref_458","doi-asserted-by":"crossref","first-page":"3907","DOI":"10.2147\/IJN.S109062","article-title":"Eupafolin nanoparticles protect HaCaT keratinocytes from particulate matter-induced inflammation and oxidative stress","volume":"11","author":"Lin","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"ref_459","doi-asserted-by":"crossref","unstructured":"Lee, C.W., Su, Y.H., Chiang, Y.C., Lee, I.T., Li, S.Y., Lee, H.C., Hsu, L.F., Yan, Y.L., Li, H.Y., and Chen, M.C. (2020). Glycofullerenes Inhibit Particulate Matter Induced Inflammation and Loss of Barrier Proteins in HaCaT Human Keratinocytes. Biomolecules, 10.","DOI":"10.3390\/biom10040514"},{"key":"ref_460","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.aquatox.2012.08.021","article-title":"Sub-lethal effects of titanium dioxide nanoparticles on the physiology and reproduction of zebrafish","volume":"126","author":"Ramsden","year":"2013","journal-title":"Aquat. Toxicol."},{"key":"ref_461","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.aquatox.2015.02.006","article-title":"Combined toxicity of two crystalline phases (anatase and rutile) of Titania nanoparticles towards freshwater microalgae: Chlorella sp","volume":"161","author":"Iswarya","year":"2015","journal-title":"Aquat. Toxicol."},{"key":"ref_462","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.impact.2016.06.004","article-title":"Zinc oxide nanoparticles trigger cardiorespiratory stress and reduce aerobic scope in the white sucker, Catostomus commersonii","volume":"2","author":"Callaghan","year":"2016","journal-title":"NanoImpact"},{"key":"ref_463","doi-asserted-by":"crossref","first-page":"156079","DOI":"10.1016\/j.scitotenv.2022.156079","article-title":"Effects of wastewater-spiked nanoparticles of silver and titanium dioxide on survival, growth, reproduction and biochemical markers of Daphnia magna","volume":"839","author":"Galhano","year":"2022","journal-title":"Sci. Total. Environ."},{"key":"ref_464","doi-asserted-by":"crossref","first-page":"137974","DOI":"10.1016\/j.scitotenv.2020.137974","article-title":"Chronic effects of wastewater-borne silver and titanium dioxide nanoparticles on the rainbow trout (Oncorhynchus mykiss)","volume":"723","author":"Zeumer","year":"2020","journal-title":"Sci. Total. Environ."},{"key":"ref_465","doi-asserted-by":"crossref","unstructured":"Gojznikar, J., Zdravkovi\u0107, B., Vidak, M., Lesko\u0161ek, B., and Ferk, P. (2022). TiO2 Nanoparticles and Their Effects on Eukaryotic Cells: A Double-Edged Sword. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232012353"},{"key":"ref_466","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s11671-010-9751-6","article-title":"Biocompatibility of Graphene Oxide","volume":"6","author":"Wang","year":"2011","journal-title":"Nanoscale Res. Lett."},{"key":"ref_467","doi-asserted-by":"crossref","first-page":"5949595","DOI":"10.1155\/2022\/5949595","article-title":"Cytotoxicity, Removal of Congo Red Dye in Aqueous Solution Using Synthesized Amorphous Iron Oxide Nanoparticles from Incense Sticks Ash Waste","volume":"2022","author":"Gnanamoorthy","year":"2022","journal-title":"J. Nanomater."},{"key":"ref_468","doi-asserted-by":"crossref","unstructured":"Paramo, L.A., Feregrino-P\u00e9rez, A.A., Guevara, R., Mendoza, S., and Esquivel, K. (2020). Nanoparticles in Agroindustry: Applications, Toxicity, Challenges, and Trends. Nanomaterials, 10.","DOI":"10.3390\/nano10091654"},{"key":"ref_469","doi-asserted-by":"crossref","first-page":"113202","DOI":"10.1016\/j.envres.2022.113202","article-title":"The impact of engineered nanomaterials on the environment: Release mechanism, toxicity, transformation, and remediation","volume":"212","author":"Karthick","year":"2022","journal-title":"Environ. Res."},{"key":"ref_470","unstructured":"Rajput, V., Minkina, T., Sushkova, S., Mandzhieva, S., and Rensing, C. (2022). Toxicity of Nanoparticles in Plants, Academic Press."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/24\/15980\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:42:01Z","timestamp":1760146921000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/24\/15980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,15]]},"references-count":470,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["ijms232415980"],"URL":"https:\/\/doi.org\/10.3390\/ijms232415980","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,15]]}}}