{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:56:00Z","timestamp":1762080960784,"version":"build-2065373602"},"reference-count":46,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T00:00:00Z","timestamp":1671148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hospital Universitario Mayor M\u00e9deri"},{"name":"Universidad del Rosario"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Primary breast angiosarcoma, with de novo appearance and not associated with exposure to radiation or lymphedema, is a rare pathology representing less than 0.05% of the neoplasms related to this organ. The pathology is characterized by its aggressiveness, poor prognosis, and difficulties in its differential diagnosis. This article reports the case of a 55-year-old white woman with no family history of cancer, with a rapidly growing mass in the left mammary gland that ulcerates and bleeds. It is confirmed as primary breast angiosarcoma by immunostaining in the tumor tissue for CD31, CD34, and FLI-1. In addition, a sample of neoplastic and healthy tissues is collected from the patient for RNA sequencing; the results are contrasted with a tissue sample from a patient with Luminal A subtype of breast cancer, as well as data from other cases of angiosarcoma available in public databases. These findings revealed a genetic profile associated with the immune and inflammatory response in the patient\u2019s sample when compared to available angiosarcoma data; these molecular patterns are consistent with other recent studies. Due to the rarity of the disease, the studies carried out on each patient contribute to the expanding knowledge of the etiology and molecular pathways that are still partially known and continue to be the subject of research. Aside from a comparative transcriptome study, this article aims to provide an update on the state of knowledge about this disease.<\/jats:p>","DOI":"10.3390\/ijms232416032","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T04:54:13Z","timestamp":1671425653000},"page":"16032","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Primary Breast Angiosarcoma: Comparative Transcriptome Analysis"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6654-0195","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Rinc\u00f3n-Riveros","sequence":"first","affiliation":[{"name":"Bioinformatics and Systems Biology Group, Universidad Nacional de Colombia, Bogot\u00e1 111221, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jairo","family":"De la Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Servicio de Mastolog\u00eda, Hospital Universitario Mayor M\u00e9deri, Bogot\u00e1 111411, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilson","family":"Rubiano","sequence":"additional","affiliation":[{"name":"Servicio de Mastolog\u00eda, Hospital Universitario Mayor M\u00e9deri, Bogot\u00e1 111411, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Olivella","sequence":"additional","affiliation":[{"name":"Servicio de Mastolog\u00eda, Hospital Universitario Mayor M\u00e9deri, Bogot\u00e1 111411, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6450-0184","authenticated-orcid":false,"given":"Mar\u00eda","family":"Martinez-Ag\u00fcero","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones en Microbiolog\u00eda y Biotecnolog\u00eda-UR (CIMBIUR), Facultad de Ciencias Naturales, Universidad del Rosario, Bogot\u00e1 111221, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4149-2307","authenticated-orcid":false,"given":"Victoria E.","family":"Villegas","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones en Microbiolog\u00eda y Biotecnolog\u00eda-UR (CIMBIUR), Facultad de Ciencias Naturales, Universidad del Rosario, Bogot\u00e1 111221, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.rpor.2013.10.003","article-title":"Primary angiosarcoma of the breast complicated by the syndrome of disseminated intravascular coagulation (DIC): Case report and literature review","volume":"19","author":"Alexandrova","year":"2014","journal-title":"Rep. 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