{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:17:51Z","timestamp":1780478271882,"version":"3.54.1"},"reference-count":206,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T00:00:00Z","timestamp":1671408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Research, Innovation and Digitization","award":["PN-III-P2-2.1-PED-2019-4524"],"award-info":[{"award-number":["PN-III-P2-2.1-PED-2019-4524"]}]},{"name":"Ministry of Research, Innovation and Digitization","award":["PN-III-P1-1.1-PD-2019-0937"],"award-info":[{"award-number":["PN-III-P1-1.1-PD-2019-0937"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The need for bone substitutes is a major challenge as the incidence of serious bone disorders is massively increasing, mainly attributed to modern world problems, such as obesity, aging of the global population, and cancer incidence. Bone cancer represents one of the most significant causes of bone defects, with reserved prognosis regarding the effectiveness of treatments and survival rate. Modern therapies, such as hyperthermia, immunotherapy, targeted therapy, and magnetic therapy, seem to bring hope for cancer treatment in general, and bone cancer in particular. Mimicking the composition of bone to create advanced scaffolds, such as bone substitutes, proved to be insufficient for successful bone regeneration, and a special attention should be given to control the changes in the bone tissue micro-environment. The magnetic manipulation by an external field can be a promising technique to control this micro-environment, and to sustain the proliferation and differentiation of osteoblasts, promoting the expression of some growth factors, and, finally, accelerating new bone formation. By incorporating stimuli responsive nanocarriers in the scaffold\u2019s architecture, such as magnetic nanoparticles functionalized with bioactive molecules, their behavior can be rigorously controlled under external magnetic driving, and stimulates the bone tissue formation.<\/jats:p>","DOI":"10.3390\/ijms232416190","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T05:25:46Z","timestamp":1671427546000},"page":"16190","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Advanced 3D Magnetic Scaffolds for Tumor-Related Bone Defects"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8076-6414","authenticated-orcid":false,"given":"Florina-Daniela","family":"Cojocaru","sequence":"first","affiliation":[{"name":"Biomedical Sciences Department, Faculty of Medical Bioengineering, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 9-13 Kogalniceanu Street, 700454 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5255-7586","authenticated-orcid":false,"given":"Vera","family":"Balan","sequence":"additional","affiliation":[{"name":"Biomedical Sciences Department, Faculty of Medical Bioengineering, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 9-13 Kogalniceanu Street, 700454 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3098-8406","authenticated-orcid":false,"given":"Liliana","family":"Verestiuc","sequence":"additional","affiliation":[{"name":"Biomedical Sciences Department, Faculty of Medical Bioengineering, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 9-13 Kogalniceanu Street, 700454 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/2309499020915989","article-title":"Incidence, prevalence, and outcomes of systemic malignancy with bone metastases","volume":"28","author":"Jiang","year":"2020","journal-title":"J. Orthop. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3389\/fbioe.2020.00061","article-title":"Reconstruction of Large Skeletal Defects: Current Clinical Therapeutic Strategies and Future Directions Using 3D Printing","volume":"8","author":"Vidal","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Caravelli, S., Ambrosino, G., Vocale, E., Di Ponte, M., Puccetti, G., Perisano, C., Greco, T., Rinaldi, V.G., Marcheggiani Muccioli, G.M., and Zaffagnini, S. (2022). Custom-Made Implants in Ankle Bone Loss: A Retrospective Assessment of Reconstruction\/Arthrodesis in Sequelae of Septic Non-Union of the Tibial Pilon. Medicina, 58.","DOI":"10.3390\/medicina58111641"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Zaj\u0105czkowska, R., Kocot-K\u0119pska, M., Leppert, W., and Wordliczek, J. (2019). Bone Pain in Cancer Patients: Mechanisms and Current Treatment. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20236047"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"7202","DOI":"10.7150\/jca.48062","article-title":"Prognostic Impact of Bone Metastasis on Survival Outcomes in Patients with Metastatic Renal Cell Carcinoma Treated by First Line Tyrosine Kinase Inhibitors: A Propensity-Score Matching Analysis","volume":"11","author":"Kang","year":"2020","journal-title":"J. Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1016\/j.injury.2021.01.043","article-title":"Autologous bone graft: Is it still the gold standard?","volume":"52","author":"Schmidt","year":"2021","journal-title":"Injury"},{"key":"ref_7","first-page":"224","article-title":"Bone grafts and biomaterials substitutes for bone defect repair: A review","volume":"2","author":"Wang","year":"2017","journal-title":"Bioact. Mater."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Tonk, G., Yadav, P.K., Agarwal, S., and Jamoh, K. (2022). Donor site morbidity in autologous bone grafting\u2014A comparison between different techniques of anterior iliac crest bone harvesting: A prospective study. J. Orthop. Trauma Rehabil., 29.","DOI":"10.1177\/22104917221092163"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s13018-018-0820-3","article-title":"Comparing morbidities of bone graft harvesting from the anterior iliac crest and proximal tibia: A retrospective study","volume":"13","author":"Huang","year":"2018","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Oliveira, \u00c9.R., Nie, L., Podstawczyk, D., Allahbakhsh, A., Ratnayake, J., Brasil, D.L., and Shavandi, A. (2021). Advances in Growth Factor Delivery for Bone Tissue Engineering. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22020903"},{"key":"ref_11","first-page":"421746","article-title":"Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells","volume":"2015","author":"Sasso","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"ref_12","first-page":"90","article-title":"Current Concepts in Scaffolding for Bone Tissue Engineering","volume":"6","author":"Ghassemi","year":"2018","journal-title":"Arch. Bone Jt. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1089\/ten.teb.2012.0012","article-title":"Vascularized bone tissue engineering: Approaches for potential improvement","volume":"18","author":"Nguyen","year":"2012","journal-title":"Tissue Eng. Part B Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40824-018-0149-3","article-title":"Bioactive calcium phosphate materials and applications in bone regeneration","volume":"23","author":"Jeong","year":"2019","journal-title":"Biomater. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1517\/17425247.2013.808183","article-title":"Composite polymer-bioceramic scaffolds with drug delivery capability for bone tissue engineering","volume":"10","author":"Cattalini","year":"2013","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e1901058","DOI":"10.1002\/adhm.201901058","article-title":"Magnetic Nanoparticles in Cancer Therapy and Diagnosis","volume":"9","author":"Farzin","year":"2020","journal-title":"Adv. Healthc. Mater."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Singh, R.K., Patel, K.D., Lee, J.H., Lee, E.J., Kim, J.H., Kim, T.H., and Kim, H.W. (2014). Potential of magnetic nanofiber scaffolds with mechanical and biological properties applicable for bone regeneration. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0091584"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1177\/0022034510377791","article-title":"Aging and bone","volume":"89","author":"Boskey","year":"2010","journal-title":"J. Dent. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"4611","DOI":"10.1002\/smll.201600626","article-title":"Hierarchical Structures of Bone and Bioinspired Bone Tissue Engineering","volume":"12","author":"Liu","year":"2016","journal-title":"Small"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/s41368-021-00147-z","article-title":"Advances in biomineralization-inspired materials for hard tissue repair","volume":"13","author":"Tang","year":"2021","journal-title":"Int. J. Oral Sci."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Ki, J.M., Lin, C., Stavre, Z., Greenblatt, M.B., and Shim, J.H. (2020). Osteoblast-Osteoclast Communication and Bone Homeostasis. Cells, 9.","DOI":"10.3390\/cells9092073"},{"key":"ref_22","unstructured":"Rowe, P., Koller, A., and Sharma, S. (2022, October 20). Physiology, Bone Remodeling, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK499863\/."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1177\/0004563218759371","article-title":"The bone remodelling cycle","volume":"55","author":"Kenkre","year":"2018","journal-title":"Ann. Clin. Biochem."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Nakamura-Utsunomiya, A. (2021). Bone Biomarkers in Mucopolysaccharidoses. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222312651"},{"key":"ref_25","first-page":"1017","article-title":"Osteoporosis: Pathophysiology and therapeutic options","volume":"19","author":"Dovjak","year":"2020","journal-title":"EXCLI J."},{"key":"ref_26","first-page":"125705","article-title":"The Role of Inflammatory Cytokines, the RANKL\/OPG Axis, and the Immunoskeletal Interface in Physiological Bone Turnover and Osteoporosis","volume":"29","year":"2013","journal-title":"Scientifica"},{"key":"ref_27","first-page":"347","article-title":"Biological basis of bone strength: Anatomy, physiology and measurement","volume":"20","author":"Hart","year":"2020","journal-title":"J. Musculoskelet. Neuronal Interact."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1152\/physiol.00061.2014","article-title":"Physiological Bone Remodeling: Systemic Regulation and Growth Factor Involvement","volume":"31","author":"Siddiqui","year":"2016","journal-title":"Physiology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s41232-019-0111-3","article-title":"RANKL biology: Bone metabolism, the immune system, and beyond","volume":"40","author":"Ono","year":"2020","journal-title":"Inflamm. Regen."},{"key":"ref_30","unstructured":"Rangel, L.B.A., Kirubamani, H., Silva, I.V., and Lyra, P.C.M. (2020). Bone Tumors: Types and Treatments, Hormone. Hormone Therapy and Replacement in Cancer and Aging-Related Diseases, IntechOpen."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00428-021-03141-2","article-title":"Grading of invasive breast carcinoma: The way forward","volume":"480","author":"Ellis","year":"2022","journal-title":"Virchows Arch."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"567844","DOI":"10.3389\/fendo.2020.567844","article-title":"Osteocytes and Bone Metastasis","volume":"11","author":"Riquelme","year":"2020","journal-title":"Front. Endocrinol."},{"key":"ref_33","first-page":"205","article-title":"Bone Cancer: Diagnosis and Treatment Principles","volume":"98","author":"Ferguson","year":"2018","journal-title":"Am. Fam. Physician"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1083\/jcb.200507106","article-title":"p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling","volume":"172","author":"Wang","year":"2006","journal-title":"J. Cell. Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1002\/stem.1647","article-title":"Bone Environment is Essential for Osteosarcoma Development from Transformed Mesenchymal Stem Cells","volume":"32","author":"Rubio","year":"2014","journal-title":"Stem Cells"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"625199","DOI":"10.3389\/fonc.2020.625199","article-title":"Game of Bones: How myeloma manipulates its microenvironment","volume":"10","author":"Joseph","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_37","first-page":"e2021552","article-title":"Surgical management of tibial metastases: A systematic review","volume":"92","author":"Greco","year":"2022","journal-title":"Acta Biomed."},{"key":"ref_38","first-page":"321","article-title":"Bone Metastases: An Overview","volume":"11","author":"Macedo","year":"2017","journal-title":"Oncol. Rev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/35065016","article-title":"Involvement of chemokine receptors in breast cancer metastasis","volume":"410","author":"Homey","year":"2001","journal-title":"Nature"},{"key":"ref_40","first-page":"1832","article-title":"Use of the stromal cell-derived factor-1\/CXCR4 pathway in prostate cancer metastasis to bone","volume":"62","author":"Taichman","year":"2002","journal-title":"Cancer Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.critrevonc.2013.08.013","article-title":"Bone sialoprotein and osteopontin in bone metastasis of osteotropic cancers","volume":"89","author":"Kruger","year":"2014","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"883523","DOI":"10.3389\/fcell.2022.883523","article-title":"Bone Morphogenetic Protein Signaling in Cancer; Some Topics in the Recent 10 Years","volume":"10","author":"Ehata","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1080\/08977190801987166","article-title":"BMP4 induces an epithelial-mesenchymal transition-like response in adult airway epithelial cells","volume":"26","author":"Molloy","year":"2008","journal-title":"Growth Factors"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cancergen.2012.05.009","article-title":"Bone morphogenetic protein 4-a fascinating regulator of cancer cell behavior","volume":"205","author":"Kallioniemi","year":"2012","journal-title":"Cancer Genet."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"692800","DOI":"10.3389\/fcell.2021.692800","article-title":"Macrophages in Acute Myeloid Leukaemia: Significant Players in Therapy Resistance and Patient Outcomes","volume":"9","author":"Miari","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Ban, J., Fock, V., Aryee, D.N.T., and Kovar, H. (2021). Mechanisms, Diagnosis and Treatment of Bone Metastases. Cells, 10.","DOI":"10.3390\/cells10112944"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13058-019-1117-0","article-title":"Osteoblasts are \u201ceducated\u201d by crosstalk with metastatic breast cancer cells in the bone tumor microenvironment","volume":"21","author":"Kolb","year":"2019","journal-title":"Breast Cancer Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s41413-022-00219-8","article-title":"Bone remodeling: An operational process ensuring survival and bone mechanical competence","volume":"10","author":"Bolamperti","year":"2022","journal-title":"Bone Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00109-013-1084-3","article-title":"Function of matrix IGF-1 in coupling bone resorption and formation","volume":"92","author":"Crane","year":"2014","journal-title":"J. Mol. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1101\/gad.314617.118","article-title":"Roles of the immune system in cancer: From tumor initiation to metastatic progression","volume":"32","author":"Gonzalez","year":"2018","journal-title":"Genes Dev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.bbrc.2004.11.070","article-title":"Crosstalk between cancer cells and bone microenvironment in bone metastasis","volume":"328","author":"Yoneda","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_52","first-page":"82","article-title":"Cross-talk between T cells and osteoclasts in bone resorption","volume":"1","author":"Roato","year":"2012","journal-title":"Bonekey Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.job.2019.02.002","article-title":"Bone metastasis: Interaction between cancer cells and bone microenvironment","volume":"61","author":"Hiraga","year":"2019","journal-title":"J. Oral Biosci."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Tamma, R., and Ribatti, D. (2017). Bone Niches, Hematopoietic Stem Cells, and Vessel Formation. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18010151"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.tips.2015.04.006","article-title":"New therapeutic targets for cancer bone metastasis","volume":"36","author":"Krzeszinski","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1158\/1541-7786.MCR-11-0404","article-title":"Disseminated prostate cancer cells can instruct ematopoietic stem and progenitor cells to regulate bone phenotype","volume":"10","author":"Joseph","year":"2012","journal-title":"Mol. Cancer Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.pharmthera.2013.01.014","article-title":"Cancer stem cells and their role in metastasis","volume":"138","author":"Shiozawa","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.stem.2012.05.007","article-title":"Cancer stem cells: Current status and evolving complexities","volume":"10","author":"Visvader","year":"2012","journal-title":"Cell Stem Cell"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13045-018-0605-5","article-title":"The biology and role of CD44 in cancer progression: Therapeutic implications","volume":"11","author":"Chen","year":"2018","journal-title":"J. Hematol. Oncol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"4112","DOI":"10.1158\/0008-5472.CAN-12-3801","article-title":"Cancer stem-like cell marker CD44 promotes bone metastases by enhancing tumorigenicity, cell motility, and hyaluronan production","volume":"73","author":"Hiraga","year":"2013","journal-title":"Cancer Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"4939","DOI":"10.2147\/DDDT.S337925","article-title":"New Progress in Improving the Delivery Methods of Bisphosphonates in the Treatment of Bone Tumors","volume":"15","author":"Zhong","year":"2021","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"428","DOI":"10.2174\/1574888X15666200101122505","article-title":"Preparation and Application of Magnetic Responsive Materials","volume":"15","author":"Li","year":"2020","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Cojocaru, F.D., Balan, V., Popa, I.M., Munteanu, A., Anghelache, A., and Verestiuc, L. (2019). Magnetic Composite Scafolds for Potential Applications in Radiochemotherapy of Malignant Bone Tumors. Medicina, 55.","DOI":"10.3390\/medicina55050153"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1200\/JCO.2017.75.1743","article-title":"Osteosarcoma, Chondrosarcoma, and Chordoma","volume":"36","author":"Whelan","year":"2018","journal-title":"J. Clin. Oncol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e28352","DOI":"10.1002\/pbc.28352","article-title":"Osteosarcoma","volume":"68","author":"Eaton","year":"2021","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1080\/10717544.2020.1856225","article-title":"The optimized drug delivery systems of treating cancer bone metastatic osteolysis with nanomaterials","volume":"28","author":"Cheng","year":"2021","journal-title":"Drug Deliv."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Habash, R.W.Y., and Romanovsky, A.A. (2018). Therapeutic hyperthermia. Handbook of Clinical Neurology, Elsevier. [3rd ed.].","DOI":"10.1016\/B978-0-444-64074-1.00053-7"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Kargozar, S., Mollazadeh, S., Kermani, F., Webster, T.J., Nazarnezhad, S., Hamzehlou, S., and Baino, F. (2022). Hydroxyapatite Nanoparticles for Improved Cancer Theranostics. J. Funct. Biomater., 13.","DOI":"10.3390\/jfb13030100"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s10147-011-0217-3","article-title":"A novel hyperthermia treatment for bone metastases using magnetic materials","volume":"16","author":"Matsumine","year":"2011","journal-title":"Int. J. Clin. Oncol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"110579","DOI":"10.1016\/j.msec.2019.110579","article-title":"Hierarchical porous Mg2SiO4-CoFe2O4 nanomagnetic scaffold for bone cancer therapy and regeneration: Surface modification and in vitro studies","volume":"109","author":"Bigham","year":"2020","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"110676","DOI":"10.1016\/j.matdes.2022.110676","article-title":"Novel degradable super-paramagnetic bone cement with self-controlled hyperthermia ability","volume":"218","author":"Zhao","year":"2022","journal-title":"Mater. Des."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jssc.2018.01.001","article-title":"Threshold heating temperature for magnetic hyperthermia: Controlling the heat exchange with the blocking temperature of magnetic nanoparticles","volume":"260","author":"Pimentel","year":"2018","journal-title":"J. Solid State Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.jallcom.2018.02.174","article-title":"Induction heating and in vitro cytotoxicity studies of MnZnFe2O4 nanoparticles for self-controlled magnetic particle hyperthermia","volume":"745","author":"Jadhav","year":"2018","journal-title":"J. Alloys Compd."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"100318","DOI":"10.1016\/j.mtbio.2022.100318","article-title":"Bifunctional scaffolds for tumor therapy and bone regeneration: Synergistic effect and interplay between therapeutic agents and scaffold materials","volume":"15","author":"Yuan","year":"2022","journal-title":"Mater. Today Bio"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.scib.2020.04.012","article-title":"Biomaterial scaffold-based local drug delivery systems for cancer immunotherapy","volume":"65","author":"Yang","year":"2020","journal-title":"Sci. Bull."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2006214","DOI":"10.1002\/adfm.202006214","article-title":"Combinatorial photothermal 3D-printing scaffold and checkpoint blockade inhibits growth\/metastasis of breast cancer to bone and accelerates osteogenesis","volume":"31","author":"He","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"e27227","DOI":"10.1002\/pbc.27227","article-title":"Immunotherapy for osteosarcoma: Where do we go from here?","volume":"65","author":"Wedekind","year":"2018","journal-title":"Pediatr. Blood Canc."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Yoshida, K., Okamoto, M., Sasaki, J., Kuroda, C., Ishida, H., Ueda, K., Ideta, H., Kamanaka, T., Sobajima, A., and Takizawa, T. (2020). Anti-PD-1 antibody decreases tumour-infiltrating regulatory T cells. BMC Cancer, 20.","DOI":"10.1186\/s12885-019-6499-y"},{"key":"ref_79","first-page":"289","article-title":"Evaluation of PD1 and PD-L1 expression in high-grade sarcomas of the limbs in the adults: Possible implications of immunotherapy","volume":"34","author":"Perisano","year":"2020","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s40425-015-0067-z","article-title":"Combination immunotherapy with alpha-CTLA-4 and alpha-PD-L1 antibody blockade prevents immune escape and leads to complete control of metastatic osteosarcoma","volume":"3","author":"Lussier","year":"2015","journal-title":"J. Immunother. Cancer"},{"key":"ref_81","unstructured":"(2022, October 10). Available online: https:\/\/ccr.cancer.gov\/research\/cancer-moonshot\/center-for-cell-based-therapy."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/s41392-022-01134-4","article-title":"Stem cell-based therapy for human diseases","volume":"7","author":"Hoang","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Qi, J., Yu, T., Hu, B., Wu, H., and Ouyang, H. (2021). Current Biomaterial-Based Bone Tissue Engineering and Translational Medicine. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221910233"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.nano.2015.02.013","article-title":"Nanotechnology in bone tissue engineering","volume":"11","author":"Walmsley","year":"2015","journal-title":"Nanomedicine"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1002\/btpr.2469","article-title":"Nanoparticles for Bone Tissue Engineering","volume":"33","author":"Vieira","year":"2017","journal-title":"Biotechnol. Progr."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1804922","DOI":"10.1002\/adma.201804922","article-title":"Magnetic Nanomaterials for Advanced Regenerative Medicine: The Promise and Challenges","volume":"31","author":"Liu","year":"2019","journal-title":"Adv. Mater."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1089\/ten.teb.2011.0184","article-title":"The use of micro- and nanospheres as functional components for bone tissue regeneration","volume":"18","author":"Wang","year":"2012","journal-title":"Tissue Eng. Part B Rev."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1007\/s10856-009-3807-0","article-title":"pH and temperature-sensitive polymeric microspheres for drug delivery: The dissolution of copolymers modulates drug release","volume":"20","author":"Fundueanu","year":"2009","journal-title":"J. Mater. Sci Mater. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1263\/jbb.104.288","article-title":"Magnetic force-based cell patterning using Arg\u2013Gly\u2013Asp (RGD) peptide-conjugated magnetite cationic liposomes","volume":"104","author":"Ito","year":"2007","journal-title":"J. Biosci. Bioeng."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"922","DOI":"10.3389\/fbioe.2020.00922","article-title":"Nanostructured Biomaterials for Bone Regeneration","volume":"8","author":"Lyons","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.biomaterials.2016.02.004","article-title":"Response of MAPK pathway to iron oxide nanoparticles in vitro treatment promotes osteogenic differentiation of hBMSCs","volume":"86","author":"Wang","year":"2016","journal-title":"Biomaterials"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/s12274-016-1322-4","article-title":"Magnetic iron oxide nanoparticles accelerate osteogenic differentiation of mesenchymal stem cells via modulation of long noncoding RNA INZEB2","volume":"10","author":"Wang","year":"2017","journal-title":"Nano Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1016\/j.biomaterials.2009.03.032","article-title":"The promotion of human mesenchymal stem cell proliferation by superparamagnetic iron oxide nanoparticles","volume":"30","author":"Huang","year":"2009","journal-title":"Biomaterials"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"19276","DOI":"10.3390\/ijms140919276","article-title":"Receptor-targeted, magneto-mechanical stimulation of osteogenic differentiation of human bone marrow derived mesenchymal stem cells","volume":"14","author":"Hu","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.nano.2013.06.014","article-title":"Control of smooth muscle alpha-actin (SMA) upregulation in HBMSCs using remote magnetic particle mechanoactivation","volume":"10","author":"Hu","year":"2014","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2015.11.007","article-title":"Engineering growth factors for regenerative medicine applications","volume":"30","author":"Mitchell","year":"2016","journal-title":"Acta Biomater."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2217\/rme.14.73","article-title":"The translation of cell-based therapies: Clinical landscape and manufacturing challenges","volume":"10","author":"Heathman","year":"2015","journal-title":"Regen. Med."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1701061","DOI":"10.1002\/adhm.201701061","article-title":"Current Approaches to Bone Tissue Engineering: The Interface between Biology and Engineering","volume":"7","author":"Li","year":"2018","journal-title":"Adv. Healthc. Mater."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.2217\/nnm.12.109","article-title":"Magnetic nanoparticle-based approaches to locally target therapy and enhance tissue regeneration in vivo","volume":"7","author":"Sensenig","year":"2012","journal-title":"Nanomedicine"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.tibtech.2015.06.006","article-title":"Harnessing magnetic-mechano actuation in regenerative medicine and tissue engineering","volume":"33","author":"Santos","year":"2015","journal-title":"Trends Biotechnol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.colsurfb.2015.12.055","article-title":"Proving the suitability of magnetoelectric stimuli for tissue engineering applications","volume":"140","author":"Ribeiro","year":"2016","journal-title":"Colloids Surf."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jmmm.2015.09.004","article-title":"The effect of low static magnetic field on osteogenic and adipogenic differentiation potential of human adipose stromal\/stem cells","volume":"398","author":"Maredziak","year":"2016","journal-title":"J. Magn. Magn. Mater."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.biomaterials.2018.08.040","article-title":"Magnetic field and nano-scaffolds with stem cells to enhance bone Regeneration","volume":"183","author":"Xia","year":"2018","journal-title":"Biomaterials"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3389\/fmats.2019.00268","article-title":"Magnetic Materials in Promoting Bone Regeneration","volume":"6","author":"Peng","year":"2019","journal-title":"Front. Mater."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"201","DOI":"10.5114\/reum.2016.62475","article-title":"The use of magnetic fields in treatment of patients with rheumatoid arthritis. Review of the literature","volume":"54","author":"Kwolek","year":"2016","journal-title":"Reumatologia"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/j.1749-6632.1974.tb26794.x","article-title":"Acceleration of fracture repair by electromagnetic fields\u2014A surgically noninvasive approach","volume":"238","author":"Bassett","year":"1974","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"15001","DOI":"10.1088\/1748-6041\/5\/1\/015001","article-title":"A novel calcium phosphate ceramic-magnetic nanoparticle composite as a potential bone substitute","volume":"5","author":"Wu","year":"2010","journal-title":"Biomed. Mater."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1002\/jbm.a.34167","article-title":"Innovative magnetic scaffolds for orthopedic tissue engineering","volume":"100","author":"Panseri","year":"2012","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s40824-022-00278-2","article-title":"Construction of magnetic nanochains to achieve magnetic energy coupling in scaffold","volume":"26","author":"Shuai","year":"2022","journal-title":"Biomater. Res."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Dasari, A., Xue, J., and Deb, S. (2022). Magnetic Nanoparticles in Bone Tissue Engineering. Nanomaterials, 12.","DOI":"10.3390\/nano12050757"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.msec.2017.05.017","article-title":"Scaffolds for Bone Tissue Engineering: State of the art and new perspectives","volume":"78","author":"Roseti","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_112","first-page":"278","article-title":"3D bioactive composite scaffolds for bone tissue engineering","volume":"3","author":"Turnbull","year":"2017","journal-title":"Bioact. Mater."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Goswami, M., Rekhi, P., Debnath, M., and Ramakrishna, S. (2021). Microbial Polyhydroxyalkanoates Granules: An Approach Targeting Biopolymer for Medical Applications and Developing Bone Scaffolds. Molecules, 26.","DOI":"10.3390\/molecules26040860"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2018.09.031","article-title":"Current state of fabrication technologies and materials for bone tissue engineering","volume":"80","author":"Wubneh","year":"2018","journal-title":"Acta Biomater."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Reddy, M.S.B., Ponnamma, D., Choudhary, R., and Sadasivuni, K.K. (2021). A Comparative Review of Natural and Synthetic Biopolymer Composite Scaffolds. Polymers, 13.","DOI":"10.3390\/polym13071105"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1208\/s12249-022-02242-8","article-title":"3D Printing: Applications in Tissue Engineering, Medical Devices, and Drug Delivery","volume":"23","author":"Kumar","year":"2022","journal-title":"AAPS PharmSciTech"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.actbio.2019.10.038","article-title":"Four-dimensional bioprinting: Current developments and applications in bone tissue engineering","volume":"101","author":"Wan","year":"2020","journal-title":"Acta Biomater."},{"key":"ref_118","unstructured":"(2022, October 08). Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=4D%20printing%20bone%20scaffolds&page=2."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1039\/C7BM00315C","article-title":"3D Printed Porous Ceramic Scaffolds for Bone Tissue Engineering: A Review","volume":"5","author":"Wen","year":"2017","journal-title":"Biomater. Sci."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/jbm.b.34706","article-title":"Review on Current Limits and Potentialities of Technologies for Biomedical Ceramic Scaffolds Production","volume":"109","author":"Marques","year":"2021","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Antoniac, I. (2016). History of Development and Use of the Bioceramics and Biocomposites. Handbook of Bioceramics and Biocomposites, Springer.","DOI":"10.1007\/978-3-319-12460-5"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.actbio.2018.08.026","article-title":"3D-printed Bioceramic Scaffolds: From Bone Tissue Engineering to Tumor Therapy","volume":"79","author":"Ma","year":"2018","journal-title":"Acta Biomater."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"100100","DOI":"10.1016\/j.mtbio.2021.100100","article-title":"Bioactive glasses and glass-ceramics for hyperthermia treatment of cancer: State-of-art, challenges, and future perspectives","volume":"10","author":"Danewalia","year":"2021","journal-title":"Mater. Today Bio"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"484003","DOI":"10.1088\/0953-8984\/25\/48\/484003","article-title":"Thermoseeds for interstitial magnetic hyperthermia: From bioceramics to nanoparticles","volume":"25","author":"Baeza","year":"2013","journal-title":"J. Phys. Condens. Matter."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jmbbm.2017.06.002","article-title":"Synergistic structures from magnetic freeze casting with surface magnetized alumina particles and platelets","volume":"76","author":"Frank","year":"2017","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.msec.2017.03.246","article-title":"Stiff, porous scaffolds from magnetized alumina particles aligned by magnetic freeze casting","volume":"77","author":"Frank","year":"2017","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1016\/j.actbio.2011.06.028","article-title":"Multifunctional magnetic mesoporous bioactive glass scaffolds with a hierarchical pore structure","volume":"7","author":"Wu","year":"2011","journal-title":"Acta Biomater."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Panseri, S., Cunha, C., D\u2019Alessandro, T., Sandri, M., Russo, A., Giavaresi, G., Marcacci, M., Hung, C.T., and Tampieri, A. (2012). Magnetic Hydroxyapatite Bone Substitutes to Enhance Tissue Regeneration: Evaluation In Vitro Using Osteoblast-Like Cells and In Vivo in a Bone Defect. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0038710"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/jbm.b.33836","article-title":"Bone regeneration in a rabbit critical femoral defect by means of magnetic hydroxyapatite macroporous scaffolds: Bone regeneration in rabbit by magnetic HA","volume":"106","author":"Russo","year":"2018","journal-title":"J. Biomed. Mater. Res."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.actbio.2011.09.032","article-title":"Intrinsic magnetism and hyperthermia in bioactive Fe-doped hydroxyapatite","volume":"8","author":"Tampieri","year":"2012","journal-title":"Acta Biomater."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13018-015-0219-3","article-title":"Acceleration of bone-defect repair by using A-W MGC loaded with BMP2 and triple point-mutant HIF1\u03b1-expressing BMSCs","volume":"10","author":"Gao","year":"2015","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1039\/C5TB01524C","article-title":"Superparamagnetic iron-doped nanocrystalline apatite as a delivery system for doxorubicin","volume":"4","author":"Iafisco","year":"2016","journal-title":"J. Mater. Chem. B"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10856-016-5704-7","article-title":"Spherical porous hydroxyapatite granules containing composites of magnetic and hydroxyapatite nanoparticles for the hyperthermia treatment of bone tumor","volume":"27","author":"Kamitakahara","year":"2016","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.msec.2016.08.060","article-title":"Multifunctional magnetic nanostructured hardystonite scaffold for hyperthermia, drug delivery and tissue engineering applications","volume":"70","author":"Farzin","year":"2017","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.jmbbm.2017.10.015","article-title":"Diopside-magnetite; A novel nanocomposite for hyperthermia applications","volume":"77","author":"Abdellahi","year":"2018","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"055006","DOI":"10.1088\/1748-605X\/ac14cc","article-title":"Magnetic 3D scaffolds for tissue engineering applications: Bioactive glass (45S5) coated with iron-loaded hydroxyapatite nanoparticles","volume":"16","author":"Dittler","year":"2021","journal-title":"Biomed. Mater."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"47820","DOI":"10.1021\/acsami.0c12769","article-title":"Elaboration of Superparamagnetic and Bioactive Multicore\u2013Shell Nanoparticles (\u03b3-Fe2O3@SiO2-CaO): A Promising Material for Bone Cancer Treatment","volume":"12","author":"Kesse","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"117680","DOI":"10.1016\/j.carbpol.2021.117680","article-title":"Magnetic bioactive glasses\/Cisplatin loaded-chitosan (CS)-grafted- poly (\u03b5-caprolactone) nanofibers against bone cancer treatment","volume":"258","author":"Amini","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.nano.2017.12.025","article-title":"Magnetic nanoparticles modified-porous scaffolds for bone regeneration and photothermal therapy against tumors","volume":"14","author":"Lu","year":"2018","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"7345","DOI":"10.1038\/s41598-018-25595-2","article-title":"Magnetic Mesoporous Calcium Sillicate\/Chitosan Porous Scaffolds for Enhanced Bone Regeneration and Photothermal-Chemotherapy of Osteosarcoma","volume":"8","author":"Yang","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1039\/C6TB00390G","article-title":"3D-printed bioceramic scaffolds with a Fe3O4\/graphene oxide nanocomposite interface for hyperthermia therapy of bone tumor cells","volume":"4","author":"Zhang","year":"2016","journal-title":"J. Mater. Chem. B"},{"key":"ref_142","first-page":"1091","article-title":"Functionalization of biopolymer fibers with magnetic nanoparticles","volume":"7","author":"Strassburg","year":"2022","journal-title":"Phys. Sci. Rev."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.actbio.2009.09.017","article-title":"A novel route in bone tissue engineering: Magnetic biomimetic scaffolds","volume":"6","author":"Bock","year":"2010","journal-title":"Acta Biomater."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.bone.2013.07.015","article-title":"Modifying bone scaffold architecture in vivo with permanent magnets to facilitate fixation of magnetic scaffolds","volume":"56","author":"Panseri","year":"2013","journal-title":"Bone"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s10856-015-5659-0","article-title":"Magnetic forces and magnetized biomaterials provide dynamic flux information during bone regeneration","volume":"27","author":"Russo","year":"2016","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"15697","DOI":"10.1021\/am5050967","article-title":"Magnetic Bioinspired Hybrid Nanostructured Collagen\u2013Hydroxyapatite Scaffolds Supporting Cell Proliferation and Tuning Regenerative Process","volume":"6","author":"Tampieri","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"110835","DOI":"10.1016\/j.msec.2020.110835","article-title":"Effect of magnetite nanoparticles on the biological and mechanical properties of hydroxyapatite porous scaffolds coated with ibuprofen drug","volume":"111","author":"Sahmani","year":"2020","journal-title":"Mater. Sci. Eng."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"23098","DOI":"10.1021\/acsami.5b06813","article-title":"Multilayered Magnetic Gelatin Membrane Scaffolds","volume":"7","author":"Samal","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"40841","DOI":"10.1039\/C4RA06621A","article-title":"Hybrid magnetic scaffolds of gelatin\u2013siloxane incorporated with magnetite nanoparticles effective for bone tissue engineering","volume":"4","author":"Dashnyam","year":"2014","journal-title":"RSC Adv."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.ijbiomac.2019.07.145","article-title":"A novel magnetic bifunctional nanocomposite scaffold for photothermal therapy and tissue engineering","volume":"138","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"e2085","DOI":"10.1002\/term.2641","article-title":"Enhanced bone regeneration and visual monitoring via superparamagnetic iron oxide nanoparticle scaffold in rats","volume":"12","author":"Hu","year":"2018","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"045013","DOI":"10.1088\/1748-605X\/ab1d9c","article-title":"Preparation and characterization of 3D porous conductive scaffolds with magnetic resonance enhancement in tissue engineering","volume":"14","author":"Chen","year":"2019","journal-title":"Biomed. Mater."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/j.ijbiomac.2019.10.269","article-title":"Silk fibroin promotes mineralization of gellan gum hydrogels","volume":"153","author":"Kundu","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.msec.2016.09.039","article-title":"Super-paramagnetic responsive silk fibroin\/chitosan\/magnetite scaffolds with tunable pore structures for bone tissue engineering applications","volume":"70","author":"Aliramaji","year":"2017","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"110714","DOI":"10.1016\/j.msec.2020.110714","article-title":"Impact of the magnetic field on 3T3-E1 preosteoblasts inside SMART silk fibroin-based scaffolds decorated with magnetic nanoparticles","volume":"110","author":"Tanasa","year":"2020","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1177\/0883911517693635","article-title":"Magnetic silk fibroin e-gel scaffolds for bone tissue engineering applications","volume":"32","author":"Demirbilek","year":"2017","journal-title":"J. Bioact. Compat."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1166\/jbn.2019.2701","article-title":"Fabrication and Biocompatibility of Core\u2013Shell Structured Magnetic Fibrous Scaffold","volume":"15","author":"Li","year":"2019","journal-title":"J. Biomed. Nanotechnol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"697","DOI":"10.3389\/fbioe.2020.00697","article-title":"Ultrasmall Superparamagnetic Iron Oxide Labeled Silk Fibroin\/Hydroxyapatite Multifunctional Scaffold Loaded with Bone Marrow-Derived Mesenchymal Stem Cells for Bone Regeneration","volume":"8","author":"Liu","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"6282","DOI":"10.1021\/acsami.5b00529","article-title":"Biomimetic Magnetic Silk Scaffolds","volume":"7","author":"Samal","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.ijpharm.2012.07.063","article-title":"Synthesis, characterization and in vitro assessment of the magnetic chitosan\u2013carboxymethylcellulose biocomposite interactions with the prokaryotic and eukaryotic cells","volume":"436","author":"Grumezescu","year":"2012","journal-title":"Int. J. Pharm."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.1016\/j.ceramint.2014.10.153","article-title":"In situ preparation of iron oxide nanoparticles in natural hydroxyapatite\/chitosan matrix for bone tissue engineering application","volume":"41","author":"Heidari","year":"2015","journal-title":"Ceram. Int."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"055008","DOI":"10.1088\/1748-6041\/6\/5\/055008","article-title":"Magnetic biodegradable Fe3O4\/CS\/PVA nanofibrous membranes for bone regeneration","volume":"6","author":"Wei","year":"2011","journal-title":"Biomed. Mater."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"5280","DOI":"10.1039\/D0TB00342E","article-title":"Magnetic lanthanum-doped hydroxyapatite\/chitosan scaffolds with endogenous stem cell-recruiting and immunomodulatory properties for bone regeneration","volume":"8","author":"Wang","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.colsurfb.2018.11.003","article-title":"Magnetic bioinspired micro\/nanostructured composite scaffold for bone regeneration","volume":"174","author":"Zhao","year":"2019","journal-title":"Colloids Surf. B"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.ijbiomac.2018.12.083","article-title":"Biopolymers\u2014Calcium phosphates composites with inclusions of magnetic nanoparticles for bone tissue engineering","volume":"125","author":"Cojocaru","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1002\/jbm.b.34491","article-title":"Orthogonal test design for the optimization of superparamagnetic chitosan plasmid gelatin microspheres that promote vascularization of artificial bone","volume":"108","author":"Tao","year":"2020","journal-title":"J. Biomed. Mater. Res."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1021\/acsbiomaterials.0c01371","article-title":"Bioprinting of Magnetically Deformable Scaffolds","volume":"7","author":"Spangenberg","year":"2021","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.jmbbm.2016.08.038","article-title":"Mechanical response of 3D Insert\u00ae PCL to compression","volume":"65","author":"Brunelli","year":"2017","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Mulla, M.Z., Rahman, M.R.T., Marcos, B., Tiwari, B., and Pathania, S. (2021). Poly Lactic Acid (PLA) Nanocomposites: Effect of Inorganic Nanoparticles Reinforcement on Its Performance and Food Packaging Applications. Molecules, 26.","DOI":"10.3390\/molecules26071967"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1111\/jam.14290","article-title":"Polylactic acid: Synthesis and biomedical applications","volume":"127","author":"Singhvi","year":"2019","journal-title":"J. Appl. Microbiol."},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Park, H.S., and Hong, C.K. (2021). Relationship between the Stereocomplex Crystallization Behavior and Mechanical Properties of PLLA\/PDLA Blends. Polymers, 13.","DOI":"10.3390\/polym13111851"},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Bin, S., Wang, A., Guo, W., Yu, L., and Feng, P. (2020). Micro Magnetic Field Produced by Fe3O4 Nanoparticles in Bone Scaffold for Enhancing Cellular Activity. Polymers, 12.","DOI":"10.3390\/polym12092045"},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"D\u00edaz, E., Valle, M.B., Ribeiro, S., Lanceros-Mendez, S., and Barandiar\u00e1n, J.M. (2019). A New Approach for the Fabrication of Cytocompatible PLLA-Magnetite Nanoparticle Composite Scaffolds. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20194664"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jare.2020.04.009","article-title":"Electrostatic self-assembly of pFe3O4 nanoparticles on graphene oxide: A co-dispersed nanosystem reinforces PLLA scaffolds","volume":"24","author":"Yang","year":"2020","journal-title":"J. Adv. Res."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jsps.2017.04.026","article-title":"Osteogenic differentiation of bone marrow mesenchymal stem cells by magnetic nanoparticle composite scaffolds under a pulsed electromagnetic field","volume":"25","author":"Huang","year":"2017","journal-title":"Saudi Pharm. J."},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Carvalho, E.O., Ribeiro, C., Correia, D.M., Botelho, G., and Lanceros-Mendez, S. (2020). Biodegradable Hydrogels Loaded with Magnetically Responsive Microspheres as 2D and 3D Scaffolds. Nanomaterials, 10.","DOI":"10.3390\/nano10122421"},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Sun, F., Sun, X., Wang, H., Li, C., Zhao, Y., Tian, J., and Lin, Y. (2022). Application of 3D-Printed, PLGA-Based Scaffolds in Bone Tissue Engineering. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23105831"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"13007","DOI":"10.1039\/c2ra22376g","article-title":"Superparamagnetic nano-composite scaffolds for promoting bone cell proliferation and defect reparation without a magnetic field","volume":"2","author":"Lai","year":"2012","journal-title":"RSC Adv."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/rb\/rbz019","article-title":"Osteogenesis effects of magnetic nanoparticles modified-porous scaffolds for the reconstruction of bone defect after bone tumor resection","volume":"6","author":"Li","year":"2019","journal-title":"Regen. Biomater."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1166\/jbn.2019.2708","article-title":"Positive Effect of Magnetic-Conductive Bifunctional Fibrous Scaffolds on Guiding Double Electrical and Magnetic Stimulations to Pre-Osteoblasts","volume":"15","author":"Li","year":"2019","journal-title":"J. Biomed. Nanotechnol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.1039\/C8TB00985F","article-title":"The promoting effect on pre-osteoblast growth under electrical and magnetic double stimulation based on PEDOT\/Fe3O4\/PLGA magnetic-conductive bi-functional scaffolds","volume":"6","author":"Li","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.msec.2018.02.003","article-title":"Preparation and biocompatibility of diphasic magnetic nanocomposite scaffold","volume":"87","author":"Huang","year":"2018","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1002\/jbm.a.37162","article-title":"3D magnetic nanocomposite scaffolds enhanced the osteogenic capacities of rat bone mesenchymal stem cells in vitro and in a rat calvarial bone defect model by promoting cell adhesion","volume":"109","author":"Han","year":"2021","journal-title":"J. Biomed. Mater. Res."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"015009","DOI":"10.1088\/1468-6996\/14\/1\/015009","article-title":"In vitro and in vivo evaluation of electrospun PCL\/PMMA fibrous scaffolds for bone regeneration","volume":"14","author":"Son","year":"2013","journal-title":"Sci. Technol. Adv. Mater."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"17325","DOI":"10.1039\/C4RA00040D","article-title":"Magnetic scaffolds of polycaprolactone with functionalized magnetite nanoparticles: Physicochemical, mechanical, and biological properties effective for bone regeneration","volume":"4","author":"Kim","year":"2014","journal-title":"RSC Adv."},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"D\u00edaz, E., Valle, M.B., Ribeiro, S., Lanceros-Mendez, S., and Barandiar\u00e1n, J.M. (2019). 3D Cytocompatible Composites of PCL\/magnetite. Materials, 12.","DOI":"10.3390\/ma12233843"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"e2000249","DOI":"10.1002\/mabi.202000249","article-title":"Magnetically Responsive Polymeric Microparticles for the Triggered Delivery of a Complex Mixture of Human Placental Proteins","volume":"21","author":"Lanier","year":"2021","journal-title":"Macromol. Biosci."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.biomaterials.2016.01.035","article-title":"Magnetic nanocomposite scaffolds combined with static magnetic field in the stimulation of osteoblastic differentiation and bone formation","volume":"85","author":"Yun","year":"2016","journal-title":"Biomaterials"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.dental.2016.06.016","article-title":"Magnetic nanofiber scaffold-induced stimulation of odontogenesis and pro-angiogenesis of human dental pulp cells through Wnt\/MAPK\/NF-\u03baB pathways","volume":"32","author":"Yun","year":"2016","journal-title":"Dent. Mater."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"20120833","DOI":"10.1098\/rsif.2012.0833","article-title":"Magnetic poly(\u03b5-caprolactone)\/iron-doped hydroxyapatite nanocomposite substrates for advanced bone tissue engineering","volume":"10","author":"Gloria","year":"2013","journal-title":"J. R. Soc. Interface"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1038\/s41598-020-58738-5","article-title":"3D Patterning of cells in Magnetic Scaffolds for Tissue Engineering","volume":"10","author":"Goranov","year":"2020","journal-title":"Sci Rep."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.procir.2015.07.037","article-title":"Viscoelastic Properties of Rapid Prototyped Magnetic Nanocomposite Scaffolds for Osteochondral Tissue Regeneration","volume":"49","author":"Gloria","year":"2016","journal-title":"Procedia CIRP"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"109913","DOI":"10.1016\/j.msec.2019.109913","article-title":"Carbon nanotube\/iron oxide hybrid particles and their PCL-based 3D composites for potential bone regeneration","volume":"104","author":"Tarasiuk","year":"2019","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ijbiomac.2019.12.149","article-title":"Electrospun poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)\/silk fibroin film is a promising scaffold for bone tissue engineering","volume":"145","author":"Ang","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Czechowska, J., Skibi\u0144ski, S., Guzik, M., and Zima, A. (2021). Silver Decorated \u03b2TCP-Poly(3hydroxybutyrate) Scaffolds for Bone Tissue Engineering. Materials, 14.","DOI":"10.3390\/ma14154227"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"3897592","DOI":"10.1155\/2016\/3897592","article-title":"P(3HB) Based Magnetic Nanocomposites: Smart Materials for Bone Tissue Engineering","volume":"2016","author":"Akaraonye","year":"2016","journal-title":"J. Nanomater."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"8906","DOI":"10.1039\/C8NR10384D","article-title":"Permanently hydrophilic, piezoelectric PVDF nanofibrous scaffolds promoting unaided electromechanical stimulation on osteoblasts","volume":"11","author":"Kitsara","year":"2019","journal-title":"Nanoscale"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.colsurfb.2019.06.023","article-title":"Hydrogel-based magnetoelectric microenvironments for tissue stimulation","volume":"181","author":"Hermenegildo","year":"2019","journal-title":"Colloids Surf. B"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"45265","DOI":"10.1021\/acsami.9b14001","article-title":"Bioinspired Three-Dimensional Magnetoactive Scaffolds for Bone Tissue Engineering","volume":"11","author":"Fernandes","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_200","unstructured":"Campodoni, E., Dozio Samuele, M., Mulazzi, M., Montanari, M., Montesi, M., Panseri, S., Sprio, S., Tampieri, A., and Sandri, M. (2022). Biomimetic Approaches for the Design and Development of Multifunctional Bioresorbable Layered Scaffolds for Dental Regeneration. Pocket Dent., Available online: https:\/\/pocketdentistry.com\/biomimetic-approaches-for-the-design-and-development-of-multifunctional-bioresorbable-layered-scaffolds-for-dental-regeneration\/."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1089\/ten.teb.2016.0289","article-title":"Biomimetic Approaches for Bone Tissue Engineering","volume":"23","author":"Ng","year":"2017","journal-title":"Tissue Eng. Part B Rev."},{"key":"ref_202","doi-asserted-by":"crossref","unstructured":"Thevenot, P., Sohaebuddin, S., Poudyal, N., Liu, J.P., and Tang, L. (2008, January 18\u201321). Magnetic nanoparticles to enhance cell seeding and distribution in tissue engineering scaffolds. Proceedings of the IEEE Conference on Nanotechnology, Arlington, TX, USA.","DOI":"10.1109\/NANO.2008.196"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/ncb2927","article-title":"Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus","volume":"16","author":"Guilluy","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"8514","DOI":"10.1016\/j.biomaterials.2014.06.028","article-title":"Effect of nano-structured bioceramic surface on osteogenic differentiation of adipose derived stem cells","volume":"35","author":"Xia","year":"2014","journal-title":"Biomaterials"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.actbio.2013.11.017","article-title":"Platelet-derived growth-factor-releasing aligned collagen-nanoparticle fibers promote the proliferation and tenogenic differentiation of adipose-derived stem cells","volume":"10","author":"Cheng","year":"2014","journal-title":"Acta Biomater."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1021\/nn400202j","article-title":"Osteogenesis of mesenchymal stem cells by nanoscale mechanotransduction","volume":"7","author":"Nikukar","year":"2013","journal-title":"ACS Nano"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/24\/16190\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:43:59Z","timestamp":1760147039000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/24\/16190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,19]]},"references-count":206,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["ijms232416190"],"URL":"https:\/\/doi.org\/10.3390\/ijms232416190","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,19]]}}}