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A sustainable option is genetic selection based on differences in susceptibility to GIN infection between and within breeds of sheep. Here, three-month-old Canaria Hair breed (GIN-resistant) and Canaria Sheep breed (GIN-susceptible) showed no significant between-breed differences after trickle infection with Teladorsagia circumcincta, whereas considerable individual variability was found in both breeds. Next, data from lambs of both breeds were used to explore the relationships between parasitological variables and T. circumcincta-specific IgA levels, local immune cell populations, and abomasal lymph node gene expression to understand the possible mechanisms underlying resistance. Mucosal IgA levels as well as numbers of globular leukocytes and MHC-II+ cells were associated with protection. Analysis of lymph node gene expression revealed the associations between lower parasite numbers and cumulative fecal egg counts and several immune pathways, such as leukocyte cell adhesion, activation and differentiation of T cells, in particular CD4+ and IL-4 production. The data obtained here may inform on the relationship between phenotypic resistance variability and protective responses at the humoral, cellular, and transcriptomic levels, thus contributing to identifying immune responses in young lambs that could be used as markers for selection.<\/jats:p>","DOI":"10.3390\/ijms24010029","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T02:31:33Z","timestamp":1671589893000},"page":"29","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Variability in the Response against Teladorsagia circumcincta in Lambs of Two Canarian Sheep Breeds"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2919-3857","authenticated-orcid":false,"given":"Tara","family":"P\u00e9rez-Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Instituto Universitario Sanidad Animal y Seguridad Alimentaria, Facultad de Veterinaria, Universidad de Las Palmas de Gran Canaria, 35413 Arucas, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia N.","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Instituto Universitario Sanidad Animal y Seguridad Alimentaria, Facultad de Veterinaria, Universidad de Las Palmas de Gran Canaria, 35413 Arucas, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia","family":"Mach\u00edn","sequence":"additional","affiliation":[{"name":"Instituto Universitario Sanidad Animal y Seguridad Alimentaria, Facultad de Veterinaria, Universidad de Las Palmas de Gran Canaria, 35413 Arucas, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6469-0512","authenticated-orcid":false,"given":"Tom N.","family":"McNeilly","sequence":"additional","affiliation":[{"name":"Moredun Research Institute, Edinburgh EH26 0PZ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4965-5396","authenticated-orcid":false,"given":"Alasdair J.","family":"Nisbet","sequence":"additional","affiliation":[{"name":"Moredun Research Institute, Edinburgh EH26 0PZ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline B.","family":"Matthews","sequence":"additional","affiliation":[{"name":"Austin Davis Biologics, Ltd., Northamptonshire NN14 4BL, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stewart T. G.","family":"Burgess","sequence":"additional","affiliation":[{"name":"Moredun Research Institute, Edinburgh EH26 0PZ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge F.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Instituto Universitario Sanidad Animal y Seguridad Alimentaria, Facultad de Veterinaria, Universidad de Las Palmas de Gran Canaria, 35413 Arucas, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"105103","DOI":"10.1016\/j.prevetmed.2020.105103","article-title":"Initial Assessment of the Economic Burden of Major Parasitic Helminth Infections to the Ruminant Livestock Industry in Europe","volume":"182","author":"Charlier","year":"2020","journal-title":"Prev. Vet. 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