{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:15:20Z","timestamp":1791224120663,"version":"4.1.0"},"reference-count":211,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000053","name":"NIH\/National Eye Institute (NEI)","doi-asserted-by":"publisher","award":["RO1EY025794"],"award-info":[{"award-number":["RO1EY025794"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"NIH\/National Eye Institute (NEI)","doi-asserted-by":"publisher","award":["R24EY028767"],"award-info":[{"award-number":["R24EY028767"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"NIH\/National Eye Institute (NEI)","doi-asserted-by":"publisher","award":["1R01HL161087"],"award-info":[{"award-number":["1R01HL161087"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute (NHLBI)","doi-asserted-by":"publisher","award":["RO1EY025794"],"award-info":[{"award-number":["RO1EY025794"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute (NHLBI)","doi-asserted-by":"publisher","award":["R24EY028767"],"award-info":[{"award-number":["R24EY028767"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute (NHLBI)","doi-asserted-by":"publisher","award":["1R01HL161087"],"award-info":[{"award-number":["1R01HL161087"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The ATP-binding cassette superfamily member ABCB5 identifies a subset of skin-resident mesenchymal stem cells (MSCs) that exhibit potent immunomodulatory and wound healing-promoting capacities along with superior homing ability. The ABCB5+ MSCs can be easily accessed from discarded skin samples, expanded, and delivered as a highly homogenous medicinal product with standardized potency. A range of preclinical studies has suggested therapeutic efficacy of ABCB5+ MSCs in a variety of currently uncurable skin and non-skin inflammatory diseases, which has been substantiated thus far by distinct clinical trials in chronic skin wounds or recessive dystrophic epidermolysis bullosa. Therefore, skin-derived ABCB5+ MSCs have the potential to provide a breakthrough at the forefront of MSC-based therapies striving to fulfill current unmet medical needs. The most recent milestones in this regard are the approval of a phase III pivotal trial of ABCB5+ MSCs for treatment of recessive dystrophic and junctional epidermolysis bullosa by the US Food and Drug Administration, and national market access of ABCB5+ MSCs (AMESANAR\u00ae) for therapy-refractory chronic venous ulcers under the national hospital exemption pathway in Germany.<\/jats:p>","DOI":"10.3390\/ijms24010066","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T03:59:26Z","timestamp":1671595166000},"page":"66","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Skin-Derived ABCB5+ Mesenchymal Stem Cells for High-Medical-Need Inflammatory Diseases: From Discovery to Entering Clinical Routine"],"prefix":"10.3390","volume":"24","author":[{"given":"Elke","family":"Niebergall-Roth","sequence":"first","affiliation":[{"name":"TICEBA GmbH, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha Y.","family":"Frank","sequence":"additional","affiliation":[{"name":"Department of Medicine, VA Boston Healthcare System, Boston, MA 02132, USA"},{"name":"Division of Genetics, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA"},{"name":"Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA"},{"name":"Transplant Research Program, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0396-6591","authenticated-orcid":false,"given":"Christoph","family":"Ganss","sequence":"additional","affiliation":[{"name":"TICEBA GmbH, 69120 Heidelberg, Germany"},{"name":"RHEACELL GmbH & Co. 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