{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:17:57Z","timestamp":1792084677668,"version":"4.4.0"},"reference-count":36,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>A significant lack of donor organs restricts the opportunity to obtain tissue-specific scaffolds for tissue-engineering technologies. One of the acceptable solutions is the development of decellularization protocols for a human donor pancreas unsuitable for transplantation. A protocol of obtaining a biocompatible tissue-specific scaffold from decellularized fragments with pronounced human pancreas lipomatosis signs with preserved basic fibrillary proteins of a pancreatic tissue extracellular matrix was developed. The scaffold supports the adhesion and proliferation of human adipose derived stem cell (hADSCs) and prolongs the viability and insulin-producing function of pancreatic islets. Experiments conducted allow for the reliance on the prospects of using the donor pancreas unsuitable for transplantation in the technologies of tissue engineering and regenerative medicine, including the development of a tissue equivalent of a pancreas.<\/jats:p>","DOI":"10.3390\/ijms24010119","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T01:33:12Z","timestamp":1671672792000},"page":"119","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Decellularization of Human Pancreatic Fragments with Pronounced Signs of Structural Changes"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1995-3373","authenticated-orcid":false,"given":"Victor I.","family":"Sevastianov","sequence":"first","affiliation":[{"name":"The Shumakov National Medical Research Center of Transplantology and Artificial Organs, 123182 Moscow, Russia"},{"name":"The Institute of Biomedical Research and Technology (IBRT), Autonomous Non-Profit Organization, 123557 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna S.","family":"Ponomareva","sequence":"additional","affiliation":[{"name":"The Shumakov National Medical Research Center of Transplantology and Artificial Organs, 123182 Moscow, Russia"},{"name":"The Institute of Biomedical Research and Technology (IBRT), Autonomous Non-Profit Organization, 123557 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia V.","family":"Baranova","sequence":"additional","affiliation":[{"name":"The Shumakov National Medical Research Center of Transplantology and Artificial Organs, 123182 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyudmila A.","family":"Kirsanova","sequence":"additional","affiliation":[{"name":"The Shumakov National Medical Research Center of Transplantology and Artificial Organs, 123182 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4807-3164","authenticated-orcid":false,"given":"Yulia B.","family":"Basok","sequence":"additional","affiliation":[{"name":"The Shumakov National Medical Research Center of Transplantology and Artificial Organs, 123182 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeniy A.","family":"Nemets","sequence":"additional","affiliation":[{"name":"The Shumakov National Medical Research Center of Transplantology and Artificial Organs, 123182 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry N.","family":"Kruglov","sequence":"additional","affiliation":[{"name":"The Shumakov National Medical Research Center of Transplantology and Artificial Organs, 123182 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor A.","family":"Miloserdov","sequence":"additional","affiliation":[{"name":"The Shumakov National Medical Research Center of Transplantology and Artificial Organs, 123182 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey V.","family":"Gautier","sequence":"additional","affiliation":[{"name":"The Shumakov National Medical Research Center of Transplantology and Artificial Organs, 123182 Moscow, Russia"},{"name":"Department of Transplantology and Artificial Organs, Faculty of Medicine, The Sechenov University, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Eguchi, N., Kimia Damyar, K., Alexander, M., Dafoe, D., Lakey, J.R.T., and Ichii, H. 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