{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T14:55:19Z","timestamp":1793890519824,"version":"4.8.0"},"reference-count":131,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Magnesium (Mg) is involved in the regulation of metabolism and in the maintenance of the homeostasis of all the tissues, including the brain, where it harmonizes nerve signal transmission and preserves the integrity of the blood\u2013brain barrier. Mg deficiency contributes to systemic low-grade inflammation, the common denominator of most diseases. In particular, neuroinflammation is the hallmark of neurodegenerative disorders. Starting from a rapid overview on the role of magnesium in the brain, this narrative review provides evidences linking the derangement of magnesium balance with multiple sclerosis, Alzheimer\u2019s, and Parkinson\u2019s diseases.<\/jats:p>","DOI":"10.3390\/ijms24010223","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T02:36:46Z","timestamp":1671763006000},"page":"223","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":123,"title":["Magnesium and the Brain: A Focus on Neuroinflammation and Neurodegeneration"],"prefix":"10.3390","volume":"24","author":[{"given":"Jeanette A. M.","family":"Maier","sequence":"first","affiliation":[{"name":"Department of Biomedical and Clinical Sciences, Universit\u00e0 di Milano, 20157 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4568-7825","authenticated-orcid":false,"given":"Laura","family":"Locatelli","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences, Universit\u00e0 di Milano, 20157 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7974-6299","authenticated-orcid":false,"given":"Giorgia","family":"Fedele","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences, Universit\u00e0 di Milano, 20157 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7153-2256","authenticated-orcid":false,"given":"Alessandra","family":"Cazzaniga","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences, Universit\u00e0 di Milano, 20157 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Mazur","sequence":"additional","affiliation":[{"name":"UNH\u2014Unit\u00e9 de Nutrition Humaine, Universit\u00e9 Clermont Auvergne, INRAE, F-63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1472-4669.2012.00323.x","article-title":"The significance of Mg in prebiotic geochemistry","volume":"10","author":"Holm","year":"2012","journal-title":"Geobiology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1007\/s10534-021-00328-7","article-title":"\u2019Magnesium\u2019-the master cation-as a drug-possibilities and evidences","volume":"34","author":"Mathew","year":"2021","journal-title":"Biometals"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00394-021-02704-y","article-title":"The relevance of magnesium homeostasis in COVID-19","volume":"61","author":"Trapani","year":"2022","journal-title":"Eur. J. Nutr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.semcdb.2020.11.002","article-title":"Magnesium and inflammation: Advances and perspectives","volume":"115","author":"Maier","year":"2021","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_5","first-page":"483","article-title":"Benzodiazepine\/GABA(A) receptors are involved in magnesium-induced anxiolytic-like behavior in mice","volume":"60","author":"Poleszak","year":"2008","journal-title":"Pharmacol. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/sj.bjp.0706796","article-title":"Mechanism of action of benzodiazepines on GABAA receptors","volume":"148","author":"Chang","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3984","DOI":"10.1016\/j.cub.2018.10.044","article-title":"GABA-Induced Intracellular Mg(2+) Mobilization Integrates and Coordinates Cellular Information Processing for the Maturation of Neural Networks","volume":"28","author":"Yamanaka","year":"2018","journal-title":"Curr. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Yamanaka, R., Shindo, Y., and Oka, K. (2019). Magnesium Is a Key Player in Neuronal Maturation and Neuropathology. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20143439"},{"key":"ref_9","first-page":"16","article-title":"Magnesium and the blood-brain barrier in vitro: Effects on permeability and magnesium transport","volume":"32","author":"Romeo","year":"2019","journal-title":"Magnes. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"a020412","DOI":"10.1101\/cshperspect.a020412","article-title":"The blood-brain barrier","volume":"7","author":"Daneman","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.cell.2021.12.003","article-title":"BDNF signaling in context: From synaptic regulation to psychiatric disorders","volume":"185","author":"Wang","year":"2022","journal-title":"Cell"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.clnesp.2020.12.022","article-title":"The effects of magnesium supplementation on serum level of brain derived neurotrophic factor (BDNF) and depression status in patients with depression","volume":"42","author":"Afsharfar","year":"2021","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Cazzaniga, A., Fedele, G., Castiglioni, S., and Maier, J.A. (2022). The Presence of Blood-Brain Barrier Modulates the Response to Magnesium Salts in Human Brain Organoids. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23095133"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.neuron.2009.12.026","article-title":"Enhancement of learning and memory by elevating brain magnesium","volume":"65","author":"Slutsky","year":"2010","journal-title":"Neuron"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e61339","DOI":"10.7554\/eLife.61339","article-title":"Magnesium efflux from Drosophila Kenyon cells is critical for normal and diet-enhanced long-term memory","volume":"9","author":"Wu","year":"2020","journal-title":"eLife"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/S0140-6736(18)33131-3","article-title":"Tetanus","volume":"393","author":"Yen","year":"2019","journal-title":"Lancet Lond. Engl."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/s12974-021-02309-6","article-title":"The semantics of microglia activation: Neuroinflammation, homeostasis, and stress","volume":"18","author":"Woodburn","year":"2021","journal-title":"J. Neuroinflamm."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/npr2.12167","article-title":"Dietary magnesium deficiency induces the expression of neuroinflammation-related genes in mouse brain","volume":"41","author":"Tsuji","year":"2021","journal-title":"Neuropsychopharmacol. Rep."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"6633","DOI":"10.2147\/JIR.S330894","article-title":"The Causal Role of Magnesium Deficiency in the Neuroinflammation, Pain Hypersensitivity and Memory\/Emotional Deficits in Ovariectomized and Aged Female Mice","volume":"14","author":"Zhang","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.jss.2013.03.034","article-title":"Magnesium sulfate provides neuroprotection in lipopolysaccharide-activated primary microglia by inhibiting NF-\u03baB pathway","volume":"184","author":"Gao","year":"2013","journal-title":"J. Surg. Res."},{"key":"ref_21","first-page":"296","article-title":"The Therapeutic Potential of Targeting Substance P\/NK-1R Interactions in Inflammatory CNS Disorders","volume":"10","author":"Johnson","year":"2016","journal-title":"Front. Cell. Neurosci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4249","DOI":"10.1007\/s00018-016-2293-z","article-title":"Neuropeptide substance P and the immune response","volume":"73","author":"Mashaghi","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"167S","DOI":"10.1684\/mrh.2009.0181","article-title":"Neutral endopeptidase inhibition enhances substance P mediated inflammation due to hypomagnesemia","volume":"22","author":"Weglicki","year":"2009","journal-title":"Magnes. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1159\/000363041","article-title":"Activation of microglia by histamine and substance P","volume":"34","author":"Zhu","year":"2014","journal-title":"Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"304","DOI":"10.3389\/fneur.2017.00304","article-title":"The Role of Substance P in Secondary Pathophysiology after Traumatic Brain Injury","volume":"8","author":"Vink","year":"2017","journal-title":"Front. Neurol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1007\/3-211-30714-1_83","article-title":"Magnesium restores altered aquaporin-4 immunoreactivity following traumatic brain injury to a pre-injury state","volume":"96","author":"Ghabriel","year":"2006","journal-title":"Acta Neurochir. Suppl."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1002\/ijc.28433","article-title":"The proinflammatory peptide substance P promotes blood-brain barrier breaching by breast cancer cells through changes in microvascular endothelial cell tight junctions","volume":"134","author":"Rodriguez","year":"2014","journal-title":"Int. J. Cancer"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.niox.2009.03.001","article-title":"Neuronal nitric oxide synthase: Structure, subcellular localization, regulation, and clinical implications","volume":"20","author":"Zhou","year":"2009","journal-title":"Nitric Oxide Biol. Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1161\/01.RES.0000250961.47984.80","article-title":"Protecting the brain with eNOS: Run for your life","volume":"99","author":"Faraci","year":"2006","journal-title":"Circ. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"732","DOI":"10.14336\/AD.2020.0523","article-title":"Deficiency of Endothelial Nitric Oxide Synthase (eNOS) Exacerbates Brain Damage and Cognitive Deficit in A Mouse Model of Vascular Dementia","volume":"12","author":"An","year":"2021","journal-title":"Aging Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/j.bbadis.2018.11.007","article-title":"Functions and dysfunctions of nitric oxide in brain","volume":"1865","year":"2019","journal-title":"Biochim. Biophys. Acta. Mol. Basis Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1016\/j.cell.2022.06.010","article-title":"Nitric oxide signaling in health and disease","volume":"185","author":"Lundberg","year":"2022","journal-title":"Cell"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1042\/CS20110506","article-title":"Endothelial cells and magnesium: Implications in atherosclerosis","volume":"122","author":"Maier","year":"2012","journal-title":"Clin. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Kirkland, A.E., Sarlo, G.L., and Holton, K.F. (2018). The Role of Magnesium in Neurological Disorders. Nutrients, 10.","DOI":"10.3390\/nu10060730"},{"key":"ref_35","first-page":"86","article-title":"Neuroprotective effects of magnesium on metabolic disturbances in fetal hippocampal slices after oxygen-glucose deprivation: Mediation by nitric oxide system","volume":"9","author":"Garnier","year":"2002","journal-title":"J. Soc. Gynecol. Investig."},{"key":"ref_36","first-page":"13","article-title":"Effect of magnesium on nitric oxide synthase of neurons in cortex during early period of cerebral ischemia","volume":"20","author":"Sun","year":"2000","journal-title":"J. Tongji Med. Univ."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.placenta.2022.07.011","article-title":"Magnesium sulphate neuroprotection mechanism is placental mediated by inhibition of inflammation, apoptosis and oxidative stress","volume":"127","author":"Khatib","year":"2022","journal-title":"Placenta"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/bs.apha.2014.06.006","article-title":"Pharmacological significance of prostaglandin E2 and D2 transport at the brain barriers","volume":"71","author":"Tachikawa","year":"2014","journal-title":"Adv. Pharmacol."},{"key":"ref_39","first-page":"104","article-title":"Neuroinflammation and J2 prostaglandins: Linking impairment of the ubiquitin-proteasome pathway and mitochondria to neurodegeneration","volume":"7","author":"Rockwell","year":"2014","journal-title":"Front. Mol. Neurosci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nature05292","article-title":"Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases","volume":"443","author":"Lin","year":"2006","journal-title":"Nature"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.redox.2018.01.008","article-title":"13 reasons why the brain is susceptible to oxidative stress","volume":"15","author":"Cobley","year":"2018","journal-title":"Redox Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2624734","DOI":"10.1155\/2020\/2624734","article-title":"Magnesium Sulfate Attenuates Lethality and Oxidative Damage Induced by Different Models of Hypoxia in Mice","volume":"2020","author":"Mohammadi","year":"2020","journal-title":"Biomed Res. Int."},{"key":"ref_43","first-page":"1032","article-title":"Magnesium sulfate ameliorates carbon monoxide-induced cerebral injury in male rats","volume":"19","author":"Bagheri","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"6338","DOI":"10.4049\/jimmunol.1101765","article-title":"Magnesium decreases inflammatory cytokine production: A novel innate immunomodulatory mechanism","volume":"188","author":"Sugimoto","year":"2012","journal-title":"J. Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2398212820979802","DOI":"10.1177\/2398212820979802","article-title":"The role of cytokines in modulating learning and memory and brain plasticity","volume":"4","author":"Bourgognon","year":"2020","journal-title":"Brain Neurosci. Adv."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s12031-017-1007-9","article-title":"Magnesium Lithospermate B Suppresses Lipopolysaccharide-Induced Neuroinflammation in BV2 Microglial Cells and Attenuates Neurodegeneration in Lipopolysaccharide-Injected Mice","volume":"64","author":"Tai","year":"2018","journal-title":"J. Mol. Neurosci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.1471-0528.2006.01162.x","article-title":"Magnesium sulphate given before very-preterm birth to protect infant brain: The randomised controlled PREMAG trial*","volume":"114","author":"Marret","year":"2007","journal-title":"BJOG"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Le Dieu-Lugon, B., Dupr\u00e9, N., Derambure, C., Janin, F., Gonzalez, B.J., Marret, S., Arabo, A., and Leroux, P. (2021). Effect of Neuroprotective Magnesium Sulfate Treatment on Brain Transcription Response to Hypoxia Ischemia in Neonate Mice. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22084253"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s42358-020-0122-4","article-title":"Relations between serum magnesium and calcium levels and body composition and metabolic parameters in women with fibromyalgia","volume":"60","author":"Andretta","year":"2020","journal-title":"Adv. Rheumatol. Lond. Engl."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Pan, K., and Garaschuk, O. (2022). The role of intracellular calcium-store-mediated calcium signals in in vivo sensor and effector functions of microglia. J. Physiol., Online ahead of print.","DOI":"10.1113\/JP279521"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.brainres.2010.10.084","article-title":"Mg2+ ions reduce microglial and THP-1 cell neurotoxicity by inhibiting Ca2+ entry through purinergic channels","volume":"1369","author":"Lee","year":"2011","journal-title":"Brain Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1113\/jphysiol.2013.267864","article-title":"Mg2+ block properties of triheteromeric GluN1-GluN2B-GluN2D NMDA receptors on neonatal rat substantia nigra pars compacta dopaminergic neurones","volume":"592","author":"Huang","year":"2014","journal-title":"J. Physiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e560","DOI":"10.1038\/cddis.2013.82","article-title":"NMDA receptor-mediated excitotoxicity depends on the coactivation of synaptic and extrasynaptic receptors","volume":"4","author":"Zhou","year":"2013","journal-title":"Cell Death Dis."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ejphar.2008.01.025","article-title":"Time course and mechanism of hippocampal neuronal death in an in vitro model of status epilepticus: Role of NMDA receptor activation and NMDA dependent calcium entry","volume":"583","author":"Deshpande","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Clerc, P., Young, C.A., Bordt, E.A., Grigore, A.M., Fiskum, G., and Polster, B.M. (2013). Magnesium sulfate protects against the bioenergetic consequences of chronic glutamate receptor stimulation. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0079982"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1007\/s12035-020-01871-z","article-title":"Magnesium Acts as a Second Messenger in the Regulation of NMDA Receptor-Mediated CREB Signaling in Neurons","volume":"57","author":"Hou","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00213-014-3671-6","article-title":"Antidepressant-like activity of magnesium in the olfactory bulbectomy model is associated with the AMPA\/BDNF pathway","volume":"232","author":"Pochwat","year":"2015","journal-title":"Psychopharmacology"},{"key":"ref_59","first-page":"1","article-title":"Randomized study of the effects of vitamin D and\/or magnesium supplementation on mood, serum levels of BDNF, inflammation, and SIRT1 in obese women with mild to moderate depressive symptoms","volume":"21","author":"Abiri","year":"2021","journal-title":"Nutr. Neurosci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3389\/fneur.2019.00515","article-title":"The Role of BDNF in the Neuroimmune Axis Regulation of Mood Disorders","volume":"10","author":"Jin","year":"2019","journal-title":"Front. Neurol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"661838","DOI":"10.3389\/fncel.2021.661838","article-title":"Blood-Brain Barrier Dysfunction Amplifies the Development of Neuroinflammation: Understanding of Cellular Events in Brain Microvascular Endothelial Cells for Prevention and Treatment of BBB Dysfunction","volume":"15","author":"Takata","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1161\/HYPERTENSIONAHA.121.17744","article-title":"Disruption of the Blood-Brain Barrier by Extracellular Vesicles from Preeclampsia Plasma and Hypoxic Placentae: Attenuation by Magnesium Sulfate","volume":"78","author":"Acurio","year":"2021","journal-title":"Hypertension"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1179\/174313209X385617","article-title":"Effect of magnesium, MK-801 and combination of magnesium and MK-801 on blood-brain barrier permeability and brain edema after experimental traumatic diffuse brain injury","volume":"31","author":"Imer","year":"2009","journal-title":"Neurol. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1007\/s11011-019-00419-y","article-title":"Magnesium sulfate protects blood-brain barrier integrity and reduces brain edema after acute ischemic stroke in rats","volume":"34","author":"Shadman","year":"2019","journal-title":"Metab. Brain Dis."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1684\/mrh.2022.0497","article-title":"A potential protective role of magnesium in neuroCOVID","volume":"35","author":"Cenacchi","year":"2022","journal-title":"Magnes. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41572-021-00269-y","article-title":"Alzheimer disease","volume":"7","author":"Knopman","year":"2021","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3934\/Neuroscience.2019.4.273","article-title":"\u03b2-Amyloid precursor protein (APP) and the human diseases","volume":"6","author":"Nguyen","year":"2019","journal-title":"AIMS Neurosci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer\u2019s disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1084\/jem.20051529","article-title":"Protection from Alzheimer\u2019s-like disease in the mouse by genetic ablation of inducible nitric oxide synthase","volume":"202","author":"Nathan","year":"2005","journal-title":"J. Exp. Med."},{"key":"ref_70","first-page":"189","article-title":"Disturbances of magnesium concentrations in various brain areas in Alzheimer\u2019s disease","volume":"13","author":"Igaz","year":"2000","journal-title":"Magnes. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3233\/JAD-2005-7402","article-title":"Brain aluminum, magnesium and phosphorus contents of control and Alzheimer-diseased patients","volume":"7","year":"2005","journal-title":"J. Alzheimers Dis."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1177\/1533317515602674","article-title":"Magnesium Status in Alzheimer\u2019s Disease: A Systematic Review","volume":"31","author":"Veronese","year":"2016","journal-title":"Am. J. Alzheimers Dis. Other Demen."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"799824","DOI":"10.3389\/fnagi.2021.799824","article-title":"Association of Circulating Magnesium Levels in Patients with Alzheimer\u2019s Disease From 1991 to 2021: A Systematic Review and Meta-Analysis","volume":"13","author":"Du","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e05390","DOI":"10.1016\/j.heliyon.2020.e05390","article-title":"Going to the roots of reduced magnesium dietary intake: A tradeoff between climate changes and sources","volume":"6","author":"Cazzola","year":"2020","journal-title":"Heliyon"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1111\/j.1532-5415.2012.04061.x","article-title":"Self-reported dietary intake of potassium, calcium, and magnesium and risk of dementia in the Japanese: The Hisayama Study","volume":"60","author":"Ozawa","year":"2012","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"971","DOI":"10.3233\/JAD-150538","article-title":"Efficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial","volume":"49","author":"Liu","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"ref_77","first-page":"5044","article-title":"By suppressing the expression of anterior pharynx-defective-1\u03b1 and -1\u03b2 and inhibiting the aggregation of \u03b2-amyloid protein, magnesium ions inhibit the cognitive decline of amyloid precursor protein\/presenilin 1 transgenic mice","volume":"29","author":"Yu","year":"2015","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/cmi.2015.93","article-title":"Magnesium ion influx reduces neuroinflammation in A\u03b2 precursor protein\/Presenilin 1 transgenic mice by suppressing the expression of interleukin-1\u03b2","volume":"14","author":"Wang","year":"2017","journal-title":"Cell. Mol. Immunol."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Xu, Z.-P., Li, L., Bao, J., Wang, Z.-H., Zeng, J., Liu, E.-J., Li, X.-G., Huang, R.-X., Gao, D., and Li, M.-Z. (2014). Magnesium protects cognitive functions and synaptic plasticity in streptozotocin-induced sporadic Alzheimer\u2019s model. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0108645"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"229","DOI":"10.7762\/cnr.2018.7.4.229","article-title":"Diabetes and Alzheimer\u2019s Disease: Mechanisms and Nutritional Aspects","volume":"7","author":"Lee","year":"2018","journal-title":"Clin. Nutr. Res."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Piuri, G., Zocchi, M., Della Porta, M., Ficara, V., Manoni, M., Zuccotti, G.V., Pinotti, L., Maier, J.A., and Cazzola, R. (2021). Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes. Nutrients, 13.","DOI":"10.3390\/nu13020320"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13195-021-00784-w","article-title":"Does insulin resistance influence neurodegeneration in non-diabetic Alzheimer\u2019s subjects?","volume":"13","author":"Femminella","year":"2021","journal-title":"Alzheimers Res. Ther."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Zou, Z.-G., Rios, F.J., Montezano, A.C., and Touyz, R.M. (2019). TRPM7, Magnesium, and Signaling. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20081877"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"3480","DOI":"10.1016\/j.celrep.2018.05.069","article-title":"TRPM7 Is Required for Normal Synapse Density, Learning, and Memory at Different Developmental Stages","volume":"23","author":"Liu","year":"2018","journal-title":"Cell Rep."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3389\/fphys.2020.00305","article-title":"Isoproterenol-Dependent Activation of TRPM7 Protects Against Neurotoxin-Induced Loss of Neuroblastoma Cells","volume":"11","author":"Sun","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1007\/s00018-019-03124-2","article-title":"Role of the chanzyme TRPM7 in the nervous system in health and disease","volume":"76","author":"Abumaria","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/nn.2395","article-title":"Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia","volume":"12","author":"Sun","year":"2009","journal-title":"Nat. Neurosci."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Nadolni, W., and Zierler, S. (2018). The Channel-Kinase TRPM7 as Novel Regulator of Immune System Homeostasis. Cells, 7.","DOI":"10.20944\/preprints201807.0237.v1"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/imm.13420","article-title":"Immunomodulatory functions of TRPM7 and its implications in autoimmune diseases","volume":"165","author":"Liang","year":"2022","journal-title":"Immunology"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1038\/s41467-017-01960-z","article-title":"TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut","volume":"8","author":"Romagnani","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"566922","DOI":"10.3389\/fnagi.2020.566922","article-title":"Interleukin-17A: The Key Cytokine in Neurodegenerative Diseases","volume":"12","author":"Chen","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3389\/fnana.2019.00095","article-title":"Th17 and Cognitive Impairment: Possible Mechanisms of Action","volume":"13","author":"Cipollini","year":"2019","journal-title":"Front. Neuroanat."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.3389\/fimmu.2018.01213","article-title":"Imbalance of Circulating T(h)17 and Regulatory T Cells in Alzheimer\u2019s Disease: A Case Control Study","volume":"9","author":"Oberstein","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"3544","DOI":"10.1111\/bph.14586","article-title":"Neutralization of IL-17 rescues amyloid-\u03b2-induced neuroinflammation and memory impairment","volume":"176","author":"Cristiano","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","article-title":"Parkinson\u2019s disease","volume":"397","author":"Bloem","year":"2021","journal-title":"Lancet Lond. Engl."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Azman, K.F., and Zakaria, R. (2022). Recent Advances on the Role of Brain-Derived Neurotrophic Factor (BDNF) in Neurodegenerative Diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23126827"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"736978","DOI":"10.3389\/fmed.2021.736978","article-title":"Alpha-Synuclein Aggregation in Parkinson\u2019s Disease","volume":"8","author":"Srinivasan","year":"2021","journal-title":"Front. Med."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jns.2011.03.035","article-title":"Dietary intake of metals and risk of Parkinson\u2019s disease: A case-control study in Japan","volume":"306","author":"Miyake","year":"2011","journal-title":"J. Neurol. Sci."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jns.2011.12.014","article-title":"NGF and nitrosative stress in patients with Huntington\u2019s disease","volume":"315","author":"Tasset","year":"2012","journal-title":"J. Neurol. Sci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.2147\/NDT.S230688","article-title":"Treatment of Magnesium-L-Threonate Elevates The Magnesium Level In The Cerebrospinal Fluid And Attenuates Motor Deficits And Dopamine Neuron Loss In A Mouse Model Of Parkinson\u2019s disease","volume":"15","author":"Shen","year":"2019","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.brainres.2014.09.053","article-title":"The possible mechanism of Parkinson\u2019s disease progressive damage and the preventive effect of GM1 in the rat model induced by 6-hydroxydopamine","volume":"1592","author":"Xu","year":"2014","journal-title":"Brain Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jns.2006.05.007","article-title":"Metal changes in CSF and peripheral compartments of parkinsonian patients","volume":"248","author":"Bocca","year":"2006","journal-title":"J. Neurol. Sci."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"23","DOI":"10.29245\/2572.942X\/2016\/9.1102","article-title":"SLC41A1 and TRPM7 in magnesium homeostasis and genetic risk for Parkinson\u2019s disease","volume":"1","author":"Sturgeon","year":"2016","journal-title":"J. Neurol. Neuromed."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1440-1789.2006.00672.x","article-title":"Magnesium deficiency over generations in rats with special references to the pathogenesis of the Parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam","volume":"26","author":"Oyanagi","year":"2006","journal-title":"Neuropathology"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Kolisek, M., Sponder, G., Mastrototaro, L., Smorodchenko, A., Launay, P., Vormann, J., and Schweigel-R\u00f6ntgen, M. (2013). Substitution p.A350V in Na+\/Mg2+ exchanger SLC41A1, potentially associated with Parkinson\u2019s disease, is a gain-of-function mutation. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0071096"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.bbadis.2007.02.008","article-title":"TRPM7 and TRPM2-Candidate susceptibility genes for Western Pacific ALS and PD?","volume":"1772","author":"Hermosura","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.brainresbull.2018.08.019","article-title":"Expression of magnesium transporter SLC41A1 in the striatum of 6-hydroxydopamine-induced parkinsonian rats","volume":"142","author":"Lin","year":"2018","journal-title":"Brain Res. Bull."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"584513","DOI":"10.3389\/fcell.2020.584513","article-title":"Transient Receptor Potential Channels as an Emerging Target for the Treatment of Parkinson\u2019s Disease: An Insight into Role of Pharmacological Interventions","volume":"8","author":"Vaidya","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1007\/s12035-019-01713-7","article-title":"Magnesium-Induced Cell Survival Is Dependent on TRPM7 Expression and Function","volume":"57","author":"Sun","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.neuroscience.2017.05.013","article-title":"Carvacrol promotes neuroprotection in the mouse hemiparkinsonian model","volume":"356","author":"Dati","year":"2017","journal-title":"Neuroscience"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s12031-016-0828-2","article-title":"Neuroprotective Role of MicroRNA-22 in a 6-Hydroxydopamine-Induced Cell Model of Parkinson\u2019s Disease via Regulation of Its Target Gene TRPM7","volume":"60","author":"Yang","year":"2016","journal-title":"J. Mol. Neurosci."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41572-018-0041-4","article-title":"Multiple sclerosis","volume":"4","author":"Filippi","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s12974-022-02446-6","article-title":"The role of Th17 cells\/IL-17A in AD, PD, ALS and the strategic therapy targeting on IL-17A","volume":"19","author":"Fu","year":"2022","journal-title":"J. Neuroinflamm."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1046\/j.1468-1331.2000.00142.x","article-title":"The effect of magnesium oral therapy on spasticity in a patient with multiple sclerosis","volume":"7","author":"Rossier","year":"2000","journal-title":"Eur. J. Neurol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"e124","DOI":"10.1097\/MJT.0000000000000538","article-title":"Magnesium Supplementation in Vitamin D Deficiency","volume":"26","author":"Reddy","year":"2019","journal-title":"Am. J. Ther."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"111674","DOI":"10.1016\/j.nut.2022.111674","article-title":"The effect of combined magnesium and vitamin D supplementation on vitamin D status, systemic inflammation, and blood pressure: A randomized double-blinded controlled trial","volume":"99\u2013100","author":"Cheung","year":"2022","journal-title":"Nutrition"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Wasnik, S., Sharma, I., Baylink, D.J., and Tang, X. (2020). Vitamin D as a Potential Therapy for Multiple Sclerosis: Where Are We?. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21093102"},{"key":"ref_118","first-page":"671","article-title":"Concentration of magnesium in the serum and the ability status of patients with relapsing-remitting multiple sclerosis","volume":"22","author":"Socha","year":"2017","journal-title":"J. Elem."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"13112","DOI":"10.1038\/s41598-020-69979-9","article-title":"A preliminary study of the concentration of metallic elements in the blood of patients with multiple sclerosis as measured by ICP-MS","volume":"10","author":"Gianeti","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s12011-021-02621-5","article-title":"Blood Trace Element Status in Multiple Sclerosis: A Systematic Review and Meta-analysis","volume":"200","author":"Nirooei","year":"2022","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/glia.23526","article-title":"Reactive astrocytes in multiple sclerosis impair neuronal outgrowth through TRPM7-mediated chondroitin sulfate proteoglycan production","volume":"67","author":"Kamermans","year":"2019","journal-title":"Glia"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2147\/CIA.S28768","article-title":"Correcting magnesium deficiencies may prolong life","volume":"7","author":"Rowe","year":"2012","journal-title":"Clin. Interv. Aging"},{"key":"ref_123","first-page":"77","article-title":"A connection between magnesium deficiency and aging: New insights from cellular studies","volume":"21","author":"Killilea","year":"2008","journal-title":"Magnes. Res."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.molmed.2022.07.003","article-title":"Cellular senescence in neuroinflammatory disease: New therapies for old cells?","volume":"28","author":"Nelke","year":"2022","journal-title":"Trends Mol. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41593-019-0372-9","article-title":"Senolytic therapy alleviates A\u03b2-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer\u2019s disease model","volume":"22","author":"Zhang","year":"2019","journal-title":"Nat. Neurosci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nature17407","article-title":"Daily magnesium fluxes regulate cellular timekeeping and energy balance","volume":"532","author":"Feeney","year":"2016","journal-title":"Nature"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S1474-4422(18)30461-7","article-title":"Association between circadian rhythms and neurodegenerative diseases","volume":"18","author":"Leng","year":"2019","journal-title":"Lancet. Neurol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11010-005-2733-9","article-title":"Intestinal and cardiac inflammatory response shows enhanced endotoxin receptor (CD14) expression in magnesium deficiency","volume":"278","author":"Chmielinska","year":"2005","journal-title":"Mol. Cell. Biochem."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1079\/BJN2002696","article-title":"Morphological and immune response alterations in the intestinal mucosa of the mouse after short periods on a low-magnesium diet","volume":"88","author":"Zimowska","year":"2002","journal-title":"Br. J. Nutr."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1017\/neu.2015.7","article-title":"Dietary magnesium deficiency affects gut microbiota and anxiety-like behaviour in C57BL\/6N mice","volume":"27","author":"Winther","year":"2015","journal-title":"Acta Neuropsychiatr."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1017\/neu.2015.7","article-title":"Dietary magnesium deficiency alters gut microbiota and leads to depressive-like behaviour","volume":"27","author":"Winther","year":"2015","journal-title":"Acta Neuropsychiatr."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/1\/223\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:48:46Z","timestamp":1760147326000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/1\/223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,23]]},"references-count":131,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["ijms24010223"],"URL":"https:\/\/doi.org\/10.3390\/ijms24010223","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,23]]}}}