{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T21:46:18Z","timestamp":1783719978586,"version":"3.55.0"},"reference-count":121,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Epstein\u2013Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV) are cancer-causing viruses that belong to human gamma-herpesviruses. They are DNA viruses known to establish lifelong infections in humans, with the ability to develop various types of cancer. Drug resistance remains the main barrier to achieving effective therapies for viral infections and cancer. Thus, new medications with dual antiviral and anticancer actions are highly needed. Flavonoids are secondary metabolites biosynthesized by plants with diverse therapeutic effects on human health. In this review, we feature the potential role of flavonoids (flavones, protoflavones, isoflavones, flavanones, flavonols, dihydroflavonols, catechins, chalcones, anthocyanins, and other flavonoid-type compounds) in controlling gamma-herpesvirus-associated cancers by blocking EBV and KSHV infections and inhibiting the formation and growth of the correlated tumors, such as nasopharyngeal carcinoma, Burkitt\u2019s lymphoma, gastric cancer, extranodal NK\/T-cell lymphoma, squamous cell carcinoma, Kaposi sarcoma, and primary effusion lymphoma. The underlying mechanisms via targeting EBV and KSHV life cycles and carcinogenesis are highlighted. Moreover, the effective concentrations or doses are emphasized.<\/jats:p>","DOI":"10.3390\/ijms24010247","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T04:24:53Z","timestamp":1671769493000},"page":"247","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Molecular Mechanisms of Flavonoids against Tumor Gamma-Herpesviruses and Their Correlated Cancers\u2014A Focus on EBV and KSHV Life Cycles and Carcinogenesis"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3922-2738","authenticated-orcid":false,"given":"Sherif T. S.","family":"Hassan","sequence":"first","affiliation":[{"name":"Department of Applied Ecology, Faculty of Environmental Sciences, Czech University of Life Sciences Prague, Kam\u00fdck\u00e1 129, 165 00 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslava","family":"\u0160udomov\u00e1","sequence":"additional","affiliation":[{"name":"Museum of Literature in Moravia, Kl\u00e1\u0161ter 1, 664 61 Rajhrad, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"605258","DOI":"10.3389\/fcimb.2021.605258","article-title":"The Role of Lytic Infection for Lymphomagenesis of Human \u03b3-Herpesviruses","volume":"11","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Wen, K.W., Wang, L., Menke, J.R., and Damania, B. (2021). 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