{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:06:59Z","timestamp":1788336419688,"version":"build-2803163510"},"reference-count":56,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Diagnosis of Mycosis Fungoides (MF) may be challenging, due to its polymorphic nature. The use of miRNAs as biomarkers to assist in diagnosis has been investigated, mainly in skin lesion biopsies. The purpose of this study is to evaluate the plasma levels of miR-146a and miR-155 in MF patients and to investigate their association with SNPs of their genes. Plasma miRNAs were quantified by RT-qPCR. Genomic DNA was used for SNPs\u2019 genotyping by Sanger sequencing. Plasma levels of miR-146a and miR-155 were significantly higher in patients vs. controls, in early MF patients vs. controls, and in advanced vs. early MF patients. Both miRNAs\u2019 levels were significantly higher in stage IIB vs. early-stage patients. miR-155 plasma levels were significantly higher in patients with skin tumors or erythroderma. CC genotype (rs2910164 C&gt;G) was significantly more frequent in healthy controls and associated with lower MF risk and lower miR-146a levels. The AA genotype (rs767649 T&gt;A) was significantly more frequent in patients and correlated with increased MF risk and increased miR-155 levels. The combination of GG+AA was only detected in patients and was correlated with higher MF susceptibility. Increased mir-146a and mir-155 plasma levels in MF is an important finding to establish putative noninvasive biomarkers. The presence of SNPs is closely associated with miRs\u2019 expression, and possibly with disease susceptibility.<\/jats:p>","DOI":"10.3390\/ijms24010271","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T04:35:43Z","timestamp":1672115743000},"page":"271","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Dysregulation of Plasma miR-146a and miR-155 Expression Profile in Mycosis Fungoides Is Associated with rs2910164 and rs767649 Polymorphisms"],"prefix":"10.3390","volume":"24","author":[{"given":"Chrysostomos","family":"Avgeros","sequence":"first","affiliation":[{"name":"Laboratory of Biological Chemistry, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9616-2001","authenticated-orcid":false,"given":"Aikaterini","family":"Patsatsi","sequence":"additional","affiliation":[{"name":"2nd Dermatology Department, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, \u201cPapageorgiou\u201d General Hospital, 56403 Thessaloniki, Greece"},{"name":"Center for Interdisciplinary Research and Innovation (CIRI-AUTH), 57001 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Dimitriadis","sequence":"additional","affiliation":[{"name":"School of Economics, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1968-7020","authenticated-orcid":false,"given":"Andigoni","family":"Malousi","sequence":"additional","affiliation":[{"name":"Laboratory of Biological Chemistry, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"},{"name":"Center for Interdisciplinary Research and Innovation (CIRI-AUTH), 57001 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4435-3532","authenticated-orcid":false,"given":"Triantafyllia","family":"Koletsa","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Despoina","family":"Papathemeli","sequence":"additional","affiliation":[{"name":"2nd Dermatology Department, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, \u201cPapageorgiou\u201d General Hospital, 56403 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Syrnioti","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paraskevi","family":"Avgerou","sequence":"additional","affiliation":[{"name":"Laboratory of Biological Chemistry, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4072-3591","authenticated-orcid":false,"given":"Elizabeth","family":"Lazaridou","sequence":"additional","affiliation":[{"name":"2nd Dermatology Department, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, \u201cPapageorgiou\u201d General Hospital, 56403 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Tzimagiorgis","sequence":"additional","affiliation":[{"name":"Laboratory of Biological Chemistry, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"},{"name":"Center for Interdisciplinary Research and Innovation (CIRI-AUTH), 57001 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8732-0610","authenticated-orcid":false,"given":"Elisavet","family":"Georgiou","sequence":"additional","affiliation":[{"name":"Laboratory of Biological Chemistry, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"},{"name":"Center for Interdisciplinary Research and Innovation (CIRI-AUTH), 57001 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Dobos, G., Pohrt, A., Ram-Wolff, C., Lebb\u00e9, C., Bouaziz, J.-D., Battistella, M., Bagot, M., and De Masson, A. (2020). Epidemiology of Cutaneous T-Cell Lymphomas: A Systematic Review and Meta-Analysis of 16,953 Patients. Cancers, 12.","DOI":"10.3390\/cancers12102921"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.21037\/cco.2018.11.03","article-title":"Update on Skin Directed Therapies in Mycosis Fungoides","volume":"8","author":"Lovgren","year":"2019","journal-title":"Chin. Clin. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1046\/j.1365-4362.2003.01566.x","article-title":"Assessment of Histologic Criteria in the Diagnosis of Mycosis Fungoides","volume":"42","author":"Naraghi","year":"2003","journal-title":"Int. J. Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1600-0560.2009.01289.x","article-title":"Diagnosis of Mycosis Fungoides with Different Algorithmic Approaches","volume":"37","author":"Furmanczyk","year":"2010","journal-title":"J. Cutan. Pathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1097\/01.pas.0000153121.57515.c6","article-title":"Histopathologic Features of Early (Patch) Lesions of Mycosis Fungoides","volume":"29","author":"Massone","year":"2005","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/bjd.17258","article-title":"The PROCLIPI International Registry of Early-Stage Mycosis Fungoides Identifies Substantial Diagnostic Delay in Most Patients","volume":"181","author":"Scarisbrick","year":"2019","journal-title":"Br. J. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation","volume":"9","author":"Hayder","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"626","DOI":"10.3389\/fgene.2019.00626","article-title":"Circulating MicroRNAs in Cancer: Potential and Challenge","volume":"10","author":"Cui","year":"2019","journal-title":"Front. Genet."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1016\/j.jid.2018.03.1500","article-title":"MicroRNA Signatures in Diagnosis and Prognosis of Cutaneous T-Cell Lymphoma","volume":"138","author":"Shen","year":"2018","journal-title":"J. Investog. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1111\/jdv.13597","article-title":"MiR-155 Expression in Primary Cutaneous T-Cell Lymphomas (CTCL)","volume":"31","author":"Fava","year":"2017","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1111\/apm.12162","article-title":"Expression of MiR-155 and MiR-126 in Situ in Cutaneous T-Cell Lymphoma","volume":"121","author":"Kopp","year":"2013","journal-title":"Apmis"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Di Raimondo, C., Han, Z., Su, C., Wu, X., Qin, H., Sanchez, J.F., Yuan, Y.C., Martinez, X., Abdulla, F., and Zain, J. (2021). Identification of a Distinct Mirna Regulatory Network in the Tumor Microenvironment of Transformed Mycosis Fungoides. Cancers, 13.","DOI":"10.3390\/cancers13225854"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.4161\/cc.24987","article-title":"STAT5-Mediated Expression of Oncogenic MiR-155 in Cutaneous T-Cell Lymphoma","volume":"12","author":"Kopp","year":"2013","journal-title":"Cell Cycle"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Manso, R., Martinez-Magunacelaya, N., Era\u00f1a-Tom\u00e1s, I., Monsalvez, V., Rodriguez-Peralto, J.L., Ortiz-Romero, P.L., Santonja, C., Crist\u00f3bal, I., Piris, M.A., and Rodriguez-Pinilla, S.M. (2018). Mycosis Fungoides Progression Could Be Regulated by MicroRNAs. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0198477"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13148-018-0492-1","article-title":"Circulating MicroRNAs as Potential Cancer Biomarkers: The Advantage and Disadvantage","volume":"10","author":"Wang","year":"2018","journal-title":"Clin. Epigenetics"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1111\/bjd.20519","article-title":"Mycosis Fungoides-Derived Exosomes Promote Cell Motility and Are Enriched with MicroRNA-155 and MicroRNA-1246, and Their Plasma-Cell-Free Expression May Serve as a Potential Biomarker for Disease Burden","volume":"185","author":"Moyal","year":"2021","journal-title":"Br. J. Dermatol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Dus\u00edlkov\u00e1, N., Ba\u0161ov\u00e1, P., Pol\u00edvka, J., Kodet, O., Kulvait, V., Pe\u0161ta, M., Trn\u011bn\u00fd, M., and Stopka, T. (2017). Plasma MiR-155, Mir-203, and MiR-205 Are Biomarkers for Monitoring of Primary Cutaneous T-Cell Lymphomas. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18102136"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"7269","DOI":"10.1073\/pnas.0802682105","article-title":"Common SNP in Pre-MiR-146a Decreases Mature MiR Expression and Predisposes to Papillary Thyroid Carcinoma","volume":"105","author":"Jazdzewski","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12032-014-0306-z","article-title":"MicroRNA-146a Rs2910164 Polymorphism and the Risk of Diffuse Large B Cell Lymphoma in the Chinese Han Population","volume":"31","author":"Zhuang","year":"2014","journal-title":"Med. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.gene.2016.10.002","article-title":"The Rs767649 Polymorphism in the Promoter of MiR-155 Contributes to the Decreased Risk for Cervical Cancer in a Chinese Population","volume":"595","author":"Wang","year":"2016","journal-title":"Gene"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"42781","DOI":"10.18632\/oncotarget.5840","article-title":"A Functional Variant in MiR-155 Regulation Region Contributes to Lung Cancer Risk and Survival","volume":"6","author":"Xie","year":"2015","journal-title":"Oncotarget"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Miyagaki, T. (2021). Diagnosis of Early Mycosis Fungoides. Diagnostics, 11.","DOI":"10.3390\/diagnostics11091721"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2","DOI":"10.12788\/j.sder.2018.002","article-title":"Mycosis Fungoides-Clinical and Histopathologic Features, Differential Diagnosis, and Treatment","volume":"37","author":"Cerroni","year":"2018","journal-title":"Semin. Cutan. Med. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"472","DOI":"10.2340\/00015555-1971","article-title":"Delay in the Histopathologic Diagnosis of Mycosis Fungoides","volume":"95","author":"Skov","year":"2015","journal-title":"Acta Derm. Venereol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Gluud, M., Willerslev-Olsen, A., Gjerdrum, L.M.R., Lindahl, L.M., Buus, T.B., Andersen, M.H., Bonefeld, C.M., Krejsgaard, T., Litvinov, I.V., and Iversen, L. (2020). MicroRNAs in the Pathogenesis, Diagnosis, Prognosis and Targeted Treatment of Cutaneous T-Cell Lymphomas. Cancers, 12.","DOI":"10.3390\/cancers12051229"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5891","DOI":"10.1182\/blood-2011-06-358382","article-title":"Diagnostic MicroRNA Profiling in Cutaneous T-Cell Lymphoma (CTCL)","volume":"118","author":"Ralfkiaer","year":"2011","journal-title":"Blood"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"957","DOI":"10.3109\/10428194.2013.815352","article-title":"Validation of a Diagnostic MicroRNA Classifier in Cutaneous T-Cell Lymphomas","volume":"55","author":"Marstrand","year":"2014","journal-title":"Leuk. Lymphoma"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/jid.2013.461","article-title":"MiR-223 Regulates Cell Growth and Targets Proto-Oncogenes in Mycosis Fungoides\/Cutaneous T-Cell Lymphoma","volume":"134","author":"McGirt","year":"2014","journal-title":"J. Investig. Dermatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e151","DOI":"10.1038\/cddis.2011.32","article-title":"MicroRNA Profiling Reveals That MiR-21, MiR486 and MiR-214 Are Upregulated and Involved in Cell Survival in S\u00e9zary Syndrome","volume":"2","author":"Narducci","year":"2011","journal-title":"Cell Death Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1182\/blood-2013-09-527739","article-title":"MicroRNA-150 Inhibits Tumor Invasion and Metastasis by Targeting the Chemokine Receptor CCR6, in Advanced Cutaneous T-Cell Lymphoma","volume":"123","author":"Ito","year":"2014","journal-title":"Blood"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Manf\u00e8, V., Biskup, E., Willumsgaard, A., Skov, A.G., Palmieri, D., Gasparini, P., Lagan\u00e1, A., Woetmann, A., \u00d8dum, N., and Croce, C.M. (2013). CMyc\/MiR-125b-5p Signalling Determines Sensitivity to Bortezomib in Preclinical Model of Cutaneous T-Cell Lymphomas. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0059390"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.molonc.2011.02.003","article-title":"MiRNA Expression Profiling of Mycosis Fungoides","volume":"5","author":"Ballabio","year":"2011","journal-title":"Mol. Oncol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1182\/blood-2017-06-788950","article-title":"Prognostic MiRNA Classifier in Early-Stage Mycosis Fungoides: Development and Validation in a Danish Nationwide Study","volume":"131","author":"Lindahl","year":"2018","journal-title":"Blood"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Talaat, I.M., Abdelmaksoud, R.E.S., Guimei, M., Agamia, N.F., Nugud, A., and El-Serafi, A.T. (2019). Potential Role for MicroRNA-16 (MiR-16) and MicroRNA-93 (MiR-93) in Diagnosis and Prediction of Disease Progression in Mycosis Fungoides in Egyptian Patients. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0224305"},{"key":"ref_35","first-page":"1148","article-title":"The MicroRNA Expression Profile Differs between Erythrodermic Mycosis Fungoides and S\u00e9zary Syndrome","volume":"99","author":"Rittig","year":"2019","journal-title":"Acta Derm. Venereol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1111\/jdv.12299","article-title":"Genetic Markers Associated with Progression in Early Mycosis Fungoides","volume":"28","author":"Johnson","year":"2014","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"5750","DOI":"10.4049\/jimmunol.1500615","article-title":"Coordinated Regulation of MiR-155 and MiR-146a Genes during Induction of Endotoxin Tolerance in Macrophages","volume":"195","author":"Doxaki","year":"2015","journal-title":"J. Immunol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/s41467-017-00972-z","article-title":"An NF-\u039aB-MicroRNA Regulatory Network Tunes Macrophage Inflammatory Responses","volume":"8","author":"Mann","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/humu.20837","article-title":"Common Genetic Variants in Pre-MicroRNAs Were Associated with Increased Risk of Breast Cancer in Chinese Women","volume":"30","author":"Hu","year":"2009","journal-title":"Hum. Mutat."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1080\/08820139.2021.1883647","article-title":"Role of miR-146a rs2910164 and UTS2 rs228648 Genetic Variants in Beh\u00e7et\u2019s Disease","volume":"51","author":"Kamal","year":"2021","journal-title":"Immunol. Investig."},{"key":"ref_41","first-page":"782","article-title":"Polymorphisms of Pre-Mir-499 Rs3746444 T\/C and Pre-Mir-146a Rs2910164 C\/G in the Autoimmune Diseases of Rheumatoid Arthritis and Systemic Lupus Erythematosus in the West of Iran","volume":"49","author":"Ahmadi","year":"2020","journal-title":"Iran. J. Public Health"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/08820139.2020.1817934","article-title":"MiRNA-146a rs2910164 Confers a Susceptibility to Digestive System Cancer: A Meta-Analysis Involving 59,098 Subjects","volume":"51","author":"Lv","year":"2020","journal-title":"Immunol. Investig."},{"key":"ref_43","first-page":"247","article-title":"Association of MicroRNA-155rs767649 Polymorphism with Susceptibility to Preeclampsia","volume":"8","author":"Ayoub","year":"2019","journal-title":"Int. J. Mol. Cell. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1530\/EC-19-0446","article-title":"Gene Polymorphism and Plasma Levels of MiR-155 in Diabetic Retinopathy","volume":"8","author":"Polina","year":"2019","journal-title":"Endocr. Connect."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1089\/jir.2019.0001","article-title":"Association between MiR-155, Its Polymorphism and Ischemia-Modified Albumin in Patients with Rheumatoid Arthritis","volume":"39","author":"Shaker","year":"2019","journal-title":"J. Interf. Cytokine Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13059-018-1463-8","article-title":"Alternative DNA Secondary Structure Formation Affects RNA Polymerase II Promoter-Proximal Pausing in Human","volume":"19","author":"Szlachta","year":"2018","journal-title":"Genome Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/bjh.16428","article-title":"The New Biology of PTCL-NOS and AITL: Current Status and Future Clinical Impact","volume":"189","author":"Timmins","year":"2020","journal-title":"Br. J. Haematol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3892\/br.2016.833","article-title":"Association of Two Synonymous Splicing-Associated CpG Single Nucleotide Polymorphisms in Calpain 10 and Solute Carrier Family 2 Member 2 with Type 2 Diabetes","volume":"6","author":"Karambataki","year":"2017","journal-title":"Biomed. Rep."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/8179415","article-title":"The MiR-146a SNP Rs2910164 and MiR-155 SNP Rs767649 Are Risk Factors for Non-Small Cell Lung Cancer in the Iranian Population","volume":"2020","author":"Dezfuli","year":"2020","journal-title":"Can. Respir. J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1182\/blood-2018-11-881268","article-title":"The 2018 Update of the WHO-EORTC Classification for Primary Cutaneous Lymphomas","volume":"133","author":"Willemze","year":"2019","journal-title":"Blood"},{"key":"ref_51","first-page":"3759","article-title":"G*Power 3: A Flexible Statistical Power Analysis Program for the Social, Behavioral, and Biomedical Sciences","volume":"7","author":"Rechchach","year":"2016","journal-title":"J. Mater. Environ. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.1093\/bioinformatics\/btz087","article-title":"G4Hunter Web Application: A Web Server for G-Quadruplex Prediction","volume":"35","author":"Bartas","year":"2019","journal-title":"Bioinformatics"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"W527","DOI":"10.1093\/nar\/gkv344","article-title":"QmRLFS-Finder: A Model, Web Server and Stand-Alone Tool for Prediction and Analysis of R-Loop Forming Sequences","volume":"43","author":"Jenjaroenpun","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0168-9525(00)02024-2","article-title":"EMBOSS: The European Molecular Biology Open Software Suite","volume":"16","author":"Rice","year":"2000","journal-title":"Trends Genet."},{"key":"ref_55","first-page":"350","article-title":"Design of RNAs: Comparing Programs for Inverse RNA Folding","volume":"19","author":"Churkin","year":"2018","journal-title":"Brief. Bioinform."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"D260","DOI":"10.1093\/nar\/gkx1126","article-title":"JASPAR 2018: Update of the Open-Access Database of Transcription Factor Binding Profiles and Its Web Framework","volume":"46","author":"Khan","year":"2018","journal-title":"Nucleic Acids Res."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/1\/271\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:49:31Z","timestamp":1760147371000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/1\/271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,23]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["ijms24010271"],"URL":"https:\/\/doi.org\/10.3390\/ijms24010271","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,23]]}}}