{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:36:43Z","timestamp":1790800603451,"version":"4.1.0"},"reference-count":26,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T00:00:00Z","timestamp":1671840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical University of Lodz","award":["503\/1-152-01\/503-11-002"],"award-info":[{"award-number":["503\/1-152-01\/503-11-002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The JAK\/STAT signal pathway is a system of intracellular proteins used by many cytokines and growth factors to express genes responsible for the process of cell activation, proliferation and differentiation. There has been numerous inflammatory and autoimmune diseases identified where the JAK\/STAT signaling is disrupted; however, there are only a few papers concerning autoimmune bullous diseases published. The aim of this study was to evaluate the expression of proteins: JAK3, STAT2, STAT4 and STAT6 in epithelium lesions in patients with pemphigus vulgaris (PV), bullous pemphigoid (BP), oral lichen planus (LP) and chronic ulcerative stomatitis (CUS), as well as in the control group. Immunohistochemistry and immunoblotting were used to evaluate expression of selected proteins. We found significantly higher expression of selected JAK\/STAT proteins in oral mucosa lesions in study groups in comparison to the control group, which indicates participation of JAK\/STAT pathway in pathogenesis of these diseases. In BP and PV there were no increased STAT2 expression, whereas in CUS and LP no increased STAT4 expression occurred. The differences in expression of JAK\/STAT proteins in selected disorders have been observed. These results create new potential therapeutic targets for the treatment.<\/jats:p>","DOI":"10.3390\/ijms24010323","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T04:40:39Z","timestamp":1672116039000},"page":"323","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Expression of the Selected Proteins of JAK\/STAT Signaling Pathway in Diseases with Oral Mucosa Involvement"],"prefix":"10.3390","volume":"24","author":[{"given":"Kamila","family":"Ociepa","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, Medical University of Lodz, 90-674 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Danilewicz","sequence":"additional","affiliation":[{"name":"Department of Pathomorphology, Medical University of Lodz, 92-213 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"W\u0105growska-Danilewicz","sequence":"additional","affiliation":[{"name":"Department of Nephropathology, Medical University of Lodz, 92-213 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00f3\u017ca","family":"Peterson-J\u0119ckowska","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Mucosa Diseases, Medical University of Lodz, 92-213 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"W\u00f3jcicka-Rubin","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Mucosa Diseases, Medical University of Lodz, 92-213 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3834-6715","authenticated-orcid":false,"given":"Natalia","family":"Lewkowicz","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Mucosa Diseases, Medical University of Lodz, 92-213 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rados\u0142aw","family":"Zajdel","sequence":"additional","affiliation":[{"name":"Department of Computer Science in Economics, Faculty of Economics and Sociology, University of Lodz, 90-255 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"\u017bebrowska","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Medical University of Lodz, 90-674 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.immuni.2012.03.014","article-title":"JAK and STAT signaling molecules in immunoregulation and immune-mediated disease","volume":"36","author":"Plenge","year":"2012","journal-title":"Immunity"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"6716419","DOI":"10.1155\/2017\/6716419","article-title":"Expression of the JAK\/STAT Signaling Pathway in Bullous Pemphigoid and Dermatitis Herpetiformis","volume":"2017","author":"Juczynska","year":"2017","journal-title":"Mediat. 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