{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:27:04Z","timestamp":1792175224939,"version":"4.4.0"},"reference-count":144,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>According to Alzheimer\u2019s Disease International, 55 million people worldwide are living with dementia. Dementia is a disorder that manifests as a set of related symptoms, which usually result from the brain being damaged by injury or disease. The symptoms involve progressive impairments in memory, thinking, and behavior, usually accompanied by emotional problems, difficulties with language, and decreased motivation. The most common variant of dementia is Alzheimer\u2019s disease with symptoms dominated by cognitive disorders, particularly memory loss, impaired personality, and judgmental disorders. So far, all attempts to treat dementias by removing their symptoms rather than their causes have failed. Therefore, in the presented narrative review, I will attempt to explain the etiology of dementia and Alzheimer\u2019s disease from the perspective of energy and cognitive metabolism dysfunction in an aging brain. I hope that this perspective, though perhaps too simplified, will bring us closer to the essence of aging-related neurodegenerative disorders and will soon allow us to develop new preventive\/therapeutic strategies in our struggle with dementia, Alzheimer\u2019s disease, and Parkinson\u2019s disease.<\/jats:p>","DOI":"10.3390\/ijms24010543","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T02:56:50Z","timestamp":1672282610000},"page":"543","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Pathogenesis of Dementia"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1073-9629","authenticated-orcid":false,"given":"Janusz Wies\u0142aw","family":"B\u0142aszczyk","sequence":"first","affiliation":[{"name":"Jerzy Kukuczka Academy of Physical Education, 72 Miko\u0142owska Street, 40-065 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3389\/fpsyt.2019.00122","article-title":"The Protracted Maturation of Associative Layer IIIC Pyramidal Neurons in the Human Prefrontal Cortex During Childhood: A Major Role in Cognitive Development and Selective Alteration in Autism","volume":"10","author":"Petanjek","year":"2019","journal-title":"Front. Psychiatry"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1016\/S1262-3636(10)70469-9","article-title":"Food for thought: The importance of glucose and other energy substrates for sustaining brain function under varying levels of activity","volume":"36","author":"Pellerin","year":"2010","journal-title":"Diabetes Metab."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1152\/physrev.00062.2017","article-title":"Brain Glucose Metabolism: Integration of Energetics with Function","volume":"99","author":"Dienel","year":"2019","journal-title":"Physiol. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/(SICI)1520-7560(199911\/12)15:6<412::AID-DMRR72>3.0.CO;2-8","article-title":"Ketone bodies: A review of physiology, pathophysiology and application of monitoring to diabetes","volume":"15","author":"Laffel","year":"1999","journal-title":"Diabetes\/Metabolism Res. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1074\/jbc.M107895200","article-title":"Mechanism for Fatty Acid \u201cSparing\u201d Effect on Glucose-induced Transcription: Regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase","volume":"277","author":"Kawaguchi","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Nguyen, T.T., Ta, Q.T.H., Nguyen, T.K.O., Nguyen, T.T.D., and Van Giau, V. (2020). Type 3 diabetes and its role implications in Alzheimer\u2019s disease. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21093165"},{"key":"ref_7","first-page":"45","article-title":"Type 2 diabetes mellitus, oxidative stress and inflammation: Examining the links","volume":"11","author":"Oguntibeju","year":"2019","journal-title":"Int. J. Physiol. Pathophysiol. Pharmacol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1073\/pnas.1417921112","article-title":"In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences","volume":"112","author":"Zhu","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.mce.2016.11.003","article-title":"NAD and the aging process: Role in life, death and everything in between","volume":"455","author":"Chini","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"111569","DOI":"10.1016\/j.mad.2021.111569","article-title":"The balance between NAD+ biosynthesis and consumption in ageing","volume":"199","author":"Diab","year":"2021","journal-title":"Mech. Ageing Dev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0960-9822(03)00135-0","article-title":"The Cost of Cortical Computation","volume":"13","author":"Lennie","year":"2003","journal-title":"Curr. Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/nature05289","article-title":"A network dysfunction perspective on neurodegenerative diseases","volume":"443","author":"Palop","year":"2006","journal-title":"Nature"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1098\/rstb.2008.0308","article-title":"On the nature of medial temporal lobe contributions to the constructive simulation of future events","volume":"364","author":"Schacter","year":"2009","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Irish, M., Hornberger, M., El Wahsh, S., Lam, B.Y.K., Lah, S., Miller, L., Hsieh, S., Hodges, J.R., and Piguet, O. (2014). Grey and White Matter Correlates of Recent and Remote Autobiographical Memory Retrieval\u2014Insights from the Dementias. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0113081"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"900715","DOI":"10.3389\/fnint.2022.900715","article-title":"Neural synchrony in cortical networks: Mechanisms and implications for neural information processing and coding","volume":"16","author":"Gansel","year":"2022","journal-title":"Front. Integr. Neurosci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s00429-019-01841-9","article-title":"The Structural Model: A theory linking connections, plasticity, pathology, development and evolution of the cerebral cortex","volume":"224","author":"Zikopoulos","year":"2019","journal-title":"Anat. Embryol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"B\u0142aszczyk, J. (2020). Energy Metabolism Decline in the Aging Brain\u2014Pathogenesis of Neurodegenerative Disorders. Metabolites, 10.","DOI":"10.20944\/preprints202009.0539.v1"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e00038-18","DOI":"10.1128\/MMBR.00038-18","article-title":"Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and Immunity","volume":"83","author":"Brady","year":"2018","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41580-020-00313-x","article-title":"NAD+ metabolism and its roles in cellular processes during ageing","volume":"22","author":"Covarrubias","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Massudi, H., Grant, R., Braidy, N., Guest, J., Farnsworth, B., and Guillemin, G. (2012). Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0042357"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.cell.2013.11.037","article-title":"Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging","volume":"155","author":"Gomes","year":"2013","journal-title":"Cell"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"18308","DOI":"10.1073\/pnas.0606526103","article-title":"Poly(ADP-ribose) (PAR) polymer is a death signal","volume":"103","author":"Andrabi","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/jcbfm.2009.35","article-title":"Blood Lactate is an Important Energy Source for the Human Brain","volume":"29","author":"Rasmussen","year":"2009","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.neuron.2015.03.035","article-title":"A Cellular Perspective on Brain Energy Metabolism and Functional Imaging","volume":"86","author":"Magistretti","year":"2015","journal-title":"Neuron"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3389\/fphar.2016.00521","article-title":"Cerebral Gluconeogenesis and Diseases","volume":"7","author":"Yip","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Tulb\u0103, D., Cozma, L., Popescu, B., and Davidescu, E. (2020). Dysautonomia in Alzheimer\u2019s Disease. Medicina, 56.","DOI":"10.3390\/medicina56070337"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/s12276-021-00705-9","article-title":"Autonomic control of energy balance and glucose homeostasis","volume":"54","author":"Hyun","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e38704","DOI":"10.7554\/eLife.38704","article-title":"Insulin regulates POMC neuronal plasticity to control glucose metabolism","volume":"7","author":"Dodd","year":"2018","journal-title":"Elife"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1365-2796.2005.01553.x","article-title":"Brain regulation of food intake and appetite: Molecules and networks","volume":"258","author":"Broberger","year":"2005","journal-title":"J. Intern. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1038\/nature04284","article-title":"Hypothalamic regulation of sleep and circadian rhythms","volume":"437","author":"Saper","year":"2005","journal-title":"Nature"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.tins.2020.09.011","article-title":"Neural Circuits of Interoception","volume":"44","author":"Berntson","year":"2021","journal-title":"Trends Neurosci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nn1456","article-title":"Hypothalamic sensing of fatty acids","volume":"8","author":"Lam","year":"2005","journal-title":"Nat. Neurosci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41572-022-00351-z","article-title":"Hypothalamic syndrome","volume":"8","author":"Tauber","year":"2022","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1016\/j.celrep.2014.11.018","article-title":"Microglia Dictate the Impact of Saturated Fat Consumption on Hypothalamic Inflammation and Neuronal Function","volume":"9","author":"Valdearcos","year":"2014","journal-title":"Cell Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00401-014-1321-z","article-title":"Microglia as a critical player in both developmental and late-life CNS pathologies","volume":"128","author":"Derecki","year":"2014","journal-title":"Acta Neuropathol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/nm.3639","article-title":"GABA from reactive astrocytes impairs memory in mouse models of Alzheimer\u2019s disease","volume":"20","author":"Jo","year":"2014","journal-title":"Nat. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2147\/JMDH.S45443","article-title":"Anatomic connections of the diaphragm influence of respiration on the body system","volume":"6","author":"Bordoni","year":"2013","journal-title":"J. Multidiscip. Healthc."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1177\/0004563214521399","article-title":"Phosphate homeostasis and disorders","volume":"51","author":"Manghat","year":"2014","journal-title":"Ann. Clin. Biochem. Int. J. Biochem. Lab. Med."},{"key":"ref_39","first-page":"130","article-title":"Novel insights into the regulation of systemic phosphate homeostasis and renal phosphate excretion","volume":"20","author":"Wagner","year":"2007","journal-title":"J. Nephrol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.cell.2010.06.003","article-title":"Insulin Signaling in Osteoblasts Integrates Bone Remodeling and Energy Metabolism","volume":"142","author":"Ferron","year":"2010","journal-title":"Cell"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/nrendo.2017.80","article-title":"Regulation of hepatic glucose metabolism in health and disease","volume":"13","author":"Petersen","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"101138","DOI":"10.1016\/j.molmet.2020.101138","article-title":"Hepatokines and metabolism: Deciphering communication from the liver","volume":"44","author":"Potthoff","year":"2021","journal-title":"Mol. Metab."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"R502","DOI":"10.1152\/ajpregu.00114.2004","article-title":"Biochemistry of exercise-induced metabolic acidosis","volume":"287","author":"Robergs","year":"2004","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/28867","article-title":"Role of HIF-1\u03b1 in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis","volume":"394","author":"Carmeliet","year":"1998","journal-title":"Nature"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1161\/01.ATV.0000258979.92828.bc","article-title":"Reactive Oxygen Species Activate the HIF-1\u03b1 Promoter Via a Functional NF\u03baB Site","volume":"27","author":"Bonello","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"19565","DOI":"10.1073\/pnas.0810654106","article-title":"Opening and closing the metabolite gate","volume":"105","author":"Neutze","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/jbmr.320","article-title":"The amazing osteocyte","volume":"26","author":"Bonewald","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"938447","DOI":"10.3389\/fphar.2022.938447","article-title":"Advances in Our Understanding of the Mechanism of Action of Drugs (including Traditional Chinese Medicines) for the Intervention and Treatment of Osteoporosis","volume":"13","author":"Lu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_49","unstructured":"Goyal, R., and Jialal, I. (2022). Hyperphosphatemia. StatPearls [Internet], StatPearls Publishing."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3389\/fcell.2015.00066","article-title":"Transcriptional regulators of Na,K-ATPase subunits","volume":"3","author":"Li","year":"2015","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"4792","DOI":"10.1210\/jc.2006-1702","article-title":"Pulsatile Secretion of Growth Hormone (GH) Persists during Continuous Stimulation by CJC-1295, a Long-Acting GH-Releasing Hormone Analog","volume":"91","author":"Ionescu","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"T69","DOI":"10.1530\/JME-17-0311","article-title":"40 YEARS OF IGF1: IGF1 receptor signaling pathways","volume":"61","author":"Hakuno","year":"2018","journal-title":"J. Mol. Endocrinol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00018-022-04201-9","article-title":"CEBP\u03b2 regulation of endogenous IGF-1 in adult sensory neurons can be mobilized to overcome diabetes-induced deficits in bioenergetics and axonal outgrowth","volume":"79","author":"Aghanoori","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"101234","DOI":"10.1016\/j.molmet.2021.101234","article-title":"The brain as an insulin-sensitive metabolic organ","volume":"52","author":"Milstein","year":"2021","journal-title":"Mol. Metab."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.2337\/db14-0568","article-title":"Insulin Action in Brain Regulates Systemic Metabolism and Brain Function","volume":"63","author":"Kleinridders","year":"2014","journal-title":"Diabetes"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/cns.12866","article-title":"Insulin receptor in the brain: Mechanisms of activation and the role in the CNS pathology and treatment","volume":"24","author":"Pomytkin","year":"2018","journal-title":"CNS Neurosci. Ther."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Riedemann, T. (2019). Diversity and Function of Somatostatin-Expressing Interneurons in the Cerebral Cortex. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20122952"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Pittaluga, A., Roggeri, A., Vallarino, G., and Olivero, G. (2021). Somatostatin, a Presynaptic Modulator of Glutamatergic Signal in the Central Nervous System. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22115864"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Liguz-Lecznar, M., Dobrzanski, G., and Kossut, M. (2022). Somatostatin and Somatostatin-Containing Interneurons\u2014From Plasticity to Pathology. Biomolecules, 12.","DOI":"10.1038\/s41598-022-22801-0"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"698","DOI":"10.3389\/fneur.2018.00698","article-title":"Endocrine Crosstalk Between Skeletal Muscle and the Brain","volume":"9","author":"Delezie","year":"2018","journal-title":"Front. Neurol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/nrendo.2017.181","article-title":"Osteocalcin in the brain: From embryonic development to age-related decline in cognition","volume":"14","author":"Obri","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s11065-010-9148-4","article-title":"The Basics of Brain Development","volume":"20","author":"Stiles","year":"2010","journal-title":"Neuropsychol. Rev."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"4187","DOI":"10.1111\/ejn.15742","article-title":"Circuit formation in the adult brain","volume":"56","author":"Seng","year":"2022","journal-title":"Eur. J. Neurosci."},{"key":"ref_64","unstructured":"Fisher, S., and Reason, J. (1988). Allostasis: A new paradigm to explain arousal pathology. Handbook of Life Stress, Cognition and Health, John Wiley & Sons."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"247879","DOI":"10.1155\/2011\/247879","article-title":"Lateral Information Processing by Spiking Neurons: A Theoretical Model of the Neural Correlate of Consciousness","volume":"2011","author":"Ebner","year":"2011","journal-title":"Comput. Intell. Neurosci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"662031","DOI":"10.3389\/fnhum.2021.662031","article-title":"Cerebral White Matter Myelination and Relations to Age, Gender, and Cognition: A Selective Review","volume":"15","author":"Buyanova","year":"2021","journal-title":"Front. Hum. Neurosci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1152\/jn.00328.2022","article-title":"Neurophysiological Mechanisms of Implicit and Explicit Memory in the Process of Consciousness","volume":"128","author":"Tucker","year":"2022","journal-title":"J. Neurophysiol."},{"key":"ref_68","first-page":"2","article-title":"Pyramidal cells in prefrontal cortex of primates: Marked differences in neuronal structure among species","volume":"5","author":"Elston","year":"2011","journal-title":"Front. Neuroanat."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0306-4522(00)00496-6","article-title":"Total number and distribution of inhibitory and excitatory synapses on hippocampal CA1 pyramidal cells","volume":"102","author":"Emri","year":"2001","journal-title":"Neuroscience"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3389\/fnana.2014.00078","article-title":"Pyramidal cell development: Postnatal spinogenesis, dendritic growth, axon growth, and electrophysiology","volume":"8","author":"Elston","year":"2014","journal-title":"Front. Neuroanat."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1097\/00004647-200110000-00001","article-title":"An Energy Budget for Signaling in the Grey Matter of the Brain","volume":"21","author":"Attwell","year":"2001","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Blanco, A., and Blanco, G. (2017). Carbohydrate Metabolism. Medical Biochemistry, Academic Press.","DOI":"10.1016\/B978-0-12-803550-4.00014-8"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nature11314","article-title":"Oligodendroglia metabolically support axons and contribute to neurodegeneration","volume":"487","author":"Lee","year":"2012","journal-title":"Nature"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1146\/annurev-cellbio-100913-013101","article-title":"Myelination of the Nervous System: Mechanisms and Functions","volume":"30","author":"Nave","year":"2014","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0896-6273(00)80194-4","article-title":"GFAP Is Necessary for the Integrity of CNS White Matter Architecture and Long-Term Maintenance of Myelination","volume":"17","author":"Liedtke","year":"1996","journal-title":"Neuron"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"4932","DOI":"10.1038\/ncomms5932","article-title":"Lifespan maturation and degeneration of human brain white matter","volume":"5","author":"Yeatman","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/dneu.22518","article-title":"Intrinsic and adaptive myelination-A sequential mechanism for smart wiring in the brain","volume":"78","author":"Bechler","year":"2017","journal-title":"Dev. Neurobiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13041-016-0224-4","article-title":"Control of adult neurogenesis by programmed cell death in the mammalian brain","volume":"9","author":"Ryu","year":"2016","journal-title":"Mol. Brain"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"4172","DOI":"10.1523\/JNEUROSCI.4956-08.2009","article-title":"Vasculature Guides Migrating Neuronal Precursors in the Adult Mammalian Forebrain via Brain-Derived Neurotrophic Factor Signaling","volume":"29","author":"Snapyan","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"7260130","DOI":"10.1155\/2017\/7260130","article-title":"Brain-Derived Neurotrophic Factor, Depression, and Physical Activity: Making the Neuroplastic Connection","volume":"2017","author":"Phillips","year":"2017","journal-title":"Neural Plast."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cobeha.2018.01.007","article-title":"Current perspectives on incentive salience and applications to clinical disorders","volume":"22","author":"Olney","year":"2018","journal-title":"Curr. Opin. Behav. Sci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"106","DOI":"10.21307\/ane-2017-041","article-title":"Nigrostriatal interaction in the aging brain: New therapeutic target for Parkinson\u2019s disease","volume":"77","year":"2017","journal-title":"Acta Neurobiol. Exp."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"156020","DOI":"10.1155\/2014\/156020","article-title":"Mitochondrial Stress Signaling Promotes Cellular Adaptations","volume":"2014","author":"Barbour","year":"2014","journal-title":"Int. J. Cell Biol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.gde.2017.03.014","article-title":"NMNAT: It\u2019s an NAD+ synthase\u2026 It\u2019s a chaperone\u2026 It\u2019s a neuroprotector","volume":"44","author":"Brazill","year":"2017","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.2741\/e527","article-title":"The contributions of unscheduled neuronal cell cycle events to the death of neurons in Alzheimer\u2019s disease","volume":"E4","author":"Herrup","year":"2012","journal-title":"Front. Biosci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1113\/jphysiol.2003.052134","article-title":"Activity of dorsal raphe cells across the sleep-waking cycle and during cataplexy in narcoleptic dogs","volume":"554","author":"Wu","year":"2003","journal-title":"J. Physiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.semcdb.2011.04.002","article-title":"Misfolded protein aggregates: Mechanisms, structures and potential for disease transmission","volume":"22","author":"Soto","year":"2011","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Hoey, S.E., Buonocore, F., Cox, C.J., Hammond, V.J., Perkinton, M.S., and Williams, R.J. (2013). AMPA Receptor Activation Promotes Non-Amyloidogenic Amyloid Precursor Protein Processing and Suppresses Neuronal Amyloid-\u03b2 Production. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0078155"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.brainresbull.2016.08.009","article-title":"Amyloid precursor protein processing and bioenergetics","volume":"133","author":"Wilkins","year":"2017","journal-title":"Brain Res. Bull."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s41586-020-1984-7","article-title":"Discriminating \u03b1-synuclein strains in Parkinson\u2019s disease and multiple system atrophy","volume":"578","author":"Shahnawaz","year":"2020","journal-title":"Nature"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/jcbfm.2009.188","article-title":"Cerebral Blood Flow Response to Functional Activation","volume":"30","author":"Paulson","year":"2010","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.tins.2009.05.001","article-title":"Tripartite synapses: Astrocytes process and control synaptic information","volume":"32","author":"Perea","year":"2009","journal-title":"Trends Neurosci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/s11914-020-00599-y","article-title":"Muscle, Bone, and Fat Crosstalk: The Biological Role of Myokines, Osteokines, and Adipokines","volume":"18","author":"Kirk","year":"2020","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_94","first-page":"278","article-title":"Elusive roles for reactive astrocytes in neurodegenerative diseases","volume":"9","author":"Escartin","year":"2015","journal-title":"Front Cell Neurosci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1007\/s11064-015-1562-9","article-title":"A Role for Astrocytes in Sensing the Brain Microenvironment and Neuro-Metabolic Integration","volume":"40","author":"Teschemacher","year":"2015","journal-title":"Neurochem. Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/glia.23120","article-title":"Astrocyte lipid metabolism is critical for synapse development and function in vivo","volume":"65","author":"Camargo","year":"2017","journal-title":"Glia"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.neuron.2013.12.026","article-title":"A Local Glutamate-Glutamine Cycle Sustains Synaptic Excitatory Transmitter Release","volume":"81","author":"Tani","year":"2014","journal-title":"Neuron"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1016\/j.neurobiolaging.2014.03.013","article-title":"Altered arginine metabolism in Alzheimer\u2019s disease brains","volume":"35","author":"Liu","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"871997","DOI":"10.3389\/fpsyt.2022.871997","article-title":"Microglial Inflammatory-Metabolic Pathways and Their Potential Therapeutic Implication in Major Depressive Disorder","volume":"13","author":"Rahimian","year":"2022","journal-title":"Front. Psychiatry"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1177\/2045125316675579","article-title":"Lactate in the brain: An update on its relevance to brain energy, neurons, glia and panic disorder","volume":"7","author":"Riske","year":"2016","journal-title":"Ther. Adv. Psychopharmacol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"572965","DOI":"10.3389\/fnins.2020.572965","article-title":"Gangliosides in the Brain: Physiology, Pathophysiology and Therapeutic Applications","volume":"14","author":"Sipione","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.jalz.2016.02.002","article-title":"In Proceedings of the Meeting of the International Working Group (IWG) and the American Alzheimer\u2019s Association on \u201cThe Preclinical State of AD\u201d, Washington DC, USA, 23 July 2015; Preclinical Alzheimer\u2019s disease: Definition, natural history, and diagnostic criteria","volume":"12","author":"Dubois","year":"2016","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1111\/j.1460-9568.2009.06870.x","article-title":"IGF-I promotes neuronal migration and positioning in the olfactory bulb and the exit of neuroblasts from the subventricular zone","volume":"30","author":"Bulfone","year":"2009","journal-title":"Eur. J. Neurosci."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.cmet.2016.07.005","article-title":"Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle","volume":"24","author":"Frederick","year":"2016","journal-title":"Cell Metab."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s11892-006-0031-x","article-title":"Fatty acid\u2014Induced inflammation and insulin resistance in skeletal muscle and liver","volume":"6","author":"Boden","year":"2006","journal-title":"Curr. Diabetes Rep."},{"key":"ref_106","unstructured":"Wisniewski, T. (2022, September 01). A New Perspective on Alzheimer\u2019s Disease as a Brain Expression of a Complex Metabolic Disorder, Alzheimer\u2019s Disease [Internet], Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK552149\/."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/pgmj.2004.020511","article-title":"Postprandial dysmetabolism and cardiovascular disease in type 2 diabetes","volume":"81","author":"Tushuizen","year":"2005","journal-title":"Postgrad. Med J."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.2174\/156802611797470312","article-title":"Synaptic Potentiation and Sleep Need: Clues from Molecular and Electrophysiological Studies","volume":"11","author":"Hanlon","year":"2011","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.sleep.2020.05.029","article-title":"The Sleep Side of Aging and Alzheimer\u2019s Disease","volume":"77","author":"Romanella","year":"2021","journal-title":"Sleep Med."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1126\/science.abb8739","article-title":"Glymphatic failure as a final common pathway to dementia","volume":"370","author":"Nedergaard","year":"2020","journal-title":"Science"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1126\/science.1241224","article-title":"Sleep Drives Metabolite Clearance from the Adult Brain","volume":"342","author":"Xie","year":"2013","journal-title":"Science"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1093\/brain\/awaa443","article-title":"Sleep deprivation impairs molecular clearance from the human brain","volume":"144","author":"Eide","year":"2021","journal-title":"Brain"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2147\/nedt.2007.3.1.145","article-title":"Prodromal non-motor symptoms of Parkinson\u2019s disease","volume":"3","author":"Pellicano","year":"2007","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1038\/nn.4143","article-title":"Basal forebrain circuit for sleep-wake control","volume":"18","author":"Xu","year":"2015","journal-title":"Nat. Neurosci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s11910-018-0868-9","article-title":"Cerebral Metabolic Changes during Sleep","volume":"18","author":"Aalling","year":"2018","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"72","DOI":"10.2174\/1570159X19666211214144639","article-title":"Neural Substrates for Regulation of Sleep and General Anesthesia","volume":"20","author":"Yang","year":"2022","journal-title":"Curr. Neuropharmacol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/S1474-4422(18)30318-1","article-title":"The glymphatic pathway in neurological disorders","volume":"17","author":"Rasmussen","year":"2018","journal-title":"Lancet Neurol."},{"key":"ref_118","first-page":"269","article-title":"Parkinson\u2019s Disease and Neurodegeneration: GABA-Collapse Hypothesis","volume":"10","year":"2016","journal-title":"Front. Neurosci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.cortex.2006.01.003","article-title":"Cerebral blood flow regulation during cognitive tasks: Effects of healthy aging","volume":"44","author":"Sorond","year":"2008","journal-title":"Cortex"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jsmc.2007.03.004","article-title":"Impact of Sleep and Sleep Loss on Glucose Homeostasis and Appetite Regulation","volume":"2","author":"Knutson","year":"2007","journal-title":"Sleep Med. Clin."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1365-2869.2008.00662.x","article-title":"A single night of sleep deprivation increases ghrelin levels and feelings of hunger in normal-weight healthy men","volume":"17","author":"Schmid","year":"2008","journal-title":"J. Sleep Res."},{"key":"ref_122","first-page":"865","article-title":"Sleep loss results in an elevation of cortisol levels the next evening","volume":"20","author":"Leproult","year":"1997","journal-title":"Sleep"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s11910-022-01220-8","article-title":"Sleep Dysfunction in Movement Disorders: A Window to the Disease Biology","volume":"22","author":"Standlee","year":"2022","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1007\/s00415-020-10334-3","article-title":"The sleep and circadian problems of Huntington\u2019s disease: When, why and their importance","volume":"268","author":"Voysey","year":"2021","journal-title":"J. Neurol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"3738","DOI":"10.1093\/brain\/awt273","article-title":"Cell number changes in Alzheimer\u2019s disease relate to dementia, not to plaques and tangles","volume":"136","author":"Szczupak","year":"2013","journal-title":"Brain"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Habich, A., Wahlund, L., Westman, E., Dierks, T., and Ferreira, D. (2022). (Dis-)Connected Dots in Dementia with Lewy Bodies\u2014A Systematic Review of Connectivity Studies. Mov. Disord.","DOI":"10.1002\/mds.29248"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/cns.13775","article-title":"Neuroimaging alterations in dementia with Lewy bodies and neuroimaging differences between dementia with Lewy bodies and Alzheimer\u2019s disease: An activation likelihood estimation meta-analysis","volume":"28","author":"Ma","year":"2021","journal-title":"CNS Neurosci. Ther."},{"key":"ref_128","first-page":"27","article-title":"MR Analysis of the Substantia Innominata in Normal Aging, Alzheimer Disease, and Other Types of Dementia","volume":"23","author":"Hanyu","year":"2002","journal-title":"Am. J. Neuroradiol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0197-4580(90)90056-6","article-title":"Cell loss and shrinkage in the nucleus basalis Meynert complex in Alzheimer\u2019s disease","volume":"11","author":"Vogels","year":"1990","journal-title":"Neurobiol. Aging"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.tins.2010.03.006","article-title":"Retrograde axonal transport: Pathways to cell death?","volume":"33","author":"Perlson","year":"2010","journal-title":"Trends Neurosci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1146\/annurev-neuro-060909-153248","article-title":"Wallerian Degeneration, WldS, and Nmnat","volume":"33","author":"Coleman","year":"2010","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00401-018-1815-1","article-title":"Functional morphology of the blood\u2013brain barrier in health and disease","volume":"135","author":"Liebner","year":"2018","journal-title":"Acta Neuropathol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nri3705","article-title":"Innate immune activation in neurodegenerative disease","volume":"14","author":"Heneka","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1083\/jcb.201709069","article-title":"Microglia in Alzheimer\u2019s disease","volume":"217","author":"Hansen","year":"2018","journal-title":"J. Cell Biol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"a020420","DOI":"10.1101\/cshperspect.a020420","article-title":"Astrogliosis","volume":"7","author":"Sofroniew","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1177\/1073858415572079","article-title":"Microgliosis in the Injured Brain","volume":"22","author":"Li","year":"2016","journal-title":"Neuroscientist"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.neuron.2013.12.034","article-title":"Reactive Gliosis and the Multicellular Response to CNS Damage and Disease","volume":"81","author":"Burda","year":"2014","journal-title":"Neuron"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.cell.2015.01.049","article-title":"TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer\u2019s Disease Model","volume":"160","author":"Wang","year":"2015","journal-title":"Cell"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1084\/jem.20151948","article-title":"TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques","volume":"213","author":"Wang","year":"2016","journal-title":"J. Exp. Med."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.15252\/embr.201743922","article-title":"TREM 2 deficiency impairs chemotaxis and microglial responses to neuronal injury","volume":"18","author":"Mazaheri","year":"2017","journal-title":"EMBO Rep."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev-immunol-032713-120240","article-title":"Microglia Development and Function","volume":"32","author":"Nayak","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev-immunol-051116-052358","article-title":"Microglia Function in the Central Nervous System During Health and Neurodegeneration","volume":"35","author":"Colonna","year":"2017","journal-title":"Annu. Rev. Immunol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.pbb.2013.11.035","article-title":"Glial activation and post-synaptic neurotoxicity: The key events in Streptozotocin (ICV) induced memory impairment in rats","volume":"117","author":"Rai","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.freeradbiomed.2016.04.200","article-title":"Energy metabolism and inflammation in brain aging and Alzheimer\u2019s disease","volume":"100","author":"Yin","year":"2016","journal-title":"Free. Radic. Biol. Med."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/1\/543\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:54:49Z","timestamp":1760147689000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/1\/543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,29]]},"references-count":144,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["ijms24010543"],"URL":"https:\/\/doi.org\/10.3390\/ijms24010543","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,29]]}}}