{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:48:16Z","timestamp":1787028496827,"version":"build-2736575974"},"reference-count":84,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Lawson Internal Research Fund and Department of Surgery Research Fund at the Schulich School of Medicine &amp; Dentistry"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Renal transplantation is the preferred treatment for patients with end-stage renal disease. The current gold standard of kidney preservation for transplantation is static cold storage (SCS) at 4 \u00b0C. However, SCS contributes to renal ischemia-reperfusion injury (IRI), a pathological process that negatively impacts graft survival and function. Recent efforts to mitigate cold renal IRI involve preserving renal grafts at higher or subnormothermic temperatures. These temperatures may be beneficial in reducing the risk of cold renal IRI, while also maintaining active biological processes such as increasing the expression of mitochondrial protective metabolites. In this review, we discuss different preservation temperatures for renal transplantation and pharmacological supplementation of kidney preservation solutions with hydrogen sulfide to determine an optimal preservation temperature to mitigate cold renal IRI and enhance renal graft function and recipient survival.<\/jats:p>","DOI":"10.3390\/ijms24010567","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T02:56:50Z","timestamp":1672282610000},"page":"567","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The Optimization of Renal Graft Preservation Temperature to Mitigate Cold Ischemia-Reperfusion Injury in Kidney Transplantation"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7272-3916","authenticated-orcid":false,"given":"Maria","family":"Abou Taka","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada"},{"name":"Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON N6A 5A5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8161-7202","authenticated-orcid":false,"given":"George J.","family":"Dugbartey","sequence":"additional","affiliation":[{"name":"Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON N6A 5A5, Canada"},{"name":"Department of Surgery, Division of Urology, London Health Sciences Centre, London, ON N6A 5A5, Canada"},{"name":"Multi-Organ Transplant Program, London Health Sciences Centre, London, ON N6A 5A5, Canada"},{"name":"Department of Pharmacology and Toxicology, School of Pharmacy, College of Health Sciences, University of Ghana, Legon, Accra P.O. Box LG 1181, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alp","family":"Sener","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada"},{"name":"Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON N6A 5A5, Canada"},{"name":"Department of Surgery, Division of Urology, London Health Sciences Centre, London, ON N6A 5A5, Canada"},{"name":"Multi-Organ Transplant Program, London Health Sciences Centre, London, ON N6A 5A5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000514550","article-title":"Global Epidemiology of End-Stage Kidney Disease and Disparities in Kidney Replacement Therapy","volume":"52","author":"Thurlow","year":"2021","journal-title":"Am. J. Nephrol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"672350","DOI":"10.3389\/fendo.2021.672350","article-title":"Global, Regional, and National Burden of Diabetes-Related Chronic Kidney Disease From 1990 to 2019","volume":"12","author":"Deng","year":"2021","journal-title":"Front. Endocrinol."},{"key":"ref_3","first-page":"1182","article-title":"Renal transplantation using non-heart-beating donors: A potential solution to the organ donor shortage in Canada","volume":"47","author":"Lacroix","year":"2004","journal-title":"Can. J. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/s41581-020-0315-4","article-title":"The current and future landscape of dialysis","volume":"16","author":"Himmelfarb","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1056\/NEJMra2014530","article-title":"Long-Term Survival after Kidney Transplantation","volume":"385","author":"Hariharan","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"9206257","DOI":"10.1155\/2018\/9206257","article-title":"Barriers and advances in kidney preservation","volume":"2018","author":"Steichen","year":"2018","journal-title":"BioMed Res. Int."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"van Eck van der Sluijs, A., Vonk, S., van Jaarsveld, B.C., Bonenkamp, A.A., and Abrahams, A.C. (2021). Good practices for dialysis education, treatment, and eHealth: A scoping review. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0255734"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1111\/j.1600-6143.2011.03686.x","article-title":"Systematic review: Kidney transplantation compared with dialysis in clinically relevant outcomes","volume":"11","author":"Tonelli","year":"2011","journal-title":"Am. J. Transplant."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"79","DOI":"10.5527\/wjn.v1.i3.79","article-title":"Kidney donation after cardiac death","volume":"1","author":"Akoh","year":"2012","journal-title":"World J. Nephrol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"631","DOI":"10.3389\/fimmu.2020.00631","article-title":"Transplanting Marginal Organs in the Era of Modern Machine Perfusion and Advanced Organ Monitoring","volume":"11","author":"Resch","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/s11255-020-02700-x","article-title":"Clinical characteristics of deceased hemodialysis patients affected by COVID-19","volume":"53","author":"Min","year":"2021","journal-title":"Int. Urol. Nephrol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1748-5908-9-80","article-title":"Design, implementation, and evaluation of a knowledge translation intervention to increase organ donation after cardiocirculatory death in Canada: A study protocol","volume":"9","author":"Squires","year":"2014","journal-title":"Implement. Sci."},{"key":"ref_13","first-page":"93","article-title":"Kidney and liver transplants from donors after cardiac death: Initial experience at the London Health Sciences Centre","volume":"53","author":"Caumartin","year":"2010","journal-title":"Can. J. Surg."},{"key":"ref_14","unstructured":"Canadian Institute for Health Information (2022, August 30). CORR Annual Statistics. Organ Replacement in Canada. Available online: https:\/\/www.cihi.ca\/en\/organ-replacement-in-canada-corr-annual-statistics."},{"key":"ref_15","unstructured":"Health Resources & Services Administration (2022, September 02). Learn About Donation. Organ Donation Statistics, Available online: https:\/\/www.organdonor.gov\/learn\/organ-donation-statistics."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/CCM.0b013e3181c025fd","article-title":"Kidney donation from children after cardiac death","volume":"38","author":"Snoeijs","year":"2010","journal-title":"Crit Care Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"52","DOI":"10.5500\/wjt.v5.i2.52","article-title":"Update on ischemia-reperfusion injury in kidney transplantation: Pathogenesis and treatment","volume":"5","author":"Salvadori","year":"2015","journal-title":"World J. Transplant."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.1681\/ASN.2014080804","article-title":"Dendritic cells in kidney transplant biopsy samples are associated with T cell infiltration and poor allograft survival","volume":"26","author":"Batal","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1016\/j.transproceed.2008.10.004","article-title":"Ischemia\/Reperfusion Injury in Kidney Transplantation: Mechanisms and Prevention","volume":"40","author":"Kosieradzki","year":"2008","journal-title":"Transplant. Proc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1034\/j.1600-6143.2003.00042.x","article-title":"Involvement of the mitochondrial pathway in cold storage and rewarming-associated apoptosis in human renal proximal tubular cells","volume":"3","author":"Salahudeen","year":"2003","journal-title":"Am J. Transplant."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1126\/science.1099320","article-title":"The pathophysiology of mitochondrial cell death","volume":"305","author":"Green","year":"2004","journal-title":"Science"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e2035048","DOI":"10.1001\/jamanetworkopen.2020.35048","article-title":"Molecular diversity of clinically stable human kidney allografts","volume":"4","author":"Rychkov","year":"2021","journal-title":"JAMA Network Open"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Nieuwenhuijs-Moeke, G.J., Pischke, S.E., Berger, S.P., Sanders, J.S.F., Pol, R.A., Struys, M.M.R.F., Ploeg, R.J., and Leuvenink, H.G.D. (2020). Ischemia and reperfusion injury in kidney transplantation: Relevant mechanisms in injury and repair. J. Clin. Med., 9.","DOI":"10.3390\/jcm9010253"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"18","DOI":"10.34172\/jrip.2021.18","article-title":"A systematic review of the relationship between acute tubular necrosis and kidney transplantation","volume":"10","author":"Elmi","year":"2021","journal-title":"J. Ren. Inj. Prev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"583702","DOI":"10.3389\/fimmu.2020.583702","article-title":"Kidney Failure Associates with T Cell Exhaustion and Imbalanced Follicular Helper T Cells","volume":"11","author":"Hartzell","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3164734","DOI":"10.1155\/2016\/3164734","article-title":"The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults","volume":"2016","author":"Nita","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1124\/jpet.104.078659","article-title":"Endogenous interleukin-6 enhances the renal injury, dysfunction, and inflammation caused by ischemia\/reperfusion","volume":"312","author":"Patel","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1189\/jlb.70.2.192","article-title":"IL-1 and TNF independent pathways mediate ICAM-1\/VCAM-1 up-regulation in ischemia reperfusion injury","volume":"70","author":"Burne","year":"2001","journal-title":"J. Leukoc. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"H540","DOI":"10.1152\/ajpheart.00072.2001","article-title":"TNF-alpha-dependent bilateral renal injury is induced by unilateral renal ischemia-reperfusion","volume":"282","author":"Meldrum","year":"2002","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1159\/000491558","article-title":"Delayed graft function: The AKI of kidney transplantation","volume":"140","author":"Mannon","year":"2018","journal-title":"Nephron"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/aor.12836","article-title":"Effect of Hypothermic Machine Perfusion on the Preservation of Kidneys Donated After Cardiac Death: A Single-Center, Randomized, Controlled Trial","volume":"41","author":"Wang","year":"2017","journal-title":"Artif. Organs"},{"key":"ref_32","first-page":"CD011671","article-title":"Machine perfusion preservation versus static cold storage for deceased donor kidney transplantation","volume":"3","author":"Tingle","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1152\/ajprenal.00164.2016","article-title":"The proximal tubule is the primary target of injury and progression of kidney disease: Role of the glomerulotubular junction","volume":"311","author":"Chevalier","year":"2016","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1046\/j.1523-1755.2001.0600031173.x","article-title":"Prolonged cold preservation augments vascular injury independent of renal transplant immunogenicity and function","volume":"60","author":"Dragun","year":"2001","journal-title":"Kidney Int."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"S110","DOI":"10.1016\/S1743-9191(13)60029-1","article-title":"Impact of static cold storage VS hypothermic machine preservation on ischemic kidney graft: Inflammatory cytokines and adhesion molecules as markers of ischemia\/reperfusion tissue damage. Our preliminary results","volume":"11","author":"Tozzi","year":"2013","journal-title":"Int. J. Surg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/bjs.10733","article-title":"Normothermic machine perfusion for the assessment and transplantation of declined human kidneys from donation after circulatory death donors","volume":"105","author":"Hosgood","year":"2018","journal-title":"Br. J. Surg."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1111\/ajt.15647","article-title":"First-in-man controlled rewarming and normothermic perfusion with cell-free solution of a kidney prior to transplantation","volume":"20","author":"Minor","year":"2020","journal-title":"Am. J. Transplant."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/MOT.0000000000000567","article-title":"Advances in machine perfusion, organ preservation, and cryobiology: Potential impact on vascularized composite allotransplantation","volume":"23","author":"Burlage","year":"2018","journal-title":"Curr. Opin. Organ Transplant."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/MOT.0b013e32835e2a1b","article-title":"Machine perfusion viability testing","volume":"18","author":"Hoogland","year":"2013","journal-title":"Curr. Opin. Organ Transplant."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1097\/SLA.0b013e3181ffc256","article-title":"Machine perfusion versus cold storage for the preservation of kidneys donated after cardiac death: A multicenter, randomized, controlled trial","volume":"252","author":"Jochmans","year":"2010","journal-title":"Ann. Surg."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1111\/tri.12389","article-title":"Subnormothermic machine perfusion for preservation of porcine kidneys in a donation after circulatory death model","volume":"27","author":"Hoyer","year":"2014","journal-title":"Transpl. Int."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1097\/TP.0000000000002967","article-title":"Renal protection against ischemia reperfusion injury: Hemoglobin-based oxygen carrier-201 versus blood as an oxygen carrier in ex vivo subnormothermic machine perfusion","volume":"104","author":"Bhattacharjee","year":"2020","journal-title":"Transplantation"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Juriasingani, S., Ruthirakanthan, A., Richard-Mohamed, M., Akbari, M., Aquil, S., Patel, S., Al-Ogaili, R., Whiteman, M., Luke, P., and Sener, A. (2021). Subnormothermic perfusion with h2s donor ap39 improves dcd porcine renal graft outcomes in an ex vivo model of kidney preservation and reperfusion. Biomolecules, 11.","DOI":"10.3390\/biom11030446"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"461","DOI":"10.12659\/AOT.893784","article-title":"Twelve-hour hypothermic machine perfusion for donor heart preservation leads to improved ultrastructural characteristics compared to conventional cold storage","volume":"20","author":"Michel","year":"2015","journal-title":"Ann. Transplant."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.healun.2021.03.002","article-title":"Prediction of donor related lung injury in clinical lung transplantation using a validated ex vivo lung perfusion inflammation score","volume":"40","author":"Sage","year":"2021","journal-title":"J. Heart Lung Transplant."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"eabf7601","DOI":"10.1126\/scitranslmed.abf7601","article-title":"Static lung storage at 10 \u00b0C maintains mitochondrial health and preserves donor organ function","volume":"13","author":"Ali","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s40659-019-0224-9","article-title":"Effects of glutamine deprivation on oxidative stress and cell survival in breast cell lines","volume":"52","author":"Gwangwa","year":"2019","journal-title":"Biol. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1038\/s12276-020-00504-8","article-title":"Glutamine reliance in cell metabolism","volume":"52","author":"Yoo","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.cmet.2016.11.005","article-title":"Defective branched-chain amino acid catabolism disrupts glucose metabolism and sensitizes the heart to ischemia-reperfusion injury","volume":"25","author":"Li","year":"2017","journal-title":"Cell Metab."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1097\/01.TP.0000153156.38617.97","article-title":"A study of the metabolites of ischemia-reperfusion injury and selected amino acids in the liver using microdialysis during transplantation","volume":"79","author":"Silva","year":"2005","journal-title":"Transplantation"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1093\/ndt\/15.8.1224","article-title":"L-Arginine-enriched preservation solution decreases ischemia\/reperfusion injury in canine kidneys after long-term cold storage","volume":"15","author":"Erkasap","year":"2000","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/01.tp.0000242524.35562.4b","article-title":"The effect of trophic factor supplementation on cold ischemia-induced early apoptotic changes","volume":"83","author":"Kwon","year":"2007","journal-title":"Transplantation"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.1016\/j.transproceed.2018.08.035","article-title":"Mechanisms of Bone Morphogenetic Protein-7 Protective Effects Against Cold Ischemia-Induced Renal Injury in Rats","volume":"50","author":"Bobinac","year":"2018","journal-title":"Transplant. Proc."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1016\/j.transproceed.2011.05.056","article-title":"Bone morphogenetic protein-7 reduces cold ischemic injury in rat kidney","volume":"43","author":"Spanjol","year":"2011","journal-title":"Transplant. Proc."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1097\/TP.0b013e318207949f","article-title":"Naked small interfering RNA of caspase-3 in preservation solution and autologous blood perfusate protects isolated ischemic porcine kidneys","volume":"91","author":"Yang","year":"2011","journal-title":"Transplantation"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Moser, M.A., Arcand, S., Lin, H.B., Wojnarowicz, C., Sawicka, J., Banerjee, T., Luo, Y., Beck, G.R., Luke, P.P., and Sawicki, G. (2016). Protection of the Transplant Kidney from Preservation Injury by Inhibition of Matrix Metalloproteinases. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0157508"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1161\/CIRCULATIONAHA.104.531616","article-title":"Degradation of myosin light chain in isolated rat hearts subjected to ischemia-reperfusion injury: A new intracellular target for matrix metalloproteinase-2","volume":"112","author":"Sawicki","year":"2005","journal-title":"Circulation"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1161\/01.CIR.0000028818.33488.7B","article-title":"Intracellular action of matrix metalloproteinase-2 accounts for acute myocardial ischemia and reperfusion injury","volume":"106","author":"Wang","year":"2002","journal-title":"Circulation"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1055\/s-2006-924365","article-title":"Effects of Hemopure on maximal oxygen uptake and endurance performance in healthy humans","volume":"28","author":"Ashenden","year":"2007","journal-title":"Int. J. Sports Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1111\/ajt.15375","article-title":"Synthetic hemoglobin-based oxygen carriers are an acceptable alternative for packed red blood cells in normothermic kidney perfusion","volume":"19","author":"Aburawi","year":"2019","journal-title":"Am. J. Transplant."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/aor.13534","article-title":"The efficacy of HBOC-201 in ex situ gradual rewarming kidney perfusion in a rat model","volume":"44","author":"Mahboub","year":"2020","journal-title":"Artif. Organs"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Juriasingani, S., Jackson, A., Zhang, M.Y., Ruthirakanthan, A., Dugbartey, G.J., Sogutdelen, E., Levine, M., Mandurah, M., Whiteman, M., and Luke, P. (2021). Evaluating the Effects of Subnormothermic Perfusion with AP39 in a Novel Blood-Free Model of Ex Vivo Kidney Preservation and Reperfusion. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22137180"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"re2","DOI":"10.1126\/scisignal.268re2","article-title":"Signaling by gasotransmitters","volume":"2","author":"Mustafa","year":"2009","journal-title":"Sci. Signal."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Wang, R. (2004). Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine, Springer Science & Business Media.","DOI":"10.1007\/978-1-59259-806-9"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1515\/revic-2018-0011","article-title":"A gentle introduction to gasotransmitters with special reference to nitric oxide: Biological and chemical implications","volume":"38","author":"Mir","year":"2018","journal-title":"Rev. Inorg. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.juro.2012.12.020","article-title":"Carbon monoxide releasing molecules inhibit cell death resulting from renal transplantation related stress","volume":"190","author":"Sener","year":"2013","journal-title":"J. Urol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"105883","DOI":"10.1016\/j.phrs.2021.105883","article-title":"Application of carbon monoxide in kidney and heart transplantation: A novel pharmacological strategy for broader use of suboptimal renal and cardiac grafts","volume":"173","author":"Dugbartey","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Untereiner, A.A., Wu, L., and Wang, R. (2012). The role of carbon monoxide as a gasotransmitter in cardiovascular and metabolic regulation. Gasotransmitters: Physiology and Pathophysiology, Springer.","DOI":"10.1007\/978-3-642-30338-8_2"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1002\/bjs.6174","article-title":"Application of nitric oxide and carbon monoxide in a model of renal preservation","volume":"95","author":"Hosgood","year":"2008","journal-title":"British J. Surg."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3109\/10408448409029321","article-title":"A critical review of the literature on hydrogen sulfide toxicity","volume":"13","author":"Beauchamp","year":"1984","journal-title":"Crit. Rev. Toxicol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/bjs.6856","article-title":"Hydrogen sulphide ameliorates ischaemia-reperfusion injury in an experimental model of non-heart-beating donor kidney transplantation","volume":"97","author":"Hosgood","year":"2010","journal-title":"Br. J. Surg."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1089\/ars.2014.5869","article-title":"Signaling molecules: Hydrogen sulfide and polysulfide","volume":"22","author":"Kimura","year":"2015","journal-title":"Antioxid. Redox. Signal."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"6452","DOI":"10.3390\/ijms22126452","article-title":"Hydrogen sulfide metabolite, sodium thiosulfate: Clinical applications and underlying molecular mechanisms","volume":"22","author":"Zhang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"E1187","DOI":"10.1111\/j.1464-410X.2012.11526.x","article-title":"Supplemental hydrogen sulfide protects transplant kidney function and prolongs recipient survival after prolonged cold ischemia-reperfusion injury by mitigating renal apoptosis and inflammation","volume":"110","author":"Lobb","year":"2012","journal-title":"BJU Int."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1016\/j.juro.2015.07.096","article-title":"Hydrogen sulfide treatment mitigates renal allograft ischemia-reperfusion injury during cold storage and improves early transplant kidney function and survival following allogeneic renal transplantation","volume":"194","author":"Lobb","year":"2015","journal-title":"J. Urol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/ajt.14080","article-title":"Hydrogen Sulfide Protects Renal Grafts Against Prolonged Cold Ischemia-Reperfusion Injury via Specific Mitochondrial Actions","volume":"17","author":"Lobb","year":"2017","journal-title":"Am. J. Transplant."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"E413","DOI":"10.5489\/cuaj.1694","article-title":"Hydrogen sulfide treatment ameliorates long-term renal dysfunction resulting from prolonged warm renal ischemia-reperfusion injury","volume":"8","author":"Lobb","year":"2014","journal-title":"Can. Urol. Assoc. J."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.niox.2018.10.004","article-title":"H2S supplementation: A novel method for successful organ preservation at subnormothermic temperatures","volume":"81","author":"Juriasingani","year":"2018","journal-title":"Nitric Oxide"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"105842","DOI":"10.1016\/j.phrs.2021.105842","article-title":"H2S donor molecules against cold ischemia-reperfusion injury in preclinical models of solid organ transplantation","volume":"172","author":"Dugbartey","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s13181-018-0688-y","article-title":"A Review on Ingested Cyanide: Risks, Clinical Presentation, Diagnostics, and Treatment Challenges","volume":"15","author":"Ng","year":"2019","journal-title":"J. Med. Toxicol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000380945","article-title":"Sodium thiosulfate: An emerging treatment for calciphylaxis in dialysis patients","volume":"5","author":"Yu","year":"2015","journal-title":"Case Rep. Nephrol. Dial."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.2215\/CJN.10241110","article-title":"Sodium thiosulfate pharmacokinetics in hemodialysis patients and healthy volunteers","volume":"6","author":"Farese","year":"2011","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1080\/02656736.2020.1795277","article-title":"Sodium thiosulfate protects from renal impairment following hyperthermic intraperitoneal chemotherapy (HIPEC) with Cisplatin","volume":"37","author":"Laplace","year":"2020","journal-title":"Int. J. Hyperthermia."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"112435","DOI":"10.1016\/j.biopha.2021.112435","article-title":"Sodium thiosulfate-supplemented UW solution protects renal grafts against prolonged cold ischemia-reperfusion injury in a murine model of syngeneic kidney transplantation","volume":"145","author":"Zhang","year":"2022","journal-title":"Biomed. Pharmacother."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/1\/567\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:54:56Z","timestamp":1760147696000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/1\/567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,29]]},"references-count":84,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["ijms24010567"],"URL":"https:\/\/doi.org\/10.3390\/ijms24010567","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,29]]}}}