{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:48:16Z","timestamp":1787028496745,"version":"build-2736575974"},"reference-count":105,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010792","name":"Tungs\u2019 Taichung MetroHarbor Hospital","doi-asserted-by":"publisher","award":["TTMHH-R1110029"],"award-info":[{"award-number":["TTMHH-R1110029"]}],"id":[{"id":"10.13039\/100010792","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Current literature has indicated that Peyronie\u2019s disease (PD) could be initiated by microtrauma and the subsequent inflammation episodes that follow. PD could be sorted into acute or chronic status, and it can differ when selecting the clinical therapeutics. PD would cause pain and penile deformity to diseased men and impair their erectile function. Occasionally, surgical revision of the penis might be needed to correct the penile curvature. We find that there are limited effective options of intra-lesion injections for the PD plaques. By searching the databases and screening the literature with the PRISMA 2020 guideline, we observed that several preclinical studies that applied stem cell therapy in treating PD were fruitful in the acute phase. Although in the chronic phase of PD, erectile parameters were not significantly improved, and therefore, future studies might be better elevated in certain aspects, such as the sites selected for harvesting stem cells or changing the centrifugation forces. In this review, we concluded the contemporary understanding of inflammatory microenvironments in PD, the stem cell therapy in PD, and our perspectives on future studies. We concluded that there may be great potential in stem cell therapy for treating both acute and chronic phases PD.<\/jats:p>","DOI":"10.3390\/ijms24010777","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T04:17:38Z","timestamp":1672633058000},"page":"777","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Immunological Microenvironment and the Emerging Role of Stem Cells Therapy in Peyronie\u2019s Disease: A Systematic Narrative Review"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2251-3379","authenticated-orcid":false,"given":"Che-Hsueh","family":"Yang","sequence":"first","affiliation":[{"name":"Division of Urology, Department of Surgery, Tungs\u2019 Taichung MetroHarbor Hospital, Taichung 435, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dian-Yu","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, Tungs\u2019 Taichung MetroHarbor Hospital, Taichung 435, Taiwan"},{"name":"Joshua Taipei Hernia Center, Central Clinic & Hospital, Taipei 106, Taiwan"},{"name":"Department of Urology, College of Medicine and Shu-Tien Urological Research Center, National Yang Ming Chiao Tung University, Taipei 106, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Sheng","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, Tungs\u2019 Taichung MetroHarbor Hospital, Taichung 435, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Yu","family":"Hsu","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, Tungs\u2019 Taichung MetroHarbor Hospital, Taichung 435, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Che","family":"Tung","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, Tungs\u2019 Taichung MetroHarbor Hospital, Taichung 435, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kok-Tong","family":"Tan","sequence":"additional","affiliation":[{"name":"Division of General Surgery, Department of Surgery, Tungs\u2019 Taichung MetroHarbor Hospital, Taichung 435, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Chuan","family":"Ou","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, Tungs\u2019 Taichung MetroHarbor Hospital, Taichung 435, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1046\/j.1464-4096.2001.02436.x","article-title":"The prevalence of Peyronie\u2019s disease: Results of a large survey","volume":"88","author":"Schwarzer","year":"2001","journal-title":"BJU Int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/S0022-5347(17)37988-0","article-title":"The incidence of Peyronie\u2019s disease in Rochester, Minnesota, 1950 through 1984","volume":"146","author":"Lindsay","year":"1991","journal-title":"J. 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