{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:02:04Z","timestamp":1777658524710,"version":"3.51.4"},"reference-count":110,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Atopic dermatitis (AD) is a chronic, pruritic, inflammatory dermatosis that imposes significant patient and population burdens. In addition to the cutaneous signs and symptoms, growing evidence suggests that AD is systemic in nature. Certain diseases can possibly co-occur with AD as a result of coincidental exposure to similar environmental factors. However, it is also suspected that they are linked to the pathogenesis of AD through more complex genetic and immunological mechanisms, but these correlations remain less understood. It is of great need to seek explanations for the higher frequency of the number of cardiovascular, autoimmune, neurological, psychiatric, and metabolic disorders that have been observed in epidemiologic investigations among AD patients. Moreover, analysing the immunology of chronic inflammation and its correction, activation, or suppression may prevent the development of a variety of comorbidities. As comorbid diseases in patients diagnosed with AD may potentially go undetected, physicians should be aware of them.<\/jats:p>","DOI":"10.3390\/ijms24010837","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T04:08:07Z","timestamp":1672805287000},"page":"837","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Is Atopic Dermatitis Only a Skin Disease?"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2930-7968","authenticated-orcid":false,"given":"Alicja","family":"Mesjasz","sequence":"first","affiliation":[{"name":"Dermatological Students Scientific Association, Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, 80-214 Gdansk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Zawadzka","sequence":"additional","affiliation":[{"name":"Department of Developmental Neurology, Faculty of Medicine, Medical University of Gdansk, 80-952 Gdansk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8311-9530","authenticated-orcid":false,"given":"Maciej","family":"Cha\u0142ubi\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Immunology and Allergy, Faculty of Medicine, Medical University of Lodz, 92-213 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8206-8441","authenticated-orcid":false,"given":"Magdalena","family":"Trzeciak","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, 80-214 Gdansk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sroka-Tomaszewska, J., and Trzeciak, M. (2021). Molecular Mechanisms of Atopic Dermatitis Pathogenesis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22084130"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.3346\/jkms.2017.32.8.1360","article-title":"Clinical Features of Atopic Dermatitis in Adults Are Different according to Onset","volume":"32","author":"Son","year":"2017","journal-title":"J. Korean Med Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.alit.2021.07.003","article-title":"Subtypes of atopic dermatitis: From phenotype to endotype","volume":"71","author":"Tokura","year":"2021","journal-title":"Allergol. Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s13671-017-0168-7","article-title":"Comorbidities of Atopic Dermatitis: Beyond Rhinitis and Asthma","volume":"6","author":"Andersen","year":"2017","journal-title":"Curr. Dermatol. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Park, D., Kim, J., Park, H.-J., and Hahm, D.-H. (2021). Comparative Analysis of the Microbiome across the Gut\u2013Skin Axis in Atopic Dermatitis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22084228"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/1346-8138.12321","article-title":"Genome-wide association studies of atopic dermatitis","volume":"41","author":"Tamari","year":"2014","journal-title":"J. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1038\/ng.3424","article-title":"Multi-ethnic genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis","volume":"47","author":"Paternoster","year":"2015","journal-title":"Nat. Genet."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s40257-018-0383-4","article-title":"Major Comorbidities of Atopic Dermatitis: Beyond Allergic Disorders","volume":"19","author":"Paller","year":"2018","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.anai.2019.04.020","article-title":"Comorbidities and the impact of atopic dermatitis","volume":"123","author":"Silverberg","year":"2019","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1503\/cmaj.051351","article-title":"Health benefits of physical activity: The evidence","volume":"174","author":"Warburton","year":"2006","journal-title":"CMAJ Can. Med. Assoc. J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1016\/j.jid.2016.04.025","article-title":"Atopic Dermatitis Is Associated with Less Physical Activity in US Adults","volume":"136","author":"Silverberg","year":"2016","journal-title":"J. Investig. Dermatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jpeds.2016.03.063","article-title":"Associations of Physical Activity and Sedentary Behavior with Atopic Disease in United States Children","volume":"174","author":"Strom","year":"2016","journal-title":"J. Pediatr."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Yang, T.-H., Chen, P.-C., Lin, Y.-C., Lee, Y.-Y., Tseng, Y.-H., Chang, W.-H., Chang, L.-S., Lin, C.-H., and Kuo, H.-C. (2022). Adolescents with Atopic Dermatitis Have Lower Peak Exercise Load Capacity and Exercise Volume Compared with Unaffected Peers. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph191610285"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.jaip.2019.08.030","article-title":"Atopic Eczema in Adulthood and Risk of Depression and Anxiety: A Population-Based Cohort Study","volume":"8","author":"Schonmann","year":"2019","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Jung, S.J., Shin, A., and Kang, D. (2015). Active smoking and exposure to secondhand smoke and their relationship to depressive symptoms in the Korea national health and nutrition examination survey (KNHANES). BMC Public Health, 15.","DOI":"10.1186\/s12889-015-2402-1"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12987-015-0022-x","article-title":"Pathobiology of tobacco smoking and neurovascular disorders: Untied strings and alternative products","volume":"12","author":"Naik","year":"2015","journal-title":"Fluids Barriers CNS"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/pai.13039","article-title":"Association between antibiotic treatment during pregnancy and infancy and the development of allergic diseases","volume":"30","author":"Metzler","year":"2019","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.21037\/tp-21-220","article-title":"Association between the use of antibiotics during pregnancy and obesity in 5-year-old children","volume":"10","author":"Zhuang","year":"2021","journal-title":"Transl. Pediatr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e215245","DOI":"10.1001\/jamanetworkopen.2021.5245","article-title":"Association of Early Life Exposure to Antibiotics with Risk of Atopic Dermatitis in Sweden","volume":"4","author":"Mubanga","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12941-022-00535-1","article-title":"Early-life antibiotic exposure increases the risk of childhood overweight and obesity in relation to dysbiosis of gut microbiota: A birth cohort study","volume":"21","author":"Li","year":"2022","journal-title":"Ann. Clin. Microbiol. Antimicrob."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.jaad.2021.10.021","article-title":"Atopic dermatitis and the risk of eating disorders: A population-based cohort study","volume":"87","author":"Kauppi","year":"2021","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_22","first-page":"57","article-title":"A review of binge eating disorder and obesity","volume":"35","year":"2020","journal-title":"Neuropsychiatrie"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1111\/jdv.18345","article-title":"European guideline (EuroGuiDerm) on atopic eczema: Part I\u2013systemic therapy","volume":"36","author":"Wollenberg","year":"2022","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1111\/all.12685","article-title":"Association between adult atopic dermatitis, cardiovascular disease, and increased heart attacks in three population-based studies","volume":"70","author":"Silverberg","year":"2015","journal-title":"Allergy"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.jid.2016.11.031","article-title":"Association of Atopic Dermatitis with Cardiovascular Risk Factors and Diseases","volume":"137","author":"Standl","year":"2016","journal-title":"J. Investig. Dermatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1016\/j.jaci.2018.11.030","article-title":"Atopic eczema and major cardiovascular outcomes: A systematic review and meta-analysis of population-based studies","volume":"143","author":"Ascott","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1111\/all.13360","article-title":"Poor agreement in questionnaire-based diagnostic criteria for adult atopic dermatitis is a challenge when examining cardiovascular comorbidity","volume":"73","author":"Andersen","year":"2017","journal-title":"Allergy"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"8439","DOI":"10.1038\/s41598-018-26378-5","article-title":"Author Correction: The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins","volume":"8","author":"Brunner","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1111\/all.14859","article-title":"Vascular inflammation in moderate-to-severe atopic dermatitis is associated with enhanced Th2 response","volume":"76","author":"Villani","year":"2021","journal-title":"Allergy"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.3389\/fimmu.2020.01768","article-title":"Tape-Strip Proteomic Profiling of Atopic Dermatitis on Dupilumab Identifies Minimally Invasive Biomarkers","volume":"11","author":"He","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.anai.2019.10.013","article-title":"Increased cardiovascular and atherosclerosis markers in blood of older patients with atopic dermatitis","volume":"124","author":"He","year":"2019","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.jaad.2019.04.036","article-title":"The blood proteomic signature of early-onset pediatric atopic dermatitis shows systemic inflammation and is distinct from adult long-standing disease","volume":"81","author":"Brunner","year":"2019","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1111\/all.15230","article-title":"Immunoglobulin E response in health and disease beyond allergic disorders","volume":"77","author":"Colas","year":"2022","journal-title":"Allergy"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00403-021-02240-z","article-title":"Controversial cardiovascular and hematologic comorbidities in atopic dermatitis","volume":"314","author":"Pandher","year":"2021","journal-title":"Arch. Dermatol. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s11239-010-0478-0","article-title":"Plasma fibrin clot properties in atopic dermatitis: Links between thrombosis and atopy","volume":"30","author":"Undas","year":"2010","journal-title":"J. Thromb. Thrombolysis"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.jaad.2022.01.009","article-title":"American Academy of Dermatology Guidelines: Awareness of comorbidities associated with atopic dermatitis in adults","volume":"86","author":"Davis","year":"2022","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s00403-020-02087-w","article-title":"Screening for cardiovascular comorbidity in United States outpatients with psoriasis, hidradenitis, and atopic dermatitis","volume":"313","author":"Singh","year":"2020","journal-title":"Arch. Dermatol. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s12016-015-8488-5","article-title":"Mediators of Chronic Pruritus in Atopic Dermatitis: Getting the Itch Out?","volume":"51","author":"Mollanazar","year":"2015","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.alit.2022.04.002","article-title":"Neuro-allergology: Mast cell\u2013nerve cross-talk","volume":"71","author":"Toyoshima","year":"2022","journal-title":"Allergol. Int."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"696784","DOI":"10.3389\/fimmu.2021.696784","article-title":"Th2 Modulation of Transient Receptor Potential Channels: An Unmet Therapeutic Intervention for Atopic Dermatitis","volume":"12","author":"Meng","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jaci.2013.10.048","article-title":"A Sensory Neuron-expressed Interleukin-31 Receptor Mediates T helper Cell-dependent Itch: Involvement of TRPV1 and TRPA1","volume":"133","author":"Cevikbas","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2013.08.057","article-title":"The Epithelial Cell-derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch","volume":"155","author":"Wilson","year":"2013","journal-title":"Cell"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1073\/pnas.1714348115","article-title":"Thymic stromal lymphopoietin drives the development of IL-13+ Th2 cells","volume":"115","author":"Ochiai","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1111\/exd.14382","article-title":"Current views on neuropeptides in atopic dermatitis","volume":"30","author":"Zhang","year":"2021","journal-title":"Exp. Dermatol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1111\/epi.12667","article-title":"Risk of epilepsy among patients with atopic dermatitis: A nationwide longitudinal study","volume":"55","author":"Chen","year":"2014","journal-title":"Epilepsia"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/all.12319","article-title":"Allergic disease is associated with epilepsy in childhood: A US population-based study","volume":"69","author":"Silverberg","year":"2013","journal-title":"Allergy"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1007\/s12035-022-02725-6","article-title":"Neuroinflammation and Proinflammatory Cytokines in Epileptogenesis","volume":"59","author":"Khaboushan","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.neubiorev.2017.05.001","article-title":"Mast cells in neuroinflammation and brain disorders","volume":"79","author":"Hendriksen","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.1016\/j.jaci.2007.12.464","article-title":"Blood T and B Lymphocytes Enter Mouse Brain After a Single Seizure and Some Switch to IL-4+ and IgE+ Cells in Neocortex: Epilepsy as an Allergic Disease?","volume":"121","author":"Silverberg","year":"2008","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"554547","DOI":"10.3389\/fnmol.2020.554547","article-title":"Interleukin 4 Affects Epilepsy by Regulating Glial Cells: Potential and Possible Mechanism","volume":"13","author":"Chen","year":"2020","journal-title":"Front. Mol. Neurosci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1111\/pde.14657","article-title":"TH2 sensitization in the skin-gut-brain axis: How early-life Th2-mediated inflammation may negatively perpetuate developmental and psychologic abnormalities","volume":"38","author":"Cole","year":"2021","journal-title":"Pediatr. Dermatol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Gao, Y., Luo, C., Yao, Y., Huang, J., Fu, H., Xia, C., Ye, G., Yu, L., Han, J., and Fan, Y. (2020). IL-33 Alleviated Brain Damage via Anti-apoptosis, Endoplasmic Reticulum Stress, and Inflammation After Epilepsy. Front. Neurosci., 14.","DOI":"10.3389\/fnins.2020.00898"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ejmg.2010.06.004","article-title":"A de novo 7.9 Mb deletion in 22q13.2\u2192qter in a boy with autistic features, epilepsy, developmental delay, atopic dermatitis and abnormal immunological findings","volume":"53","author":"Chen","year":"2010","journal-title":"Eur. J. Med. Genet."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s40257-015-0145-5","article-title":"Association Between Atopic Dermatitis and Autism Spectrum Disorders: A Systematic Review","volume":"16","author":"Billeci","year":"2015","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41398-022-02185-5","article-title":"Eczema and related atopic diseases are associated with increased symptom severity in children with autism spectrum disorder","volume":"12","author":"Jameson","year":"2022","journal-title":"Transl. Psychiatry"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"842755","DOI":"10.3389\/fpsyt.2022.842755","article-title":"Neuronal Cell Adhesion Molecules May Mediate Neuroinflammation in Autism Spectrum Disorder","volume":"13","author":"Eve","year":"2022","journal-title":"Front. Psychiatry"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1007\/s00431-020-03826-x","article-title":"Association of food hypersensitivity in children with the risk of autism spectrum disorder: A meta-analysis","volume":"180","author":"Li","year":"2020","journal-title":"Eur. J. Pediatr."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"645","DOI":"10.2147\/JAA.S348609","article-title":"Food Allergy-Induced Autism-Like Behavior is Associated with Gut Microbiota and Brain mTOR Signaling","volume":"15","author":"Cao","year":"2022","journal-title":"J. Asthma Allergy"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Shin, K.-O., Crumrine, D.A., Kim, S., Lee, Y., Kim, B., Abuabara, K., Park, C., Uchida, Y., Wakefield, J.S., and Meyer, J.M. (2021). Phenotypic overlap between atopic dermatitis and autism. BMC Neurosci., 22.","DOI":"10.1186\/s12868-021-00645-0"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Kim, J.H., Yi, Y.Y., Ha, E.K., Cha, H.R., Han, M.Y., and Baek, H.-S. (2022). Neurodevelopment at 6 years of age in children with atopic dermatitis. Allergol. Int.","DOI":"10.1016\/j.alit.2022.08.002"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/all.13326","article-title":"Increased attention-deficit\/hyperactivity symptoms in atopic dermatitis are associated with history of antihistamine use","volume":"73","author":"Schmitt","year":"2017","journal-title":"Allergy"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.neubiorev.2017.01.011","article-title":"Association of atopic diseases and attention-deficit\/hyperactivity disorder: A systematic review and meta-analyses","volume":"74","author":"Hak","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1038\/s41598-022-07232-1","article-title":"Two meta-analyses of the association between atopic diseases and core symptoms of attention deficit hyperactivity disorder","volume":"12","author":"Chuang","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1159\/000500831","article-title":"Risk of Atopic Diseases among Siblings of Patients with Attention-Deficit Hyperactivity Disorder: A Nationwide Population-Based Cohort Study","volume":"180","author":"Chang","year":"2019","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.1111\/all.14411","article-title":"ADHD in school-age children is related to infant exposure to systemic H1-antihistamines","volume":"75","author":"Fuhrmann","year":"2020","journal-title":"Allergy"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2058738420962902","DOI":"10.1177\/2058738420962902","article-title":"Childhood atopic dermatitis as a precursor for developing attention deficit\/hyperactivity disorder","volume":"34","author":"Xu","year":"2020","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.jaad.2018.08.063","article-title":"Association between atopic dermatitis, depression, and suicidal ideation: A systematic review and meta-analysis","volume":"80","author":"Patel","year":"2018","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jaad.2018.03.017","article-title":"Association of atopic dermatitis with depression, anxiety, and suicidal ideation in children and adults: A systematic review and meta-analysis","volume":"79","author":"Hamann","year":"2018","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1080\/09546634.2019.1612836","article-title":"Dupilumab improves patient-reported symptoms of atopic dermatitis, symptoms of anxiety and depression, and health-related quality of life in moderate-to-severe atopic dermatitis: Analysis of pooled data from the randomized trials SOLO 1 and SOLO 2","volume":"31","author":"Cork","year":"2019","journal-title":"J. Dermatol. Treat."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"E71","DOI":"10.1192\/j.eurpsy.2021.2249","article-title":"A systematic review on shared biological mechanisms of depression and anxiety in comorbidity with psoriasis, atopic dermatitis, and hidradenitis suppurativa","volume":"64","author":"Fabrazzo","year":"2021","journal-title":"Eur. Psychiatry"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1210\/jc.2001-010872","article-title":"Altered Responsiveness of the Hypothalamus-Pituitary-Adrenal Axis and the Sympathetic Adrenomedullary System to Stress in Patients with Atopic Dermatitis","volume":"87","author":"Geiben","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1600-0447.2007.00967.x","article-title":"Pathophysiology of hypercortisolism in depression","volume":"115","author":"Carroll","year":"2007","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1159\/000504388","article-title":"Biological Sex and IgE Sensitization Influence Severity of Depression and Cortisol Levels in Atopic Dermatitis","volume":"236","author":"Vinnik","year":"2020","journal-title":"Dermatology"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1084\/jem.194.1.71","article-title":"Brain Mast Cells Act as an Immune Gate to the Hypothalamic-Pituitary-Adrenal Axis in Dogs","volume":"194","author":"Matsumoto","year":"2001","journal-title":"J. Exp. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.anai.2020.11.008","article-title":"Childhood atopic dermatitis is associated with cognitive dysfunction: A National Health Interview Survey study from 2008 to 2018","volume":"126","author":"Cole","year":"2021","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1001\/jamadermatol.2014.3324","article-title":"Association of Vitiligo and Alopecia Areata with Atopic Dermatitis: A Systematic Review and Meta-analysis","volume":"151","author":"Mohan","year":"2015","journal-title":"JAMA Dermatol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1038\/sj.jid.5700915","article-title":"Loss-of-Function Mutations in the Filaggrin Gene and Alopecia Areata: Strong Risk Factor for a Severe Course of Disease in Patients Comorbid for Atopic Disease","volume":"127","author":"Betz","year":"2007","journal-title":"J. Investig. Dermatol."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Kageyama, R., Ito, T., Hanai, S., Morishita, N., Nakazawa, S., Fujiyama, T., Honda, T., and Tokura, Y. (2021). Immunological Properties of Atopic Dermatitis-Associated Alopecia Areata. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22052618"},{"key":"ref_79","first-page":"897","article-title":"Phase 2a randomized clinical trial of dupilumab (anti-IL-4R\u03b1) for alopecia areata patients","volume":"77","author":"Bares","year":"2021","journal-title":"Allergy"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"104157","DOI":"10.1016\/j.amsu.2022.104157","article-title":"Olumniant (Baricitinib) oral tablets: An insight into FDA-approved systemic treatment for Alopecia Areata","volume":"80","author":"Ali","year":"2022","journal-title":"Ann. Med. Surg."},{"key":"ref_81","unstructured":"(2022, September 23). Olumiant|European Medicines Agency. Available online: https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/olumiant."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Uchida, H., Kamata, M., Nagata, M., Fukaya, S., Hayashi, K., Fukuyasu, A., Tanaka, T., Ishikawa, T., Ohnishi, T., and Tada, Y. (2021). Baricitinib improved alopecia areata concomitant with atopic dermatitis: A case report. J. Dermatol., 48.","DOI":"10.1111\/1346-8138.16024"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.jaci.2022.03.030","article-title":"Atopic dermatitis and risk of autoimmune conditions: Population-based cohort study","volume":"150","author":"Alexander","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/15384101.2019.1707455","article-title":"Skin immunity and its dysregulation in atopic dermatitis, hidradenitis suppurativa and vitiligo","volume":"19","author":"Campione","year":"2020","journal-title":"Cell Cycle"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1001\/jamadermatol.2013.4228","article-title":"Association Between Vitiligo and Atopic Disorders: A Pilot Study","volume":"149","author":"Silverberg","year":"2013","journal-title":"JAMA Dermatol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1097\/DER.0000000000000781","article-title":"Atopic Dermatitis is a Risk Factor for Rheumatoid Arthritis: A Systematic Review and Meta-Analysis","volume":"32","author":"Rittiphairoj","year":"2021","journal-title":"Dermatitis"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.anai.2021.10.015","article-title":"Small molecule drugs for atopic dermatitis, rheumatoid arthritis, and hereditary angioedema","volume":"128","author":"Geng","year":"2021","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.jaci.2012.02.002","article-title":"Does \u201cautoreactivity\u201d play a role in atopic dermatitis?","volume":"129","author":"Tang","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1136\/rmdopen-2021-002018","article-title":"Original research: Allergic conditions and risk of rheumatoid arthritis: A Swedish case\u2013control study","volume":"8","author":"Kronzer","year":"2022","journal-title":"RMD Open"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"8112","DOI":"10.3390\/ijerph110808112","article-title":"Atopic Diseases and Systemic Lupus Erythematosus: An Epidemiological Study of the Risks and Correlations","volume":"11","author":"Hsiao","year":"2014","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/s11882-011-0216-5","article-title":"Basophils and Autoreactive IgE in the Pathogenesis of Systemic Lupus Erythematosus","volume":"11","author":"Charles","year":"2011","journal-title":"Curr. Allergy Asthma Rep."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"500","DOI":"10.3109\/08830185.2014.994815","article-title":"RANTES Gene Polymorphisms Are Not Associated with Rheumatoid Arthritis and Atopic Dermatitis: A Meta-Analysis","volume":"34","author":"Wen","year":"2015","journal-title":"Int. Rev. Immunol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3899\/jrheum.200583","article-title":"Rheumatoid Arthritis Known HLA Associations Are Unlikely to Be Associated with Atopic Dermatitis","volume":"48","author":"Margolis","year":"2020","journal-title":"J. Rheumatol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jaci.2015.06.029","article-title":"Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes","volume":"137","author":"Schmitt","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_95","unstructured":"(2022, September 23). Rinvoq|European Medicines Agency. Available online: https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/rinvoq."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1365-2222.2004.01864.x","article-title":"The Norwegian Childhood Diabetes Study Group Atopic disorders and risk of childhood-onset type 1 diabetes in individuals","volume":"34","author":"Stene","year":"2004","journal-title":"Clin. Exp. Allergy"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/bjd.14166","article-title":"Childhood type 1 diabetes may increase the risk of atopic dermatitis","volume":"174","author":"Lin","year":"2015","journal-title":"Br. J. Dermatol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1752-699X.2011.00239.x","article-title":"Correlation of worldwide incidence of type 1 diabetes (DiaMond) with prevalence of asthma and atopic eczema (ISAAC)","volume":"6","author":"Fsadni","year":"2011","journal-title":"Clin. Respir. J."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"a007799","DOI":"10.1101\/cshperspect.a007799","article-title":"The Hygiene Hypothesis: An Explanation for the Increased Frequency of Insulin-Dependent Diabetes","volume":"2","author":"Bach","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1007\/s00125-020-05188-3","article-title":"Association of diabetes-related autoantibodies with the incidence of asthma, eczema and allergic rhinitis in the TRIGR randomised clinical trial","volume":"63","author":"Krischer","year":"2020","journal-title":"Diabetologia"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.2337\/diacare.26.9.2568","article-title":"A Meta-Analysis of the Association Between Childhood Type 1 Diabetes and Atopic Disease","volume":"26","author":"Cardwell","year":"2003","journal-title":"Diabetes Care"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/j.1398-9995.2010.02517.x","article-title":"Relationship between type 1 diabetes and atopic diseases in a twin population","volume":"66","author":"Thomsen","year":"2010","journal-title":"Allergy"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.jaad.2014.12.013","article-title":"Association of atopic dermatitis with being overweight and obese: A systematic review and metaanalysis","volume":"72","author":"Zhang","year":"2015","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00019053-199400051-00003","article-title":"Worldwide epidemiology of obesity","volume":"5","author":"VanItallie","year":"1994","journal-title":"Pharmacoeconomics"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1468-3083.2009.03503.x","article-title":"The impact of obesity on skin disease and epidermal permeability barrier status","volume":"24","author":"Guida","year":"2010","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"100064","DOI":"10.1016\/j.xjidi.2021.100064","article-title":"Emerging Roles of Adipose Tissue in the Pathogenesis of Psoriasis and Atopic Dermatitis in Obesity","volume":"2","author":"Guo","year":"2021","journal-title":"JID Innov."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Jaworek, A.K., Szepietowski, J.C., Szafraniec, K., Jaworek, M., Ha\u0142ubiec, P., Wojas-Pelc, A., and Pokorski, M. (2020). Adipokines as Biomarkers of Atopic Dermatitis in Adults. J. Clin. Med., 9.","DOI":"10.3390\/jcm9092858"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1159\/000353972","article-title":"Obesity\u2013A Promoter of Allergy?","volume":"162","author":"Baumann","year":"2013","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/s41586-022-04536-0","article-title":"Obesity alters pathology and treatment response in inflammatory disease","volume":"604","author":"Bapat","year":"2022","journal-title":"Nature"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.3945\/ajcn.2009.27567","article-title":"Adiposity and human regional body temperature","volume":"90","author":"Savastano","year":"2009","journal-title":"Am. J. Clin. 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