{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:39:50Z","timestamp":1790026790837,"version":"4.0.1"},"reference-count":163,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015496","name":"CIBERNED","doi-asserted-by":"publisher","award":["CB07\/502"],"award-info":[{"award-number":["CB07\/502"]}],"id":[{"id":"10.13039\/501100015496","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015496","name":"CIBERNED","doi-asserted-by":"publisher","award":["PI2021\/03"],"award-info":[{"award-number":["PI2021\/03"]}],"id":[{"id":"10.13039\/501100015496","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015496","name":"CIBERNED","doi-asserted-by":"publisher","award":["2020\/0123"],"award-info":[{"award-number":["2020\/0123"]}],"id":[{"id":"10.13039\/501100015496","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fundacion Espa\u00f1ola para la Investigaci\u00f3n en Parkinson","award":["CB07\/502"],"award-info":[{"award-number":["CB07\/502"]}]},{"name":"Fundacion Espa\u00f1ola para la Investigaci\u00f3n en Parkinson","award":["PI2021\/03"],"award-info":[{"award-number":["PI2021\/03"]}]},{"name":"Fundacion Espa\u00f1ola para la Investigaci\u00f3n en Parkinson","award":["2020\/0123"],"award-info":[{"award-number":["2020\/0123"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The glymphatic system, a fluid-clearance pathway involved in brain waste clearance, is known to be impaired in neurological disorders, including Alzheimer\u2019s disease (AD). For this reason, it is important to understand the specific mechanisms and factors controlling glymphatic function. This pathway enables the flow of cerebrospinal fluid (CSF) into the brain and subsequently the brain interstitium, supported by aquaporins (AQPs). Continuous CSF transport through the brain parenchyma is critical for the effective transport and drainage of waste solutes, such as toxic proteins, through the glymphatic system. However, a balance between CSF production and secretion from the choroid plexus, through AQP regulation, is also needed. Thus, any condition that affects CSF homeostasis will also interfere with effective waste removal through the clearance glymphatic pathway and the subsequent processes of neurodegeneration. In this review, we highlight the role of AQPs in the choroid plexus in the modulation of CSF homeostasis and, consequently, the glymphatic clearance pathway, with a special focus on AD.<\/jats:p>","DOI":"10.3390\/ijms24010878","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T04:28:17Z","timestamp":1672806497000},"page":"878","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Choroid Plexus Aquaporins in CSF Homeostasis and the Glymphatic System: Their Relevance for Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"24","author":[{"given":"Cristina","family":"Municio","sequence":"first","affiliation":[{"name":"Group of Neurodegenerative Diseases, Hospital Universitario 12 de Octubre Research Institute (imas12), 28041 Madrid, Spain"},{"name":"Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), ISCIII, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Carrero","sequence":"additional","affiliation":[{"name":"Group of Neurodegenerative Diseases, Hospital Universitario 12 de Octubre Research Institute (imas12), 28041 Madrid, Spain"},{"name":"Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), ISCIII, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desire\u00e9","family":"Antequera","sequence":"additional","affiliation":[{"name":"Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), ISCIII, 28031 Madrid, Spain"},{"name":"Neurobiology of Alzheimer\u2019s Disease Unit, Functional Unit for Research into Chronic Diseases, Instituto de Salud Carlos III, 28222 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6504-4579","authenticated-orcid":false,"given":"Eva","family":"Carro","sequence":"additional","affiliation":[{"name":"Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), ISCIII, 28031 Madrid, Spain"},{"name":"Neurobiology of Alzheimer\u2019s Disease Unit, Functional Unit for Research into Chronic Diseases, Instituto de Salud Carlos III, 28222 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/ana.22615","article-title":"Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders","volume":"70","author":"Jucker","year":"2011","journal-title":"Ann. 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