{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:29:21Z","timestamp":1790980161116,"version":"4.1.0"},"reference-count":60,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CIBERNED employment plan","award":["CNV-304-PRF-866"],"award-info":[{"award-number":["CNV-304-PRF-866"]}]},{"name":"CIBERNED employment plan","award":["FJC2018-036012-I"],"award-info":[{"award-number":["FJC2018-036012-I"]}]},{"name":"CIBERNED employment plan","award":["FI20\/00215"],"award-info":[{"award-number":["FI20\/00215"]}]},{"name":"CIBERNED employment plan","award":["PI13\/02434"],"award-info":[{"award-number":["PI13\/02434"]}]},{"name":"CIBERNED employment plan","award":["PI16\/01861"],"award-info":[{"award-number":["PI16\/01861"]}]},{"name":"CIBERNED employment plan","award":["PI17\/01474"],"award-info":[{"award-number":["PI17\/01474"]}]},{"name":"CIBERNED employment plan","award":["PI19\/01240"],"award-info":[{"award-number":["PI19\/01240"]}]},{"name":"CIBERNED employment plan","award":["PI19\/01301"],"award-info":[{"award-number":["PI19\/01301"]}]},{"name":"CIBERNED employment plan","award":["FP-829-029"],"award-info":[{"award-number":["FP-829-029"]}]},{"name":"Spanish Ministry of Science, Innovation, and Universities","award":["CNV-304-PRF-866"],"award-info":[{"award-number":["CNV-304-PRF-866"]}]},{"name":"Spanish Ministry of Science, Innovation, and Universities","award":["FJC2018-036012-I"],"award-info":[{"award-number":["FJC2018-036012-I"]}]},{"name":"Spanish Ministry of Science, Innovation, and Universities","award":["FI20\/00215"],"award-info":[{"award-number":["FI20\/00215"]}]},{"name":"Spanish Ministry of Science, Innovation, and Universities","award":["PI13\/02434"],"award-info":[{"award-number":["PI13\/02434"]}]},{"name":"Spanish Ministry of Science, Innovation, and Universities","award":["PI16\/01861"],"award-info":[{"award-number":["PI16\/01861"]}]},{"name":"Spanish Ministry of Science, Innovation, and Universities","award":["PI17\/01474"],"award-info":[{"award-number":["PI17\/01474"]}]},{"name":"Spanish Ministry of Science, Innovation, and Universities","award":["PI19\/01240"],"award-info":[{"award-number":["PI19\/01240"]}]},{"name":"Spanish Ministry of Science, Innovation, and Universities","award":["PI19\/01301"],"award-info":[{"award-number":["PI19\/01301"]}]},{"name":"Spanish Ministry of Science, Innovation, and Universities","award":["FP-829-029"],"award-info":[{"award-number":["FP-829-029"]}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CNV-304-PRF-866"],"award-info":[{"award-number":["CNV-304-PRF-866"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FJC2018-036012-I"],"award-info":[{"award-number":["FJC2018-036012-I"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FI20\/00215"],"award-info":[{"award-number":["FI20\/00215"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI13\/02434"],"award-info":[{"award-number":["PI13\/02434"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI16\/01861"],"award-info":[{"award-number":["PI16\/01861"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/01474"],"award-info":[{"award-number":["PI17\/01474"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI19\/01240"],"award-info":[{"award-number":["PI19\/01240"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI19\/01301"],"award-info":[{"award-number":["PI19\/01301"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FP-829-029"],"award-info":[{"award-number":["FP-829-029"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"JPco-fuND","award":["CNV-304-PRF-866"],"award-info":[{"award-number":["CNV-304-PRF-866"]}]},{"name":"JPco-fuND","award":["FJC2018-036012-I"],"award-info":[{"award-number":["FJC2018-036012-I"]}]},{"name":"JPco-fuND","award":["FI20\/00215"],"award-info":[{"award-number":["FI20\/00215"]}]},{"name":"JPco-fuND","award":["PI13\/02434"],"award-info":[{"award-number":["PI13\/02434"]}]},{"name":"JPco-fuND","award":["PI16\/01861"],"award-info":[{"award-number":["PI16\/01861"]}]},{"name":"JPco-fuND","award":["PI17\/01474"],"award-info":[{"award-number":["PI17\/01474"]}]},{"name":"JPco-fuND","award":["PI19\/01240"],"award-info":[{"award-number":["PI19\/01240"]}]},{"name":"JPco-fuND","award":["PI19\/01301"],"award-info":[{"award-number":["PI19\/01301"]}]},{"name":"JPco-fuND","award":["FP-829-029"],"award-info":[{"award-number":["FP-829-029"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Mosaic loss of chromosome Y (mLOY) is a common ageing-related somatic event and has been previously associated with Alzheimer\u2019s disease (AD). However, mLOY estimation from genotype microarray data only reflects the mLOY degree of subjects at the moment of DNA sampling. Therefore, mLOY phenotype associations with AD can be severely age-confounded in the context of genome-wide association studies. Here, we applied Mendelian randomisation to construct an age-independent mLOY polygenic risk score (mloy-PRS) using 114 autosomal variants. The mloy-PRS instrument was associated with an 80% increase in mLOY risk per standard deviation unit (p = 4.22 \u00d7 10\u221220) and was orthogonal with age. We found that a higher genetic risk for mLOY was associated with faster progression to AD in men with mild cognitive impairment (hazard ratio (HR) = 1.23, p = 0.01). Importantly, mloy-PRS had no effect on AD conversion or risk in the female group, suggesting that these associations are caused by the inherent loss of the Y chromosome. Additionally, the blood mLOY phenotype in men was associated with increased cerebrospinal fluid levels of total tau and phosphorylated tau181 in subjects with mild cognitive impairment and dementia. Our results strongly suggest that mLOY is involved in AD pathogenesis.<\/jats:p>","DOI":"10.3390\/ijms24020898","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T04:28:17Z","timestamp":1672806497000},"page":"898","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Mendelian Randomisation Confirms the Role of Y-Chromosome Loss in Alzheimer\u2019s Disease Aetiopathogenesis in Men"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0125-5403","authenticated-orcid":false,"given":"Pablo","family":"Garc\u00eda-Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08017 Barcelona, Spain"},{"name":"CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2148-381X","authenticated-orcid":false,"given":"Itziar","family":"de Rojas","sequence":"additional","affiliation":[{"name":"Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08017 Barcelona, Spain"},{"name":"CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Moreno-Grau","sequence":"additional","affiliation":[{"name":"Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08017 Barcelona, Spain"},{"name":"Galatea Bio Inc., Hialeah, FL 33010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Montrreal","sequence":"additional","affiliation":[{"name":"Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08017 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1191-5893","authenticated-orcid":false,"given":"Raquel","family":"Puerta","sequence":"additional","affiliation":[{"name":"Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08017 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Alarc\u00f3n-Mart\u00edn","sequence":"additional","affiliation":[{"name":"Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08017 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e9s","family":"Quintela","sequence":"additional","affiliation":[{"name":"Grupo de Medicina Xen\u00f3mica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Universidade de Santiago de Compostela, 15705 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adela","family":"Orellana","sequence":"additional","affiliation":[{"name":"Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08017 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Andrade","sequence":"additional","affiliation":[{"name":"Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, 50937 Cologne, Germany"},{"name":"Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Clinic Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela V. Martino","family":"Adami","sequence":"additional","affiliation":[{"name":"Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, 50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Heilmann-Heimbach","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, School of Medicine & University Hospital Bonn, University of Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Gomez-Garre","sequence":"additional","affiliation":[{"name":"CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain"},{"name":"Unidad de Trastornos del Movimiento, Servicio de Neurolog\u00eda y Neurofisiolog\u00eda, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, 41013 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Teresa","family":"Peri\u00f1\u00e1n","sequence":"additional","affiliation":[{"name":"CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain"},{"name":"Unidad de Trastornos del Movimiento, Servicio de Neurolog\u00eda y Neurofisiolog\u00eda, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, 41013 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8537-3935","authenticated-orcid":false,"given":"Ignacio","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3 Doc\u00e8ncia i Recerca M\u00fatuaTerrassa, 08221 Terrassa, Spain"},{"name":"Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, 08221 Terrassa, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Diez-Fairen","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3 Doc\u00e8ncia i Recerca M\u00fatuaTerrassa, 08221 Terrassa, Spain"},{"name":"Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, 08221 Terrassa, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Nu\u00f1ez Llaves","sequence":"additional","affiliation":[{"name":"Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08017 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9438-5639","authenticated-orcid":false,"given":"Claudia","family":"Oliv\u00e9 Roig","sequence":"additional","affiliation":[{"name":"Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08017 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Garcia-Ribas","sequence":"additional","affiliation":[{"name":"Hospital Universitario Ramon y Cajal, IRYCIS, 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5218-0774","authenticated-orcid":false,"given":"Manuel","family":"Men\u00e9ndez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Servicio de Neurolog\u00eda, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011 Asturias, Spain"},{"name":"Departamento de Medicina, Universidad de Oviedo, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011 Asturias, Spain"},{"name":"Servicio de Neurolog\u00eda, Hospital Universitario de Cabue\u00f1es, 33394 Gij\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miquel","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3 Doc\u00e8ncia i Recerca M\u00fatuaTerrassa, 08221 Terrassa, Spain"},{"name":"Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, 08221 Terrassa, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariateresa","family":"Buongiorno","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3 Doc\u00e8ncia i Recerca M\u00fatuaTerrassa, 08221 Terrassa, Spain"},{"name":"Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, 08221 Terrassa, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Franco-Mac\u00edas","sequence":"additional","affiliation":[{"name":"Unidad de Demencias, Servicio de Neurolog\u00eda y Neurofisiolog\u00eda, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo, CSIC, Universidad de Sevilla, 41013 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9299-2534","authenticated-orcid":false,"given":"Maria Eugenia","family":"Saez","sequence":"additional","affiliation":[{"name":"CAEBI, Centro Andaluz de Estudios Bioinform\u00e1ticos, 41013 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Cano","sequence":"additional","affiliation":[{"name":"Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08017 Barcelona, Spain"},{"name":"CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6477-1117","authenticated-orcid":false,"given":"Maria J.","family":"Bullido","sequence":"additional","affiliation":[{"name":"CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain"},{"name":"Centro de Biolog\u00eda Molecular Severo Ochoa (UAM-CSIC), 28049 Madrid, Spain"},{"name":"Instituto de Investigacion Sanitaria \u2018Hospital la Paz\u2019 (IdIPaz), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4932-7429","authenticated-orcid":false,"given":"Luis Miguel","family":"Real","sequence":"additional","affiliation":[{"name":"Unidad Cl\u00ednica de Enfermedades Infecciosas y Microbiolog\u00eda, Hospital Universitario de Valme, 41013 Sevilla, Spain"},{"name":"Depatamento de Especialidades Quir\u00fargicas, Bioqu\u00edmica e Inmunolog\u00eda, Facultad de Medicina, Universidad de M\u00e1laga, 29016 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloy","family":"Rodr\u00edguez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain"},{"name":"Neurology Service, Marqu\u00e9s de Valdecilla University Hospital, University of Cantabria and IDIVAL, 39008 Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Lu\u00eds","family":"Royo","sequence":"additional","affiliation":[{"name":"Depatamento de Especialidades Quir\u00fargicas, Bioqu\u00edmica e Inmunolog\u00eda, Facultad de Medicina, Universidad de M\u00e1laga, 29016 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1916-2523","authenticated-orcid":false,"given":"Victoria","family":"\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011 Asturias, Spain"},{"name":"Laboratorio de Gen\u00e9tica, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pau","family":"Pastor","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3 Doc\u00e8ncia i Recerca M\u00fatuaTerrassa, 08221 Terrassa, Spain"},{"name":"Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, 08221 Terrassa, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4495-2113","authenticated-orcid":false,"given":"Gerard","family":"Pi\u00f1ol-Ripoll","sequence":"additional","affiliation":[{"name":"Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, 25198 Lleida, Spain"},{"name":"Institut de Recerca Biomedica de Lleida (IRBLLeida), 25198 Lleida, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1656-302X","authenticated-orcid":false,"given":"Pablo","family":"Mir","sequence":"additional","affiliation":[{"name":"CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain"},{"name":"Unidad de Trastornos del Movimiento, Servicio de Neurolog\u00eda y Neurofisiolog\u00eda, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, 41013 Sevilla, Spain"},{"name":"Departamento de Medicina, Facultad de Medicina, Universidad de Sevilla, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5366-3324","authenticated-orcid":false,"given":"Miguel Calero","family":"Lara","sequence":"additional","affiliation":[{"name":"CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain"},{"name":"Instituto de Salud Carlos III, 28222 Majadahonda, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7016-5340","authenticated-orcid":false,"given":"Miguel Medina","family":"Padilla","sequence":"additional","affiliation":[{"name":"CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain"},{"name":"CIEN Foundation\/Queen Sofia Foundation Alzheimer Center, 28220 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascual","family":"S\u00e1nchez-Juan","sequence":"additional","affiliation":[{"name":"CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain"},{"name":"Neurology Service, Marqu\u00e9s de Valdecilla University Hospital, University of Cantabria and IDIVAL, 39008 Santander, Spain"},{"name":"CIEN Foundation\/Queen Sofia Foundation Alzheimer Center, 28220 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1085-8986","authenticated-orcid":false,"given":"Angel","family":"Carracedo","sequence":"additional","affiliation":[{"name":"Grupo de Medicina Xen\u00f3mica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Universidade de Santiago de Compostela, 15705 Santiago de Compostela, Spain"},{"name":"Fundaci\u00f3n P\u00fablica Galega de Medicina Xen\u00f3mica-CIBERER-IDIS, 15705 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergi","family":"Valero","sequence":"additional","affiliation":[{"name":"Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08017 Barcelona, Spain"},{"name":"CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08017 Barcelona, Spain"},{"name":"CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lluis","family":"T\u00e0rraga","sequence":"additional","affiliation":[{"name":"Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08017 Barcelona, Spain"},{"name":"CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4991-763X","authenticated-orcid":false,"given":"Alfredo","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, 50937 Cologne, Germany"},{"name":"Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Clinic Bonn, 53127 Bonn, Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany"},{"name":"Department of Psychiatry and Glenn Biggs Institute for Alzheimer\u2019s and Neurodegenerative Diseases, San Antonio, TX 78229, USA"},{"name":"Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merc\u00e9","family":"Boada","sequence":"additional","affiliation":[{"name":"Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08017 Barcelona, Spain"},{"name":"CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2633-2495","authenticated-orcid":false,"given":"Agust\u00edn","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Research Center and Memory Clinic, Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08017 Barcelona, Spain"},{"name":"CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"The Alzheimer\u2019s association (2021). 2021 Alzheimer\u2019s Disease Facts and Figures. Alzheimer\u2019s Dement., 17, 327\u2013406.","DOI":"10.1002\/alz.12328"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1001\/archneurol.2011.221","article-title":"Autosomal Recessive Causes Likely in Early-Onset Alzheimer Disease","volume":"69","author":"Wingo","year":"2012","journal-title":"Arch. Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1001\/archpsyc.63.2.168","article-title":"Role of Genes and Environments for Explaining Alzheimer Disease","volume":"63","author":"Gatz","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1073\/pnas.90.5.1977","article-title":"Apolipoprotein E: High-Avidity Binding to \u03b2-Amyloid and Increased Frequency of Type 4 Allele in Late-Onset Familial Alzheimer Disease","volume":"90","author":"Strittmatter","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"16755","DOI":"10.1523\/JNEUROSCI.4521-10.2010","article-title":"Reimagining Alzheimer\u2019s Disease\u2014An Age-Based Hypothesis","volume":"30","author":"Herrup","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.trci.2015.07.001","article-title":"Marked Gender Differences in Progression of Mild Cognitive Impairment over 8 Years. Alzheimer\u2019s Dement","volume":"1","author":"Lin","year":"2015","journal-title":"Transl. Res. Clin. Interv."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.3174\/ajnr.A3601","article-title":"Higher Rates of Decline for Women and Apolipoprotein e \u03954 Carriers","volume":"34","author":"Holland","year":"2013","journal-title":"Am. J. Neuroradiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.jalz.2016.08.004","article-title":"Sex Biology Contributions to Vulnerability to Alzheimer\u2019s Disease: A Think Tank Convened by the Women\u2019s Alzheimer\u2019s Research Initiative","volume":"12","author":"Snyder","year":"2016","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41582-018-0032-9","article-title":"Sex Differences in Alzheimer Disease\u2014The Gateway to Precision Medicine","volume":"14","author":"Ferretti","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/ng.2966","article-title":"Mosaic Loss of Chromosome y in Peripheral Blood Is Associated with Shorter Survival and Higher Risk of Cancer","volume":"46","author":"Forsberg","year":"2014","journal-title":"Nat. Genet."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1038\/1971080a0","article-title":"Change of Human Chromosome Count Distributions with Age: Evidence for a Sex Difference","volume":"197","author":"Jacobs","year":"1963","journal-title":"Nature"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/1911178a0","article-title":"Distribution of Human Chromosome Counts in Relation to Age","volume":"191","author":"Jacobs","year":"1961","journal-title":"Nature"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00439-020-02114-w","article-title":"Mosaic Loss of Human Y Chromosome: What, How and Why","volume":"139","author":"Guo","year":"2020","journal-title":"Hum. Genet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/s41586-019-1765-3","article-title":"Genetic Predisposition to Mosaic Y Chromosome Loss in Blood","volume":"575","author":"Thompson","year":"2019","journal-title":"Nature"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"United Kingdom Cancer Cytogenetics Group (1992). Loss of the Y Chromosome from Normal and Neoplastic Bone Marrows. Genes Chromosom. Cancer, 5, 83\u201388.","DOI":"10.1002\/gcc.2870050112"},{"key":"ref_16","first-page":"11","article-title":"Clinical Significance of Y Chromosome Loss in Hematologic Disease. Genes Chromosom","volume":"27","author":"Wiktor","year":"2000","journal-title":"Cancer"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0921-8734(95)00016-Y","article-title":"Sex Chromosome Aneuploidy and Aging","volume":"338","author":"Stone","year":"1995","journal-title":"Mutat. Res. DNAging"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.5858\/2008-132-1329-LOTYCA","article-title":"Loss of the Y Chromosome: An Age-Related or Clonal Phenomenon in Acute Myelogenous Leukemia\/Myelodysplastic Syndrome?","volume":"132","author":"Wong","year":"2008","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/j.ajhg.2016.05.014","article-title":"Mosaic Loss of Chromosome y in Blood Is Associated with Alzheimer Disease","volume":"98","author":"Dumanski","year":"2016","journal-title":"Am. J. Hum. Genet."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Noveski, P., Madjunkova, S., Stefanovska, E.S., Geshkovska, N.M., Kuzmanovska, M., Dimovski, A., and Plaseska-Karanfilska, D. (2016). Loss of Y Chromosome in Peripheral Blood of Colorectal and Prostate Cancer Patients. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0146264"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e001544","DOI":"10.1161\/CIRCGENETICS.116.001544","article-title":"Loss of y Chromosome in Blood Is Associated with Major Cardiovascular Events during Follow-Up in Men after Carotid Endarterectomy","volume":"10","author":"Haitjema","year":"2017","journal-title":"Circ. Cardiovasc. Genet."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"12316","DOI":"10.1038\/s41598-018-30759-1","article-title":"Predictors of Mosaic Chromosome Y Loss and Associations with Mortality in the UK Biobank","volume":"8","author":"Loftfield","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s00439-017-1799-2","article-title":"Loss of Chromosome Y (LOY) in Blood Cells Is Associated with Increased Risk for Disease and Mortality in Aging Men","volume":"136","author":"Forsberg","year":"2017","journal-title":"Hum. Genet."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4019","DOI":"10.1007\/s00018-021-03822-w","article-title":"Immune Cells Lacking Y Chromosome Show Dysregulation of Autosomal Gene Expression","volume":"78","author":"Dumanski","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"7081","DOI":"10.1007\/s00018-021-03935-2","article-title":"Loss of Y Chromosome at the Interface between Aging and Alzheimer\u2019s Disease","volume":"78","author":"Guo","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.jalz.2019.06.4950","article-title":"Genome-Wide Association Analysis of Dementia and Its Clinical Endophenotypes Reveal Novel Loci Associated with Alzheimer\u2019s Disease and Three Causality Networks: The GR@ACE Project","volume":"15","author":"Quintela","year":"2019","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1038\/s41467-021-22491-8","article-title":"Common Variants in Alzheimer\u2019s Disease and Risk Stratification by Polygenic Risk Scores","volume":"12","author":"Tesi","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez, J.R., L\u00f3pez-S\u00e1nchez, M., C\u00e1ceres, A., Puig, P., Esko, T., and P\u00e9rez-Jurado, L.A. (2020). MADloy: Robust Detection of Mosaic Loss of Chromosome Y from Genotype-Array-Intensity Data. BMC Bioinform., 21.","DOI":"10.1186\/s12859-020-03768-z"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.jalz.2013.03.006","article-title":"Design of a Comprehensive Alzheimer\u2019s Disease Clinic and Research Center in Spain to Meet Critical Patient and Family Needs","volume":"10","author":"Boada","year":"2014","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"15160","DOI":"10.1038\/s41598-021-94588-5","article-title":"Leukocytes with Chromosome Y Loss Have Reduced Abundance of the Cell Surface Immunoprotein CD99","volume":"11","author":"Mattisson","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.trci.2018.06.014","article-title":"Inflammation as a Central Mechanism in Alzheimer\u2019s Disease","volume":"4","author":"Kinney","year":"2018","journal-title":"Alzheimer\u2019s Dement. Transl. Res. Clin. Interv."},{"key":"ref_32","first-page":"150.e1","article-title":"Extreme Downregulation of Chromosome Y and Alzheimer\u2019s Disease in Men. Neurobiol","volume":"90","author":"Caceres","year":"2020","journal-title":"Aging"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s13578-021-00716-z","article-title":"A Polygenic Risk Score Predicts Mosaic Loss of Chromosome Y in Circulating Blood Cells","volume":"11","author":"Riaz","year":"2021","journal-title":"Cell Biosci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41582-021-00549-x","article-title":"Peripheral and Central Immune System Crosstalk in Alzheimer Disease\u2014A Research Prospectus","volume":"17","author":"Bettcher","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41588-022-01024-z","article-title":"New Insights into the Genetic Etiology of Alzheimer\u2019s Disease and Related Dementias","volume":"54","author":"Bellenguez","year":"2022","journal-title":"Nat. Genet."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/ni749","article-title":"CD99 Plays a Major Role in the Migration of Monocytes through Endothelial Junctions","volume":"3","author":"Schenkel","year":"2002","journal-title":"Nat. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/nri3908","article-title":"How Leukocytes Cross the Vascular Endothelium","volume":"15","author":"Vestweber","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/gps.2353","article-title":"Cerebrospinal Fluid Total Tau as a Marker of Alzheimer\u2019s Disease Intensity","volume":"25","author":"Zetterberg","year":"2010","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3233\/JAD-122002","article-title":"A Longitudinal Follow-up of 550 Mild Cognitive Impairment Patients: Evidence for Large Conversion to Dementia Rates and Detection of Major Risk Factors Involved","volume":"34","author":"Espinosa","year":"2013","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/mp.2016.18","article-title":"Genome-Wide Significant Risk Factors for Alzheimer\u2019s Disease: Role in Progression to Dementia Due to Alzheimer\u2019s Disease among Subjects with Mild Cognitive Impairment","volume":"22","author":"Lacour","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical Diagnosis of Alzheimer\u2019s Disease: Report of the NINCDS-ADRDA Work Group\u22c6 under the Auspices of Department of Health and Human Services Task Force on Alzheimer\u2019s Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The Diagnosis of Dementia Due to Alzheimer\u2019s Disease: Recommendations from the National Institute on Aging-Alzheimer\u2019s Association Workgroups on Diagnostic Guidelines for Alzheimer\u2019s Disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1212\/WNL.43.2.250","article-title":"Vascular Dementia: Diagnostic Criteria for Research Studies: Report of the Ninds-Airen International Workshop","volume":"43","author":"Tatemichi","year":"1993","journal-title":"Neurology"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1212\/WNL.51.6.1546","article-title":"Frontotemporal Lobar Degeneration: A Consensus on Clinical Diagnostic Criteria","volume":"51","author":"Neary","year":"1998","journal-title":"Neurology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1093\/brain\/awr179","article-title":"Sensitivity of Revised Diagnostic Criteria for the Behavioural Variant of Frontotemporal Dementia","volume":"134","author":"Rascovsky","year":"2011","journal-title":"Brain"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1212\/01.wnl.0000187889.17253.b1","article-title":"Diagnosis and Management of Dementia with Lewy Bodies: Third Report of the DLB Consortium","volume":"65","author":"McKeith","year":"2005","journal-title":"Neurology"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1001\/archneur.56.3.303","article-title":"Mild Cognitive Impairment: Clinical Characterization and Outcome","volume":"56","author":"Petersen","year":"1999","journal-title":"Arch. Neurol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-2796.2004.01388.x","article-title":"Mild Cognitive Impairment as a Diagnostic Entity","volume":"256","author":"Petersen","year":"2004","journal-title":"J. Intern. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e126","DOI":"10.1093\/nar\/gkn556","article-title":"Adjustment of Genomic Waves in Signal Intensities from Whole-Genome SNP Genotyping Platforms","volume":"36","author":"Diskin","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1101\/gr.6861907","article-title":"PennCNV: An Integrated Hidden Markov Model Designed for High-Resolution Copy Number Variation Detection in Whole-Genome SNP Genotyping Data","volume":"17","author":"Wang","year":"2007","journal-title":"Genome Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e138","DOI":"10.1093\/nar\/gkn641","article-title":"Modeling Genetic Inheritance of Copy Number Variations","volume":"21","author":"Wang","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.biopsych.2016.08.014","article-title":"Cognitive Performance Among Carriers of Pathogenic Copy Number Variants: Analysis of 152,000 UK Biobank Subjects","volume":"82","author":"Kendall","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"5346","DOI":"10.1093\/bioinformatics\/btz567","article-title":"Genetic Association Testing Using the GENESIS R\/Bioconductor Package","volume":"35","author":"Gogarten","year":"2019","journal-title":"Bioinformatics"},{"key":"ref_54","first-page":"100","article-title":"FACEHBI: A Prospective Study of Risk Factors, Biomarkers and Cognition in a Cohort of Individuals with Subjective Cognitive Decline. Study Rationale and Research Protocols","volume":"4","author":"Sanabria","year":"2017","journal-title":"J. Prev. Alzheimer\u2019s Dis."},{"key":"ref_55","first-page":"604141","article-title":"Reliable Measurements of the \u03b2 -Amyloid Pool in Blood Could Help in the Early Diagnosis of AD","volume":"2012","author":"Pesini","year":"2012","journal-title":"Int. J. Alzheimers. Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1093\/brain\/awac024","article-title":"Matrix Metalloproteinase 10 Is Linked to the Risk of Progression to Dementia of the Alzheimer\u2019s Type","volume":"145","author":"Adami","year":"2022","journal-title":"Brain"},{"key":"ref_57","unstructured":"R Core Team (2020). R: A Language and Environment for Statistical Computing, R Foundation for Statistical Computing."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Therneau, T.M., and Grambsch, P.M. (2000). Modeling Survival Data: Extending the Cox Model, Springer. Statistics for Biology and Health.","DOI":"10.1007\/978-1-4757-3294-8"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1002\/1097-0142(197210)30:4<889::AID-CNCR2820300405>3.0.CO;2-1","article-title":"Age-associated Aneuploidy: Loss of Y Chromosome from Human Bone Marrow Cells with Aging","volume":"30","author":"Pierre","year":"1972","journal-title":"Cancer"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v036.i03","article-title":"Conducting Meta-Analysis in R with the Metafor Package","volume":"36","author":"Viechtbauer","year":"2010","journal-title":"J. Stat. Softw."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/2\/898\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T17:58:08Z","timestamp":1760119088000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/2\/898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,4]]},"references-count":60,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["ijms24020898"],"URL":"https:\/\/doi.org\/10.3390\/ijms24020898","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,4]]}}}