{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T23:01:11Z","timestamp":1773788471468,"version":"3.50.1"},"reference-count":32,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T00:00:00Z","timestamp":1672876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002261","name":"RFBR perspective","doi-asserted-by":"publisher","award":["19-34-60012"],"award-info":[{"award-number":["19-34-60012"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002261","name":"RFBR perspective","doi-asserted-by":"publisher","award":["PRIORITY-2030"],"award-info":[{"award-number":["PRIORITY-2030"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002261","name":"RFBR perspective","doi-asserted-by":"publisher","award":["22-44-02007"],"award-info":[{"award-number":["22-44-02007"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Kazan Federal University Strategic Academic Leadership Program","award":["19-34-60012"],"award-info":[{"award-number":["19-34-60012"]}]},{"name":"Kazan Federal University Strategic Academic Leadership Program","award":["PRIORITY-2030"],"award-info":[{"award-number":["PRIORITY-2030"]}]},{"name":"Kazan Federal University Strategic Academic Leadership Program","award":["22-44-02007"],"award-info":[{"award-number":["22-44-02007"]}]},{"name":"RSF-DST","award":["19-34-60012"],"award-info":[{"award-number":["19-34-60012"]}]},{"name":"RSF-DST","award":["PRIORITY-2030"],"award-info":[{"award-number":["PRIORITY-2030"]}]},{"name":"RSF-DST","award":["22-44-02007"],"award-info":[{"award-number":["22-44-02007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Hemorrhagic fever with renal syndrome (HFRS) remains a prevalent zoonosis in the Republic of Tatarstan (RT), Russian Federation. Puumala orthohantavirus (PUUV), carried by bank voles (Myodes glareolus), is the principal zoonotic pathogen of HFRS in the RT. In this study, we sought to demonstrate the similarity of the PUUV genetic sequences detected in HFRS case patients and bank vole samples previously collected in some areas of the RT. Furthermore, we intended to identify the reassortant PUUV genomes and locate a potential site for their emergence. During 2019 outbreaks, the PUUV genome sequences of the S and M segments from 42 HFRS cases were analysed and compared with the corresponding sequences from bank voles previously trapped in the RT. Most of the PUUV strains from HFRS patients turned out to be closely related to those isolated from bank voles captured near the site of the human infection. We also found possible reassortant PUUV genomes in five patients while they were absent in bank voles. The location of the corresponding HFRS infection sites suggests that reassortant PUUV genomes could emerge in the bank voles that inhabit the forests on the watershed between the Kazanka River and Myosha River. These findings could facilitate the search for the naturally occurring reassortants of PUUV in bank vole populations.<\/jats:p>","DOI":"10.3390\/ijms24021018","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T04:51:31Z","timestamp":1672894291000},"page":"1018","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Puumala Orthohantavirus Reassortant Genome Variants Likely Emerging in the Watershed Forests"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4328-8190","authenticated-orcid":false,"given":"Emmanuel","family":"Kabwe","sequence":"first","affiliation":[{"name":"OpenLab \u201cGene and Cell Technologies\u201d, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia"},{"name":"Kazan Research Institute of Epidemiology and Microbiology, 420012 Kazan, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton F.","family":"Shamsutdinov","sequence":"additional","affiliation":[{"name":"OpenLab \u201cGene and Cell Technologies\u201d, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Setora","family":"Suleimanova","sequence":"additional","affiliation":[{"name":"OpenLab \u201cGene and Cell Technologies\u201d, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekaterina V.","family":"Martynova","sequence":"additional","affiliation":[{"name":"OpenLab \u201cGene and Cell Technologies\u201d, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruzilya K.","family":"Ismagilova","sequence":"additional","affiliation":[{"name":"OpenLab \u201cOmics Technology\u201d, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venera G.","family":"Shakirova","sequence":"additional","affiliation":[{"name":"Medical Academy of the Ministry of Health of the Russian Federation, 420012 Kazan, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana A.","family":"Savitskaya","sequence":"additional","affiliation":[{"name":"Kazan Research Institute of Epidemiology and Microbiology, 420012 Kazan, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guzel S.","family":"Isaeva","sequence":"additional","affiliation":[{"name":"Kazan Research Institute of Epidemiology and Microbiology, 420012 Kazan, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9427-5739","authenticated-orcid":false,"given":"Albert A.","family":"Rizvanov","sequence":"additional","affiliation":[{"name":"OpenLab \u201cGene and Cell Technologies\u201d, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana F.","family":"Khaiboullina","sequence":"additional","affiliation":[{"name":"OpenLab \u201cGene and Cell Technologies\u201d, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey P.","family":"Morzunov","sequence":"additional","affiliation":[{"name":"OpenLab \u201cGene and Cell Technologies\u201d, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia"},{"name":"Department of Pathology, University of Nevada, Reno, NV 89557, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4409-2942","authenticated-orcid":false,"given":"Yuriy N.","family":"Davidyuk","sequence":"additional","affiliation":[{"name":"OpenLab \u201cGene and Cell Technologies\u201d, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"545372","DOI":"10.3389\/fcimb.2020.545372","article-title":"Pre-Clinical Studies of Inactivated Polyvalent HFRS Vaccine","volume":"10","author":"Dzagurova","year":"2020","journal-title":"Front. 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