{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:44:05Z","timestamp":1791895445673,"version":"4.3.4"},"reference-count":37,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sociedad Asturiana de Diabetes-SADENO","award":["PRDAS18003FERN"],"award-info":[{"award-number":["PRDAS18003FERN"]}]},{"name":"University of Barcelona","award":["PRDAS18003FERN"],"award-info":[{"award-number":["PRDAS18003FERN"]}]},{"name":"Spanish Association Against Cancer (AECC)","award":["PRDAS18003FERN"],"award-info":[{"award-number":["PRDAS18003FERN"]}]},{"name":"Fundaci\u00f3n Caja Rural","award":["PRDAS18003FERN"],"award-info":[{"award-number":["PRDAS18003FERN"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance that is diagnosed for the first time during pregnancy. The objective of this study is to know the glucose tolerance status after 15 years of pregnancy in patients diagnosed with gestational diabetes and to assess the long-term effect of GDM on the circulating miRNA profile of these women. To answer these, 30 randomly selected women diagnosed with GDM during 2005\u20132006 were included in the study, and glucose tolerance was measured using the National Diabetes Data Group criteria. Additionally, four miRNAs (hsa-miR-1-3p, hsa-miR-24-3p, hsa-miR-329-3p, hsa-miR-543) were selected for their analysis in the plasma of women 15 years after the diagnosis of GDM. In our study we discovered that, fifteen years after the diagnosis of GDM, 50% of women have some degree of glucose intolerance directly related to body weight and body mass index during pregnancy. Dysglycemic women also showed a significantly increased level of circulating hsa-miR-24-3p. Thus, we can conclude that initial weight and BMI, together with circulating expression levels of hsa-miR-24-3p, could be good predictors of the future development of dysglycemia in women with a previous diagnosis of GDM.<\/jats:p>","DOI":"10.3390\/ijms24021152","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T02:09:39Z","timestamp":1673230179000},"page":"1152","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["miR-24-3p and Body Mass Index as Type 2 Diabetes Risk Factors in Spanish Women 15 Years after Gestational Diabetes Mellitus Diagnosis"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4307-8145","authenticated-orcid":false,"given":"Jessica","family":"Ares Blanco","sequence":"first","affiliation":[{"name":"Endocrinology, Nutrition, Diabetes and Obesity Group, Health Research Institute of the Principality of Asturias (ISPA), 33011 Oviedo, Spain"},{"name":"Endocrinology and Nutrition Department, Asturias Central University Hospital, Av. Roma s\/n, 33011 Oviedo, Spain"},{"name":"Medicine Department, University of Oviedo, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7929-4990","authenticated-orcid":false,"given":"Carmen","family":"Lambert","sequence":"additional","affiliation":[{"name":"Endocrinology, Nutrition, Diabetes and Obesity Group, Health Research Institute of the Principality of Asturias (ISPA), 33011 Oviedo, Spain"},{"name":"University of Barcelona, 08007 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4687-3379","authenticated-orcid":false,"given":"Manuel","family":"Fernandez-Sanjurjo","sequence":"additional","affiliation":[{"name":"Department of Functional Biology, University of Oviedo, 33007 Oviedo, Spain"},{"name":"Translational Health Interventions Group, Health Research Institute of the Principality of Asturias (ISPA), 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9563-668X","authenticated-orcid":false,"given":"Paula","family":"Morales-Sanchez","sequence":"additional","affiliation":[{"name":"Endocrinology, Nutrition, Diabetes and Obesity Group, Health Research Institute of the Principality of Asturias (ISPA), 33011 Oviedo, Spain"},{"name":"Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Pujante","sequence":"additional","affiliation":[{"name":"Endocrinology, Nutrition, Diabetes and Obesity Group, Health Research Institute of the Principality of Asturias (ISPA), 33011 Oviedo, Spain"},{"name":"University of Barcelona, 08007 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4155-2015","authenticated-orcid":false,"given":"Paola","family":"Pinto-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Functional Biology, University of Oviedo, 33007 Oviedo, Spain"},{"name":"Translational Health Interventions Group, Health Research Institute of the Principality of Asturias (ISPA), 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3063-1562","authenticated-orcid":false,"given":"Eduardo","family":"Iglesias-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Department of Functional Biology, University of Oviedo, 33007 Oviedo, Spain"},{"name":"Translational Health Interventions Group, Health Research Institute of the Principality of Asturias (ISPA), 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9548-7821","authenticated-orcid":false,"given":"Edelmiro","family":"Menendez Torre","sequence":"additional","affiliation":[{"name":"Endocrinology, Nutrition, Diabetes and Obesity Group, Health Research Institute of the Principality of Asturias (ISPA), 33011 Oviedo, Spain"},{"name":"Endocrinology and Nutrition Department, Asturias Central University Hospital, Av. Roma s\/n, 33011 Oviedo, Spain"},{"name":"Medicine Department, University of Oviedo, 33011 Oviedo, Spain"},{"name":"Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6114-9712","authenticated-orcid":false,"given":"Elias","family":"Delgado","sequence":"additional","affiliation":[{"name":"Endocrinology, Nutrition, Diabetes and Obesity Group, Health Research Institute of the Principality of Asturias (ISPA), 33011 Oviedo, Spain"},{"name":"Endocrinology and Nutrition Department, Asturias Central University Hospital, Av. Roma s\/n, 33011 Oviedo, Spain"},{"name":"Medicine Department, University of Oviedo, 33011 Oviedo, Spain"},{"name":"Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,6]]},"reference":[{"key":"ref_1","unstructured":"IDF (2021). IDF Diabetes Atlas, 10th Edition Committee, International Diabetes Federation."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1210\/endrev\/bnac003","article-title":"A Clinical Update on Gestational Diabetes Mellitus","volume":"43","author":"Sweeting","year":"2022","journal-title":"Endocr. 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