{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:20:10Z","timestamp":1790864410076,"version":"4.1.0"},"reference-count":83,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Arterial hypertension is a chronic disease which is very prevalent contemporarily. The aim of this review was to investigate the impact of gut microbiota on the development and potential treatment of hypertension, taking into consideration underlying molecular mechanisms. The bacteria present in the intestines have the ability to secrete different metabolites, which might play a significant role in the regulation of blood pressure. The most important include short-chain fatty acids (SCFAs), vasoactive hormones, trimethylamine (TMA) and trimethylamine N-oxide (TMAO) and uremic toxins, such as indoxyl sulfate (IS) and p-cresyl sulfate (PCS). Their action in regulating blood pressure is mainly based on their pro- or anti-inflammatory function. The use of specifically formulated probiotics to modify the composition of gut microbiota might be a beneficial way of supportive treatment of hypertension; however, further research on this topic is needed to choose the species of bacteria that could induce the hypotensive pattern.<\/jats:p>","DOI":"10.3390\/ijms24021377","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T02:06:03Z","timestamp":1673402763000},"page":"1377","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Does the Composition of Gut Microbiota Affect Hypertension? Molecular Mechanisms Involved in Increasing Blood Pressure"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4527-3355","authenticated-orcid":false,"given":"Julita","family":"Tokarek","sequence":"first","affiliation":[{"name":"Department of Nephrocardiology, Medical University of Lodz, ul. Zeromskiego 113, 90-549 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7737-5689","authenticated-orcid":false,"given":"Emilian","family":"Budny","sequence":"additional","affiliation":[{"name":"Department of Nephrocardiology, Medical University of Lodz, ul. Zeromskiego 113, 90-549 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Saar","sequence":"additional","affiliation":[{"name":"Department of Nephrocardiology, Medical University of Lodz, ul. Zeromskiego 113, 90-549 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2773-2733","authenticated-orcid":false,"given":"Joanna","family":"Ku\u0107mierz","sequence":"additional","affiliation":[{"name":"Department of Nephrocardiology, Medical University of Lodz, ul. Zeromskiego 113, 90-549 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6799-4746","authenticated-orcid":false,"given":"Ewelina","family":"M\u0142ynarska","sequence":"additional","affiliation":[{"name":"Department of Nephrocardiology, Medical University of Lodz, ul. Zeromskiego 113, 90-549 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Rysz","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, ul. Zeromskiego 113, 90-549 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Franczyk","sequence":"additional","affiliation":[{"name":"Department of Nephrocardiology, Medical University of Lodz, ul. 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Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00003495-199856002-00001","article-title":"Pathog\u00e9nie et \u00e9pid\u00e9miologie de l\u2019hypertension art\u00e9rielle","volume":"56","author":"Pardell","year":"1998","journal-title":"Drugs"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/S0140-6736(08)60655-8","article-title":"Global burden of blood-pressure-related disease, 2001","volume":"371","author":"Lawes","year":"2008","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"M\u0142ynarska, E., Gadzinowska, J., Tokarek, J., Forycka, J., Szuman, A., Franczyk, B., and Rysz, J. (2022). The Role of the Microbiome-Brain-Gut Axis in the Pathogenesis of Depressive Disorder. Nutrients, 14.","DOI":"10.3390\/nu14091921"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Abenavoli, L., Scarpellini, E., Colica, C., Boccuto, L., Salehi, B., Sharifi-Rad, J., Aiello, V., Romano, B., De Lorenzo, A., and Izzo, A.A. (2019). Gut Microbiota and Obesity: A Role for Probiotics. Nutrients, 11.","DOI":"10.3390\/nu11112690"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s11154-019-09512-0","article-title":"Dietary lipids, gut microbiota and lipid metabolism","volume":"20","author":"Schoeler","year":"2019","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00018-018-2943-4","article-title":"An insight into gut microbiota and its functionalities","volume":"76","author":"Adak","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Verhaar, B.J.H., Prodan, A., Nieuwdorp, M., and Muller, M. (2020). Gut Microbiota in Hypertension and Atherosclerosis: A Review. Nutrients, 12.","DOI":"10.3390\/nu12102982"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Bier, A., Braun, T., Khasbab, R., Di Segni, A., Grossman, E., Haberman, Y., and Leibowitz, A. (2018). A High Salt Diet Modulates the Gut Microbiota and Short Chain Fatty Acids Production in a Salt-Sensitive Hypertension Rat Model. Nutrients, 10.","DOI":"10.3390\/nu10091154"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nature24628","article-title":"Salt-responsive gut commensal modulates TH17 axis and disease","volume":"551","author":"Wilck","year":"2017","journal-title":"Nature"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1194\/jlr.M500507-JLR200","article-title":"Oxidized low density lipoprotein impairs endothelial progenitor cells by regulation of endothelial nitric oxide synthase","volume":"47","author":"Ma","year":"2006","journal-title":"J. Lipid Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.cardiores.2006.11.013","article-title":"Estrogen protection, oxidized LDL, endothelial dysfunction and vasorelaxation in cardiovascular disease: New insights into a complex issue","volume":"73","author":"Subahpacker","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.metabol.2015.01.007","article-title":"New Aspects on the Metabolic role of Intestinal Microbiota in the Development of Atherosclerosis","volume":"64","author":"Drosos","year":"2015","journal-title":"Metabolism"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature09922","article-title":"Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease","volume":"472","author":"Wang","year":"2011","journal-title":"Nature"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"4592","DOI":"10.1073\/pnas.1011383107","article-title":"Human oral, gut, and plaque microbiota in patients with atherosclerosis","volume":"108","author":"Koren","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40168-016-0222-x","article-title":"Gut microbiota dysbiosis contributes to the development of hypertension","volume":"5","author":"Li","year":"2017","journal-title":"Microbiome"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1042\/CS20180087","article-title":"Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in patients with high blood pressure","volume":"132","author":"Kim","year":"2018","journal-title":"Clin. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1161\/HYPERTENSIONAHA.115.05315","article-title":"Gut Dysbiosis Is Linked to Hypertension","volume":"65","author":"Yang","year":"2015","journal-title":"Hypertension"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1161\/HYPERTENSIONAHA.118.12109","article-title":"Gut Microbiota Composition and Blood Pressure: The CARDIA Study","volume":"73","author":"Sun","year":"2019","journal-title":"Hypertension"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"872","DOI":"10.7150\/ijms.29322","article-title":"Differential Analysis of Hypertension-Associated Intestinal Microbiota","volume":"16","author":"Xie","year":"2019","journal-title":"Int. J. Med. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3389\/fcimb.2017.00381","article-title":"Alterations of the Gut Microbiome in Hypertension","volume":"7","author":"Yan","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1093\/eurheartj\/ehaa704","article-title":"Associations between gut microbiota, faecal short-chain fatty acids, and blood pressure across ethnic groups: The HELIUS study","volume":"41","author":"Verhaar","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s11906-019-0964-5","article-title":"Hypertension as a Metabolic Disorder and the Novel Role of the Gut","volume":"21","author":"Tanaka","year":"2019","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/jvim.15454","article-title":"The renin-angiotensin-aldosterone system and its suppression","volume":"33","author":"Ames","year":"2019","journal-title":"J. Vet. Intern. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1152\/physrev.1991.71.3.617","article-title":"Reflexes from the heart","volume":"71","author":"Hainsworth","year":"1991","journal-title":"Physiol. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"441","DOI":"10.5603\/KP.2013.0089","article-title":"Sympathetic nervous system and arterial hypertension: New perspectives, new data","volume":"71","author":"Hering","year":"2013","journal-title":"Kardiol. Pol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1097\/FJC.0000000000000064","article-title":"The Sympathetic Nervous System as a Target for the Treatment of Hypertension and Cardiometabolic Diseases","volume":"63","author":"Sorota","year":"2014","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_29","first-page":"341","article-title":"Natriuretic Peptides: Their Structures, Receptors, Physiologic Functions and Therapeutic Applications","volume":"Volume 191","author":"Schmidt","year":"2009","journal-title":"cGMP: Generators, Effectors and Therapeutic Implications"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s40292-021-00483-5","article-title":"The Natriuretic Peptides for Hypertension Treatment","volume":"29","author":"Rubattu","year":"2022","journal-title":"High Blood Press Cardiovasc. Prev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3109\/1354750X.2013.787544","article-title":"The kinin\u2013kallikrein system: Physiological roles, pathophysiology and its relationship to cancer biomarkers","volume":"18","author":"Kashuba","year":"2013","journal-title":"Biomarkers"},{"key":"ref_32","first-page":"15","article-title":"The kallikrein-kinin pathways in hypertension and diabetes","volume":"69","author":"Sharma","year":"2014","journal-title":"Prog. Drug Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1093\/ajh\/hpaa103","article-title":"Microbiota and Hypertension: Role of the Sympathetic Nervous System and the Immune System","volume":"33","author":"Toral","year":"2020","journal-title":"Am. J. Hypertens."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1097\/MNH.0000000000000149","article-title":"Gut microbiota in hypertension","volume":"24","author":"Jose","year":"2015","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1053\/j.gastro.2012.01.053","article-title":"Double pylorus: An optical illusion or reality?","volume":"143","author":"Sharma","year":"2012","journal-title":"Gastroenterology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1097\/HJH.0000000000001378","article-title":"Sodium butyrate suppresses angiotensin II-induced hypertension by inhibition of renal (pro)renin receptor and intrarenal renin\u2013angiotensin system","volume":"35","author":"Wang","year":"2017","journal-title":"J. Hypertens."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11906-017-0722-5","article-title":"Microbial Short-Chain Fatty Acids and Blood Pressure Regulation","volume":"19","author":"Pluznick","year":"2017","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1073\/pnas.1322269111","article-title":"The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition","volume":"111","author":"Chang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1161\/HYPERTENSIONAHA.110.154567","article-title":"HDAC Inhibition Attenuates Inflammatory, Hypertrophic, and Hypertensive Responses in Spontaneously Hypertensive Rats","volume":"56","author":"Cardinale","year":"2010","journal-title":"Hypertension"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3389\/fphar.2018.00533","article-title":"The Anti-inflammatory Effects of Short Chain Fatty Acids on Lipopolysaccharide- or Tumor Necrosis Factor \u03b1-Stimulated Endothelial Cells via Activation of GPR41\/43 and Inhibition of HDACs","volume":"9","author":"Li","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1096\/fj.00-0359fje","article-title":"Anti-inflammatory effects of sodium butyrate on human monocytes: Potent inhibition of IL-12 and up-regulation of IL-10 production","volume":"14","author":"Burtscher","year":"2000","journal-title":"FASEB J."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"G907","DOI":"10.1152\/ajpgi.2001.281.4.G907","article-title":"Vagal afferent responses to fatty acids of different chain length in the rat","volume":"281","author":"Lal","year":"2001","journal-title":"Am. J. Physiol.-Gastrointest. Liver Physiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1007\/s00424-019-02322-y","article-title":"Butyric acid, a gut bacteria metabolite, lowers arterial blood pressure via colon-vagus nerve signaling and GPR41\/43 receptors","volume":"471","author":"Onyszkiewicz","year":"2019","journal-title":"Pflug. Arch."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.clinre.2017.09.006","article-title":"Gut microbiota and hypertension: From pathogenesis to new therapeutic strategies","volume":"42","author":"Kang","year":"2018","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/bies.201100024","article-title":"Probiotics function mechanistically as delivery vehicles for neuroactive compounds: Microbial endocrinology in the design and use of probiotics","volume":"33","author":"Lyte","year":"2011","journal-title":"Bioessays"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/ajh\/hps085","article-title":"Serotonin and Dopamine in Essential Hypertension","volume":"26","author":"Stier","year":"2013","journal-title":"Am. J. Hypertens."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1161\/01.HYP.3.2.149","article-title":"Norepinephrine kinetics in essential hypertension. Defective neuronal uptake of norepinephrine in some patients","volume":"3","author":"Esler","year":"1981","journal-title":"Hypertension"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cmet.2012.12.011","article-title":"Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation","volume":"17","author":"Bennett","year":"2013","journal-title":"Cell Metab."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1136\/gutjnl-2018-317155","article-title":"Identification of TMAO-producer phenotype and host-diet-gut dysbiosis by carnitine challenge test in human and germ-free mice","volume":"68","author":"Wu","year":"2019","journal-title":"Gut"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1186\/s12967-022-03687-y","article-title":"Trimethylamine, a gut bacteria metabolite and air pollutant, increases blood pressure and markers of kidney damage including proteinuria and KIM-1 in rats","volume":"20","author":"Maksymiuk","year":"2022","journal-title":"J. Transl. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/j.cjca.2014.09.010","article-title":"Trimethylamine-N-Oxide: A Carnitine-Derived Metabolite That Prolongs the Hypertensive Effect of Angiotensin II in Rats","volume":"30","author":"Ufnal","year":"2014","journal-title":"Can. J. Cardiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"102115","DOI":"10.1016\/j.redox.2021.102115","article-title":"Gut microbiota dependent trimethylamine N-oxide aggravates angiotensin II\u2013induced hypertension","volume":"46","author":"Jiang","year":"2021","journal-title":"Redox Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1161\/CIRCRESAHA.116.305360","article-title":"Gut Microbiota-Dependent Trimethylamine N-Oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease","volume":"116","author":"Tang","year":"2015","journal-title":"Circ. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1161\/ATVBAHA.114.303252","article-title":"Comparative Genome-Wide Association Studies in Mice and Humans for Trimethylamine N-Oxide, a Proatherogenic Metabolite of Choline and l-Carnitine","volume":"34","author":"Hartiala","year":"2014","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s11886-006-0098-7","article-title":"Hypertension and kidney disease: A deadly connection","volume":"8","author":"Barri","year":"2006","journal-title":"Curr. Cardiol. Rep."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1161\/HYPERTENSIONAHA.120.16895","article-title":"Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure with Aging in Mice and Humans","volume":"78","author":"Brunt","year":"2021","journal-title":"Hypertension"},{"key":"ref_57","first-page":"e28165","article-title":"Analyzing the Complicated Connection between Intestinal Microbiota and Cardiovascular Diseases","volume":"14","author":"Kumar","year":"2022","journal-title":"Cureus"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"9101","DOI":"10.1021\/bi970247h","article-title":"A Naturally Occurring Protective System in Urea-Rich Cells: Mechanism of Osmolyte Protection of Proteins against Urea Denaturation","volume":"36","author":"Wang","year":"1997","journal-title":"Biochemistry"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"H1805","DOI":"10.1152\/ajpheart.00536.2018","article-title":"Chronic, low-dose TMAO treatment reduces diastolic dysfunction and heart fibrosis in hypertensive rats","volume":"315","author":"Huc","year":"2018","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Opdebeeck, B., D\u2019Haese, P.C., and Verhulst, A. (2020). Molecular and Cellular Mechanisms that Induce Arterial Calcification by Indoxyl Sulfate and P-Cresyl Sulfate. Toxins, 12.","DOI":"10.3390\/toxins12010058"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Rysz, J., Franczyk, B., \u0141awi\u0144ski, J., Olszewski, R., Cia\u0142kowska-Rysz, A., and Gluba-Brz\u00f3zka, A. (2021). The Impact of CKD on Uremic Toxins and Gut Microbiota. Toxins, 13.","DOI":"10.3390\/toxins13040252"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/s41440-021-00804-0","article-title":"Role of the microbiota in hypertension and antihypertensive drug metabolism","volume":"45","author":"Mishima","year":"2022","journal-title":"Hypertens. Res."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Graboski, A.L., and Redinbo, M.R. (2020). Gut-Derived Protein-Bound Uremic Toxins. Toxins, 12.","DOI":"10.3390\/toxins12090590"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MNH.0000000000000293","article-title":"The gut microbiome and hypertension","volume":"26","author":"Blacher","year":"2017","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1158\/1541-7786.692.2.12","article-title":"Histone deacetylase inhibitors up-regulate the expression of tight junction proteins","volume":"2","author":"Bordin","year":"2004","journal-title":"Mol. Cancer Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1016\/j.bcp.2011.09.004","article-title":"The association of minocycline and the probiotic Escherichia coli Nissle 1917 results in an additive beneficial effect in a DSS model of reactivated colitis in mice","volume":"82","author":"Utrilla","year":"2011","journal-title":"Biochem. Pharmacol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.phrs.2010.12.011","article-title":"The intestinal anti-inflammatory effect of minocycline in experimental colitis involves both its immunomodulatory and antimicrobial properties","volume":"63","author":"Camuesco","year":"2011","journal-title":"Pharmacol. Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.jnutbio.2015.01.002","article-title":"Reshaping faecal gut microbiota composition by the intake of trans-resveratrol and quercetin in high-fat sucrose diet-fed rats","volume":"26","author":"Etxeberria","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1111\/jam.14441","article-title":"Quercetin reduces atherosclerotic lesions by altering the gut microbiota and reducing atherogenic lipid metabolites","volume":"127","author":"Nie","year":"2019","journal-title":"J. Appl. Microbiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1002\/mnfr.201500761","article-title":"Flavonoid metabolite 3-(3-hydroxyphenyl)propionic acid formed by human microflora decreases arterial blood pressure in rats","volume":"60","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"F439","DOI":"10.1152\/ajprenal.00252.2013","article-title":"Renal and cardiovascular sensory receptors and blood pressure regulation","volume":"305","author":"Pluznick","year":"2013","journal-title":"Am. J. Physiol.-Ren. Physiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1152\/physiolgenomics.00136.2014","article-title":"Evidence for a link between gut microbiota and hypertension in the Dahl rat","volume":"47","author":"Mell","year":"2015","journal-title":"Physiol. Genom."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nature07540","article-title":"A core gut microbiome in obese and lean twins","volume":"457","author":"Turnbaugh","year":"2009","journal-title":"Nature"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.1210\/jc.2008-0222","article-title":"Primary Prevention of Cardiovascular Disease and Type 2 Diabetes in Patients at Metabolic Risk: An Endocrine Society Clinical Practice Guideline","volume":"93","author":"Rosenzweig","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1161\/HYPERTENSIONAHA.114.03469","article-title":"Effect of probiotics on blood pressure: A systematic review and meta-analysis of randomized, controlled trials","volume":"64","author":"Khalesi","year":"2014","journal-title":"Hypertension"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/1475-2891-12-138","article-title":"Hypocaloric diet supplemented with probiotic cheese improves body mass index and blood pressure indices of obese hypertensive patients\u2014A randomized double-blind placebo-controlled pilot study","volume":"12","author":"Sharafedtinov","year":"2013","journal-title":"Nutr. J."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nature18848","article-title":"The microbiota in adaptive immune homeostasis and disease","volume":"535","author":"Honda","year":"2016","journal-title":"Nature"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1042\/CS20130339","article-title":"The probiotic Lactobacillus coryniformis CECT5711 reduces the vascular pro-oxidant and pro-inflammatory status in obese mice","volume":"127","author":"Toral","year":"2014","journal-title":"Clin. Sci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1093\/ajcn\/77.2.326","article-title":"A fermented milk high in bioactive peptides has a blood pressure-lowering effect in hypertensive subjects","volume":"77","author":"Seppo","year":"2003","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1161\/HYPERTENSIONAHA.118.12588","article-title":"Gut Microbiota and Fecal Levels of Short-Chain Fatty Acids Differ Upon 24-Hour Blood Pressure Levels in Men","volume":"74","author":"Huart","year":"2019","journal-title":"Hypertension"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"109040","DOI":"10.1016\/j.biopha.2019.109040","article-title":"Candesartan attenuates hypertension-associated pathophysiological alterations in the gut","volume":"116","author":"Wu","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_82","first-page":"1479","article-title":"Potential benefits of garlic and other dietary supplements for the management of hypertension (Review)","volume":"19","author":"Matsutomo","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"104663","DOI":"10.1016\/j.phrs.2020.104663","article-title":"Effect of Lactobacillusplantarum containing probiotics on blood pressure: A systematic review and meta-analysis","volume":"153","author":"Davoodvandi","year":"2020","journal-title":"Pharmacol. Res."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/2\/1377\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:06:06Z","timestamp":1760119566000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/2\/1377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,10]]},"references-count":83,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["ijms24021377"],"URL":"https:\/\/doi.org\/10.3390\/ijms24021377","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,10]]}}}