{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:48:18Z","timestamp":1787028498382,"version":"build-2736575974"},"reference-count":69,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fujian Province Science and Technology Major Special Projects","award":["2021NZ0101"],"award-info":[{"award-number":["2021NZ0101"]}]},{"name":"Fujian Province Science and Technology Major Special Projects","award":["XKJC-712021030"],"award-info":[{"award-number":["XKJC-712021030"]}]},{"name":"Fujian Province Science and Technology Major Special Projects","award":["2021L3007"],"award-info":[{"award-number":["2021L3007"]}]},{"name":"Interdisciplinary Integration to Promote the High-quality Development Projects of Juncao Science and Industry","award":["2021NZ0101"],"award-info":[{"award-number":["2021NZ0101"]}]},{"name":"Interdisciplinary Integration to Promote the High-quality Development Projects of Juncao Science and Industry","award":["XKJC-712021030"],"award-info":[{"award-number":["XKJC-712021030"]}]},{"name":"Interdisciplinary Integration to Promote the High-quality Development Projects of Juncao Science and Industry","award":["2021L3007"],"award-info":[{"award-number":["2021L3007"]}]},{"name":"Science and Technology Planning Project of Fujian Province","award":["2021NZ0101"],"award-info":[{"award-number":["2021NZ0101"]}]},{"name":"Science and Technology Planning Project of Fujian Province","award":["XKJC-712021030"],"award-info":[{"award-number":["XKJC-712021030"]}]},{"name":"Science and Technology Planning Project of Fujian Province","award":["2021L3007"],"award-info":[{"award-number":["2021L3007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Alcoholic liver damage is caused by long-term drinking, and it further develops into alcoholic liver diseases. In this study, we prepared a probiotic fermentation product of Grifola frondosa total active components (PFGF) by fermentation with Lactobacillus acidophilus, Lactobacillus rhamnosus, and Pediococcus acidilactici. After fermentation, the total sugar and protein content in the PFGF significantly decreased, while the lactic acid level and antioxidant activity of the PFGF increased. Afterward, we investigated the alleviating effect of PFGF on alcoholic liver injury in alcohol-fed mice. The results showed that the PFGF intervention reduced the necrosis of the liver cells, attenuated the inflammation of the liver and intestines, restored the liver function, increased the antioxidant factors of the liver, and maintained the cecum tissue barrier. Additionally, the results of the 16S rRNA sequencing analysis indicated that the PFGF intervention increased the relative abundance of beneficial bacteria, such as Lactobacillus, Ruminococcaceae, Parabacteroids, Parasutterella, and Alistipes, to attenuate intestinal inflammation. These results demonstrate that PFGF can potentially alleviate alcoholic liver damage by restoring the intestinal barrier and regulating the intestinal microflora.<\/jats:p>","DOI":"10.3390\/ijms24021406","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T02:06:03Z","timestamp":1673402763000},"page":"1406","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Probiotics-Fermented Grifola frondosa Total Active Components: Better Antioxidation and Microflora Regulation for Alleviating Alcoholic Liver Damage in Mice"],"prefix":"10.3390","volume":"24","author":[{"given":"Xiao-Yu","family":"He","sequence":"first","affiliation":[{"name":"National Engineering Research Center of JUNCAO Technology, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Xian","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Qin","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Rong","family":"Zhu","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of JUNCAO Technology, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Juan","family":"Luo","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of JUNCAO Technology, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Yang","family":"Qiu","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of JUNCAO Technology, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0822-352X","authenticated-orcid":false,"given":"Zi-Rui","family":"Huang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of JUNCAO Technology, Fuzhou 350002, China"},{"name":"School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6219-3093","authenticated-orcid":false,"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of JUNCAO Technology, Fuzhou 350002, China"},{"name":"College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zeng","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of JUNCAO Technology, Fuzhou 350002, China"},{"name":"College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"},{"name":"Engineering Research Centre of Fujian Subtropical Fruit and Vegetable Processing, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cld.2018.09.011","article-title":"Epidemiology of Alcohol Consumption and Societal Burden of Alcoholism and Alcoholic Liver Disease","volume":"23","author":"Axley","year":"2019","journal-title":"Clin. Liver Dis."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Xiao, T., Luo, Z., Guo, Z., Wang, X., Ding, M., Wang, W., Shen, X., and Zhao, Y. (2021). Multiple Roles of Black Raspberry Anthocyanins Protecting against Alcoholic Liver Disease. Molecules, 26.","DOI":"10.3390\/molecules26082313"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Hsu, J., Lin, H., Hsu, C., Chen, B., and Chen, J. (2018). Aqueous Extract of Pepino (Solanum muriactum Ait) Leaves Ameliorate Lipid Accumulation and Oxidative Stress in Alcoholic Fatty Liver Disease. Nutrients, 10.","DOI":"10.3390\/nu10070931"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3748\/wjg.v22.i1.37","article-title":"Relationships among alcoholic liver disease, antioxidants, and antioxidant enzymes","volume":"22","author":"Han","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1172\/JCI90562","article-title":"Intestinal fungi contribute to development of alcoholic liver disease","volume":"127","author":"Yang","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nrgastro.2015.35","article-title":"Alcoholic liver disease: Mechanisms of injury and targeted treatment","volume":"12","author":"Louvet","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3389\/fcimb.2022.840164","article-title":"Gut Microbiome Dysbiosis in Alcoholism: Consequences for Health and Recovery","volume":"12","author":"Day","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"6161","DOI":"10.3748\/wjg.v27.i37.6161","article-title":"Significance of gut microbiota in alcoholic and non-alcoholic fatty liver diseases","volume":"27","author":"Sharma","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1111\/acer.13498","article-title":"Continued Alcohol Misuse in Human Cirrhosis is Associated with an Impaired Gut-Liver Axis","volume":"41","author":"Bajaj","year":"2017","journal-title":"Alcoholism"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/hep.24018","article-title":"Enteric dysbiosis associated with a mouse model of alcoholic liver disease","volume":"53","author":"Yan","year":"2011","journal-title":"Hepatology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41575-018-0099-1","article-title":"Alcohol, liver disease and the gut microbiota","volume":"16","author":"Bajaj","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.tifs.2016.09.011","article-title":"Paraprobiotics: Evidences on their ability to modify biological responses, inactivation methods and perspectives on their application in foods","volume":"58","author":"Caroline","year":"2016","journal-title":"Trends Food Sci. Technol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Ranadheera, C., Vidanarachchi, J., Rocha, R., Cruz, A., and Ajlouni, S. (2017). Probiotic Delivery through Fermentation: Dairy vs. Non-Dairy Beverages. Fermentation, 3.","DOI":"10.3390\/fermentation3040067"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"110590","DOI":"10.1016\/j.lwt.2020.110590","article-title":"Enhancement of functional characteristics of blueberry juice fermented by Lactobacillus plantarum","volume":"139","author":"Zhang","year":"2021","journal-title":"LWT"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1039\/C9FO00475K","article-title":"Fermented carrot juice attenuates type 2 diabetes by mediating gut microbiota in rats","volume":"10","author":"Hu","year":"2019","journal-title":"Food Funct."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"380s","DOI":"10.1093\/ajcn\/73.2.380s","article-title":"Probiotics in foods not containing milk or milk constituents, with special reference to Lactobacillus plantarum 299v1","volume":"73","author":"Molin","year":"2001","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jsps.2013.07.001","article-title":"Role of Probiotics in health improvement, infection control and disease treatment and management","volume":"23","author":"Amara","year":"2015","journal-title":"Saudi Pharm. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1186\/1475-2859-13-S1-S7","article-title":"Towards a better understanding of Lactobacillus rhamnosus GG-host interactions","volume":"13","author":"Segers","year":"2014","journal-title":"Microb. Cell Fact."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.alcohol.2008.12.009","article-title":"Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis","volume":"43","author":"Forsyth","year":"2009","journal-title":"Alcohol"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.micinf.2012.11.003","article-title":"Differences in TLR9-dependent inhibitory effects of H2O2-induced IL-8 secretion and NF-kappa B\/I kappa B-alpha system activation by genomic DNA from five Lactobacillus species","volume":"15","author":"Hiramatsu","year":"2013","journal-title":"Microbes Infect."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e38421","DOI":"10.1128\/mSystems.00384-21","article-title":"Lactobacillus acidophilus LA14 Alleviates Liver Injury","volume":"6","author":"Lv","year":"2021","journal-title":"mSystems"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1111\/ijfs.12768","article-title":"Pediococcus acidilactici as a potential probiotic to be used in food industry","volume":"50","author":"Barbosa","year":"2015","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.crfs.2022.04.009","article-title":"Pediococcus acidilactici FZU106 alleviates high-fat diet-induced lipid metabolism disorder in association with the modulation of intestinal microbiota in hyperlipidemic rats","volume":"5","author":"Zhang","year":"2022","journal-title":"Curr. Res. Food Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"11790","DOI":"10.1007\/s11356-021-16524-4","article-title":"Effect of lactic acid bacteria isolated from some fermented dairy products on carbon tetrachloride-induced hepatotoxicity and nephrotoxicity of albino rats","volume":"29","author":"Bikheet","year":"2022","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.ijbiomac.2017.03.177","article-title":"Polysaccharides in Grifola frondosa mushroom and their health promoting properties: A review","volume":"101","author":"He","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.carbpol.2012.02.045","article-title":"Isolation, purification and antioxidant activities of polysaccharides from Grifola frondosa","volume":"89","author":"Chen","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"104649","DOI":"10.1016\/j.jff.2021.104649","article-title":"Coumarin-rich Grifola frondosa ethanol extract alleviate lipid metabolism disorders and modulates intestinal flora compositions of high-fat diet rats","volume":"85","author":"Wang","year":"2021","journal-title":"J. Funct. Food."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Li, X., Zeng, F., Huang, Y., and Liu, B. (2019). The Positive Effects of Grifola frondosa Heteropolysaccharide on NAFLD and Regulation of the Gut Microbiota. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20215302"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"6268","DOI":"10.1039\/C8FO01116H","article-title":"Effect of Grifola frondosa 95% ethanol extract on lipid metabolism and gut microbiota composition in high-fat diet-fed rats","volume":"9","author":"Pan","year":"2018","journal-title":"Food Funct."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Ma, C., Zhang, S., Lu, J., Zhang, C., Pang, X., and Lv, J. (2019). Screening for Cholesterol-Lowering Probiotics from Lactic Acid Bacteria Isolated from Corn Silage Based on Three Hypothesized Pathways. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20092073"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"122473","DOI":"10.1016\/j.biortech.2019.122473","article-title":"A short-chain dehydrogenase plays a key role in cellulosic D-lactic acid fermentability of Pediococcus acidilactici","volume":"297","author":"Qiu","year":"2020","journal-title":"Bioresour. Technol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Jin, X., Chen, W., Chen, H., Chen, W., and Zhong, Q. (2019). Combination of Lactobacillus plantarum and Saccharomyces cerevisiae DV10 as Starter Culture to Produce Mango Slurry: Microbiological, Chemical Parameters and Antioxidant Activity. Molecules, 24.","DOI":"10.3390\/molecules24234349"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.foodcont.2014.06.034","article-title":"Antibacterial mechanism of lactic acid on physiological and morphological properties of Salmonella Enteritidis, Escherichia coli and Listeria monocytogenes","volume":"47","author":"Wang","year":"2015","journal-title":"Food Control"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ijfoodmicro.2013.04.016","article-title":"Application\u2019 and validation of autochthonous lactic acid bacteria starter cultures for controlled leek fermentations and their influence on the antioxidant properties of leek","volume":"165","author":"Wouters","year":"2013","journal-title":"Int. J. Food Microbiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1016\/j.foodchem.2012.06.048","article-title":"Antioxidant activity of Lactobacillus plantarum strains isolated from traditional Chinese fermented foods","volume":"135","author":"Li","year":"2012","journal-title":"Food Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.foodres.2017.09.031","article-title":"Fruits and vegetables, as a source of nutritional compounds and phytochemicals: Changes in bioactive compounds during lactic fermentation","volume":"104","author":"Remize","year":"2018","journal-title":"Food Res. Int."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3389\/fphys.2019.00325","article-title":"Chlorogenic Acid Ameliorates Colitis and Alters Colonic Microbiota in a Mouse Model of Dextran Sulfate Sodium-Induced Colitis","volume":"10","author":"Zhang","year":"2019","journal-title":"Front. Physiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jare.2019.09.002","article-title":"Benefits of non-invasive methods compared to telemetry for distress analysis in a murine model of pancreatic cancer","volume":"21","author":"Kumstel","year":"2020","journal-title":"J. Adv. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.chom.2015.03.005","article-title":"Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function","volume":"17","author":"Kelly","year":"2015","journal-title":"Cell Host Microbe"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Wang, R., Yang, Z., Zhang, J., Mu, J., Zhou, X., and Zhao, X. (2019). Liver Injury Induced by Carbon Tetrachloride in Mice Is Prevented by the Antioxidant Capacity of Anji White Tea Polyphenols. Antioxidants, 8.","DOI":"10.3390\/antiox8030064"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1189\/jlb.1005613","article-title":"Chronic ethanol feeding increases activation of NADPH oxidase by lipopolysaccharide in rat Kupffer cells: Role of increased reactive oxygen in LPS-stimulated ERK1\/2 activation and TNF-\u03b1 production","volume":"79","author":"Thakur","year":"2006","journal-title":"J. Leukoc. Biol."},{"key":"ref_42","first-page":"2266","article-title":"The hepatoprotective role of reduced glutathione and its underlying mechanism in oxaliplatin-induced acute liver injury","volume":"15","author":"Lin","year":"2018","journal-title":"Oncol. Lett."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1097\/MIB.0000000000000364","article-title":"Beneficial Effects of Probiotics, Prebiotics, Synbiotics, and Psychobiotics in Inflammatory Bowel Disease","volume":"21","author":"Wasilewski","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s12602-017-9378-3","article-title":"Oral Administration of Compound Probiotics Ameliorates HFD-Induced Gut Microbe Dysbiosis and Chronic Metabolic Inflammation via the G Protein-Coupled Receptor 43 in Non-alcoholic Fatty Liver Disease Rats","volume":"11","author":"Liang","year":"2019","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"102791","DOI":"10.1016\/j.algal.2022.102791","article-title":"Spirulina compounds show hypoglycemic activity and intestinal flora regulation in type 2 diabetes mellitus mice","volume":"66","author":"He","year":"2022","journal-title":"Algal Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.3389\/fmicb.2018.02209","article-title":"Dietary Bile Salt Types Influence the Composition of Biliary Bile Acids and Gut Microbiota in Grass Carp","volume":"9","author":"Xiong","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Huang, Z., Zhao, L., Zhu, F., Liu, Y., Xiao, J., Chen, Z., Lv, X., Huang, Y., and Liu, B. (2022). Anti-Diabetic Effects of Ethanol Extract from Sanghuangporous vaninii in High-Fat\/Sucrose Diet and Streptozotocin-Induced Diabetic Mice by Modulating Gut Microbiota. Foods, 11.","DOI":"10.3390\/foods11070974"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Bull-Otterson, L., Feng, W., Kirpich, I., Wang, Y., Qin, X., Liu, Y., Gobejishvili, L., Joshi-Barve, S., Ayvaz, T., and Petrosino, J. (2013). Metagenomic analyses of alcohol induced pathogenic alterations in the intestinal microbiome and the effect of Lactobacillus rhamnosus GG treatment. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0053028"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1013466","DOI":"10.3389\/fnut.2022.1013466","article-title":"Sanghuangporus vaninii fruit body polysaccharide alleviates hyperglycemia and hyperlipidemia via modulating intestinal microflora in type 2 diabetic mice","volume":"9","author":"Huang","year":"2022","journal-title":"Front. Nutr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.chom.2020.01.021","article-title":"Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation","volume":"27","author":"Sinha","year":"2020","journal-title":"Cell Host Microbe"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.1039\/C6FO00309E","article-title":"Dietary fucoidan modulates the gut microbiota in mice by increasing the abundance of Lactobacillus and Ruminococcaceae","volume":"7","author":"Shang","year":"2016","journal-title":"Food Funct."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"5813","DOI":"10.1038\/s41467-019-13721-1","article-title":"Relationship between gut microbiota and circulating metabolites in population-based cohorts","volume":"10","author":"Vojinovic","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"fnac072","DOI":"10.1093\/femsle\/fnac072","article-title":"Roles of intestinal Parabacteroides in human health and diseases","volume":"369","author":"Cui","year":"2022","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Li, B., Mao, Q., Zhou, D., Luo, M., Gan, R., Li, H., Huang, S., Saimaiti, A., Shang, A., and Li, H. (2021). Effects of Tea against Alcoholic Fatty Liver Disease by Modulating Gut Microbiota in Chronic Alcohol-Exposed Mice. Foods, 10.","DOI":"10.3390\/foods10061232"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Liu, H., Liu, M., Fu, X., Zhang, Z., Zhu, L., Zheng, X., and Liu, J. (2018). Astaxanthin Prevents Alcoholic Fatty Liver Disease by Modulating Mouse Gut Microbiota. Nutrients, 10.","DOI":"10.3390\/nu10091298"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1038\/s41396-019-0364-5","article-title":"Defining the role of Parasutterella, a previously uncharacterized member of the core gut microbiota","volume":"13","author":"Ju","year":"2019","journal-title":"ISME J."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Osaka, T., Moriyama, E., Arai, S., Date, Y., Yagi, J., Kikuchi, J., and Tsuneda, S. (2017). Meta-Analysis of Fecal Microbiota and Metabolites in Experimental Colitic Mice during the Inflammatory and Healing Phases. Nutrients, 9.","DOI":"10.3390\/nu9121329"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"585066","DOI":"10.3389\/fmicb.2020.585066","article-title":"Naringin Attenuates High Fat Diet Induced Non-alcoholic Fatty Liver Disease and Gut Bacterial Dysbiosis in Mice","volume":"11","author":"Mu","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"200","DOI":"10.4056\/sigs.1714269","article-title":"Complete genome sequence of Odoribacter splanchnicus type strain (1651\/6T)","volume":"4","author":"Gronow","year":"2011","journal-title":"Stand. Genom. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Yun, K.E., Kim, J., Kim, M., Park, E., Kim, H., Chang, Y., Ryu, S., and Kim, H. (2020). Major Lipids, Apolipoproteins, and Alterations of Gut Microbiota. J. Clin. Med., 9.","DOI":"10.3390\/jcm9051589"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.3389\/fmicb.2018.03002","article-title":"Non-isoflavones Diet Incurred Metabolic Modifications Induced by Constipation in Rats via Targeting Gut Microbiota","volume":"9","author":"Liu","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ab.2004.12.001","article-title":"Carbohydrate analysis by a phenol\u2013sulfuric acid method in microplate format","volume":"339","author":"Masuko","year":"2005","journal-title":"Anal. Biochem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1021\/ac60147a030","article-title":"Use of Dinitrosalicylic Acid Reagent for Determination of Reducing Sugar","volume":"31","author":"Miller","year":"1959","journal-title":"Anal. Chem."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Toro-Uribe, S., Iba\u00f1ez, E., Decker, E.A., Villamizar-Jaimes, A.R., and L\u00f3pez-Giraldo, L.J. (2020). Food-Safe Process for High Recovery of Flavonoids from Cocoa Beans: Antioxidant and HPLC-DAD-ESI-MS\/MS Analysis. Antioxidants, 9.","DOI":"10.3390\/antiox9050364"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"112716","DOI":"10.1016\/j.lwt.2021.112716","article-title":"Phytochemical content, and antioxidant activity, and volatile compounds associated with the aromatic property, of the vinegar produced from rosehip fruit (Rosa canina L.)","volume":"154","author":"Pashazadeh","year":"2022","journal-title":"LWT"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.etap.2014.01.011","article-title":"Chemical composition and bioactivities of flavonoids-rich extract from Davallia cylindrica Ching","volume":"37","author":"Cao","year":"2014","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cld.2018.09.001","article-title":"Histopathology of Alcohol-Related Liver Diseases","volume":"23","author":"Roth","year":"2019","journal-title":"Clin. Liver Dis."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"3572","DOI":"10.1039\/D2FO00021K","article-title":"6,8-(1,3-Diaminoguanidine) luteolin and its Cr complex show hypoglycemic activities and alter intestinal microbiota composition in type 2 diabetes mice","volume":"13","author":"Ge","year":"2022","journal-title":"Food Funct."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"109511","DOI":"10.1016\/j.foodres.2020.109511","article-title":"Monascus purpureus-fermented common buckwheat protects against dyslipidemia and non-alcoholic fatty liver disease through the regulation of liver metabolome and intestinal microbiome","volume":"136","author":"Huang","year":"2020","journal-title":"Food Res. 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