{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:16:16Z","timestamp":1792638976274,"version":"4.5.0"},"reference-count":51,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T00:00:00Z","timestamp":1673481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Centro Mexicano de Innovaci\u00f3n en Energ\u00eda del Oc\u00e9ano (CEMIE-Oc\u00e9ano)","award":["FSE-2014-06-249795"],"award-info":[{"award-number":["FSE-2014-06-249795"]}]},{"name":"Centro Mexicano de Innovaci\u00f3n en Energ\u00eda del Oc\u00e9ano (CEMIE-Oc\u00e9ano)","award":["IG100321"],"award-info":[{"award-number":["IG100321"]}]},{"name":"\u201cDirecci\u00f3n General de Asuntos del Personal Acad\u00e9-mico\u201d (DGAPA), of the \u201cUniversidad Nacional Aut\u00f3noma de M\u00e9xico\u201d (UNAM)","award":["FSE-2014-06-249795"],"award-info":[{"award-number":["FSE-2014-06-249795"]}]},{"name":"\u201cDirecci\u00f3n General de Asuntos del Personal Acad\u00e9-mico\u201d (DGAPA), of the \u201cUniversidad Nacional Aut\u00f3noma de M\u00e9xico\u201d (UNAM)","award":["IG100321"],"award-info":[{"award-number":["IG100321"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The present work shows the synthesis of ZnO nanoparticles through a green method, using sargassum extracts, which provide the reducing and stabilizing compounds. The conditions of the medium in which the reaction was carried out was evaluated, that is, magnetic stirring, ultrasound assisted, and resting condition. UV-Vis, FTIR spectroscopy, and X-ray diffraction results confirmed the synthesis of ZnO with nanometric crystal size. The scanning electron microscopy analysis showed that the morphology and size of the particles depends on the synthesis condition used. It obtained particles between 20 and 200 nm in the sample without agitation, while the samples with stirring and ultrasound were 80 nm and 100 nm, respectively. ZnO nanoparticles showed antibacterial activity against Gram-positive S. aureus and Gram-negative P. aeruginosa. A quantitative analysis was performed by varying the concentration of ZnO nanoparticles. In all cases, the antibacterial activity against Gram-positives was greater than against Gram-negatives. Ultrasound-assisted ZnO nanoparticles showed the highest activity, around 99% and 80% for S. aureus and P. aeruginosa, respectively. Similar results were obtained in the study of the anti-inflammatory activity of ZnO nanoparticles; the ultrasound-assisted sample exhibited the highest percentage (93%), even above that shown by diclofenac, which was used as a reference. Therefore, the ZnO nanoparticles synthesized with sargassum extracts have properties that can be used safely and efficiently in the field of biomedicine.<\/jats:p>","DOI":"10.3390\/ijms24021474","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T01:32:26Z","timestamp":1673487146000},"page":"1474","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Antibacterial and Anti-Inflammatory Properties of ZnO Nanoparticles Synthesized by a Green Method Using Sargassum Extracts"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7846-3780","authenticated-orcid":false,"given":"Jose Luis","family":"Lopez-Miranda","sequence":"first","affiliation":[{"name":"Centro de F\u00edsica Aplicada y Tecnolog\u00eda Avanzada, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Boulevard Juriquilla 3001, Quer\u00e9taro 76230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7673-0518","authenticated-orcid":false,"given":"Gustavo A.","family":"Molina","sequence":"additional","affiliation":[{"name":"Centro de F\u00edsica Aplicada y Tecnolog\u00eda Avanzada, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Boulevard Juriquilla 3001, Quer\u00e9taro 76230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7640-8390","authenticated-orcid":false,"given":"Marlen Alexis","family":"Gonz\u00e1lez-Reyna","sequence":"additional","affiliation":[{"name":"Centro de F\u00edsica Aplicada y Tecnolog\u00eda Avanzada, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Boulevard Juriquilla 3001, Quer\u00e9taro 76230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6015-6037","authenticated-orcid":false,"given":"Beatriz Liliana","family":"Espa\u00f1a-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"CONACYT_Centro de Investigaci\u00f3n y Desarrollo Tecnol\u00f3gico en Electroqu\u00edmica SC, Parque Tecnol\u00f3gico Quer\u00e9taro s\/n Sanfandila, Pedro Escobedo 76703, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9743-8559","authenticated-orcid":false,"given":"Rodrigo","family":"Esparza","sequence":"additional","affiliation":[{"name":"Centro de F\u00edsica Aplicada y Tecnolog\u00eda Avanzada, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Boulevard Juriquilla 3001, Quer\u00e9taro 76230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0064-9558","authenticated-orcid":false,"given":"Rodolfo","family":"Silva","sequence":"additional","affiliation":[{"name":"Instituto de Ingenier\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Edificio 17, Ciudad Universitaria, Coyoac\u00e1n 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Est\u00e9vez","sequence":"additional","affiliation":[{"name":"Centro de F\u00edsica Aplicada y Tecnolog\u00eda Avanzada, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Boulevard Juriquilla 3001, Quer\u00e9taro 76230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"102495","DOI":"10.1016\/j.cis.2021.102495","article-title":"A state of the art review on the synthesis, antibacterial, antioxidant, antidiabetic and tissue regeneration activities of zinc oxide nanoparticles","volume":"295","author":"Singh","year":"2021","journal-title":"Adv. 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