{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:03:45Z","timestamp":1788401025262,"version":"build-2803163510"},"reference-count":153,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T00:00:00Z","timestamp":1673481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Labo\u2019Life France"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Allergic diseases consist of improper inflammatory reactions to antigens and are currently an important healthcare concern, especially considering their increasing worldwide development in recent decades. The \u201catopic march\u201d defines the paradigm of allergic diseases occurring in chronological order and displaying specific spatial manifestations, as they usually start as atopic dermatitis (AD) and food allergies during infancy and progressively evolve into allergic asthma (AA) and allergic rhinitis (AR) or rhino-conjunctivitis in childhood. Many immune cell subtypes and inflammatory factors are involved in these hypersensitivity reactions. In particular, the T helpers 2 (Th2) subset, through its cytokine signatures made of interleukins (ILs), such as IL-4, IL-5, IL-10, and IL-13, as well as mast cells and their related histamine pathways, contribute greatly to the perpetuation and evolution of the atopic march. By providing low doses (LD) and ultra-low doses (ULD) of ILs and immune factors to the body, micro-immunotherapy (MI) constitutes an interesting therapeutic strategy for the management of the atopic march and its symptoms. One of the aims of this review is to shed light on the current concept of the atopic march and the underlying immune reactions occurring during the IgE-mediated responses. Moreover, the different classes of traditional and innovative treatments employed in allergic diseases will also be discussed, with a special emphasis on the potential benefits of the MI medicine 2LALERG\u00ae formulation in this context.<\/jats:p>","DOI":"10.3390\/ijms24021483","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T03:47:01Z","timestamp":1673495221000},"page":"1483","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["How an Immune-Factor-Based Formulation of Micro-Immunotherapy Could Interfere with the Physiological Processes Involved in the Atopic March"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8044-0545","authenticated-orcid":false,"given":"Camille","family":"Jacques","sequence":"first","affiliation":[{"name":"Preclinical Research Department, Labo\u2019Life France, Pescalis-Les Magnys, 79320 Moncoutant sur Sevre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4089-3133","authenticated-orcid":false,"given":"Ilaria","family":"Floris","sequence":"additional","affiliation":[{"name":"Preclinical Research Department, Labo\u2019Life France, Pescalis-Les Magnys, 79320 Moncoutant sur Sevre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,12]]},"reference":[{"key":"ref_1","unstructured":"(2022, July 06). EAACI Patients\u2014Dedicated to Allergy Science: Committed to Your Health. Available online: https:\/\/patients.eaaci.org\/."},{"key":"ref_2","first-page":"163","article-title":"On the Classification of the Phenomena of Hypersensitiveness","volume":"8","author":"Coca","year":"1923","journal-title":"J. Immunol. Am. Assoc. Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/2045-7022-1-5","article-title":"Allergy as an epithelial barrier disease","volume":"1","author":"Mattila","year":"2011","journal-title":"Clin. Transl. Allergy"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1182\/blood-2008-05-078154","article-title":"CD4 T cells: Fates, functions, and faults","volume":"112","author":"Zhu","year":"2008","journal-title":"Blood"},{"key":"ref_5","unstructured":"Figueras-Nart, I., and Palomares-Gracia, O. (2019). Atopic Dermatitis: From Physiopathology to the Clinics, IntechOpen."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4168\/aair.2011.3.2.67","article-title":"The atopic march: Progression from atopic dermatitis to allergic rhinitis and asthma","volume":"3","author":"Zheng","year":"2011","journal-title":"Allergy Asthma Immunol. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.iac.2010.05.001","article-title":"The Infectious Aspects of Atopic Dermatitis","volume":"30","author":"Ong","year":"2010","journal-title":"Immunol. Allergy Clin. N. Am."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.3389\/fimmu.2020.01907","article-title":"Research Progress in Atopic March","volume":"11","author":"Yang","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1600-065X.2011.01027.x","article-title":"Atopic Dermatitis: A Disease of Altered Skin Barrier and Immune Dysregulation","volume":"242","author":"Boguniewicz","year":"2011","journal-title":"Immunol. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.jaci.2004.01.772","article-title":"T regulatory cells in atopic dermatitis and subversion of their activity by superantigens","volume":"113","author":"Ou","year":"2004","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.jaad.2006.04.064","article-title":"Long-term follow-up of atopic dermatitis: Retrospective analysis of related risk factors and association with concomitant allergic diseases","volume":"55","author":"Ricci","year":"2006","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/s12016-018-8710-3","article-title":"IgE-Mediated Food Allergy","volume":"57","author":"Anvari","year":"2019","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s12016-012-8339-6","article-title":"Clinical spectrum of food allergies: A comprehensive review","volume":"46","author":"Ho","year":"2014","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/all.12268","article-title":"Atopic dermatitis and the atopic march revisited","volume":"69","author":"Dharmage","year":"2014","journal-title":"Allergy"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"100069","DOI":"10.1016\/j.waojou.2019.100069","article-title":"History of allergic rhinitis and risk of asthma; a systematic review and meta-analysis","volume":"12","author":"Tohidinik","year":"2019","journal-title":"World Allergy Organ. J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.jaci.2014.06.036","article-title":"Allergens and the airway epithelium response: Gateway to allergic sensitization","volume":"134","author":"Lambrecht","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.immuni.2015.07.007","article-title":"Barrier Epithelial Cells and the Control of Type 2 Immunity","volume":"43","author":"Hammad","year":"2015","journal-title":"Immunity"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/nm.2755","article-title":"IgE and mast cells in allergic disease","volume":"18","author":"Galli","year":"2012","journal-title":"Nat. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1183\/16000617.00008114","article-title":"National and regional asthma programmes in Europe","volume":"24","author":"Selroos","year":"2015","journal-title":"Eur. Respir. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1183\/09031936.04.00013904","article-title":"Prevalence and rate of diagnosis of allergic rhinitis in Europe","volume":"24","author":"Bauchau","year":"2004","journal-title":"Eur. Respir. J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1399-3038.1997.tb00156.x","article-title":"Worldwide variations in prevalence of symptoms of allergic rhinoconjunctivitis in children: The International Study of Asthma and Allergies in Childhood (ISAAC)","volume":"8","author":"Strachan","year":"1997","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1177\/0194599814562166","article-title":"Clinical practice guideline: Allergic rhinitis executive summary","volume":"152","author":"Seidman","year":"2015","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1111\/cea.12780","article-title":"Pathogenesis of rhinitis","volume":"46","author":"Eifan","year":"2016","journal-title":"Clin. Exp. Allergy"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.jaci.2007.03.034","article-title":"Seasonal allergic rhinitis is associated with a detrimental effect on examination performance in United Kingdom teenagers: Case-control study","volume":"120","author":"Walker","year":"2007","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1159\/000328789","article-title":"Association between maternal allergic rhinitis and asthma on the prevalence of atopic disease in offspring","volume":"157","author":"Wang","year":"2012","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1056\/NEJMoa0906312","article-title":"A large-scale, consortium-based genomewide association study of asthma","volume":"363","author":"Moffatt","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S1081-1206(10)63530-2","article-title":"Allergic rhinitis and polymorphisms of the interleukin 1 gene complex","volume":"91","author":"Karjalainen","year":"2003","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.jaci.2011.12.989","article-title":"Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency","volume":"129","author":"Kezic","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13223-016-0158-5","article-title":"Genetic and epigenetic studies of atopic dermatitis","volume":"12","author":"Bin","year":"2016","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"ref_30","first-page":"89","article-title":"Association between the interleukin 6 genotype at position -174 and atopic dermatitis","volume":"23","author":"Gharagozlou","year":"2013","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"822091","DOI":"10.3389\/fgene.2022.822091","article-title":"Effects of IL-6 Polymorphisms on Individual Susceptibility to Allergic Diseases: A Systematic Review and Meta-Analysis","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Genet."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"BSR20210522","DOI":"10.1042\/BSR20210522","article-title":"IL-4 rs2243250 polymorphism associated with susceptibility to allergic rhinitis: A meta-analysis","volume":"41","author":"Jiang","year":"2021","journal-title":"Biosci. Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.4049\/jimmunol.1601434","article-title":"IL-4 Haploinsufficiency Specifically Impairs IgE Responses against Allergens in Mice","volume":"198","author":"Robinson","year":"2017","journal-title":"J. Immunol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"8804","DOI":"10.1038\/ncomms9804","article-title":"Meta-analysis identifies seven susceptibility loci involved in the atopic march","volume":"6","author":"Marenholz","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.jaci.2016.02.045","article-title":"Resolving the etiology of atopic disorders by using genetic analysis of racial ancestry","volume":"138","author":"Gupta","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s12026-021-09189-1","article-title":"Association of interleukin-12B rs6887695 with susceptibility to allergic rhinitis","volume":"69","author":"Falahi","year":"2021","journal-title":"Immunol. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"104467","DOI":"10.1016\/j.yexmp.2020.104467","article-title":"TNF-\u03b1 (rs1800629) polymorphism modifies the effect of sensitization to house dust mite on asthma and bronchial hyperresponsiveness in children","volume":"115","author":"Lee","year":"2020","journal-title":"Exp. Mol. Pathol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/exd.13514","article-title":"Atopic dermatitis in diverse racial and ethnic groups-Variations in epidemiology, genetics, clinical presentation and treatment","volume":"27","author":"Kaufman","year":"2018","journal-title":"Exp. Dermatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"112","DOI":"10.17554\/j.issn.2412-2424.2017.03.32","article-title":"HLA loci and respiratory allergic diseases","volume":"3","year":"2017","journal-title":"J. Respir. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.anai.2015.10.008","article-title":"The Evolving Story of HLA and the Immunogenetics of Peanut Allergy","volume":"115","author":"Hemler","year":"2015","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Harju, M., Keski-Nisula, L., Georgiadis, L., and Heinonen, S. (2016). Parental smoking and cessation during pregnancy and the risk of childhood asthma. BMC Public Health, 16.","DOI":"10.1186\/s12889-016-3029-6"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Pagano, F., Conti, M.G., Boscarino, G., Pannucci, C., Dito, L., Regoli, D., Di Chiara, M., Battaglia, G., Prota, R., and Cinicola, B. (2021). Atopic Manifestations in Children Born Preterm: A Long-Term Observational Study. Children, 8.","DOI":"10.3390\/children8100843"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"eaax9929","DOI":"10.1126\/scitranslmed.aax9929","article-title":"Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma","volume":"12","author":"Stokholm","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12931-021-01644-9","article-title":"Breastfeeding duration modified the effects of neonatal and familial risk factors on childhood asthma and allergy: A population-based study","volume":"22","author":"Hu","year":"2021","journal-title":"Respir. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s10654-015-0038-1","article-title":"Antibiotic exposure in the first year of life and later treated asthma, a population based birth cohort study of 143,000 children","volume":"31","author":"Pitter","year":"2016","journal-title":"Eur. J. Epidemiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.anai.2017.05.013","article-title":"Influence of antibiotic use in early childhood on asthma and allergic diseases at age 5","volume":"119","author":"Yang","year":"2017","journal-title":"Ann. Allergy. Asthma. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s40521-015-0056-y","article-title":"Skin Barrier Dysfunction and the Atopic March","volume":"2","author":"Clausen","year":"2015","journal-title":"Curr. Treat. Options Allergy"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s12016-019-08730-3","article-title":"The Effects of Air Pollution on the Development of Atopic Disease","volume":"57","author":"Hassoun","year":"2019","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.jaad.2016.07.017","article-title":"Association of atopic dermatitis with smoking: A systematic review and meta-analysis","volume":"75","author":"Kantor","year":"2016","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Tsuge, M., Ikeda, M., Matsumoto, N., Yorifuji, T., and Tsukahara, H. (2021). Current Insights into Atopic March. Child. Basel Switz., 8.","DOI":"10.3390\/children8111067"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1002\/alr.21383","article-title":"Environmental controls and avoidance measures","volume":"4","author":"Krouse","year":"2014","journal-title":"Int. Forum Allergy Rhinol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.intimp.2014.08.007","article-title":"Vitamin E and D regulation of allergic asthma immunopathogenesis","volume":"23","author":"Avila","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.3390\/nu4111747","article-title":"Associations between Maternal Antioxidant Intakes in Pregnancy and Infant Allergic Outcomes","volume":"4","author":"West","year":"2012","journal-title":"Nutrients"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"720393","DOI":"10.3389\/fimmu.2021.720393","article-title":"Gut Microbiota, Probiotics, and Their Interactions in Prevention and Treatment of Atopic Dermatitis: A Review","volume":"12","author":"Fang","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Anania, C., Brindisi, G., Martinelli, I., Bonucci, E., D\u2019Orsi, M., Ialongo, S., Nyffenegger, A., Raso, T., Spatuzzo, M., and De Castro, G. (2022). Probiotics Function in Preventing Atopic Dermatitis in Children. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23105409"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Kawauchi, H., Yanai, K., Wang, D.-Y., Itahashi, K., and Okubo, K. (2019). Antihistamines for Allergic Rhinitis Treatment from the Viewpoint of Nonsedative Properties. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20010213"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3109\/08923979109019704","article-title":"Cytokine inhibition by a novel steroid, mometasone furoate","volume":"13","author":"Barton","year":"1991","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1159\/000359984","article-title":"Glucocorticoids","volume":"100","author":"Barnes","year":"2014","journal-title":"Chem. Immunol. Allergy"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.1016\/S0091-6749(03)01878-5","article-title":"H1-receptors: Localization and role in airway physiology and in immune functions","volume":"112","author":"Togias","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.24966\/ADT-749X\/100003","article-title":"Antihistamines in Atopic Dermatitis Therapy","volume":"2","author":"Potekaev","year":"2015","journal-title":"Allergy Disord. Ther."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0149-2918(97)80071-9","article-title":"Sedative effects of antihistamines: Safety, performance, learning, and quality of life","volume":"19","author":"Nolen","year":"1997","journal-title":"Clin. Ther."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jaad.2017.12.077","article-title":"An assessment of the use of antihistamines in the management of atopic dermatitis","volume":"79","author":"He","year":"2018","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1034\/j.1399-3038.2002.01047.x","article-title":"Long-term treatment with cetirizine of infants with atopic dermatitis: A multi-country, double-blind, randomized, placebo-controlled trial (the ETACTM trial) over 18 months","volume":"13","author":"Diepgen","year":"2002","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"221","DOI":"10.4168\/aair.2015.7.3.221","article-title":"Specific Immunotherapy in Atopic Dermatitis","volume":"7","author":"Lee","year":"2015","journal-title":"Allergy Asthma Immunol. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"747323","DOI":"10.3389\/falgy.2021.747323","article-title":"Allergic Rhinitis: What Do We Know About Allergen-Specific Immunotherapy?","volume":"2","author":"Boonpiyathad","year":"2021","journal-title":"Front. Allergy"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0140-6736(16)30307-5","article-title":"Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting \u03b22 agonist: A randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial","volume":"388","author":"Wenzel","year":"2016","journal-title":"Lancet"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1165\/rcmb.2012-0080TR","article-title":"Targeting Interleukin-4 in Asthma: Lost in Translation?","volume":"47","author":"Maes","year":"2012","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1056\/NEJMoa1403290","article-title":"Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma","volume":"371","author":"Ortega","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1900588","DOI":"10.1183\/13993003.00588-2019","article-title":"Management of severe asthma: A European Respiratory Society\/American Thoracic Society guideline","volume":"55","author":"Holguin","year":"2020","journal-title":"Eur. Respir. J."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1056\/NEJMoa1403291","article-title":"SIRIUS Investigators Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma","volume":"371","author":"Bel","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/s12931-021-01775-z","article-title":"Real-life evidence of low-dose mepolizumab efficacy in EGPA: A case series","volume":"22","author":"Detoraki","year":"2021","journal-title":"Respir. Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/S2213-2600(15)00197-6","article-title":"Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: A randomised, double-blind, placebo-controlled, phase 2b trial","volume":"3","author":"Brightling","year":"2015","journal-title":"Lancet Respir. Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S2213-2600(16)30265-X","article-title":"Efficacy and safety of lebrikizumab in patients with uncontrolled asthma (LAVOLTA I and LAVOLTA II): Replicate, phase 3, randomised, double-blind, placebo-controlled trials","volume":"4","author":"Hanania","year":"2016","journal-title":"Lancet Respir. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.jaci.2011.09.009","article-title":"Interrupting IL-6\u2013receptor signaling improves atopic dermatitis but associates with bacterial superinfection","volume":"128","author":"Navarini","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Klonowska, J., Gle\u0144, J., Nowicki, R.J., and Trzeciak, M. (2018). New Cytokines in the Pathogenesis of Atopic Dermatitis\u2014New Therapeutic Targets. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19103086"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/ijos.2014.48","article-title":"The mucosal immune system in the oral cavity-an orchestra of T cell diversity","volume":"6","author":"Wu","year":"2014","journal-title":"Int. J. Oral Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nri3738","article-title":"Regional specialization within the intestinal immune system","volume":"14","author":"Mowat","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1038\/cti.2015.47","article-title":"Oral immune therapy: Targeting the systemic immune system via the gut immune system for the treatment of inflammatory bowel disease","volume":"5","author":"Ilan","year":"2016","journal-title":"Clin. Transl. Immunol."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Jacques, C., Chatelais, M., Fekir, K., Brulefert, A., and Floris, I. (2022). The Unitary Micro-Immunotherapy Medicine Interferon-\u03b3 (4 CH) Displays Similar Immunostimulatory and Immunomodulatory Effects than Those of Biologically Active Human Interferon-\u03b3 on Various Cell Types. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23042314"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"17842","DOI":"10.1038\/s41598-017-17865-2","article-title":"Cytokine profiling in healthy children shows association of age with cytokine concentrations","volume":"7","author":"Decker","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1559325820961723","DOI":"10.1177\/1559325820961723","article-title":"Pro-Inflammatory Cytokines at Ultra-Low Dose Exert Anti-Inflammatory Effect In Vitro: A Possible Mode of Action Involving Sub-Micron Particles?","volume":"18","author":"Floris","year":"2020","journal-title":"Dose Response Publ. Int. Hormesis Soc."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"397","DOI":"10.2147\/JIR.S174326","article-title":"2LARTH\u00ae, a micro-immunotherapy medicine, exerts anti-inflammatory effects in vitro and reduces TNF-\u03b1 and IL-1\u03b2 secretion","volume":"11","author":"Floris","year":"2018","journal-title":"J. Inflamm. Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1594573","DOI":"10.1155\/2020\/1594573","article-title":"The Micro-Immunotherapy Medicine 2LARTH\u00ae Reduces Inflammation and Symptoms of Rheumatoid Arthritis In Vivo","volume":"2020","author":"Floris","year":"2020","journal-title":"Int. J. Rheumatol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1164\/ajrccm.149.2.8306027","article-title":"Proinflammatory cytokines in nasal secretions of allergic subjects after antigen challenge","volume":"149","author":"Sim","year":"1994","journal-title":"Am. J. Respir Crit. Care Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13223-019-0368-8","article-title":"Serum IL-1\u03b2 can be a biomarker in children with severe persistent allergic rhinitis","volume":"15","author":"Han","year":"2019","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1093\/intimm\/dxg054","article-title":"IL-1 is required for allergen-specific Th2 cell activation and the development of airway hypersensitivity response","volume":"15","author":"Nakae","year":"2003","journal-title":"Int. Immunol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1002\/eji.200323801","article-title":"The IL-1 receptor 1 is critical for Th2 cell type airway immune responses in a mild but not in a more severe asthma model","volume":"33","author":"Schmitz","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"ref_88","first-page":"251","article-title":"Therapeutic effects of interleukin-1 receptor antagonist on allergic rhinitis of guinea pig","volume":"24","author":"Zhang","year":"2003","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"43568","DOI":"10.1038\/srep43568","article-title":"A possible role for neutrophils in allergic rhinitis revealed after cellular subclassification","volume":"7","author":"Arebro","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1080\/00016480310015173","article-title":"A role for neutrophils in intermittent allergic rhinitis","volume":"124","author":"Fransson","year":"2004","journal-title":"Acta Otolaryngol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"e48448","DOI":"10.7554\/eLife.48448","article-title":"Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis","volume":"8","author":"Walsh","year":"2019","journal-title":"eLife"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.jaci.2014.07.039","article-title":"IL-1 receptor antagonist reduces endotoxin-induced airway inflammation in healthy volunteers","volume":"135","author":"Hernandez","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cyto.2015.05.014","article-title":"IL-4 and IL-13 Signaling in Allergic Airway Disease","volume":"75","author":"Gour","year":"2015","journal-title":"Cytokine"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/35037009","article-title":"The role of allergy in the development of asthma","volume":"402","author":"Holt","year":"1999","journal-title":"Nature"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1084\/jem.20062211","article-title":"Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells","volume":"204","author":"Allakhverdi","year":"2007","journal-title":"J. Exp. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-7961-9-1","article-title":"Thymic stromal lymphopoietin (TSLP) is associated with allergic rhinitis in children with asthma","volume":"9","author":"Bunyavanich","year":"2011","journal-title":"Clin. Mol. Allergy"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1038\/ncomms3847","article-title":"Skin thymic stromal lymphopoietin initiates Th2 responses through an orchestrated immune cascade","volume":"4","author":"Hener","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/imr.12546","article-title":"The atopic march: Current insights into skin barrier dysfunction and epithelial cell-derived cytokines","volume":"278","author":"Han","year":"2017","journal-title":"Immunol. Rev."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"R7","DOI":"10.1016\/j.jaci.2009.07.012","article-title":"Cytokine modulation of atopic dermatitis filaggrin skin expression","volume":"124","author":"Howell","year":"2009","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"593","DOI":"10.4168\/aair.2019.11.5.593","article-title":"Interactions Between Atopic Dermatitis and Staphylococcus aureus Infection: Clinical Implications","volume":"11","author":"Kim","year":"2019","journal-title":"Allergy Asthma Immunol. Res."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jaci.2008.04.022","article-title":"Defective killing of Staphylococcus aureus in atopic dermatitis is associated with reduced mobilization of human beta-defensin-3","volume":"122","author":"Kisich","year":"2008","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1067\/mai.2001.118600","article-title":"IL-13 induces eosinophil recruitment into the lung by an IL-5\u2013 and eotaxin-dependent mechanism","volume":"108","author":"Pope","year":"2001","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"L134","DOI":"10.1152\/ajplung.2001.280.1.L134","article-title":"IL-13 induces mucin production by stimulating epidermal growth factor receptors and by activating neutrophils","volume":"280","author":"Shim","year":"2001","journal-title":"Am. J. Physiol.-Lung Cell Mol. Physiol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1084\/jem.188.9.1621","article-title":"Mechanisms of Acute Eosinophil Mobilization from the Bone Marrow Stimulated by Interleukin 5: The Role of Specific Adhesion Molecules and Phosphatidylinositol 3-Kinase","volume":"188","author":"Palframan","year":"1998","journal-title":"J. Exp. Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.4049\/jimmunol.1400732","article-title":"IL-5 triggers a cooperative cytokine network that promotes eosinophil precursor maturation","volume":"193","author":"Fulkerson","year":"2014","journal-title":"J. Immunol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1038\/aps.2013.88","article-title":"Mast cells and basophils are essential for allergies: Mechanisms of allergic inflammation and a proposed procedure for diagnosis","volume":"34","author":"He","year":"2013","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1016\/j.jaci.2009.11.017","article-title":"IgE, Mast Cells, Basophils, and Eosinophils","volume":"125","author":"Stone","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/0091-6749(88)91002-0","article-title":"Recombinant human interleukin-1 beta causes histamine release from human basophils","volume":"82","author":"Dinarello","year":"1988","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0165-2478(97)00115-6","article-title":"Tumor necrosis factor \u03b1 (TNF-\u03b1) activates human adenoidal and cutaneous mast cells to histamine secretion","volume":"59","author":"Pietrzak","year":"1997","journal-title":"Immunol. Lett."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1084\/jem.172.6.1577","article-title":"Interleukin 5 modifies histamine release and leukotriene generation by human basophils in response to diverse agonists","volume":"172","author":"Bischoff","year":"1990","journal-title":"J. Exp. Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1016\/j.jaci.2013.02.042","article-title":"Anti-IL-5 Therapy Reduces Mast Cells and IL-9 Cells in Pediatric Eosinophilic Esophagitis","volume":"131","author":"Otani","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.4049\/jimmunol.166.4.2712","article-title":"IL-13 Overexpression Predisposes to Anaphylaxis Following Antigen Sensitization","volume":"166","author":"Fallon","year":"2001","journal-title":"J. Immunol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"e2019524118","DOI":"10.1073\/pnas.2019524118","article-title":"Diverse innate stimuli activate basophils through pathways involving Syk and I\u03baB kinases","volume":"118","author":"Pellefigues","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_114","first-page":"129","article-title":"The role of IL-13 in IgE synthesis by allergic asthma patients","volume":"111","author":"Boeije","year":"1998","journal-title":"Clin. Exp. Immunol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"8080","DOI":"10.1073\/pnas.96.14.8080","article-title":"IL-4 enhances proliferation and mediator release in mature human mast cells","volume":"96","author":"Bischoff","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"4699","DOI":"10.1182\/blood-2009-07-230631","article-title":"IL-6 increases B-cell IgG production in a feed-forward proinflammatory mechanism to skew hematopoiesis and elevate myeloid production","volume":"115","author":"Maeda","year":"2010","journal-title":"Blood"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1475-2840-9-62","article-title":"The ubiquitous interleukin-6: A time for reappraisal","volume":"9","author":"Fisman","year":"2010","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/1523-1747.ep12469875","article-title":"Increased Interleukin 6 Production by T Cells Derived from Patients with Atopic Dermatitis","volume":"100","author":"Toshitani","year":"1993","journal-title":"J. Investig. Dermatol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/0091-6749(93)90066-O","article-title":"Interleukin-6 and interleukin-1 alpha production is associated with antigen-induced late nasal response","volume":"92","author":"Gosset","year":"1993","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1006\/cyto.2002.2010","article-title":"IL-6 Enhances Ige-Dependent Histamine Release from Human Peripheral Blood-Derived Cultured Mast Cells","volume":"20","author":"Kikuchi","year":"2002","journal-title":"Cytokine"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1346-8138.2001.tb00126.x","article-title":"Acute Urticaria with Elevated Circulating Interleukin-6 Is Resistant to Anti-Histamine Treatment","volume":"28","author":"Fujii","year":"2001","journal-title":"J. Dermatol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1016\/j.jaci.2015.09.059","article-title":"IL-6 promotes an increase in human mast cell number and reactivity through suppression of SOCS3","volume":"137","author":"Desai","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.4049\/jimmunol.154.4.1956","article-title":"Overexpression of IL-10 in atopic dermatitis. Contrasting cytokine patterns with delayed-type hypersensitivity reactions","volume":"154","author":"Ohmen","year":"1995","journal-title":"J. Immunol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1172\/JCI18246","article-title":"IL-10 is critical for Th2 responses in a murine model of allergic dermatitis","volume":"112","author":"Laouini","year":"2003","journal-title":"J. Clin. Investig."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"4865","DOI":"10.4049\/jimmunol.1600066","article-title":"IL-10 enhances IgE-mediated mast cell responses and is essential for the development of experimental food allergy in IL-10-deficient mice","volume":"196","author":"Polukort","year":"2016","journal-title":"J. Immunol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s00011-003-1242-0","article-title":"Histamine dilutions modulate basophil activation","volume":"53","author":"Belon","year":"2004","journal-title":"Inflamm. Res."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.homp.2013.02.007","article-title":"A randomized placebo-controlled pilot study of Cat saliva 9cH and Histaminum 9cH in cat allergic adults","volume":"102","author":"Naidoo","year":"2013","journal-title":"Homeopathy"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1164\/rccm.2201035","article-title":"Effect of cat and dog ownership on sensitization and development of asthma among preteenage children","volume":"166","author":"Perzanowski","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Khaheshi, I., Keshavarz, S., Imani Fooladi, A.A., Ebrahimi, M., Yazdani, S., Panahi, Y., Shohrati, M., and Nourani, M.R. (2011). Loss of expression of TGF-\u03b2s and their receptors in chronic skin lesions induced by sulfur mustard as compared with chronic contact dermatitis patients. BMC Dermatol., 11.","DOI":"10.1186\/1471-5945-11-2"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1067\/mai.2001.117259","article-title":"Atopic dermatitis is associated with a low-producer transforming growth factor \u03b21 cytokine genotype","volume":"108","author":"Arkwright","year":"2001","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"10618","DOI":"10.1074\/jbc.270.18.10618","article-title":"Processing of transforming growth factor beta 1 precursor by human furin convertase","volume":"270","author":"Dubois","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1146\/annurev.biochem.67.1.753","article-title":"TGF-beta signal transduction","volume":"67","year":"1998","journal-title":"Annu. Rev. Biochem."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/jcp.30529","article-title":"TGF-\u03b2 signaling: A recap of SMAD-independent and SMAD-dependent pathways","volume":"237","author":"Aashaq","year":"2022","journal-title":"J. Cell Physiol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3389\/fimmu.2020.00311","article-title":"NK Cell Function Regulation by TGF-\u03b2-Induced Epigenetic Mechanisms","volume":"11","author":"Regis","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"ra19","DOI":"10.1126\/scisignal.aad1884","article-title":"TGF-\u03b2 inhibits the activation and functions of NK cells by repressing the mTOR pathway","volume":"9","author":"Viel","year":"2016","journal-title":"Sci. Signal."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1600-065X.2007.00565.x","article-title":"\u201cYin-Yang\u201d functions of transforming growth factor-beta and T regulatory cells in immune regulation","volume":"220","author":"Wan","year":"2007","journal-title":"Immunol. Rev."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/jmcb\/mjr033","article-title":"TGF-\u03b2: The sword, the wand, and the shield of FOXP3(+) regulatory T cells","volume":"4","author":"Tran","year":"2012","journal-title":"J. Mol. Cell Biol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s13223-021-00577-8","article-title":"CD8+ Tregs ameliorate inflammatory reactions in a murine model of allergic rhinitis","volume":"17","author":"Lin","year":"2021","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"7318","DOI":"10.4049\/jimmunol.180.11.7318","article-title":"Regulatory role of B cells in a murine model of allergic airway disease","volume":"180","author":"Singh","year":"2008","journal-title":"J. Immunol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1038\/sj.jid.5700809","article-title":"Smad3 Signal Transducer Regulates Skin Inflammation and Specific IgE Response in Murine Model of Atopic Dermatitis","volume":"127","author":"Anthoni","year":"2007","journal-title":"J. Investig. Dermatol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"a016873","DOI":"10.1101\/cshperspect.a016873","article-title":"MHC Class II Antigen Presentation by Dendritic Cells Regulated through Endosomal Sorting","volume":"5","author":"Broeke","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1365-2222.1996.tb00594.x","article-title":"Antigen presenting cells in the nasal mucosa of patients with allergic rhinitis during allergen provocation","volume":"26","author":"Godthelp","year":"1996","journal-title":"Clin. Exp. Allergy"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1369\/jhc.4A6539.2005","article-title":"HLA-DR- and CD11c-positive Dendritic Cells Penetrate beyond Well-developed Epithelial Tight Junctions in Human Nasal Mucosa of Allergic Rhinitis","volume":"53","author":"Takano","year":"2005","journal-title":"J. Histochem. Cytochem."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0190-9622(89)70073-6","article-title":"Characterization of intercellular adhesion molecule-1 and HLA-DR expression in normal inflamed skin: Modulation by recombinant gamma interferon and tumor necrosis factor","volume":"20","author":"Griffiths","year":"1989","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.3389\/fimmu.2018.01352","article-title":"Phenotype, Function, and Mobilization of 6-Sulfo LacNAc-Expressing Monocytes in Atopic Dermatitis","volume":"9","author":"Baran","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s41385-018-0130-4","article-title":"Pulmonary group 2 innate lymphoid cells: Surprises and challenges","volume":"12","author":"Starkey","year":"2019","journal-title":"Mucosal Immunol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1111\/all.14835","article-title":"Effect of intranasal corticosteroid treatment on allergen-induced changes in group 2 innate lymphoid cells in allergic rhinitis with mild asthma","volume":"76","author":"Xie","year":"2021","journal-title":"Allergy"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1559325820914092","DOI":"10.1177\/1559325820914092","article-title":"Potential Role of the Micro-Immunotherapy Medicine 2LALERG in the Treatment of Pollen-Induced Allergic Inflammation","volume":"18","author":"Floris","year":"2020","journal-title":"Dose-Response Publ. Int. Hormesis Soc."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.reval.2011.03.008","article-title":"Efficacit\u00e9 clinique du 2L\u00aeALERG, un nouveau traitement de type immunomodulateur par voie sublinguale dans le rhume des foins: Une \u00e9tude en double insu contre placebo","volume":"51","author":"Cumps","year":"2011","journal-title":"Rev. Fr. Allergol."},{"key":"ref_150","unstructured":"Labo\u2019Life (2022, August 12). Randomized, Double-Blind, Placebo-Controlled Study to Measure 2L\u00aeALERG (Homeopathic Drug) Efficacy on Symptoms of Allergic Rhinitis and Allergic Rhinoconjunctivitis in Patients with a Seasonal Allergy to Grass Pollen. Clinicaltrials.gov; Report No.: Study\/NCT02690935, Available online: https:\/\/clinicaltrials.gov\/ct2\/show\/study\/NCT02690935."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13601-017-0153-z","article-title":"Multi-morbidities of allergic rhinitis in adults: European Academy of Allergy and Clinical Immunology Task Force Report","volume":"7","author":"Cingi","year":"2017","journal-title":"Clin. Transl. Allergy"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/pai.13036","article-title":"Early molecular biomarkers predicting the evolution of allergic rhinitis and its comorbidities: A longitudinal multicenter study of a patient cohort","volume":"30","author":"Cipriani","year":"2019","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1111\/all.13701","article-title":"ARIA pharmacy 2018 \u201cAllergic rhinitis care pathways for community pharmacy\u201d","volume":"74","author":"Costa","year":"2019","journal-title":"Allergy"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/2\/1483\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:04:04Z","timestamp":1760119444000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/2\/1483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,12]]},"references-count":153,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["ijms24021483"],"URL":"https:\/\/doi.org\/10.3390\/ijms24021483","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,12]]}}}