{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T21:56:47Z","timestamp":1773611807658,"version":"3.50.1"},"reference-count":33,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T00:00:00Z","timestamp":1673481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>In a basic medium, 5-Mercapto-1,2,4-triazoles pass into the thiol form, allowing their transformation into sodium salts, which, in reaction with sodium monochloroacetate, lead to sodium 5-thioacetates of 1,2,4-triazoles-3,4-disubstituted. Sulfur derivatives converted to pivalic mixed anhydrides were used as active forms in the acylation of 6-amino penicillanic acid (6-AP) to obtain new semisynthetic penicillins. They contain in the molecule, together with the \u03b2-lactam ring, the nucleus 3-[(5-nitroindazol-1\u2032-yl-methyl)]-4-aryl-5-mercapto-1,2,4-triazole, both contributing to an important antibacterial effect. The structure of the new antibiotics was confirmed by the results of elemental and spectral analysis (FT-IR, 1H- and 13C-NMR). The synthetic penicillins were tested for toxicological action and antibacterial activity and the obtained results were close to those for amoxicillin, the reference drug.<\/jats:p>","DOI":"10.3390\/ijms24021497","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T04:29:38Z","timestamp":1673497778000},"page":"1497","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["New Semisynthetic Penicillins Obtained by Coupling of the 6-Aminopenicillanic Acid with 5-Mercapto-1,2,4-triazoles-3,4-disubstituted"],"prefix":"10.3390","volume":"24","author":[{"given":"Corina","family":"Cheptea","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Medical Bioengineering, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 9-13 M. Kogalniceanu Str., RO-700454 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandru","family":"Zara","sequence":"additional","affiliation":[{"name":"Faculty of Physics, Alexandru Ioan Cuza University, 11 Carol I Blvd., RO-700506 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2474-5133","authenticated-orcid":false,"given":"Dan Gheorghe","family":"Dimitriu","sequence":"additional","affiliation":[{"name":"Faculty of Physics, Alexandru Ioan Cuza University, 11 Carol I Blvd., RO-700506 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeriu","family":"Sunel","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Alexandru Ioan Cuza University, 11 Carol I Blvd., RO-700506 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana Ortansa","family":"Dorohoi","sequence":"additional","affiliation":[{"name":"Faculty of Physics, Alexandru Ioan Cuza University, 11 Carol I Blvd., RO-700506 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0531-504X","authenticated-orcid":false,"given":"Toni Andor","family":"Cigu","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Alexandru Ioan Cuza University, 11 Carol I Blvd., RO-700506 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0065-2164(08)70404-0","article-title":"Structure-activity relationships among semisynthetic cephalosporins","volume":"13","author":"Sassiver","year":"1970","journal-title":"Adv. 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