{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:59:37Z","timestamp":1792547977673,"version":"4.5.0"},"reference-count":32,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>(1) Background: In developed countries, the prevalence of apical periodontitis (AP) varies from 20% to 50% for reasons that could be associated with the apical periodontitis microbiota ecology. (2) Methods: We performed a clinical study in the Odontology department of Toulouse hospital in France, to sequence the 16S rRNA gene of AP microbiota and collect clinical parameters from 94 patients. Forty-four patients were characterized with a PAI (periapical index of AP severity) score lower or equal to 3, while the others had superior scores (n = 50). (3) Results: The low diversity of granuloma microbiota is associated with the highest severity (PAI = 5) of periapical lesions (Odds Ratio 4.592, IC 95% [1.6329; 14.0728]; p = 0.001; notably, a lower relative abundance of Burkholderiaceae and a higher relative abundance of Pseudomonas and Prevotella). We also identified that high blood pressure (HBP) is associated with the increase in PAI scores. (4) Conclusions: Our data show that a low diversity of bacterial ecology of the AP is associated with severe PAI scores, suggesting a causal mechanism. Furthermore, a second risk factor was blood pressure associated with the severity of apical periodontitis.<\/jats:p>","DOI":"10.3390\/ijms24021589","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T04:02:04Z","timestamp":1673582524000},"page":"1589","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Low-Diversity Microbiota in Apical Periodontitis and High Blood Pressure Are Signatures of the Severity of Apical Lesions in Humans"],"prefix":"10.3390","volume":"24","author":[{"given":"Matthieu","family":"Minty","sequence":"first","affiliation":[{"name":"D\u00e9partement Dentaire, Universit\u00e9 Paul Sabatier III (UPS), 3 Chemin des Mara\u00eechers, CEDEX 9, 31062 Toulouse, France"},{"name":"Service d\u2019Odontologie Toulouse, CHU Toulouse, 3 Chemin des Mara\u00eechers, CEDEX 9, 31062 Toulouse, France"},{"name":"UMR1297 Inserm, Team InCOMM\/Intestine ClinicOmics Metabolism & Microbiota, Institut des Maladies M\u00e9taboliques et Cardiovasculaires (I2MC), Universit\u00e9 Paul Sabatier, 1 Avenue Jean Poulhes, 31432 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"L\u00ea","sequence":"additional","affiliation":[{"name":"D\u00e9partement Dentaire, Universit\u00e9 Paul Sabatier III (UPS), 3 Chemin des Mara\u00eechers, CEDEX 9, 31062 Toulouse, France"},{"name":"Service d\u2019Odontologie Toulouse, CHU Toulouse, 3 Chemin des Mara\u00eechers, CEDEX 9, 31062 Toulouse, France"},{"name":"UMR1297 Inserm, Team InCOMM\/Intestine ClinicOmics Metabolism & Microbiota, Institut des Maladies M\u00e9taboliques et Cardiovasculaires (I2MC), Universit\u00e9 Paul Sabatier, 1 Avenue Jean Poulhes, 31432 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0049-7622","authenticated-orcid":false,"given":"Thibault","family":"Canceill","sequence":"additional","affiliation":[{"name":"D\u00e9partement Dentaire, Universit\u00e9 Paul Sabatier III (UPS), 3 Chemin des Mara\u00eechers, CEDEX 9, 31062 Toulouse, France"},{"name":"Service d\u2019Odontologie Toulouse, CHU Toulouse, 3 Chemin des Mara\u00eechers, CEDEX 9, 31062 Toulouse, France"},{"name":"UMR1297 Inserm, Team InCOMM\/Intestine ClinicOmics Metabolism & Microbiota, Institut des Maladies M\u00e9taboliques et Cardiovasculaires (I2MC), Universit\u00e9 Paul Sabatier, 1 Avenue Jean Poulhes, 31432 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Thomas","sequence":"additional","affiliation":[{"name":"D\u00e9partement Dentaire, Universit\u00e9 Paul Sabatier III (UPS), 3 Chemin des Mara\u00eechers, CEDEX 9, 31062 Toulouse, 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