{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:41:05Z","timestamp":1781880065006,"version":"3.54.5"},"reference-count":43,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Program of Medical Discipline Leader in Yunnan Health System","award":["D-2019027"],"award-info":[{"award-number":["D-2019027"]}]},{"name":"Program of Medical Discipline Leader in Yunnan Health System","award":["2019FB089"],"award-info":[{"award-number":["2019FB089"]}]},{"name":"Program of Medical Discipline Leader in Yunnan Health System","award":["D-2019023"],"award-info":[{"award-number":["D-2019023"]}]},{"name":"Program of Medical Discipline Leader in Yunnan Health System","award":["2019HB044"],"award-info":[{"award-number":["2019HB044"]}]},{"DOI":"10.13039\/501100005273","name":"Natural Science Foundation of Yunnan Province","doi-asserted-by":"publisher","award":["D-2019027"],"award-info":[{"award-number":["D-2019027"]}],"id":[{"id":"10.13039\/501100005273","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005273","name":"Natural Science Foundation of Yunnan Province","doi-asserted-by":"publisher","award":["2019FB089"],"award-info":[{"award-number":["2019FB089"]}],"id":[{"id":"10.13039\/501100005273","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005273","name":"Natural Science Foundation of Yunnan Province","doi-asserted-by":"publisher","award":["D-2019023"],"award-info":[{"award-number":["D-2019023"]}],"id":[{"id":"10.13039\/501100005273","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005273","name":"Natural Science Foundation of Yunnan Province","doi-asserted-by":"publisher","award":["2019HB044"],"award-info":[{"award-number":["2019HB044"]}],"id":[{"id":"10.13039\/501100005273","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Program of Medical Discipline Leader in Yunnan Health System","award":["D-2019027"],"award-info":[{"award-number":["D-2019027"]}]},{"name":"Program of Medical Discipline Leader in Yunnan Health System","award":["2019FB089"],"award-info":[{"award-number":["2019FB089"]}]},{"name":"Program of Medical Discipline Leader in Yunnan Health System","award":["D-2019023"],"award-info":[{"award-number":["D-2019023"]}]},{"name":"Program of Medical Discipline Leader in Yunnan Health System","award":["2019HB044"],"award-info":[{"award-number":["2019HB044"]}]},{"name":"Technological Innovation Talents of Yunnan Province","award":["D-2019027"],"award-info":[{"award-number":["D-2019027"]}]},{"name":"Technological Innovation Talents of Yunnan Province","award":["2019FB089"],"award-info":[{"award-number":["2019FB089"]}]},{"name":"Technological Innovation Talents of Yunnan Province","award":["D-2019023"],"award-info":[{"award-number":["D-2019023"]}]},{"name":"Technological Innovation Talents of Yunnan Province","award":["2019HB044"],"award-info":[{"award-number":["2019HB044"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cancer-associated factors have been largely identified in the understanding of tumorigenesis and progression. However, aminoacyl-transfer RNA (tRNA) synthetases (aaRSs) have so far been neglected in cancer research due to their canonical activities in protein translation and synthesis. FARSA, the alpha subunit of the phenylalanyl-tRNA synthetase is elevated across many cancer types, but its function in mantle cell lymphoma (MCL) remains undetermined. Herein, we found the lowest levels of FARSA in patients with MCL compared with other subtypes of lymphomas, and the same lower levels of FARSA were observed in chemoresistant MCL cell lines. Unexpectedly, despite the essential catalytic roles of FARSA, knockdown of FARSA in MCL cells did not lead to cell death but resulted in accelerated cell proliferation and cell cycle, whereas overexpression of FARSA induced remarkable cell-cycle arrest and overwhelming apoptosis. Further RNA sequencing (RNA-seq) analysis and validation experiments confirmed a strong connection between FARSA and cell cycle in MCL cells. Importantly, FARSA leads to the alteration of cell cycle and survival via both PI3K-AKT and FOXO1-RAG1 axes, highlighting a FARSA-mediated regulatory network in MCL cells. Our findings, for the first time, reveal the noncanonical roles of FARSA in MCL cells, and provide novel insights into understanding the pathogenesis and progression of B-cell malignancies.<\/jats:p>","DOI":"10.3390\/ijms24021608","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T05:09:32Z","timestamp":1673586572000},"page":"1608","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["First Report of FARSA in the Regulation of Cell Cycle and Survival in Mantle Cell Lymphoma Cells via PI3K-AKT and FOXO1-RAG1 Axes"],"prefix":"10.3390","volume":"24","author":[{"given":"Min","family":"Feng","sequence":"first","affiliation":[{"name":"Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China"},{"name":"School of Life Sciences, Yunnan University, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China"},{"name":"School of Life Sciences, Yunnan University, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilan","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2684-512X","authenticated-orcid":false,"given":"Han","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/nrc3124","article-title":"Aminoacyl-tRNA synthetases and tumorigenesis: More than housekeeping","volume":"11","author":"Kim","year":"2011","journal-title":"Nat. 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