{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:36:36Z","timestamp":1790843796178,"version":"4.1.0"},"reference-count":79,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T00:00:00Z","timestamp":1673827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"FWF Austrian Science Fund","doi-asserted-by":"publisher","award":["P31186-B28"],"award-info":[{"award-number":["P31186-B28"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The clinical success of solid organ transplantation is still limited by the insufficiency of immunosuppressive regimens to control chronic rejection and late graft loss. Moreover, serious side effects caused by chronic immunosuppressive treatment increase morbidity and mortality in transplant patients. Regulatory T cells (Tregs) have proven to be efficient in the induction of allograft tolerance and prolongation of graft survival in numerous preclinical models, and treatment has now moved to the clinics. The results of the first Treg-based clinical trials seem promising, proving the feasibility and safety of Treg therapy in clinical organ transplantation. However, many questions regarding Treg phenotype, optimum dosage, antigen-specificity, adjunct immunosuppressants and efficacy remain open. This review summarizes the results of the first Treg-based clinical trials for tolerance induction in solid organ transplantation and recapitulates what we have learnt so far and which questions need to be resolved before Treg therapy can become part of daily clinical practice. In addition, we discuss new strategies being developed for induction of donor-specific tolerance in solid organ transplantation with the clinical aims of prolonged graft survival and minimization of immunosuppression.<\/jats:p>","DOI":"10.3390\/ijms24021752","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T02:29:55Z","timestamp":1673836195000},"page":"1752","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Treg Therapy for the Induction of Immune Tolerance in Transplantation\u2014Not Lost in Translation?"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4071-9397","authenticated-orcid":false,"given":"Nina","family":"Pilat","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Medical University of Vienna, 1090 Vienna, Austria"},{"name":"Center for Biomedical Research, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5514-7232","authenticated-orcid":false,"given":"Romy","family":"Steiner","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical University of Vienna, 1090 Vienna, Austria"},{"name":"Center for Biomedical Research, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9161-7502","authenticated-orcid":false,"given":"Jonathan","family":"Sprent","sequence":"additional","affiliation":[{"name":"Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia"},{"name":"St Vincent\u2019s Clinical School, University of New South Wales, Sydney, NSW 2010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/172603a0","article-title":"Actively acquired tolerance of foreign cells","volume":"172","author":"Billingham","year":"1953","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"688460","DOI":"10.3389\/fimmu.2021.688460","article-title":"Harnessing Mechanisms of Immune Tolerance to Improve Outcomes in Solid Organ Transplantation: A Review","volume":"12","author":"Slepicka","year":"2021","journal-title":"Front. 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